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The map label for this gene is nhaK [H]

Identifier: 116516836

GI number: 116516836

Start: 589861

End: 591915

Strand: Direct

Name: nhaK [H]

Synonym: SPD_0569

Alternate gene names: 116516836

Gene position: 589861-591915 (Clockwise)

Preceding gene: 116516269

Following gene: 116516563

Centisome position: 28.83

GC content: 41.7

Gene sequence:

>2055_bases
GTGGAATTACTGATTTACCTCATCCTATTTTTACTGGTTTTGATTGTCTCAAGTACAACCAATAAGCTCCTGCCCTTTTT
GCCTCTCCCTTTGGTGCAAATTCTTTTGGGAATTGTGATTGGTCTCTTTTTACCCAATACCGACTTTCACCTCAATACGG
AGTTGTTTTTGGCCCTGGTTATCGGACCCTTGCTTTTCCGAGAGGCTGAAGAAGCAGATGTTACGGCTATTTTAAAACAC
TGGCGAATCATTGTTTATCTCATATTTCCAGTGATTTTTATCTCGACCCTGAGTTTGGGTGGCTTGGCCCATCTTCTTTG
GTTCAGCCTTCCCTTGGCAGCTTGCTTGGCTGTTGGGGCAGCCCTTGGTCCTACGGACTTGGTGGCCTTTGCCTCTCTTT
CGGAGCGTTTTAGCTTTCCTAAGCGCGTGTCCAATATTCTTAAGGGCGAAGGACTCTTGAATGATGCTTCTGGTTTGGTG
GCTTTTCAGGTAGCTTTGACAGCTTGGACAACTGGAGCTTTTTCTCTGGGGCAAGCTAGCAGTTCGCTCATCTTTTCAAT
CCTAGGCGGTTTTTTAATTGGATTTTTAACAGCCATGACCAACCGCTTCCTCCATACCTTCTTGCTAAGTGTGCGCGCAA
CGGATATTGCCAGTGAACTTTTATTAGAATTAAGTTTGCCTCTAGTGACCTTCTTTCTGGCAGAAGAAGTTCATGTTTCA
GGGATTATTGCCGTCGTAGTTGCTGGAATTTTAAAGGCAAGTCGTTTCAAGAAAATCACGCTCCTCGAAGCCCAAGTGGA
TACGGTGACCGAGACGGTCTGGCATACAGTGACCTTTATGCTCAACGGTTCTGTCTTTGTGATTTTAGGGATGGAGTTGG
AAATGATAGCAGAACCTATCTTGACCAATCCAATCTATAATCCTCTACTTTTATTGCTATCTCTCATCGCCCTTACCTTT
GTCCTCTTTGTCATTCGTTTTATTATGATCTATGGCTATTATGCCTATAGAACCCGACGCCTCAAGAAAAAGCTAAATAA
GTATATGAAGGACATGTTTCTCTTGACCTTTTCAGGTGTTAAGGGAACGGTGTCGATTGCTACGATTCTCTTGATACCAA
GTAATCTAGAACAAGAGTATCCTCTTTTGCTTTTCCTTGTTGCAGGTGTGACGCTTGTCAGCTTTTTAACAGGTCTCTTG
ATCTTGCCTCATCTTTCTGATGAAGAGGAAGAAAGCAAGGATTATCTCATGCATATCGCCATTTTGAATGAAGTAACGCT
AGAGTTGGAAAAAGAGTTGGAAGACACCAGAAATAAACTTCCCCTCTATGCGGCTATTGACAATTATCATGGACGTATTG
AAAATCTCATTTTAAGCCAAGAAAACCAGGATGATCAAGAAGACTGGGCTGCTTTGAAACTCTTGATTCTTAGTATTGAA
AGTGATGGTTTGGAACAGGCCTATGAAGAGGGGAACATTAGCAATCGTGCTTACCGAGTTTACCAACGTTATCTGAAAAA
TATAGAACAAGGAATCAATCGTAAACTTGCCTCAAGACTGACCTATTATTTTCTTGTTTCCTTGAGGATTTTACGTTTTC
TCCTTCATGAAGTTTTTACTCTTGGAAAGACCTTCCGTAGCTGGAAGGACAAGGAGCAAAGCCGTCTCCGTGCTCTTGAT
TATGACCAAATTGCAGAGCTCTATCTTGCCAATACGGAGATGATTATTGAAAGTTTGGAAAACCTGAAGGGAGTCTACAG
ACGCTCTTTGATTAGTTTTATGCAGGAGTCTCGTCTTCGAGAAACAACTATTATCAGCAGTGGTGCCTTTGTCGAACGGG
TTATCAATCGTGTCAAACCCAACAATATCAATGAAATGCTGAGAGGCTATTATCTGGAGCGCAAGTTGATTTTCGAATAC
GAAGAAAAACGATTAATTACAACTAAGTATGCCAAGAAATTACGACAAAATGTAAATAACTTAGAGAACTATTCCTTGAA
GGAAGCTGCCAATACCCTGCCGTATGATATGGTGGAATTGGTAAGAAGAAATTAG

Upstream 100 bases:

>100_bases
GAAAAATTGAGCACAAAGACTGTTCCAAGATTGACCAAAAAATCAAAGAGCAGAAGGAGATATTTGAATCCTGTTGTAAA
AAAGATTAAGGAGGACGTGC

Downstream 100 bases:

>100_bases
TTAATACTCTTCGAAAATCTCTTCAAACCACGTCAGCGTCGCCTTACCGTATGTATGTGACTGACTTCGTCAGTCTTATC
TACAACCTCAAAACAGTGTT

Product: sodium/hydrogen exchanger family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 684; Mature: 684

Protein sequence:

>684_residues
MELLIYLILFLLVLIVSSTTNKLLPFLPLPLVQILLGIVIGLFLPNTDFHLNTELFLALVIGPLLFREAEEADVTAILKH
WRIIVYLIFPVIFISTLSLGGLAHLLWFSLPLAACLAVGAALGPTDLVAFASLSERFSFPKRVSNILKGEGLLNDASGLV
AFQVALTAWTTGAFSLGQASSSLIFSILGGFLIGFLTAMTNRFLHTFLLSVRATDIASELLLELSLPLVTFFLAEEVHVS
GIIAVVVAGILKASRFKKITLLEAQVDTVTETVWHTVTFMLNGSVFVILGMELEMIAEPILTNPIYNPLLLLLSLIALTF
VLFVIRFIMIYGYYAYRTRRLKKKLNKYMKDMFLLTFSGVKGTVSIATILLIPSNLEQEYPLLLFLVAGVTLVSFLTGLL
ILPHLSDEEEESKDYLMHIAILNEVTLELEKELEDTRNKLPLYAAIDNYHGRIENLILSQENQDDQEDWAALKLLILSIE
SDGLEQAYEEGNISNRAYRVYQRYLKNIEQGINRKLASRLTYYFLVSLRILRFLLHEVFTLGKTFRSWKDKEQSRLRALD
YDQIAELYLANTEMIIESLENLKGVYRRSLISFMQESRLRETTIISSGAFVERVINRVKPNNINEMLRGYYLERKLIFEY
EEKRLITTKYAKKLRQNVNNLENYSLKEAANTLPYDMVELVRRN

Sequences:

>Translated_684_residues
MELLIYLILFLLVLIVSSTTNKLLPFLPLPLVQILLGIVIGLFLPNTDFHLNTELFLALVIGPLLFREAEEADVTAILKH
WRIIVYLIFPVIFISTLSLGGLAHLLWFSLPLAACLAVGAALGPTDLVAFASLSERFSFPKRVSNILKGEGLLNDASGLV
AFQVALTAWTTGAFSLGQASSSLIFSILGGFLIGFLTAMTNRFLHTFLLSVRATDIASELLLELSLPLVTFFLAEEVHVS
GIIAVVVAGILKASRFKKITLLEAQVDTVTETVWHTVTFMLNGSVFVILGMELEMIAEPILTNPIYNPLLLLLSLIALTF
VLFVIRFIMIYGYYAYRTRRLKKKLNKYMKDMFLLTFSGVKGTVSIATILLIPSNLEQEYPLLLFLVAGVTLVSFLTGLL
ILPHLSDEEEESKDYLMHIAILNEVTLELEKELEDTRNKLPLYAAIDNYHGRIENLILSQENQDDQEDWAALKLLILSIE
SDGLEQAYEEGNISNRAYRVYQRYLKNIEQGINRKLASRLTYYFLVSLRILRFLLHEVFTLGKTFRSWKDKEQSRLRALD
YDQIAELYLANTEMIIESLENLKGVYRRSLISFMQESRLRETTIISSGAFVERVINRVKPNNINEMLRGYYLERKLIFEY
EEKRLITTKYAKKLRQNVNNLENYSLKEAANTLPYDMVELVRRN
>Mature_684_residues
MELLIYLILFLLVLIVSSTTNKLLPFLPLPLVQILLGIVIGLFLPNTDFHLNTELFLALVIGPLLFREAEEADVTAILKH
WRIIVYLIFPVIFISTLSLGGLAHLLWFSLPLAACLAVGAALGPTDLVAFASLSERFSFPKRVSNILKGEGLLNDASGLV
AFQVALTAWTTGAFSLGQASSSLIFSILGGFLIGFLTAMTNRFLHTFLLSVRATDIASELLLELSLPLVTFFLAEEVHVS
GIIAVVVAGILKASRFKKITLLEAQVDTVTETVWHTVTFMLNGSVFVILGMELEMIAEPILTNPIYNPLLLLLSLIALTF
VLFVIRFIMIYGYYAYRTRRLKKKLNKYMKDMFLLTFSGVKGTVSIATILLIPSNLEQEYPLLLFLVAGVTLVSFLTGLL
ILPHLSDEEEESKDYLMHIAILNEVTLELEKELEDTRNKLPLYAAIDNYHGRIENLILSQENQDDQEDWAALKLLILSIE
SDGLEQAYEEGNISNRAYRVYQRYLKNIEQGINRKLASRLTYYFLVSLRILRFLLHEVFTLGKTFRSWKDKEQSRLRALD
YDQIAELYLANTEMIIESLENLKGVYRRSLISFMQESRLRETTIISSGAFVERVINRVKPNNINEMLRGYYLERKLIFEY
EEKRLITTKYAKKLRQNVNNLENYSLKEAANTLPYDMVELVRRN

Specific function: Transporter involved in the efflux of sodium, potassium, lithium and rubidium [H]

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. Nhak (TC 2.A.36.3.2) subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790501, Length=548, Percent_Identity=28.4671532846715, Blast_Score=176, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6320663, Length=386, Percent_Identity=23.5751295336788, Blast_Score=68, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR018417
- InterPro:   IPR004705
- InterPro:   IPR002014 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 77787; Mature: 77787

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELLIYLILFLLVLIVSSTTNKLLPFLPLPLVQILLGIVIGLFLPNTDFHLNTELFLALV
CHHHHHHHHHHHHHHHHCCCHHCCCCCCHHHHHHHHHHHHHHHCCCCCCEECHHHHHHHH
IGPLLFREAEEADVTAILKHWRIIVYLIFPVIFISTLSLGGLAHLLWFSLPLAACLAVGA
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
ALGPTDLVAFASLSERFSFPKRVSNILKGEGLLNDASGLVAFQVALTAWTTGAFSLGQAS
CCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCHHCCHH
SSLIFSILGGFLIGFLTAMTNRFLHTFLLSVRATDIASELLLELSLPLVTFFLAEEVHVS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIIAVVVAGILKASRFKKITLLEAQVDTVTETVWHTVTFMLNGSVFVILGMELEMIAEPI
HHHHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHH
LTNPIYNPLLLLLSLIALTFVLFVIRFIMIYGYYAYRTRRLKKKLNKYMKDMFLLTFSGV
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
KGTVSIATILLIPSNLEQEYPLLLFLVAGVTLVSFLTGLLILPHLSDEEEESKDYLMHIA
CHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
ILNEVTLELEKELEDTRNKLPLYAAIDNYHGRIENLILSQENQDDQEDWAALKLLILSIE
HHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHC
SDGLEQAYEEGNISNRAYRVYQRYLKNIEQGINRKLASRLTYYFLVSLRILRFLLHEVFT
CCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGKTFRSWKDKEQSRLRALDYDQIAELYLANTEMIIESLENLKGVYRRSLISFMQESRLR
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ETTIISSGAFVERVINRVKPNNINEMLRGYYLERKLIFEYEEKRLITTKYAKKLRQNVNN
HHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LENYSLKEAANTLPYDMVELVRRN
HHCCCHHHHHCCCCHHHHHHHHCC
>Mature Secondary Structure
MELLIYLILFLLVLIVSSTTNKLLPFLPLPLVQILLGIVIGLFLPNTDFHLNTELFLALV
CHHHHHHHHHHHHHHHHCCCHHCCCCCCHHHHHHHHHHHHHHHCCCCCCEECHHHHHHHH
IGPLLFREAEEADVTAILKHWRIIVYLIFPVIFISTLSLGGLAHLLWFSLPLAACLAVGA
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
ALGPTDLVAFASLSERFSFPKRVSNILKGEGLLNDASGLVAFQVALTAWTTGAFSLGQAS
CCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCHHCCHH
SSLIFSILGGFLIGFLTAMTNRFLHTFLLSVRATDIASELLLELSLPLVTFFLAEEVHVS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIIAVVVAGILKASRFKKITLLEAQVDTVTETVWHTVTFMLNGSVFVILGMELEMIAEPI
HHHHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHH
LTNPIYNPLLLLLSLIALTFVLFVIRFIMIYGYYAYRTRRLKKKLNKYMKDMFLLTFSGV
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
KGTVSIATILLIPSNLEQEYPLLLFLVAGVTLVSFLTGLLILPHLSDEEEESKDYLMHIA
CHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
ILNEVTLELEKELEDTRNKLPLYAAIDNYHGRIENLILSQENQDDQEDWAALKLLILSIE
HHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHC
SDGLEQAYEEGNISNRAYRVYQRYLKNIEQGINRKLASRLTYYFLVSLRILRFLLHEVFT
CCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGKTFRSWKDKEQSRLRALDYDQIAELYLANTEMIIESLENLKGVYRRSLISFMQESRLR
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ETTIISSGAFVERVINRVKPNNINEMLRGYYLERKLIFEYEEKRLITTKYAKKLRQNVNN
HHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LENYSLKEAANTLPYDMVELVRRN
HHCCCHHHHHCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA