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The map label for this gene is folP [H]

Identifier: 116516653

GI number: 116516653

Start: 268042

End: 269016

Strand: Direct

Name: folP [H]

Synonym: SPD_0269

Alternate gene names: 116516653

Gene position: 268042-269016 (Clockwise)

Preceding gene: 116516578

Following gene: 116516745

Centisome position: 13.1

GC content: 46.26

Gene sequence:

>975_bases
ATGATGAAAATCCTTGAGGGAGTGACCGATATGTCAAGTAAAGCCAATCATGCAAAGACAGTTATTTGCGGAATTATCAA
TGTAACCCCAGACTCCTTTTCGGACGGTGGTCAATTTTTTGCTCTTGAGCAGGCACTCCAGCAGGCTCGTAAATTGATAG
CAGAAGGAGCCAGTATGCTCGATATCGGCGGAGAATCGACTCGGCCGGGCAGTAGCTATGTTGAGATAGAAGAGGAAATC
CAGCGTGTTGTTCCAGTGATCAAAGCGATTCGCAAGGAAAGTGATGTCCTCATCTCTATTGATACTTGGAAGAGCCAAGT
AGCAGAGGCTGCTTTGGCTGCTGGTGCCGATCTAGTCAATGATATCACTGGTCTTATGGGTGATGAGAAAATGCCTCATG
TGGTAGCTGAAGCGAGAGCGCAAGTGGTCATCATGTTTAATCCAGTTATGGCGCGACCTCAGCACCCTAGCTCGCTCATC
TTCCCTCATTTTGGTTTTGGTCAAGCTTTTACAGAGGAAGAGTTAGCTGACTTTGAAACATTGCCAATCGAAGAATTGAT
GGAGGCTTTCTTTGAACGAGCACTAGCGAGAGCGGCAGAAGCTGGTATTGCACCAGAAAATATCCTGTTGGATCCAGGAA
TTGGCTTTGGTCTGACCAAGAAAGAAAATCTGCTTCTTTTACGGGACCTGGATAAACTACATCAGAAGGGCTATCCAATC
TTTCTCGGAGTGTCGCGCAAGCGATTTGTCATCAATATCCTAGAGGAGAATGGTTTTGAAGTCAATCCTGAGACAGAGCT
TGGTTTCCGCAATCGGGACACGGCTTCGGCTCATGTAACCAGTATCGCTGCAAGACAGGGTGTAGAAGTGGTGCGCGTGC
ATGACGTAGCTAGTCACAGGATGGCAGTTGAAATTGCCTCTGCCATTCGTCTGGCTGATGAAGCGGAAAATTTAGATTTA
AAACAATATAAATAA

Upstream 100 bases:

>100_bases
GTGTAAAAGTTTTTATGTAGGAACCGACCTCTTTCTACTAGGGAAAGATGAATGCAATCGTGTCCATCTTTTTCTTTTTA
TGGTAAAATAGAAAAATAAT

Downstream 100 bases:

>100_bases
GATGAAAGAAATTGAAAACAATCAATGGATTGCTAACTACCGGACGGATCAACCGCATTTTGGCTTGGAACGAATGGTGG
AACTGTTAGCTTTGCGTGGC

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MMKILEGVTDMSSKANHAKTVICGIINVTPDSFSDGGQFFALEQALQQARKLIAEGASMLDIGGESTRPGSSYVEIEEEI
QRVVPVIKAIRKESDVLISIDTWKSQVAEAALAAGADLVNDITGLMGDEKMPHVVAEARAQVVIMFNPVMARPQHPSSLI
FPHFGFGQAFTEEELADFETLPIEELMEAFFERALARAAEAGIAPENILLDPGIGFGLTKKENLLLLRDLDKLHQKGYPI
FLGVSRKRFVINILEENGFEVNPETELGFRNRDTASAHVTSIAARQGVEVVRVHDVASHRMAVEIASAIRLADEAENLDL
KQYK

Sequences:

>Translated_324_residues
MMKILEGVTDMSSKANHAKTVICGIINVTPDSFSDGGQFFALEQALQQARKLIAEGASMLDIGGESTRPGSSYVEIEEEI
QRVVPVIKAIRKESDVLISIDTWKSQVAEAALAAGADLVNDITGLMGDEKMPHVVAEARAQVVIMFNPVMARPQHPSSLI
FPHFGFGQAFTEEELADFETLPIEELMEAFFERALARAAEAGIAPENILLDPGIGFGLTKKENLLLLRDLDKLHQKGYPI
FLGVSRKRFVINILEENGFEVNPETELGFRNRDTASAHVTSIAARQGVEVVRVHDVASHRMAVEIASAIRLADEAENLDL
KQYK
>Mature_324_residues
MMKILEGVTDMSSKANHAKTVICGIINVTPDSFSDGGQFFALEQALQQARKLIAEGASMLDIGGESTRPGSSYVEIEEEI
QRVVPVIKAIRKESDVLISIDTWKSQVAEAALAAGADLVNDITGLMGDEKMPHVVAEARAQVVIMFNPVMARPQHPSSLI
FPHFGFGQAFTEEELADFETLPIEELMEAFFERALARAAEAGIAPENILLDPGIGFGLTKKENLLLLRDLDKLHQKGYPI
FLGVSRKRFVINILEENGFEVNPETELGFRNRDTASAHVTSIAARQGVEVVRVHDVASHRMAVEIASAIRLADEAENLDL
KQYK

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=293, Percent_Identity=35.4948805460751, Blast_Score=162, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6324073, Length=347, Percent_Identity=31.700288184438, Blast_Score=152, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 35537; Mature: 35537

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKILEGVTDMSSKANHAKTVICGIINVTPDSFSDGGQFFALEQALQQARKLIAEGASML
CCHHHHHHHHHHCCCCCHHEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEE
DIGGESTRPGSSYVEIEEEIQRVVPVIKAIRKESDVLISIDTWKSQVAEAALAAGADLVN
ECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHCHHHHH
DITGLMGDEKMPHVVAEARAQVVIMFNPVMARPQHPSSLIFPHFGFGQAFTEEELADFET
HHHHHCCCCCCCHHHHHCCCCEEEEECCCCCCCCCCCCEECCCCCCCCCCCHHHHHCCCC
LPIEELMEAFFERALARAAEAGIAPENILLDPGIGFGLTKKENLLLLRDLDKLHQKGYPI
CCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCEEHHHHHHHHHHCCCCE
FLGVSRKRFVINILEENGFEVNPETELGFRNRDTASAHVTSIAARQGVEVVRVHDVASHR
EEECCCCEEEEEEECCCCEEECCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEHHHHHH
MAVEIASAIRLADEAENLDLKQYK
HHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MMKILEGVTDMSSKANHAKTVICGIINVTPDSFSDGGQFFALEQALQQARKLIAEGASML
CCHHHHHHHHHHCCCCCHHEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEE
DIGGESTRPGSSYVEIEEEIQRVVPVIKAIRKESDVLISIDTWKSQVAEAALAAGADLVN
ECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHCHHHHH
DITGLMGDEKMPHVVAEARAQVVIMFNPVMARPQHPSSLIFPHFGFGQAFTEEELADFET
HHHHHCCCCCCCHHHHHCCCCEEEEECCCCCCCCCCCCEECCCCCCCCCCCHHHHHCCCC
LPIEELMEAFFERALARAAEAGIAPENILLDPGIGFGLTKKENLLLLRDLDKLHQKGYPI
CCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCEEHHHHHHHHHHCCCCE
FLGVSRKRFVINILEENGFEVNPETELGFRNRDTASAHVTSIAARQGVEVVRVHDVASHR
EEECCCCEEEEEEECCCCEEECCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEHHHHHH
MAVEIASAIRLADEAENLDLKQYK
HHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3114239; 11463916 [H]