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The map label for this gene is lspA

Identifier: 116516537

GI number: 116516537

Start: 837170

End: 837631

Strand: Direct

Name: lspA

Synonym: SPD_0819

Alternate gene names: 116516537

Gene position: 837170-837631 (Clockwise)

Preceding gene: 116515669

Following gene: 116515398

Centisome position: 40.92

GC content: 41.13

Gene sequence:

>462_bases
ATGAAAAAAAGAGCAATAGTGGCAGTCATTGTACTGCTTTTAATTGGGCTGGATCAGTTGGTCAAATCCTATATCGTCCA
GCAGATTCCACTGGGTGAAGTGCGCTCCTGGATTCCCAATTTCGTTAGCTTGACCTACCTGCAAAATCGAGGTGCAGCCT
TTTCTATCTTACAAGATCAGCAGCTGTTATTCGCTGTCATTACTCTGGTTGTCGTGATAGGTGCCATTTGGTATTTACAT
AAACACATGGAGGACTCATTCTGGATGGTCTTGGGTTTGACTCTAATAATCGCGGGTGGTCTTGGAAACTTTATTGACAG
GGTCAGTCAGGGCTTTGTTGTGGATATGTTCCACCTTGACTTTATCAACTTTGCAATTTTCAATGTGGCAGATAGCTATC
TGACGGTTGGAGTGATTATTTTATTGATTGCAATGCTAAAAGAGGAAATAAATGGAAATTAA

Upstream 100 bases:

>100_bases
ACCGCATGGTCTATGTTAAACGTGAAGAAGTGGAGCTTAGTCAAGCTGGGACTCTCTTCGTAGAAGTCATGCAAGAATAT
TTTGATCAAAAGAGGAAATC

Downstream 100 bases:

>100_bases
AATTGAAACTGGTGGTCTGCGTTTGGATAAGGCTTTGTCAGATTTGTCAGAATTATCACGTAGTCTCGCGAATGAACAAA
TTAAATCAGGCCAGGTCTTG

Product: lipoprotein signal peptidase

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II

Number of amino acids: Translated: 153; Mature: 153

Protein sequence:

>153_residues
MKKRAIVAVIVLLLIGLDQLVKSYIVQQIPLGEVRSWIPNFVSLTYLQNRGAAFSILQDQQLLFAVITLVVVIGAIWYLH
KHMEDSFWMVLGLTLIIAGGLGNFIDRVSQGFVVDMFHLDFINFAIFNVADSYLTVGVIILLIAMLKEEINGN

Sequences:

>Translated_153_residues
MKKRAIVAVIVLLLIGLDQLVKSYIVQQIPLGEVRSWIPNFVSLTYLQNRGAAFSILQDQQLLFAVITLVVVIGAIWYLH
KHMEDSFWMVLGLTLIIAGGLGNFIDRVSQGFVVDMFHLDFINFAIFNVADSYLTVGVIILLIAMLKEEINGN
>Mature_153_residues
MKKRAIVAVIVLLLIGLDQLVKSYIVQQIPLGEVRSWIPNFVSLTYLQNRGAAFSILQDQQLLFAVITLVVVIGAIWYLH
KHMEDSFWMVLGLTLIIAGGLGNFIDRVSQGFVVDMFHLDFINFAIFNVADSYLTVGVIILLIAMLKEEINGN

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family

Homologues:

Organism=Escherichia coli, GI1786210, Length=148, Percent_Identity=35.8108108108108, Blast_Score=66, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LSPA_STRR6 (Q8DQ64)

Other databases:

- EMBL:   AE007317
- PIR:   C95107
- PIR:   E97975
- RefSeq:   NP_358423.1
- STRING:   Q8DQ64
- MEROPS:   A08.001
- EnsemblBacteria:   EBSTRT00000015794
- GeneID:   934374
- GenomeReviews:   AE007317_GR
- KEGG:   spr:spr0829
- eggNOG:   COG0597
- GeneTree:   EBGT00050000027710
- HOGENOM:   HBG724422
- OMA:   NFELRES
- PhylomeDB:   Q8DQ64
- ProtClustDB:   PRK14797
- BioCyc:   SPNE171101:SPR0829-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_00161
- InterPro:   IPR001872
- PRINTS:   PR00781
- TIGRFAMs:   TIGR00077

Pfam domain/function: PF01252 Peptidase_A8

EC number: =3.4.23.36

Molecular weight: Translated: 17151; Mature: 17151

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00855 SPASE_II

Important sites: ACT_SITE 106-106 ACT_SITE 131-131

Signals:

None

Transmembrane regions:

HASH(0x1ae658d4)-; HASH(0x1b4a1708)-; HASH(0x1aa34210)-; HASH(0x1b1150f8)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKRAIVAVIVLLLIGLDQLVKSYIVQQIPLGEVRSWIPNFVSLTYLQNRGAAFSILQDQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCEEHHHHHH
QLLFAVITLVVVIGAIWYLHKHMEDSFWMVLGLTLIIAGGLGNFIDRVSQGFVVDMFHLD
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHH
FINFAIFNVADSYLTVGVIILLIAMLKEEINGN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
>Mature Secondary Structure
MKKRAIVAVIVLLLIGLDQLVKSYIVQQIPLGEVRSWIPNFVSLTYLQNRGAAFSILQDQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCEEHHHHHH
QLLFAVITLVVVIGAIWYLHKHMEDSFWMVLGLTLIIAGGLGNFIDRVSQGFVVDMFHLD
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHH
FINFAIFNVADSYLTVGVIILLIAMLKEEINGN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11544234