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The map label for this gene is parE [H]

Identifier: 116516535

GI number: 116516535

Start: 757418

End: 759361

Strand: Direct

Name: parE [H]

Synonym: SPD_0746

Alternate gene names: 116516535

Gene position: 757418-759361 (Clockwise)

Preceding gene: 116516674

Following gene: 116516296

Centisome position: 37.02

GC content: 45.16

Gene sequence:

>1944_bases
GTGTCAAAAAAGGAAATCAATATTAACAATTATAATGATGATGCTATTCAGGTGCTAGAAGGGTTGGATGCGGTCCGAAA
ACGTCCAGGGATGTATATTGGATCGACCGATGGCGCTGGTCTTCATCACCTAGTTTGGGAAATCGTTGATAATGCAGTCG
ATGAAGCCTTGTCTGGGTTTGGTGATCGTATTGATGTAACTATCAATAAAGACGGTAGTCTAACGGTTCAAGACCATGGA
CGTGGGATGCCGACAGGTATGCACGCTATGGGAATTCCAACTGTTGAGGTTATCTTTACCATTCTTCATGCCGGAGGGAA
ATTCGGTCAAGGTGGCTATAAGACATCAGGTGGACTTCACGGAGTGGGTTCTTCCGTTGTTAACGCCCTTTCTAGCTGGT
TAGAAGTTGAAATTACCCGTGATGGCGCAGTTTACAAGCAACGTTTTGAAAATGGTGGAAAACCTGTCACGACTTTGAAG
AAAATCGGTACAGCACTCAAGTCTAAAACAGGCACCAAAGTTACTTTTATGCCTGACGCGACTATCTTTTCTACGACAGA
TTTCAAGTACAATACCATTTCAGAGCGCCTTAATGAATCAGCCTTTCTCTTGAAAAATGTGACCTTGTCTTTAACGGACA
AGCGAACAGATGAAGCGATTGAGTTCCACTATGAGAATGGAGTACAAGATTTTGTTTCTTATCTCAACGAAGATAAGGAA
ATCTTGACGCCAGTTCTTTACTTTGAAGGGGAAGACAATGGTTTTCAAGTGGAAGTAGCCCTCCAGTACAATGACGGATT
CTCAGATAACATTCTATCCTTTGTCAATAACGTTCGCACCAAGGACGGTGGAACGCACGAGACAGGACTCAAGTCTGCCA
TTACCAAGGTCATGAATGACTATGCACGTAAAACAGGTCTTCTCAAGGAAAAAGATAAAAACCTTGAAGGTTCAGACTAT
CGTGAGGGACTAGCGGCCGTTCTTTCTATCTTAGTTCCTGAAGAACACTTGCAGTTTGAAGGACAGACCAAGGATAAACT
AGGAAGCCCCCTAGCTCGCCCAGTTGTGGATGGAATAGTGGCTGATAAGTTGACCTTTTTCCTTATGGAAAATGGGGAAT
TAGCTTCTAACCTCATCCGCAAGGCTATCAAGGCCCGTGATGCTCGTGAAGCAGCACGTAAGGCGCGTGATGAGAGCCGA
AATGGGAAGAAAAACAAGAAAGATAAGGGCTTGTTGTCTGGGAAATTGACCCCAGCCCAATCTAAGAATCCTGCTAAGAA
TGAACTCTATCTAGTTGAGGGGGACTCTGCCGGTGGTTCTGCCAAACAAGGTCGTGACCGCAAGTTCCAGGCTATTCTAC
CTCTTCGTGGTAAGGTTATCAATACAGCCAAGGCCAAGATGGCGGATATCCTCAAAAATGAAGAGATCAATACCATGATT
TATACCATTGGTGCGGGTGTTGGAGCAGACTTCTCTATTGAAGATGCCAACTATGATAAGATCATTATCATGACCGATGC
GGATACCGACGGTGCCCATATCCAGACCTTGCTCTTGACATTTTTCTACCGTTACATGCGTCCGCTAGTCGAGGCAGGTC
ATGTCTATATTGCCCTCCCACCTCTTTACAAGATGTCCAAAGGTAAAGGCAAGAAAGAAGAAGTGGCCTACGCTTGGACG
GACGGAGAACTAGAAGAACTCCGTAAACAGTTCGGTAAAGGCGCTACCCTCCAACGATACAAAGGACTTGGTGAGATGAA
TGCGGACCAGCTCTGGGAAACAACCATGAACCCAGAAACACGTACCCTCATCCGTGTCACAATTGAAGATTTAGCGCGCG
CCGAACGCCGCGTCAATGTTCTCATGGGAGATAAGGTAGAACCACGCCGTAAATGGATTGAAGATAATGTCAAGTTTACG
CTAGAAGAAGCGACAGTGTTTTAA

Upstream 100 bases:

>100_bases
GAGAATCTCTGCTGAAATTGTCACATCGGAGAAAGAAAAATTTTGCAAAATCCTTGGAAAACCTGTAGAATAGTAAAGAT
GAACGAATAGGAGGTTCCTT

Downstream 100 bases:

>100_bases
TGAAAGAAAATAATATGTTAGTAAACTGGAAATTAGAGTCGGATGTGAATGACTATGTGAAAAAGCAGTTTGAAAATCTT
GGTTTGAAAAAATTGCAGGA

Product: DNA topoisomerase IV subunit B

Products: NA

Alternate protein names: Topoisomerase IV subunit B [H]

Number of amino acids: Translated: 647; Mature: 646

Protein sequence:

>647_residues
MSKKEININNYNDDAIQVLEGLDAVRKRPGMYIGSTDGAGLHHLVWEIVDNAVDEALSGFGDRIDVTINKDGSLTVQDHG
RGMPTGMHAMGIPTVEVIFTILHAGGKFGQGGYKTSGGLHGVGSSVVNALSSWLEVEITRDGAVYKQRFENGGKPVTTLK
KIGTALKSKTGTKVTFMPDATIFSTTDFKYNTISERLNESAFLLKNVTLSLTDKRTDEAIEFHYENGVQDFVSYLNEDKE
ILTPVLYFEGEDNGFQVEVALQYNDGFSDNILSFVNNVRTKDGGTHETGLKSAITKVMNDYARKTGLLKEKDKNLEGSDY
REGLAAVLSILVPEEHLQFEGQTKDKLGSPLARPVVDGIVADKLTFFLMENGELASNLIRKAIKARDAREAARKARDESR
NGKKNKKDKGLLSGKLTPAQSKNPAKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTAKAKMADILKNEEINTMI
YTIGAGVGADFSIEDANYDKIIIMTDADTDGAHIQTLLLTFFYRYMRPLVEAGHVYIALPPLYKMSKGKGKKEEVAYAWT
DGELEELRKQFGKGATLQRYKGLGEMNADQLWETTMNPETRTLIRVTIEDLARAERRVNVLMGDKVEPRRKWIEDNVKFT
LEEATVF

Sequences:

>Translated_647_residues
MSKKEININNYNDDAIQVLEGLDAVRKRPGMYIGSTDGAGLHHLVWEIVDNAVDEALSGFGDRIDVTINKDGSLTVQDHG
RGMPTGMHAMGIPTVEVIFTILHAGGKFGQGGYKTSGGLHGVGSSVVNALSSWLEVEITRDGAVYKQRFENGGKPVTTLK
KIGTALKSKTGTKVTFMPDATIFSTTDFKYNTISERLNESAFLLKNVTLSLTDKRTDEAIEFHYENGVQDFVSYLNEDKE
ILTPVLYFEGEDNGFQVEVALQYNDGFSDNILSFVNNVRTKDGGTHETGLKSAITKVMNDYARKTGLLKEKDKNLEGSDY
REGLAAVLSILVPEEHLQFEGQTKDKLGSPLARPVVDGIVADKLTFFLMENGELASNLIRKAIKARDAREAARKARDESR
NGKKNKKDKGLLSGKLTPAQSKNPAKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTAKAKMADILKNEEINTMI
YTIGAGVGADFSIEDANYDKIIIMTDADTDGAHIQTLLLTFFYRYMRPLVEAGHVYIALPPLYKMSKGKGKKEEVAYAWT
DGELEELRKQFGKGATLQRYKGLGEMNADQLWETTMNPETRTLIRVTIEDLARAERRVNVLMGDKVEPRRKWIEDNVKFT
LEEATVF
>Mature_646_residues
SKKEININNYNDDAIQVLEGLDAVRKRPGMYIGSTDGAGLHHLVWEIVDNAVDEALSGFGDRIDVTINKDGSLTVQDHGR
GMPTGMHAMGIPTVEVIFTILHAGGKFGQGGYKTSGGLHGVGSSVVNALSSWLEVEITRDGAVYKQRFENGGKPVTTLKK
IGTALKSKTGTKVTFMPDATIFSTTDFKYNTISERLNESAFLLKNVTLSLTDKRTDEAIEFHYENGVQDFVSYLNEDKEI
LTPVLYFEGEDNGFQVEVALQYNDGFSDNILSFVNNVRTKDGGTHETGLKSAITKVMNDYARKTGLLKEKDKNLEGSDYR
EGLAAVLSILVPEEHLQFEGQTKDKLGSPLARPVVDGIVADKLTFFLMENGELASNLIRKAIKARDAREAARKARDESRN
GKKNKKDKGLLSGKLTPAQSKNPAKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTAKAKMADILKNEEINTMIY
TIGAGVGADFSIEDANYDKIIIMTDADTDGAHIQTLLLTFFYRYMRPLVEAGHVYIALPPLYKMSKGKGKKEEVAYAWTD
GELEELRKQFGKGATLQRYKGLGEMNADQLWETTMNPETRTLIRVTIEDLARAERRVNVLMGDKVEPRRKWIEDNVKFTL
EEATVF

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Toprim domain [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=626, Percent_Identity=25.5591054313099, Blast_Score=112, Evalue=9e-25,
Organism=Homo sapiens, GI19913408, Length=673, Percent_Identity=24.81426448737, Blast_Score=107, Evalue=5e-23,
Organism=Escherichia coli, GI48994957, Length=549, Percent_Identity=51.3661202185792, Blast_Score=509, Evalue=1e-145,
Organism=Escherichia coli, GI1789408, Length=637, Percent_Identity=40.8163265306122, Blast_Score=427, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI17535065, Length=623, Percent_Identity=26.8057784911718, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI212645845, Length=542, Percent_Identity=25.0922509225092, Blast_Score=116, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI212645657, Length=183, Percent_Identity=30.6010928961749, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324241, Length=642, Percent_Identity=25.7009345794392, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI17136538, Length=635, Percent_Identity=26.6141732283465, Blast_Score=125, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR005740
- InterPro:   IPR006171 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c; PF01751 Toprim [H]

EC number: 5.99.1.-

Molecular weight: Translated: 71666; Mature: 71535

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKEININNYNDDAIQVLEGLDAVRKRPGMYIGSTDGAGLHHLVWEIVDNAVDEALSGF
CCCCEECCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCC
GDRIDVTINKDGSLTVQDHGRGMPTGMHAMGIPTVEVIFTILHAGGKFGQGGYKTSGGLH
CCEEEEEECCCCCEEEEECCCCCCCCCHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCC
GVGSSVVNALSSWLEVEITRDGAVYKQRFENGGKPVTTLKKIGTALKSKTGTKVTFMPDA
CCHHHHHHHHHHHEEEEEECCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEEECCC
TIFSTTDFKYNTISERLNESAFLLKNVTLSLTDKRTDEAIEFHYENGVQDFVSYLNEDKE
EEEECCCCCHHHHHHHHCCCCEEEECEEEEECCCCCCCCEEEHHHCCHHHHHHHHCCCHH
ILTPVLYFEGEDNGFQVEVALQYNDGFSDNILSFVNNVRTKDGGTHETGLKSAITKVMND
HCCEEEEEECCCCCEEEEEEEEECCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
YARKTGLLKEKDKNLEGSDYREGLAAVLSILVPEEHLQFEGQTKDKLGSPLARPVVDGIV
HHHHCCCCHHHCCCCCCCHHHHHHHHHHHHHCCHHHHCCCCCCHHHHCCCHHHHHHHHHH
ADKLTFFLMENGELASNLIRKAIKARDAREAARKARDESRNGKKNKKDKGLLSGKLTPAQ
HHHEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
SKNPAKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTAKAKMADILKNEEINTMI
CCCCCCCEEEEEECCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCEEE
YTIGAGVGADFSIEDANYDKIIIMTDADTDGAHIQTLLLTFFYRYMRPLVEAGHVYIALP
EEECCCCCCCEEECCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEC
PLYKMSKGKGKKEEVAYAWTDGELEELRKQFGKGATLQRYKGLGEMNADQLWETTMNPET
CCHHHCCCCCCCCCEEEEECCCHHHHHHHHHCCCCCHHHHCCCCCCCHHHHHHHCCCCCC
RTLIRVTIEDLARAERRVNVLMGDKVEPRRKWIEDNVKFTLEEATVF
EEEEEEEHHHHHHHHHHEEHHCCCCCCHHHHHHHCCCEEEEECCCCC
>Mature Secondary Structure 
SKKEININNYNDDAIQVLEGLDAVRKRPGMYIGSTDGAGLHHLVWEIVDNAVDEALSGF
CCCEECCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCC
GDRIDVTINKDGSLTVQDHGRGMPTGMHAMGIPTVEVIFTILHAGGKFGQGGYKTSGGLH
CCEEEEEECCCCCEEEEECCCCCCCCCHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCC
GVGSSVVNALSSWLEVEITRDGAVYKQRFENGGKPVTTLKKIGTALKSKTGTKVTFMPDA
CCHHHHHHHHHHHEEEEEECCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEEECCC
TIFSTTDFKYNTISERLNESAFLLKNVTLSLTDKRTDEAIEFHYENGVQDFVSYLNEDKE
EEEECCCCCHHHHHHHHCCCCEEEECEEEEECCCCCCCCEEEHHHCCHHHHHHHHCCCHH
ILTPVLYFEGEDNGFQVEVALQYNDGFSDNILSFVNNVRTKDGGTHETGLKSAITKVMND
HCCEEEEEECCCCCEEEEEEEEECCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
YARKTGLLKEKDKNLEGSDYREGLAAVLSILVPEEHLQFEGQTKDKLGSPLARPVVDGIV
HHHHCCCCHHHCCCCCCCHHHHHHHHHHHHHCCHHHHCCCCCCHHHHCCCHHHHHHHHHH
ADKLTFFLMENGELASNLIRKAIKARDAREAARKARDESRNGKKNKKDKGLLSGKLTPAQ
HHHEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
SKNPAKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTAKAKMADILKNEEINTMI
CCCCCCCEEEEEECCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCEEE
YTIGAGVGADFSIEDANYDKIIIMTDADTDGAHIQTLLLTFFYRYMRPLVEAGHVYIALP
EEECCCCCCCEEECCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEC
PLYKMSKGKGKKEEVAYAWTDGELEELRKQFGKGATLQRYKGLGEMNADQLWETTMNPET
CCHHHCCCCCCCCCEEEEECCCHHHHHHHHHCCCCCHHHHCCCCCCCHHHHHHHCCCCCC
RTLIRVTIEDLARAERRVNVLMGDKVEPRRKWIEDNVKFTLEEATVF
EEEEEEEHHHHHHHHHHEEHHCCCCCCHHHHHHHCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8763932; 11463916; 8891124 [H]