| Definition | Streptococcus pneumoniae D39, complete genome. |
|---|---|
| Accession | NC_008533 |
| Length | 2,046,115 |
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The map label for this gene is clpB [H]
Identifier: 116516069
GI number: 116516069
Start: 2000461
End: 2002893
Strand: Reverse
Name: clpB [H]
Synonym: SPD_2022
Alternate gene names: 116516069
Gene position: 2002893-2000461 (Counterclockwise)
Preceding gene: 116516436
Following gene: 116515451
Centisome position: 97.89
GC content: 45.5
Gene sequence:
>2433_bases ATGAACTATTCAAAAGCATTGAATGAATGTATCGAAAGTGCCTACATGGTTGCTGGACATTTTGGAGCTCGTTATCTAGA GTCTTGGCACTTGTTGATTGCCATGTCTAATCACAGTTATAGTGTAGCAGGGGCAACTTTAAATGATTATCCGTATGAGA TGGACCGTTTAGAAGAGGTGGCTTTGGAACTGACTGAAACGGACTATAGCCAGGATGAAACTTTTACGGAATTGCCGTTC TCCCGTCGTTTGCAGATTCTTTTTGACGAAGCAGAGTATGTAGCGTCAGTGGTCCATGCTAAGGTGCTAGGTACAGAGCA CGTCCTCTATGCGATTTTGCATGATGGCAATGCCTTGGCGACTCGTATCTTGGAGAGGGCTGGTTTTTCTTATGAAGACA AGAAAGATCAGGTCAAGATTGCTGCTCTTCGTCGAAATTTAGAAGAACGGGCAGGCTGGACTCGTGAAGATCTCAAGGCT TTACGCCAACGCCATCGTACAGTAGCTGACAAGCAAAATTCTATGGCCAATATGATGGGCATGCCGCAGACTCCTAGTGG TGGTCTCGAGGACTATACGCATGATTTGACAGAGCAAGCGCGTTCTGGCAAGTTAGAACCAGTCATCGGTCGGGACAAGG AAATCTCACGTATGATTCAAATCTTAAGCCGGAAGACTAAGAACAACCCTGTCTTGGTTGGGGATGCTGGTGTCGGGAAA ACAGCTCTGGCGCTTGGTCTTGCTCAGCGTATTGCCAGTGGTGACGTGCCTGCGGAAATGGCTAAGATGCGCGTGTTAGA ACTTGATTTGATGAATGTCGTTGCAGGGACACGCTTCCGTGGTGACTTTGAAGAACGCATGAATAATATCATCAAGGATA TTGAAGAAGATGGCCAAGTCATCCTCTTTATCGATGAACTCCACACCATCATGGGTTCTGGTAGCGGGATTGATTCGACT CTGGATGCGGCCAATATCTTGAAACCAGCCTTGGCGCGTGGAACTTTGAGAACGGTTGGTGCCACCACTCAGGAAGAATA TCAAAAACATATCGAAAAAGATGCGGCACTTTCTCGTCGTTTCGCTAAAGTGACGATTGAAGAACCAAGTGTGGCAGATA GTATGACTATTTTACAAGGTTTGAAGGCGACTTATGAGAAACATCACCGTGTACAAATCACAGATGAAGCGGTTGAAACA GCGGTTAAGATGGCTCATCGTTATTTAACCAGTCGTCACTTGCCAGACTCTGCTATCGACCTCTTGGACGAAGCAGCAGC AACAGTGCAAAATAAGGCAAAGCATGTAAAAGCAGACGATTCAGATTTGAGTCCAGCTGACAAGGCCCTGATGGATGGCA AGTGGAAACAGGCAGCCCAGCTAATCGCAAAAGAAGAGGAAGTACCTGTCTACAAAGACTTGGTGACAGAGTCTGATATT TTGACCACCTTGAGTCGCTTGTCAGGAATCCCAGTTCAAAAACTGACTCAGACTGACGCTAAGAAATATCTAAATCTTGA AGCAGAACTCCATAAACGGGTTATCGGTCAAGATCAAGCTGTTTCAAGTATTAGTCGTGCGATTCGCCGTAATCAGTCAG GAATTCGCAGTCACAAGCGTCCGATCGGTTCCTTTATGTTCCTAGGACCCACAGGTGTCGGTAAGACCGAGTTGGCCAAG GCTTTGGCAGAAGTTCTCTTTGATGACGAATCAGCCCTTATCCGCTTTGATATGAGTGAGTATATGGAGAAATTCGCAGC CAGCCGTCTAAATGGAGCTCCTCCAGGCTATGTGGGTTACGAAGAAGGTGGGGAGTTGACAGAGAAGGTTCGCAATAAAC CCTATTCCGTTCTCCTCTTTGATGAGGTAGAGAAGGCCCACCCAGATATCTTTAATGTTCTCTTGCAGGTTCTGGATGAC GGTGTCTTGACAGATAGCAAGGGACGCAAGGTCGATTTTTCAAATACCATTATCATTATGACATCGAATCTAGGTGCGAC TGCCCTTCGTGATGATAAGACTGTTGGTTTTGGGGCTAAGGATATTCGTTTTGACCAGGAAAATATGGAAAAACGCATGT TTGAAGAACTGAAAAAAGCTTATAGACCGGAATTCATCAACCGTATTGATGAGAAGGTGGTCTTCCATAGCCTATCTAGT GACCATATGCAGGAAGTGGTGAAGATTATGGTCAAGCCTTTAGTGGCAAGTTTGGCTGAAAAAGGCATTGACTTGAAATT ACAAGCTTCAGCTCTGAAATTGTTAGCAAATCAAGGATATGACCCAGAGATGGGAGCTCGCCCACTTCGCAGAACCCTGC AAACAGAAGTGGAGGACAAGTTGGCAGAACTTCTTCTTAAGGGAGATTTAGTGGCAGGCAGCATACTTAAGATTGGTGTC AAAGCAGGCCAGTTAAAATTTGATATTGCATAA
Upstream 100 bases:
>100_bases TCAGTAGCTTTGGATCGCGTTTTAGGAGAAGAAGCTCCAGTTGTTCGAGCAAACATGCTACGTCAGGTCATACAAGAGGT AGATAGAAAAGGGAAGTAAG
Downstream 100 bases:
>100_bases AAGAATAAAAGTATCAGCATCTGACCATAAGTCACAGTGGAGTGAAACTCAATGAAAATCAAAGAGCAAACTAGGCAGCT AGCCGCAGGTTGCTCAAAAC
Product: ATP-dependent Clp protease, ATP-binding subunit
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 810; Mature: 810
Protein sequence:
>810_residues MNYSKALNECIESAYMVAGHFGARYLESWHLLIAMSNHSYSVAGATLNDYPYEMDRLEEVALELTETDYSQDETFTELPF SRRLQILFDEAEYVASVVHAKVLGTEHVLYAILHDGNALATRILERAGFSYEDKKDQVKIAALRRNLEERAGWTREDLKA LRQRHRTVADKQNSMANMMGMPQTPSGGLEDYTHDLTEQARSGKLEPVIGRDKEISRMIQILSRKTKNNPVLVGDAGVGK TALALGLAQRIASGDVPAEMAKMRVLELDLMNVVAGTRFRGDFEERMNNIIKDIEEDGQVILFIDELHTIMGSGSGIDST LDAANILKPALARGTLRTVGATTQEEYQKHIEKDAALSRRFAKVTIEEPSVADSMTILQGLKATYEKHHRVQITDEAVET AVKMAHRYLTSRHLPDSAIDLLDEAAATVQNKAKHVKADDSDLSPADKALMDGKWKQAAQLIAKEEEVPVYKDLVTESDI LTTLSRLSGIPVQKLTQTDAKKYLNLEAELHKRVIGQDQAVSSISRAIRRNQSGIRSHKRPIGSFMFLGPTGVGKTELAK ALAEVLFDDESALIRFDMSEYMEKFAASRLNGAPPGYVGYEEGGELTEKVRNKPYSVLLFDEVEKAHPDIFNVLLQVLDD GVLTDSKGRKVDFSNTIIIMTSNLGATALRDDKTVGFGAKDIRFDQENMEKRMFEELKKAYRPEFINRIDEKVVFHSLSS DHMQEVVKIMVKPLVASLAEKGIDLKLQASALKLLANQGYDPEMGARPLRRTLQTEVEDKLAELLLKGDLVAGSILKIGV KAGQLKFDIA
Sequences:
>Translated_810_residues MNYSKALNECIESAYMVAGHFGARYLESWHLLIAMSNHSYSVAGATLNDYPYEMDRLEEVALELTETDYSQDETFTELPF SRRLQILFDEAEYVASVVHAKVLGTEHVLYAILHDGNALATRILERAGFSYEDKKDQVKIAALRRNLEERAGWTREDLKA LRQRHRTVADKQNSMANMMGMPQTPSGGLEDYTHDLTEQARSGKLEPVIGRDKEISRMIQILSRKTKNNPVLVGDAGVGK TALALGLAQRIASGDVPAEMAKMRVLELDLMNVVAGTRFRGDFEERMNNIIKDIEEDGQVILFIDELHTIMGSGSGIDST LDAANILKPALARGTLRTVGATTQEEYQKHIEKDAALSRRFAKVTIEEPSVADSMTILQGLKATYEKHHRVQITDEAVET AVKMAHRYLTSRHLPDSAIDLLDEAAATVQNKAKHVKADDSDLSPADKALMDGKWKQAAQLIAKEEEVPVYKDLVTESDI LTTLSRLSGIPVQKLTQTDAKKYLNLEAELHKRVIGQDQAVSSISRAIRRNQSGIRSHKRPIGSFMFLGPTGVGKTELAK ALAEVLFDDESALIRFDMSEYMEKFAASRLNGAPPGYVGYEEGGELTEKVRNKPYSVLLFDEVEKAHPDIFNVLLQVLDD GVLTDSKGRKVDFSNTIIIMTSNLGATALRDDKTVGFGAKDIRFDQENMEKRMFEELKKAYRPEFINRIDEKVVFHSLSS DHMQEVVKIMVKPLVASLAEKGIDLKLQASALKLLANQGYDPEMGARPLRRTLQTEVEDKLAELLLKGDLVAGSILKIGV KAGQLKFDIA >Mature_810_residues MNYSKALNECIESAYMVAGHFGARYLESWHLLIAMSNHSYSVAGATLNDYPYEMDRLEEVALELTETDYSQDETFTELPF SRRLQILFDEAEYVASVVHAKVLGTEHVLYAILHDGNALATRILERAGFSYEDKKDQVKIAALRRNLEERAGWTREDLKA LRQRHRTVADKQNSMANMMGMPQTPSGGLEDYTHDLTEQARSGKLEPVIGRDKEISRMIQILSRKTKNNPVLVGDAGVGK TALALGLAQRIASGDVPAEMAKMRVLELDLMNVVAGTRFRGDFEERMNNIIKDIEEDGQVILFIDELHTIMGSGSGIDST LDAANILKPALARGTLRTVGATTQEEYQKHIEKDAALSRRFAKVTIEEPSVADSMTILQGLKATYEKHHRVQITDEAVET AVKMAHRYLTSRHLPDSAIDLLDEAAATVQNKAKHVKADDSDLSPADKALMDGKWKQAAQLIAKEEEVPVYKDLVTESDI LTTLSRLSGIPVQKLTQTDAKKYLNLEAELHKRVIGQDQAVSSISRAIRRNQSGIRSHKRPIGSFMFLGPTGVGKTELAK ALAEVLFDDESALIRFDMSEYMEKFAASRLNGAPPGYVGYEEGGELTEKVRNKPYSVLLFDEVEKAHPDIFNVLLQVLDD GVLTDSKGRKVDFSNTIIIMTSNLGATALRDDKTVGFGAKDIRFDQENMEKRMFEELKKAYRPEFINRIDEKVVFHSLSS DHMQEVVKIMVKPLVASLAEKGIDLKLQASALKLLANQGYDPEMGARPLRRTLQTEVEDKLAELLLKGDLVAGSILKIGV KAGQLKFDIA
Specific function: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase
COG id: COG0542
COG function: function code O; ATPases with chaperone activity, ATP-binding subunit
Gene ontology:
Cell location: Cytoplasm (Probable) [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 UVR domain [H]
Homologues:
Organism=Homo sapiens, GI13540606, Length=346, Percent_Identity=32.9479768786127, Blast_Score=180, Evalue=4e-45, Organism=Escherichia coli, GI1787109, Length=641, Percent_Identity=42.4336973478939, Blast_Score=518, Evalue=1e-148, Organism=Escherichia coli, GI1788943, Length=331, Percent_Identity=52.5679758308157, Blast_Score=369, Evalue=1e-103, Organism=Saccharomyces cerevisiae, GI6320464, Length=340, Percent_Identity=49.1176470588235, Blast_Score=324, Evalue=3e-89, Organism=Saccharomyces cerevisiae, GI6323002, Length=333, Percent_Identity=43.2432432432432, Blast_Score=268, Evalue=2e-72,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003593 - InterPro: IPR013093 - InterPro: IPR003959 - InterPro: IPR018368 - InterPro: IPR001270 - InterPro: IPR019489 - InterPro: IPR004176 - InterPro: IPR023150 - InterPro: IPR001943 [H]
Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small; PF02151 UVR [H]
EC number: NA
Molecular weight: Translated: 90181; Mature: 90181
Theoretical pI: Translated: 5.86; Mature: 5.86
Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.1 %Cys (Translated Protein) 3.2 %Met (Translated Protein) 3.3 %Cys+Met (Translated Protein) 0.1 %Cys (Mature Protein) 3.2 %Met (Mature Protein) 3.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MNYSKALNECIESAYMVAGHFGARYLESWHLLIAMSNHSYSVAGATLNDYPYEMDRLEEV CCHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEECCCCEEEECCCCCCCCCHHHHHHHH ALELTETDYSQDETFTELPFSRRLQILFDEAEYVASVVHAKVLGTEHVLYAILHDGNALA HHHHHHCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHEEEEEECCHHHH TRILERAGFSYEDKKDQVKIAALRRNLEERAGWTREDLKALRQRHRTVADKQNSMANMMG HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC MPQTPSGGLEDYTHDLTEQARSGKLEPVIGRDKEISRMIQILSRKTKNNPVLVGDAGVGK CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCH TALALGLAQRIASGDVPAEMAKMRVLELDLMNVVAGTRFRGDFEERMNNIIKDIEEDGQV HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCE ILFIDELHTIMGSGSGIDSTLDAANILKPALARGTLRTVGATTQEEYQKHIEKDAALSRR EEEHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHHHH FAKVTIEEPSVADSMTILQGLKATYEKHHRVQITDEAVETAVKMAHRYLTSRHLPDSAID HHEEEECCCCHHHHHHHHHHHHHHHHHCCEEEECHHHHHHHHHHHHHHHHHCCCCHHHHH LLDEAAATVQNKAKHVKADDSDLSPADKALMDGKWKQAAQLIAKEEEVPVYKDLVTESDI HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHH LTTLSRLSGIPVQKLTQTDAKKYLNLEAELHKRVIGQDQAVSSISRAIRRNQSGIRSHKR HHHHHHHCCCCHHHHHHHHHHHHHCHHHHHHHHHHCCHHHHHHHHHHHHHCHHHHHHHCC PIGSFMFLGPTGVGKTELAKALAEVLFDDESALIRFDMSEYMEKFAASRLNGAPPGYVGY CCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHCCCCCCCCCCC EEGGELTEKVRNKPYSVLLFDEVEKAHPDIFNVLLQVLDDGVLTDSKGRKVDFSNTIIIM CCCCHHHHHHCCCCCEEEEEHHHHHHCHHHHHHHHHHHCCCCEECCCCCEEECCCEEEEE TSNLGATALRDDKTVGFGAKDIRFDQENMEKRMFEELKKAYRPEFINRIDEKVVFHSLSS ECCCCCCCCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCH DHMQEVVKIMVKPLVASLAEKGIDLKLQASALKLLANQGYDPEMGARPLRRTLQTEVEDK HHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH LAELLLKGDLVAGSILKIGVKAGQLKFDIA HHHHHHHCCHHHCHHHHHCCCCCCEEEECC >Mature Secondary Structure MNYSKALNECIESAYMVAGHFGARYLESWHLLIAMSNHSYSVAGATLNDYPYEMDRLEEV CCHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEECCCCEEEECCCCCCCCCHHHHHHHH ALELTETDYSQDETFTELPFSRRLQILFDEAEYVASVVHAKVLGTEHVLYAILHDGNALA HHHHHHCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHEEEEEECCHHHH TRILERAGFSYEDKKDQVKIAALRRNLEERAGWTREDLKALRQRHRTVADKQNSMANMMG HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC MPQTPSGGLEDYTHDLTEQARSGKLEPVIGRDKEISRMIQILSRKTKNNPVLVGDAGVGK CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCH TALALGLAQRIASGDVPAEMAKMRVLELDLMNVVAGTRFRGDFEERMNNIIKDIEEDGQV HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCE ILFIDELHTIMGSGSGIDSTLDAANILKPALARGTLRTVGATTQEEYQKHIEKDAALSRR EEEHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHHHH FAKVTIEEPSVADSMTILQGLKATYEKHHRVQITDEAVETAVKMAHRYLTSRHLPDSAID HHEEEECCCCHHHHHHHHHHHHHHHHHCCEEEECHHHHHHHHHHHHHHHHHCCCCHHHHH LLDEAAATVQNKAKHVKADDSDLSPADKALMDGKWKQAAQLIAKEEEVPVYKDLVTESDI HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHH LTTLSRLSGIPVQKLTQTDAKKYLNLEAELHKRVIGQDQAVSSISRAIRRNQSGIRSHKR HHHHHHHCCCCHHHHHHHHHHHHHCHHHHHHHHHHCCHHHHHHHHHHHHHCHHHHHHHCC PIGSFMFLGPTGVGKTELAKALAEVLFDDESALIRFDMSEYMEKFAASRLNGAPPGYVGY CCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHCCCCCCCCCCC EEGGELTEKVRNKPYSVLLFDEVEKAHPDIFNVLLQVLDDGVLTDSKGRKVDFSNTIIIM CCCCHHHHHHCCCCCEEEEEHHHHHHCHHHHHHHHHHHCCCCEECCCCCEEECCCEEEEE TSNLGATALRDDKTVGFGAKDIRFDQENMEKRMFEELKKAYRPEFINRIDEKVVFHSLSS ECCCCCCCCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCH DHMQEVVKIMVKPLVASLAEKGIDLKLQASALKLLANQGYDPEMGARPLRRTLQTEVEDK HHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH LAELLLKGDLVAGSILKIGVKAGQLKFDIA HHHHHHHCCHHHCHHHHHCCCCCCEEEECC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 12235376 [H]