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The map label for this gene is htpX

Identifier: 116516057

GI number: 116516057

Start: 1172177

End: 1173076

Strand: Reverse

Name: htpX

Synonym: SPD_1138

Alternate gene names: 116516057

Gene position: 1173076-1172177 (Counterclockwise)

Preceding gene: 116516003

Following gene: 116516761

Centisome position: 57.33

GC content: 44.22

Gene sequence:

>900_bases
ATGTTGTTTGATCAAATTGCAAGCAATAAACGAAAAACCTGGATTTTGTTGCTGGTATTTTTCCTACTCTTAGCTCTTGT
TGGTTATGCGGTTGGTTATCTCTTTATAAGATCTGGACTTGGTGGTTTGGTTATCGCACTGATTATCGGCTTTATCTACG
CTTTGTCTATGATTTTTCAATCGACAGAGATTGTCATGTCCATGAATGGAGCGCGTGAGGTGGATGAGCAAACGGCACCA
GACCTCTACCATGTAGTGGAAGATATGGCTCTGGTCGCTCAGATTCCTATGCCCCGTGTTTTCATCATTGATGATCCAGC
CTTAAATGCCTTTGCGACAGGTTCTAATCCTCAAAATGCGGCTGTTGCTGCGACTTCAGGTCTACTAGCTATCATGAATC
GTGAAGAACTAGAAGCTGTTATGGGACATGAAGTCAGTCATATTCGTAATTATGATATCCGTATTTCGACTATTGCAGTT
GCCCTTGTTAGTGCTATCACCATGCTTTCTGGTATGGCAGGTCGTATGATGTGGTGGGGTGGAGCAGGTCGCAGACGAAG
TGATGATGACCGAGATGGAAATGGTCTTGAAATCATTATGCTAGTGGTTTCCCTACTAGCTATTGTACTGGCACCTCTCG
CTGCAACCTTGGTTCAGCTCGCTATTTCTCGTCAGAGGGAATTTCTGGCAGATGCATCTAGTGTCGAGCTGACTCGCAAT
CCCCAGGGAATGATTAATGCCCTAGATAAGTTGGACAATAGCAAACCTATGAGTCGCCACGTCGATGATGCTAGCAGTGC
TCTTTATATCAATGATCCCAAGAAAGGTGGGGGGTTCCAAAAACTCTTTTATACCCACCCACCTATCTCAGAACGGATTG
AACGTTTAAAACAGATGTAA

Upstream 100 bases:

>100_bases
ATCGCTGGAATGTTTGGATTTAAAGCGGCAGATTTCCTTCAAACACCTGAAGAGGAAAAGTCGGTTCCTAAAGTTGATTT
TAGCGGTTTAGGTGACTAAG

Downstream 100 bases:

>100_bases
AATGAAGGCTGGAAAAAAGTCTTTAAAATCTGAAAAACGCATAATATCAGGTGTGAAAACTTGATATTATGCGTTTTACT
ATGGGAAGATTTACTTCTTT

Product: heat shock protein HtpX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MLFDQIASNKRKTWILLLVFFLLLALVGYAVGYLFIRSGLGGLVIALIIGFIYALSMIFQSTEIVMSMNGAREVDEQTAP
DLYHVVEDMALVAQIPMPRVFIIDDPALNAFATGSNPQNAAVAATSGLLAIMNREELEAVMGHEVSHIRNYDIRISTIAV
ALVSAITMLSGMAGRMMWWGGAGRRRSDDDRDGNGLEIIMLVVSLLAIVLAPLAATLVQLAISRQREFLADASSVELTRN
PQGMINALDKLDNSKPMSRHVDDASSALYINDPKKGGGFQKLFYTHPPISERIERLKQM

Sequences:

>Translated_299_residues
MLFDQIASNKRKTWILLLVFFLLLALVGYAVGYLFIRSGLGGLVIALIIGFIYALSMIFQSTEIVMSMNGAREVDEQTAP
DLYHVVEDMALVAQIPMPRVFIIDDPALNAFATGSNPQNAAVAATSGLLAIMNREELEAVMGHEVSHIRNYDIRISTIAV
ALVSAITMLSGMAGRMMWWGGAGRRRSDDDRDGNGLEIIMLVVSLLAIVLAPLAATLVQLAISRQREFLADASSVELTRN
PQGMINALDKLDNSKPMSRHVDDASSALYINDPKKGGGFQKLFYTHPPISERIERLKQM
>Mature_299_residues
MLFDQIASNKRKTWILLLVFFLLLALVGYAVGYLFIRSGLGGLVIALIIGFIYALSMIFQSTEIVMSMNGAREVDEQTAP
DLYHVVEDMALVAQIPMPRVFIIDDPALNAFATGSNPQNAAVAATSGLLAIMNREELEAVMGHEVSHIRNYDIRISTIAV
ALVSAITMLSGMAGRMMWWGGAGRRRSDDDRDGNGLEIIMLVVSLLAIVLAPLAATLVQLAISRQREFLADASSVELTRN
PQGMINALDKLDNSKPMSRHVDDASSALYINDPKKGGGFQKLFYTHPPISERIERLKQM

Specific function: Unknown Function. Overexpression Of A Truncated Form Of The Htpx Protein Leads To An Increase In The Degradation Of Abnormal Proteins. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family

Homologues:

Organism=Escherichia coli, GI1788133, Length=295, Percent_Identity=34.9152542372881, Blast_Score=114, Evalue=8e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HTPX_STRP2 (Q04K41)

Other databases:

- EMBL:   CP000410
- RefSeq:   YP_816607.1
- ProteinModelPortal:   Q04K41
- STRING:   Q04K41
- EnsemblBacteria:   EBSTRT00000018907
- GeneID:   4442766
- GenomeReviews:   CP000410_GR
- KEGG:   spd:SPD_1138
- eggNOG:   COG0501
- GeneTree:   EBGT00050000027537
- HOGENOM:   HBG739460
- OMA:   RTHPETH
- ProtClustDB:   PRK04897
- GO:   GO:0006508
- HAMAP:   MF_00188
- InterPro:   IPR022919
- InterPro:   IPR001915

Pfam domain/function: PF01435 Peptidase_M48

EC number: 3.4.24.-

Molecular weight: Translated: 32795; Mature: 32795

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: ACT_SITE 144-144

Signals:

None

Transmembrane regions:

HASH(0x1b2476c0)-; HASH(0x1b4116ec)-; HASH(0x1bd664b4)-; HASH(0x1bd686e8)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFDQIASNKRKTWILLLVFFLLLALVGYAVGYLFIRSGLGGLVIALIIGFIYALSMIFQ
CCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHH
STEIVMSMNGAREVDEQTAPDLYHVVEDMALVAQIPMPRVFIIDDPALNAFATGSNPQNA
HHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEECCCCCCCC
AVAATSGLLAIMNREELEAVMGHEVSHIRNYDIRISTIAVALVSAITMLSGMAGRMMWWG
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEC
GAGRRRSDDDRDGNGLEIIMLVVSLLAIVLAPLAATLVQLAISRQREFLADASSVELTRN
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCC
PQGMINALDKLDNSKPMSRHVDDASSALYINDPKKGGGFQKLFYTHPPISERIERLKQM
CHHHHHHHHHCCCCCCHHHHCCCCCCEEEEECCCCCCCCEEEEECCCCHHHHHHHHHCH
>Mature Secondary Structure
MLFDQIASNKRKTWILLLVFFLLLALVGYAVGYLFIRSGLGGLVIALIIGFIYALSMIFQ
CCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHH
STEIVMSMNGAREVDEQTAPDLYHVVEDMALVAQIPMPRVFIIDDPALNAFATGSNPQNA
HHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEECCCCCCCC
AVAATSGLLAIMNREELEAVMGHEVSHIRNYDIRISTIAVALVSAITMLSGMAGRMMWWG
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEC
GAGRRRSDDDRDGNGLEIIMLVVSLLAIVLAPLAATLVQLAISRQREFLADASSVELTRN
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCC
PQGMINALDKLDNSKPMSRHVDDASSALYINDPKKGGGFQKLFYTHPPISERIERLKQM
CHHHHHHHHHCCCCCCHHHHCCCCCCEEEEECCCCCCCCEEEEECCCCHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA