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The map label for this gene is rnr [H]

Identifier: 116515936

GI number: 116515936

Start: 875464

End: 877818

Strand: Direct

Name: rnr [H]

Synonym: SPD_0862

Alternate gene names: 116515936

Gene position: 875464-877818 (Clockwise)

Preceding gene: 116516845

Following gene: 116516450

Centisome position: 42.79

GC content: 42.46

Gene sequence:

>2355_bases
ATGAAAGATAGAATAAAAGAATATTTACAAGACAAGGGAAAGGTGACTGTTAATGATTTGGCTCAGGCTTTGGGAAAAGA
CAGTTCCAAGGATTTTCGTGAGTTGATTAAAACCTTGTCCTTAATGGAAAGAAAGCACCAGATTCGCTTTGAAGAAGATG
GCAGTCTGACCTTGGAAGCCAAGAAAAAACATGAGATTACCCTCAAGGGGATTTTTCATGCCCATAAAAATGGTTTTGGT
TTTGTCAGCCTAGAAGGGGAAGAGGACGACCTTTTTGTAGGGAAAAATGATGTCAACTATGCTATTGATGGTGATACCGT
CGAGGTAGTGATTAAGAAAGTCGCTGACCGCAATAAGGGAACAGCAGCAGAAGCCAAAATTATTGATATCCTAGAACACA
GTTTGACAACAGTTGTCGGGCAAATCGTTCTGGATCAGGAAAAGCCTAAGTATGCTGGCTATATTCGTTCAAAAAATCAG
AAAATCAGTCAACCGATTTATGTTAAGAAATCAGCCCTAAAGTTAGAAGGAACAGAAGTTCTCAAGGTCTTTATCGATAA
ATACCCAAGCAAGAAACATGATTTCTTTGTCGCGAGTGTTCTCGATGTAGTGGGACACTCAACGGATGTCGGAATTGATG
TTCTTGAGGTCTTGGAATCAATGGACATTGTATCCGAGTTTCCAGAAGCTGTTGTTAAGGAAGCAGAAAGTGTGCCTGAT
GCTCCGTCTCAAAAGGATATGGAAGGTCGTCTGGATCTAAGAGATGAAATTACCTTTACCATTGACGGTGCGGATGCCAA
GGACTTGGACGATGCAGTGCATATCAAGGCTCTGAAAAATGGCAATCTGGAGCTTGGGGTTCACATCGCAGATGTTTCTT
ATTATGTGACCGAGGGGTCTGCCCTTGACAAGGAAGCCCTTAACCGTGCGACTTCTGTTTACGTGACAGACCGAGTGGTG
CCAATGCTTCCAGAACGACTATCAAATGGCATCTGCTCTCTCAATCCCCAAGTTGACCGCCTGACCCAGTCTGCTATTAT
GGAGATTGATAAACATGGTCGTGTGGTCAACTATACCATTACACAAACAGTTATCAAGACCAGTTTTCGTATGACCTATA
GCGATGTCAATGATATCCTAGCTGGCGATGAAGAAAAGAGAAAAGAATATCATAAAATTGTATCAAGTATCGAACTCATG
GCCAAGCTTCATGAAACTTTAGAAAACATGCGTGTGAAACGTGGAGCTCTCAATTTTGATACCAATGAAGCGAAGATTTT
AGTGGATAAACAAGGTAAGCCTGTTGATATCGTTCTTCGGCAGCGTGGTATTGCCGAGCGGATGATTGAGTCTTTTATGT
TGATGGCTAATGAAACAGTTGCCGAACATTTCAGCAAGTTGGATTTGCCTTTTATCTATCGAATTCACGAGGAGCCTAAG
GCTGAAAAGGTTCAGAAGTTTATTGATTATGCTTCGAGTTTTGGCTTGCGCATTTATGGGACTGCCAGTGAGATTAGTCA
GGAGGCACTTCAAGACATCATGCGTGCTGTTGAGGGAGAACCTTATGCAGATGTATTGTCCATGATGCTTCTTCGCTCTA
TGCAGCAGGCTCGTTATTCGGAGCACAATCACGGCCACTATGGACTAGCTGCTGACTATTATACTCACTTTACCAGTCCA
ATTCGTCGTTATCCAGACCTTCTTGTTCACCGTATGATTCGGGATTACGGCCGTTCTAAGGAAATAGCAGAGCATTTTGA
ACAAGTGATTCCAGAGATTGCGACCCAGTCTTCCAACCGTGAACGTCGTGCCATAGAAGCTGAGCGTGAAGTTGAAGCCA
TGAAAAAGGCTGAGTATATGGAAGAATACGTGGGTGAAGAGTATGATGCAGTTGTATCAAGTATTGTCAAATTCGGTCTC
TTTGTCGAATTGCCAAACACAGTTGAAGGCTTGATTCACATCACTAATCTACCTGAATTTTATCATTTCAATGAGCGTGA
TTTGACTCTTCGTGGAGAAAAATCAGGTATCACTTTCCGAGTGGGTCAGCAGATCCGTATCCGTGTTGAAAGAGCGGATA
AAATGACTGGAGAGATTGATTTTTCATTCGTACCTAGTGAGTTTGATGTGATTGAAAAAGGCTTGAAACAGTCTAGTCGT
AGTGGCAGAGGGCGTGGTTCAAATCGTCGTTCGGATAAGAAGGAAGACAAGAGAAAATCAGGACGCTCAAATGATAAGCG
TAAGCATTCACAAAAAGACAAGAAGAAAAAAGGAAAGAAACCTTTTTACAAGGAAGTAGCTAAGAAAGGAGCCAAGCATG
GCAAAGGGCGAGGGAAAGGTCGTCGCACAAAATAA

Upstream 100 bases:

>100_bases
AAAATAATGGGCAGGACTAGGTCTTTGCCTCTTTTTATTTTTAAAGGATGTTTGAGAAGGTTTTACAGTAAAAGAAAATT
AAAAAATCTAGAAAGAAAAT

Downstream 100 bases:

>100_bases
AAAGGCACGCCACGACTATACAATCGTAGATACGCTAGAGGCAGGGATGGTCCTGACTGGAACTGAAATCAAGAGTGTAC
GAGCTGCTCGAATTAATCTC

Product: ribonuclease R

Products: NA

Alternate protein names: RNase R 1; VacB protein homolog 1 [H]

Number of amino acids: Translated: 784; Mature: 784

Protein sequence:

>784_residues
MKDRIKEYLQDKGKVTVNDLAQALGKDSSKDFRELIKTLSLMERKHQIRFEEDGSLTLEAKKKHEITLKGIFHAHKNGFG
FVSLEGEEDDLFVGKNDVNYAIDGDTVEVVIKKVADRNKGTAAEAKIIDILEHSLTTVVGQIVLDQEKPKYAGYIRSKNQ
KISQPIYVKKSALKLEGTEVLKVFIDKYPSKKHDFFVASVLDVVGHSTDVGIDVLEVLESMDIVSEFPEAVVKEAESVPD
APSQKDMEGRLDLRDEITFTIDGADAKDLDDAVHIKALKNGNLELGVHIADVSYYVTEGSALDKEALNRATSVYVTDRVV
PMLPERLSNGICSLNPQVDRLTQSAIMEIDKHGRVVNYTITQTVIKTSFRMTYSDVNDILAGDEEKRKEYHKIVSSIELM
AKLHETLENMRVKRGALNFDTNEAKILVDKQGKPVDIVLRQRGIAERMIESFMLMANETVAEHFSKLDLPFIYRIHEEPK
AEKVQKFIDYASSFGLRIYGTASEISQEALQDIMRAVEGEPYADVLSMMLLRSMQQARYSEHNHGHYGLAADYYTHFTSP
IRRYPDLLVHRMIRDYGRSKEIAEHFEQVIPEIATQSSNRERRAIEAEREVEAMKKAEYMEEYVGEEYDAVVSSIVKFGL
FVELPNTVEGLIHITNLPEFYHFNERDLTLRGEKSGITFRVGQQIRIRVERADKMTGEIDFSFVPSEFDVIEKGLKQSSR
SGRGRGSNRRSDKKEDKRKSGRSNDKRKHSQKDKKKKGKKPFYKEVAKKGAKHGKGRGKGRRTK

Sequences:

>Translated_784_residues
MKDRIKEYLQDKGKVTVNDLAQALGKDSSKDFRELIKTLSLMERKHQIRFEEDGSLTLEAKKKHEITLKGIFHAHKNGFG
FVSLEGEEDDLFVGKNDVNYAIDGDTVEVVIKKVADRNKGTAAEAKIIDILEHSLTTVVGQIVLDQEKPKYAGYIRSKNQ
KISQPIYVKKSALKLEGTEVLKVFIDKYPSKKHDFFVASVLDVVGHSTDVGIDVLEVLESMDIVSEFPEAVVKEAESVPD
APSQKDMEGRLDLRDEITFTIDGADAKDLDDAVHIKALKNGNLELGVHIADVSYYVTEGSALDKEALNRATSVYVTDRVV
PMLPERLSNGICSLNPQVDRLTQSAIMEIDKHGRVVNYTITQTVIKTSFRMTYSDVNDILAGDEEKRKEYHKIVSSIELM
AKLHETLENMRVKRGALNFDTNEAKILVDKQGKPVDIVLRQRGIAERMIESFMLMANETVAEHFSKLDLPFIYRIHEEPK
AEKVQKFIDYASSFGLRIYGTASEISQEALQDIMRAVEGEPYADVLSMMLLRSMQQARYSEHNHGHYGLAADYYTHFTSP
IRRYPDLLVHRMIRDYGRSKEIAEHFEQVIPEIATQSSNRERRAIEAEREVEAMKKAEYMEEYVGEEYDAVVSSIVKFGL
FVELPNTVEGLIHITNLPEFYHFNERDLTLRGEKSGITFRVGQQIRIRVERADKMTGEIDFSFVPSEFDVIEKGLKQSSR
SGRGRGSNRRSDKKEDKRKSGRSNDKRKHSQKDKKKKGKKPFYKEVAKKGAKHGKGRGKGRRTK
>Mature_784_residues
MKDRIKEYLQDKGKVTVNDLAQALGKDSSKDFRELIKTLSLMERKHQIRFEEDGSLTLEAKKKHEITLKGIFHAHKNGFG
FVSLEGEEDDLFVGKNDVNYAIDGDTVEVVIKKVADRNKGTAAEAKIIDILEHSLTTVVGQIVLDQEKPKYAGYIRSKNQ
KISQPIYVKKSALKLEGTEVLKVFIDKYPSKKHDFFVASVLDVVGHSTDVGIDVLEVLESMDIVSEFPEAVVKEAESVPD
APSQKDMEGRLDLRDEITFTIDGADAKDLDDAVHIKALKNGNLELGVHIADVSYYVTEGSALDKEALNRATSVYVTDRVV
PMLPERLSNGICSLNPQVDRLTQSAIMEIDKHGRVVNYTITQTVIKTSFRMTYSDVNDILAGDEEKRKEYHKIVSSIELM
AKLHETLENMRVKRGALNFDTNEAKILVDKQGKPVDIVLRQRGIAERMIESFMLMANETVAEHFSKLDLPFIYRIHEEPK
AEKVQKFIDYASSFGLRIYGTASEISQEALQDIMRAVEGEPYADVLSMMLLRSMQQARYSEHNHGHYGLAADYYTHFTSP
IRRYPDLLVHRMIRDYGRSKEIAEHFEQVIPEIATQSSNRERRAIEAEREVEAMKKAEYMEEYVGEEYDAVVSSIVKFGL
FVELPNTVEGLIHITNLPEFYHFNERDLTLRGEKSGITFRVGQQIRIRVERADKMTGEIDFSFVPSEFDVIEKGLKQSSR
SGRGRGSNRRSDKKEDKRKSGRSNDKRKHSQKDKKKKGKKPFYKEVAKKGAKHGKGRGKGRRTK

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014623, Length=418, Percent_Identity=33.7320574162679, Blast_Score=216, Evalue=8e-56,
Organism=Homo sapiens, GI190014625, Length=418, Percent_Identity=33.7320574162679, Blast_Score=216, Evalue=9e-56,
Organism=Homo sapiens, GI134288890, Length=394, Percent_Identity=32.741116751269, Blast_Score=201, Evalue=2e-51,
Organism=Homo sapiens, GI19115966, Length=500, Percent_Identity=28.2, Blast_Score=167, Evalue=4e-41,
Organism=Homo sapiens, GI219521928, Length=500, Percent_Identity=28.2, Blast_Score=166, Evalue=6e-41,
Organism=Homo sapiens, GI156105695, Length=368, Percent_Identity=23.0978260869565, Blast_Score=85, Evalue=3e-16,
Organism=Homo sapiens, GI156105693, Length=133, Percent_Identity=32.3308270676692, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI87082383, Length=720, Percent_Identity=33.75, Blast_Score=396, Evalue=1e-111,
Organism=Escherichia coli, GI1787542, Length=676, Percent_Identity=24.5562130177515, Blast_Score=142, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI17553506, Length=455, Percent_Identity=30.3296703296703, Blast_Score=201, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI212645896, Length=555, Percent_Identity=27.7477477477477, Blast_Score=173, Evalue=4e-43,
Organism=Saccharomyces cerevisiae, GI6324552, Length=588, Percent_Identity=29.5918367346939, Blast_Score=194, Evalue=4e-50,
Organism=Saccharomyces cerevisiae, GI6320499, Length=319, Percent_Identity=25.0783699059561, Blast_Score=104, Evalue=7e-23,
Organism=Saccharomyces cerevisiae, GI6323943, Length=468, Percent_Identity=23.2905982905983, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24649634, Length=574, Percent_Identity=29.9651567944251, Blast_Score=216, Evalue=6e-56,
Organism=Drosophila melanogaster, GI24654592, Length=515, Percent_Identity=27.7669902912621, Blast_Score=169, Evalue=6e-42,
Organism=Drosophila melanogaster, GI19922976, Length=515, Percent_Identity=27.7669902912621, Blast_Score=169, Evalue=6e-42,
Organism=Drosophila melanogaster, GI24654597, Length=515, Percent_Identity=27.7669902912621, Blast_Score=169, Evalue=6e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805 [H]

Pfam domain/function: PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 89139; Mature: 89139

Theoretical pI: Translated: 7.71; Mature: 7.71

Prosite motif: PS50126 S1 ; PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDRIKEYLQDKGKVTVNDLAQALGKDSSKDFRELIKTLSLMERKHQIRFEEDGSLTLEA
CCHHHHHHHHCCCCEEHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEE
KKKHEITLKGIFHAHKNGFGFVSLEGEEDDLFVGKNDVNYAIDGDTVEVVIKKVADRNKG
CCCCEEEEEHHHHHCCCCEEEEEEECCCCCEEECCCCCCEEECCHHHHHHHHHHHCCCCC
TAAEAKIIDILEHSLTTVVGQIVLDQEKPKYAGYIRSKNQKISQPIYVKKSALKLEGTEV
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCEEEEHHHHCCCHHHH
LKVFIDKYPSKKHDFFVASVLDVVGHSTDVGIDVLEVLESMDIVSEFPEAVVKEAESVPD
HHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
APSQKDMEGRLDLRDEITFTIDGADAKDLDDAVHIKALKNGNLELGVHIADVSYYVTEGS
CCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHEEEEECCCCEEEEEEEEEEEEEEECCC
ALDKEALNRATSVYVTDRVVPMLPERLSNGICSLNPQVDRLTQSAIMEIDKHGRVVNYTI
CCCHHHHHHHHEEEEECCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEH
TQTVIKTSFRMTYSDVNDILAGDEEKRKEYHKIVSSIELMAKLHETLENMRVKRGALNFD
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
TNEAKILVDKQGKPVDIVLRQRGIAERMIESFMLMANETVAEHFSKLDLPFIYRIHEEPK
CCCCEEEEECCCCCEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
AEKVQKFIDYASSFGLRIYGTASEISQEALQDIMRAVEGEPYADVLSMMLLRSMQQARYS
HHHHHHHHHHHHHCCEEEEECHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHC
EHNHGHYGLAADYYTHFTSPIRRYPDLLVHRMIRDYGRSKEIAEHFEQVIPEIATQSSNR
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCC
ERRAIEAEREVEAMKKAEYMEEYVGEEYDAVVSSIVKFGLFVELPNTVEGLIHITNLPEF
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEECCCHHHHHEEECCCCHH
YHFNERDLTLRGEKSGITFRVGQQIRIRVERADKMTGEIDFSFVPSEFDVIEKGLKQSSR
HCCCCCCEEEECCCCCCEEEECCEEEEEEEHHHCCCCCEEEEECCCHHHHHHHHHHHHCC
SGRGRGSNRRSDKKEDKRKSGRSNDKRKHSQKDKKKKGKKPFYKEVAKKGAKHGKGRGKG
CCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCC
RRTK
CCCC
>Mature Secondary Structure
MKDRIKEYLQDKGKVTVNDLAQALGKDSSKDFRELIKTLSLMERKHQIRFEEDGSLTLEA
CCHHHHHHHHCCCCEEHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEE
KKKHEITLKGIFHAHKNGFGFVSLEGEEDDLFVGKNDVNYAIDGDTVEVVIKKVADRNKG
CCCCEEEEEHHHHHCCCCEEEEEEECCCCCEEECCCCCCEEECCHHHHHHHHHHHCCCCC
TAAEAKIIDILEHSLTTVVGQIVLDQEKPKYAGYIRSKNQKISQPIYVKKSALKLEGTEV
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCEEEEHHHHCCCHHHH
LKVFIDKYPSKKHDFFVASVLDVVGHSTDVGIDVLEVLESMDIVSEFPEAVVKEAESVPD
HHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
APSQKDMEGRLDLRDEITFTIDGADAKDLDDAVHIKALKNGNLELGVHIADVSYYVTEGS
CCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHEEEEECCCCEEEEEEEEEEEEEEECCC
ALDKEALNRATSVYVTDRVVPMLPERLSNGICSLNPQVDRLTQSAIMEIDKHGRVVNYTI
CCCHHHHHHHHEEEEECCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEH
TQTVIKTSFRMTYSDVNDILAGDEEKRKEYHKIVSSIELMAKLHETLENMRVKRGALNFD
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
TNEAKILVDKQGKPVDIVLRQRGIAERMIESFMLMANETVAEHFSKLDLPFIYRIHEEPK
CCCCEEEEECCCCCEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
AEKVQKFIDYASSFGLRIYGTASEISQEALQDIMRAVEGEPYADVLSMMLLRSMQQARYS
HHHHHHHHHHHHHCCEEEEECHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHC
EHNHGHYGLAADYYTHFTSPIRRYPDLLVHRMIRDYGRSKEIAEHFEQVIPEIATQSSNR
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCC
ERRAIEAEREVEAMKKAEYMEEYVGEEYDAVVSSIVKFGLFVELPNTVEGLIHITNLPEF
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEECCCHHHHHEEECCCCHH
YHFNERDLTLRGEKSGITFRVGQQIRIRVERADKMTGEIDFSFVPSEFDVIEKGLKQSSR
HCCCCCCEEEECCCCCCEEEECCEEEEEEEHHHCCCCCEEEEECCCHHHHHHHHHHHHCC
SGRGRGSNRRSDKKEDKRKSGRSNDKRKHSQKDKKKKGKKPFYKEVAKKGAKHGKGRGKG
CCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCC
RRTK
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]