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The map label for this gene is adk

Identifier: 116515877

GI number: 116515877

Start: 207070

End: 207708

Strand: Direct

Name: adk

Synonym: SPD_0214

Alternate gene names: 116515877

Gene position: 207070-207708 (Clockwise)

Preceding gene: 116516915

Following gene: 116517117

Centisome position: 10.12

GC content: 39.44

Gene sequence:

>639_bases
ATGAATCTTTTGATTATGGGCTTACCTGGTGCAGGTAAGGGAACTCAAGCAGCAAAAATCGTAGAACAATTCCATGTTGC
ACATATCTCAACAGGTGATATGTTCCGCGCTGCAATGGCAAATCAAACTGAAATGGGTGTTCTTGCTAAGTCATATATTG
ACAAGGGTGAATTGGTTCCTGACGAAGTTACAAATGGAATCGTAAAAGAACGCCTTTCACAAGATGATATTAAAGAAACA
GGATTCTTATTGGATGGTTACCCACGTACAATTGAACAAGCTCATGCCTTGGACAAAACATTGGCTGAACTTGGCATTGA
ACTAGAAGGTATTATCAATATTGAAGTGAACCCTGACAGCCTCTTGGAACGTTTGAGTGGCCGTATCATCCACCGCGTAA
CTGGAGAAACTTTCCACAAGGTCTTTAACCCACCAGTTGACTATAAAGAAGAAGATTACTACCAACGTGAAGATGATAAG
CCTGAGACAGTAAAACGTCGTTTGGATGTTAATATTGCTCAAGGAGAACCAATCATTGCTCACTACCGTGCCAAAGGTTT
GGTTCATGACATCGAAGGTAATCAAGATATCAATGATGTCTTCTCAGATATTGAAAAAGTATTGACAAATTTGAAATAA

Upstream 100 bases:

>100_bases
ACATTTGTAAGAGTTGGATCTCCCCTCTTCTATTTTGTTTTTAAATCGGGGTGAAAAAACTTTTTGCTTCTATTTAAAAA
CAAAATAAGGAGATCAAATC

Downstream 100 bases:

>100_bases
AGCGTTTTTCACACTTGCAAAAATCCGCTACAAATGTTATACTGAAATAGTCTGACTTATAATTGTTGTCTCTGTGTCTA
GAGGCATCGAATCGAAATTT

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MNLLIMGLPGAGKGTQAAKIVEQFHVAHISTGDMFRAAMANQTEMGVLAKSYIDKGELVPDEVTNGIVKERLSQDDIKET
GFLLDGYPRTIEQAHALDKTLAELGIELEGIINIEVNPDSLLERLSGRIIHRVTGETFHKVFNPPVDYKEEDYYQREDDK
PETVKRRLDVNIAQGEPIIAHYRAKGLVHDIEGNQDINDVFSDIEKVLTNLK

Sequences:

>Translated_212_residues
MNLLIMGLPGAGKGTQAAKIVEQFHVAHISTGDMFRAAMANQTEMGVLAKSYIDKGELVPDEVTNGIVKERLSQDDIKET
GFLLDGYPRTIEQAHALDKTLAELGIELEGIINIEVNPDSLLERLSGRIIHRVTGETFHKVFNPPVDYKEEDYYQREDDK
PETVKRRLDVNIAQGEPIIAHYRAKGLVHDIEGNQDINDVFSDIEKVLTNLK
>Mature_212_residues
MNLLIMGLPGAGKGTQAAKIVEQFHVAHISTGDMFRAAMANQTEMGVLAKSYIDKGELVPDEVTNGIVKERLSQDDIKET
GFLLDGYPRTIEQAHALDKTLAELGIELEGIINIEVNPDSLLERLSGRIIHRVTGETFHKVFNPPVDYKEEDYYQREDDK
PETVKRRLDVNIAQGEPIIAHYRAKGLVHDIEGNQDINDVFSDIEKVLTNLK

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI19923437, Length=200, Percent_Identity=38.5, Blast_Score=152, Evalue=2e-37,
Organism=Homo sapiens, GI7524346, Length=207, Percent_Identity=39.1304347826087, Blast_Score=152, Evalue=2e-37,
Organism=Homo sapiens, GI4502013, Length=207, Percent_Identity=39.1304347826087, Blast_Score=152, Evalue=2e-37,
Organism=Homo sapiens, GI310110345, Length=215, Percent_Identity=34.8837209302326, Blast_Score=132, Evalue=2e-31,
Organism=Homo sapiens, GI53832003, Length=215, Percent_Identity=34.8837209302326, Blast_Score=132, Evalue=2e-31,
Organism=Homo sapiens, GI8051579, Length=215, Percent_Identity=34.8837209302326, Blast_Score=132, Evalue=2e-31,
Organism=Homo sapiens, GI53832001, Length=215, Percent_Identity=34.8837209302326, Blast_Score=132, Evalue=2e-31,
Organism=Homo sapiens, GI4502011, Length=210, Percent_Identity=29.0476190476191, Blast_Score=111, Evalue=5e-25,
Organism=Homo sapiens, GI22749187, Length=209, Percent_Identity=30.622009569378, Blast_Score=106, Evalue=1e-23,
Organism=Homo sapiens, GI28144897, Length=199, Percent_Identity=28.643216080402, Blast_Score=98, Evalue=5e-21,
Organism=Homo sapiens, GI28144899, Length=199, Percent_Identity=28.643216080402, Blast_Score=98, Evalue=6e-21,
Organism=Homo sapiens, GI7706497, Length=213, Percent_Identity=27.6995305164319, Blast_Score=94, Evalue=8e-20,
Organism=Escherichia coli, GI1786680, Length=218, Percent_Identity=38.5321100917431, Blast_Score=154, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI17552384, Length=216, Percent_Identity=31.9444444444444, Blast_Score=135, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17533833, Length=208, Percent_Identity=30.2884615384615, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17567503, Length=201, Percent_Identity=28.8557213930348, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17537943, Length=214, Percent_Identity=28.9719626168224, Blast_Score=94, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17550688, Length=210, Percent_Identity=26.1904761904762, Blast_Score=85, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6320432, Length=209, Percent_Identity=40.6698564593301, Blast_Score=177, Evalue=9e-46,
Organism=Saccharomyces cerevisiae, GI6321018, Length=195, Percent_Identity=32.8205128205128, Blast_Score=116, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6322828, Length=209, Percent_Identity=28.2296650717703, Blast_Score=99, Evalue=5e-22,
Organism=Drosophila melanogaster, GI22026816, Length=213, Percent_Identity=35.6807511737089, Blast_Score=153, Evalue=7e-38,
Organism=Drosophila melanogaster, GI17737899, Length=197, Percent_Identity=36.5482233502538, Blast_Score=123, Evalue=7e-29,
Organism=Drosophila melanogaster, GI24645822, Length=197, Percent_Identity=36.5482233502538, Blast_Score=123, Evalue=7e-29,
Organism=Drosophila melanogaster, GI221459597, Length=207, Percent_Identity=26.5700483091787, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI21356893, Length=207, Percent_Identity=26.5700483091787, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI17647141, Length=202, Percent_Identity=26.2376237623762, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24663208, Length=202, Percent_Identity=26.2376237623762, Blast_Score=84, Evalue=7e-17,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_STRP2 (Q04ML5)

Other databases:

- EMBL:   CP000410
- RefSeq:   YP_815733.1
- ProteinModelPortal:   Q04ML5
- SMR:   Q04ML5
- STRING:   Q04ML5
- PhosSite:   Q04ML5
- EnsemblBacteria:   EBSTRT00000018906
- GeneID:   4441374
- GenomeReviews:   CP000410_GR
- KEGG:   spd:SPD_0214
- eggNOG:   COG0563
- GeneTree:   EBGT00050000027692
- HOGENOM:   HBG630208
- OMA:   RTYHVKY
- ProtClustDB:   PRK00279
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; SSF57774 Adenylate_kinase_Znf_lid

EC number: =2.7.4.3

Molecular weight: Translated: 23721; Mature: 23721

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLLIMGLPGAGKGTQAAKIVEQFHVAHISTGDMFRAAMANQTEMGVLAKSYIDKGELVP
CCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHCCCCCCCH
DEVTNGIVKERLSQDDIKETGFLLDGYPRTIEQAHALDKTLAELGIELEGIINIEVNPDS
HHHHHHHHHHHHCHHHHHHCCCEECCCHHHHHHHHHHHHHHHHHCCCEEEEEEEEECHHH
LLERLSGRIIHRVTGETFHKVFNPPVDYKEEDYYQREDDKPETVKRRLDVNIAQGEPIIA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCCCHHHHHHHHCCEECCCCCEEE
HYRAKGLVHDIEGNQDINDVFSDIEKVLTNLK
HHHHCCCEEECCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNLLIMGLPGAGKGTQAAKIVEQFHVAHISTGDMFRAAMANQTEMGVLAKSYIDKGELVP
CCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHCCCCCCCH
DEVTNGIVKERLSQDDIKETGFLLDGYPRTIEQAHALDKTLAELGIELEGIINIEVNPDS
HHHHHHHHHHHHCHHHHHHCCCEECCCHHHHHHHHHHHHHHHHHCCCEEEEEEEEECHHH
LLERLSGRIIHRVTGETFHKVFNPPVDYKEEDYYQREDDKPETVKRRLDVNIAQGEPIIA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCCCHHHHHHHHCCEECCCCCEEE
HYRAKGLVHDIEGNQDINDVFSDIEKVLTNLK
HHHHCCCEEECCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA