| Definition | Streptococcus pneumoniae D39, complete genome. |
|---|---|
| Accession | NC_008533 |
| Length | 2,046,115 |
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The map label for this gene is pcrA [H]
Identifier: 116515714
GI number: 116515714
Start: 986673
End: 988964
Strand: Direct
Name: pcrA [H]
Synonym: SPD_0973
Alternate gene names: 116515714
Gene position: 986673-988964 (Clockwise)
Preceding gene: 116516586
Following gene: 116516612
Centisome position: 48.22
GC content: 43.24
Gene sequence:
>2292_bases ATGAACGCATTATTAAATGGAATGAATGACCGTCAGGCTGAGGCGGTGCAAACGACAGAAGGTCCCTTGCTAATCATGGC AGGGGCTGGTTCTGGAAAGACTCGTGTTTTAACCCACCGTATCGCTTATTTGATTGATGAAAAGCTGGTCAATCCTTGGA ATATCTTGGCCATTACCTTTACCAACAAGGCTGCGCGTGAGATGAAAGAGCGTGCTTATAGCCTCAATCCAGCTACTCAG GACTGTCTGATTGCGACCTTCCACTCCATGTGTGTGCGTATTTTGCGTCGCGATGCGGACCATATTGGCTACAATCGTAA TTTTACAATTGTGGATCCTGGTGAACAGCGAACGCTCATGAAACGTATTCTCAAACAGTTGAACTTGGATCCTAAAAAAT GGAATGAACGAACTATTTTGGGGACCATTTCCAATGCTAAGAATGATTTGATTGATGATGTTGCTTATGCTGCCCAAGCT GGCGATATGTATACGCAAATTGTGGCCCAGTGTTATACAGCCTATCAAAAAGAACTTCGTCAGTCTGAATCCGTTGACTT TGATGATTTGATTATGCTGACCTTGCGTCTCTTTGATCAAAATCCTGATGTTTTGACCTACTACCAGCAAAAATTCCAAT ACATCCACGTTGATGAGTACCAAGATACCAACCACGCTCAGTACCAATTGGTCAAACTCTTGGCTTCCCGTTTTAAAAAT ATCTGTGTGGTTGGGGATGCGGACCAGTCTATCTACGGTTGGCGTGGTGCTGATATGCAGAATATCTTGGACTTTGAAAA GGATTACCCCAAAGCCAAGGTTGTTTTGCTGGAGGAAAATTACCGCTCAACCAAAACCATTCTTCAAGCGGCCAACGAGG TTATTAAAAATAATAAAAATCGCCGTCCTAAAAATCTCTGGACTCAAAACGCTGATGGGGAGCAAATCGTTTACTATCGT GCCGATGATGAGCTGGATGAGGCTGTATTTGTAGCCAGAACCATCGATGAACTTAGTCGCAGTCAAAACTTCCTTCATAA GGATTTTGCAGTTCTCTATCGGACTAATGCCCAGTCCCGTACAATTGAGGAAGCCCTGCTCAAGTCTAACATTCCTTATA CCATGGTTGGCGGAACCAAATTCTACAGCCGTAAGGAAATTCGCGATATTATTGCTTATCTCAACCTTATTGCTAATTTG AGTGACAATATTAGTTTTGAGCGTATTATCAACGAGCCTAAACGTGGAATTGGTCTAGGTACAGTTGAGAAAATCCGTGA TTTTGCAAATTTGCAAAATATGTCTATGCTGGATGCTTCTGCTAATATTATGTTGTCTGGTATCAAGGGTAAGGCAGCCC AATCTATCTGGGATTTTGCCAATATGATGCTTGATTTGCGGGAGCAGCTAGACCACTTAAGCATTACAGAGTTGGTTGAG TCCGTCCTAGAAAAAACAGGTTATGTCGATATTCTTAACGCCCAAGCGACTCTAGAAAGCAAGGCACGGGTTGAAAATAT CGAAGAGTTTCTTTCTGTTACGAAGAACTTTGATGACACCACGGATGTGACAGAAGAGGAAACTGGTCTGGACAAACTGA GTCGTTTCTTAAATGACTTGGCTTTGATTGCCGACACAGATTCAGGTAGTCAGGAGACATCAGAAGTGACCTTGATGACC CTGCATGCTGCCAAAGGTCTCGAATTTCCAGTTGTCTTTTTGATTGGGATGGAAGAAAATGTCTTTCCACTTAGTCGTGC GACTGAAGATCCAGATGAATTAGAAGAAGAGCGCCGTCTAGCCTATGTAGGTATCACGCGTGCAGAGAAAATTCTCTATC TGACCAATGCCAACTCACGCTTGCTTTTTGGTCGTACCAATTATAACCGTCCGACTCGTTTTATTAACGAAATCAGTTCA GATTTGCTTGAGTATCAAGGTCTGGCTCGTCCTGCAAATACAAGCTTTAAGGCATCATATAGCAGTGGTAGTATTTCCTT TGGTCAAGGTATGAGTTTGGCTCAGGCTCTTCAAGACCGTAAACGCGGTGCTGCCCCAAAATCAATCCAGTCAAGCGGTC TTCCATTTGGTCAATTTACAGCTGGCGCAAAACCAGCATCTAGCGAGGCAAATTGGTCCATTGGTGATATTGCTCTCCAC AAGAAATGGGGAGAGGGAACCGTTCTGGAAGTTTCAGGTAGCGGTGCTAGGCAGGAATTGAAAATCAATTTCCCAGAAGT AGGTTTGAAAAAACTTTTAGCCAGTGTGGCTCCAATTGAGAAAAAAATCTAA
Upstream 100 bases:
>100_bases TAGTTTCAATCCACTATATTTTGCTACTCCCCGTAAAGTTTCTATTTTCCCTGATTTCTGATATAATAGAAATATTGACT TCAAGAGTAAGGAAGAGAAG
Downstream 100 bases:
>100_bases TTTTCCATCCTTCTCACGAATAATAAAGTGAGGAGGATTTTTATGTACAGTATTTCATTCCAAGAAGATTCACTATTACC AAGAGAAAGGCTGGCCAAGG
Product: ATP-dependent DNA helicase PcrA
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 763; Mature: 763
Protein sequence:
>763_residues MNALLNGMNDRQAEAVQTTEGPLLIMAGAGSGKTRVLTHRIAYLIDEKLVNPWNILAITFTNKAAREMKERAYSLNPATQ DCLIATFHSMCVRILRRDADHIGYNRNFTIVDPGEQRTLMKRILKQLNLDPKKWNERTILGTISNAKNDLIDDVAYAAQA GDMYTQIVAQCYTAYQKELRQSESVDFDDLIMLTLRLFDQNPDVLTYYQQKFQYIHVDEYQDTNHAQYQLVKLLASRFKN ICVVGDADQSIYGWRGADMQNILDFEKDYPKAKVVLLEENYRSTKTILQAANEVIKNNKNRRPKNLWTQNADGEQIVYYR ADDELDEAVFVARTIDELSRSQNFLHKDFAVLYRTNAQSRTIEEALLKSNIPYTMVGGTKFYSRKEIRDIIAYLNLIANL SDNISFERIINEPKRGIGLGTVEKIRDFANLQNMSMLDASANIMLSGIKGKAAQSIWDFANMMLDLREQLDHLSITELVE SVLEKTGYVDILNAQATLESKARVENIEEFLSVTKNFDDTTDVTEEETGLDKLSRFLNDLALIADTDSGSQETSEVTLMT LHAAKGLEFPVVFLIGMEENVFPLSRATEDPDELEEERRLAYVGITRAEKILYLTNANSRLLFGRTNYNRPTRFINEISS DLLEYQGLARPANTSFKASYSSGSISFGQGMSLAQALQDRKRGAAPKSIQSSGLPFGQFTAGAKPASSEANWSIGDIALH KKWGEGTVLEVSGSGARQELKINFPEVGLKKLLASVAPIEKKI
Sequences:
>Translated_763_residues MNALLNGMNDRQAEAVQTTEGPLLIMAGAGSGKTRVLTHRIAYLIDEKLVNPWNILAITFTNKAAREMKERAYSLNPATQ DCLIATFHSMCVRILRRDADHIGYNRNFTIVDPGEQRTLMKRILKQLNLDPKKWNERTILGTISNAKNDLIDDVAYAAQA GDMYTQIVAQCYTAYQKELRQSESVDFDDLIMLTLRLFDQNPDVLTYYQQKFQYIHVDEYQDTNHAQYQLVKLLASRFKN ICVVGDADQSIYGWRGADMQNILDFEKDYPKAKVVLLEENYRSTKTILQAANEVIKNNKNRRPKNLWTQNADGEQIVYYR ADDELDEAVFVARTIDELSRSQNFLHKDFAVLYRTNAQSRTIEEALLKSNIPYTMVGGTKFYSRKEIRDIIAYLNLIANL SDNISFERIINEPKRGIGLGTVEKIRDFANLQNMSMLDASANIMLSGIKGKAAQSIWDFANMMLDLREQLDHLSITELVE SVLEKTGYVDILNAQATLESKARVENIEEFLSVTKNFDDTTDVTEEETGLDKLSRFLNDLALIADTDSGSQETSEVTLMT LHAAKGLEFPVVFLIGMEENVFPLSRATEDPDELEEERRLAYVGITRAEKILYLTNANSRLLFGRTNYNRPTRFINEISS DLLEYQGLARPANTSFKASYSSGSISFGQGMSLAQALQDRKRGAAPKSIQSSGLPFGQFTAGAKPASSEANWSIGDIALH KKWGEGTVLEVSGSGARQELKINFPEVGLKKLLASVAPIEKKI >Mature_763_residues MNALLNGMNDRQAEAVQTTEGPLLIMAGAGSGKTRVLTHRIAYLIDEKLVNPWNILAITFTNKAAREMKERAYSLNPATQ DCLIATFHSMCVRILRRDADHIGYNRNFTIVDPGEQRTLMKRILKQLNLDPKKWNERTILGTISNAKNDLIDDVAYAAQA GDMYTQIVAQCYTAYQKELRQSESVDFDDLIMLTLRLFDQNPDVLTYYQQKFQYIHVDEYQDTNHAQYQLVKLLASRFKN ICVVGDADQSIYGWRGADMQNILDFEKDYPKAKVVLLEENYRSTKTILQAANEVIKNNKNRRPKNLWTQNADGEQIVYYR ADDELDEAVFVARTIDELSRSQNFLHKDFAVLYRTNAQSRTIEEALLKSNIPYTMVGGTKFYSRKEIRDIIAYLNLIANL SDNISFERIINEPKRGIGLGTVEKIRDFANLQNMSMLDASANIMLSGIKGKAAQSIWDFANMMLDLREQLDHLSITELVE SVLEKTGYVDILNAQATLESKARVENIEEFLSVTKNFDDTTDVTEEETGLDKLSRFLNDLALIADTDSGSQETSEVTLMT LHAAKGLEFPVVFLIGMEENVFPLSRATEDPDELEEERRLAYVGITRAEKILYLTNANSRLLFGRTNYNRPTRFINEISS DLLEYQGLARPANTSFKASYSSGSISFGQGMSLAQALQDRKRGAAPKSIQSSGLPFGQFTAGAKPASSEANWSIGDIALH KKWGEGTVLEVSGSGARQELKINFPEVGLKKLLASVAPIEKKI
Specific function: Essential helicase [H]
COG id: COG0210
COG function: function code L; Superfamily I DNA and RNA helicases
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]
Homologues:
Organism=Escherichia coli, GI2367296, Length=761, Percent_Identity=38.2391590013141, Blast_Score=513, Evalue=1e-146, Organism=Escherichia coli, GI48994965, Length=649, Percent_Identity=38.6748844375963, Blast_Score=410, Evalue=1e-115, Organism=Escherichia coli, GI1787196, Length=347, Percent_Identity=25.0720461095101, Blast_Score=86, Evalue=7e-18, Organism=Saccharomyces cerevisiae, GI6322369, Length=727, Percent_Identity=29.7111416781293, Blast_Score=232, Evalue=1e-61, Organism=Saccharomyces cerevisiae, GI6324477, Length=672, Percent_Identity=24.2559523809524, Blast_Score=122, Evalue=2e-28,
Paralogues:
None
Copy number: 3000 [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR005751 - InterPro: IPR013986 - InterPro: IPR014017 - InterPro: IPR000212 - InterPro: IPR014016 [H]
Pfam domain/function: PF00580 UvrD-helicase [H]
EC number: =3.6.4.12 [H]
Molecular weight: Translated: 85976; Mature: 85976
Theoretical pI: Translated: 5.27; Mature: 5.27
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.5 %Cys (Translated Protein) 2.4 %Met (Translated Protein) 2.9 %Cys+Met (Translated Protein) 0.5 %Cys (Mature Protein) 2.4 %Met (Mature Protein) 2.9 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MNALLNGMNDRQAEAVQTTEGPLLIMAGAGSGKTRVLTHRIAYLIDEKLVNPWNILAITF CCCHHCCCCCHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEE TNKAAREMKERAYSLNPATQDCLIATFHSMCVRILRRDADHIGYNRNFTIVDPGEQRTLM CCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCHHHCCCCCCEEEECCCHHHHHH KRILKQLNLDPKKWNERTILGTISNAKNDLIDDVAYAAQAGDMYTQIVAQCYTAYQKELR HHHHHHCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH QSESVDFDDLIMLTLRLFDQNPDVLTYYQQKFQYIHVDEYQDTNHAQYQLVKLLASRFKN HHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHCEEEEEECCCCCCHHHHHHHHHHHHHCCC ICVVGDADQSIYGWRGADMQNILDFEKDYPKAKVVLLEENYRSTKTILQAANEVIKNNKN EEEECCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHCCCC RRPKNLWTQNADGEQIVYYRADDELDEAVFVARTIDELSRSQNFLHKDFAVLYRTNAQSR CCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHH TIEEALLKSNIPYTMVGGTKFYSRKEIRDIIAYLNLIANLSDNISFERIINEPKRGIGLG HHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCC TVEKIRDFANLQNMSMLDASANIMLSGIKGKAAQSIWDFANMMLDLREQLDHLSITELVE HHHHHHHHHHHCCCHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH SVLEKTGYVDILNAQATLESKARVENIEEFLSVTKNFDDTTDVTEEETGLDKLSRFLNDL HHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCHHHHHHHHHHH ALIADTDSGSQETSEVTLMTLHAAKGLEFPVVFLIGMEENVFPLSRATEDPDELEEERRL EEEEECCCCCCCCCCEEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHCE AYVGITRAEKILYLTNANSRLLFGRTNYNRPTRFINEISSDLLEYQGLARPANTSFKASY EEEEEECCCEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEC SSGSISFGQGMSLAQALQDRKRGAAPKSIQSSGLPFGQFTAGAKPASSEANWSIGDIALH CCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEE KKWGEGTVLEVSGSGARQELKINFPEVGLKKLLASVAPIEKKI EECCCCCEEEEECCCCCCEEEECCCHHHHHHHHHHHCCHHHCC >Mature Secondary Structure MNALLNGMNDRQAEAVQTTEGPLLIMAGAGSGKTRVLTHRIAYLIDEKLVNPWNILAITF CCCHHCCCCCHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEE TNKAAREMKERAYSLNPATQDCLIATFHSMCVRILRRDADHIGYNRNFTIVDPGEQRTLM CCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCHHHCCCCCCEEEECCCHHHHHH KRILKQLNLDPKKWNERTILGTISNAKNDLIDDVAYAAQAGDMYTQIVAQCYTAYQKELR HHHHHHCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH QSESVDFDDLIMLTLRLFDQNPDVLTYYQQKFQYIHVDEYQDTNHAQYQLVKLLASRFKN HHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHCEEEEEECCCCCCHHHHHHHHHHHHHCCC ICVVGDADQSIYGWRGADMQNILDFEKDYPKAKVVLLEENYRSTKTILQAANEVIKNNKN EEEECCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHCCCC RRPKNLWTQNADGEQIVYYRADDELDEAVFVARTIDELSRSQNFLHKDFAVLYRTNAQSR CCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHH TIEEALLKSNIPYTMVGGTKFYSRKEIRDIIAYLNLIANLSDNISFERIINEPKRGIGLG HHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCC TVEKIRDFANLQNMSMLDASANIMLSGIKGKAAQSIWDFANMMLDLREQLDHLSITELVE HHHHHHHHHHHCCCHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH SVLEKTGYVDILNAQATLESKARVENIEEFLSVTKNFDDTTDVTEEETGLDKLSRFLNDL HHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCHHHHHHHHHHH ALIADTDSGSQETSEVTLMTLHAAKGLEFPVVFLIGMEENVFPLSRATEDPDELEEERRL EEEEECCCCCCCCCCEEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHCE AYVGITRAEKILYLTNANSRLLFGRTNYNRPTRFINEISSDLLEYQGLARPANTSFKASY EEEEEECCCEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEC SSGSISFGQGMSLAQALQDRKRGAAPKSIQSSGLPFGQFTAGAKPASSEANWSIGDIALH CCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEE KKWGEGTVLEVSGSGARQELKINFPEVGLKKLLASVAPIEKKI EECCCCCEEEEECCCCCCEEEECCCHHHHHHHHHHHCCHHHCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA