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The map label for this gene is sodA

Identifier: 116515547

GI number: 116515547

Start: 687572

End: 688177

Strand: Direct

Name: sodA

Synonym: SPD_0667

Alternate gene names: 116515547

Gene position: 687572-688177 (Clockwise)

Preceding gene: 116515334

Following gene: 116516259

Centisome position: 33.6

GC content: 43.23

Gene sequence:

>606_bases
ATGGCTATTATCTTACCAGAACTTCCATATGCATACGACGCTTTGGAACCATACATCGATGCGGAAACAATGCATTTGCA
CCATGACAAACACCATCAAACTTATGTCAACAATGCCAATGCAGCTTTAGAAAAACACCCTGAAATCGGTGAAGACCTTG
AAGCCTTGCTTGCTGATGTAGAATCTATCCCAGCTGATATCCGTCAAGCACTTATCAACAATGGTGGCGGACACTTGAAC
CACGCTCTTTTCTGGGAATTGATGACTCCCGAGAAAACAGCTCCTTCAGCAGAACTGGCAGCAGCAATCGATGCAACATT
TGGTTCATTTGAAGAATTCCAAGCAGCCTTCACTGCAGCAGCAACAACTCGTTTTGGTTCAGGTTGGGCATGGTTGGTTG
TCAACAAAGAAGGGAAACTTGAAGTGACTTCAACAGCAAACCAAGACACACCAATCTCAGAAGGTAAAAAACCAATCTTG
GGCTTGGACGTTTGGGAACATGCTTACTACGTGAAATACCGCAACGTGCGTCCTGACTATATCAAAGCTTTCTTTTCAGT
AATCAACTGGAATAAAGTAGATGAATTGTACGCAGCTGCTAAATAA

Upstream 100 bases:

>100_bases
GAAAGTATGTCAGTGATTTCCTTATCTATAAGCAAAAAACTTGAAAAAAGTGAATGTTTGCGTTATCATTTTCATATAGA
AAGAAAAAGAGGTATTACAG

Downstream 100 bases:

>100_bases
TGATAGTTGGAGGGAAGAATTGTTCTTCTCTTTTTTAGGTTATAAGATTCTGGTCTGACAAAATCGTCAGACTTTTTTCA
TTTTTATGAGAAACGTGCTA

Product: superoxide dismutase, manganese-dependent

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 201; Mature: 200

Protein sequence:

>201_residues
MAIILPELPYAYDALEPYIDAETMHLHHDKHHQTYVNNANAALEKHPEIGEDLEALLADVESIPADIRQALINNGGGHLN
HALFWELMTPEKTAPSAELAAAIDATFGSFEEFQAAFTAAATTRFGSGWAWLVVNKEGKLEVTSTANQDTPISEGKKPIL
GLDVWEHAYYVKYRNVRPDYIKAFFSVINWNKVDELYAAAK

Sequences:

>Translated_201_residues
MAIILPELPYAYDALEPYIDAETMHLHHDKHHQTYVNNANAALEKHPEIGEDLEALLADVESIPADIRQALINNGGGHLN
HALFWELMTPEKTAPSAELAAAIDATFGSFEEFQAAFTAAATTRFGSGWAWLVVNKEGKLEVTSTANQDTPISEGKKPIL
GLDVWEHAYYVKYRNVRPDYIKAFFSVINWNKVDELYAAAK
>Mature_200_residues
AIILPELPYAYDALEPYIDAETMHLHHDKHHQTYVNNANAALEKHPEIGEDLEALLADVESIPADIRQALINNGGGHLNH
ALFWELMTPEKTAPSAELAAAIDATFGSFEEFQAAFTAAATTRFGSGWAWLVVNKEGKLEVTSTANQDTPISEGKKPILG
LDVWEHAYYVKYRNVRPDYIKAFFSVINWNKVDELYAAAK

Specific function: Destroys radicals which are normally produced within the cells and which are toxic to biological systems. May play a critical role against oxidative stress, affecting both the survival and the virulence of S.pneumoniae

COG id: COG0605

COG function: function code P; Superoxide dismutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron/manganese superoxide dismutase family

Homologues:

Organism=Homo sapiens, GI67782307, Length=201, Percent_Identity=49.2537313432836, Blast_Score=191, Evalue=5e-49,
Organism=Homo sapiens, GI67782305, Length=201, Percent_Identity=49.2537313432836, Blast_Score=191, Evalue=5e-49,
Organism=Homo sapiens, GI67782309, Length=200, Percent_Identity=42, Blast_Score=150, Evalue=7e-37,
Organism=Escherichia coli, GI1790342, Length=208, Percent_Identity=53.8461538461538, Blast_Score=223, Evalue=6e-60,
Organism=Escherichia coli, GI1787946, Length=200, Percent_Identity=44.5, Blast_Score=179, Evalue=9e-47,
Organism=Caenorhabditis elegans, GI17506561, Length=201, Percent_Identity=45.771144278607, Blast_Score=173, Evalue=6e-44,
Organism=Caenorhabditis elegans, GI17569479, Length=200, Percent_Identity=43.5, Blast_Score=165, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6321796, Length=211, Percent_Identity=40.7582938388626, Blast_Score=152, Evalue=4e-38,
Organism=Drosophila melanogaster, GI17136812, Length=200, Percent_Identity=46.5, Blast_Score=180, Evalue=4e-46,

Paralogues:

None

Copy number: 2980 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 20 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): SODM_STRPN (P0A4J6)

Other databases:

- EMBL:   AF162664
- EMBL:   AE005672
- EMBL:   Z49246
- EMBL:   Z95914
- EMBL:   Z99200
- EMBL:   Z99201
- EMBL:   Z99202
- EMBL:   Z99203
- EMBL:   Z99204
- EMBL:   Z99205
- EMBL:   Z99206
- EMBL:   AB021544
- EMBL:   AB021605
- EMBL:   AB021606
- EMBL:   AB021607
- EMBL:   AB021608
- EMBL:   AB021609
- EMBL:   AB021610
- EMBL:   AB021611
- EMBL:   AB021612
- EMBL:   AB021613
- EMBL:   AB021614
- EMBL:   AB021615
- EMBL:   AB021616
- EMBL:   AB021617
- EMBL:   AB021618
- EMBL:   AB021619
- PIR:   G95088
- PIR:   S54795
- RefSeq:   NP_345264.1
- ProteinModelPortal:   P0A4J6
- SMR:   P0A4J6
- IntAct:   P0A4J6
- EnsemblBacteria:   EBSTRT00000026632
- GeneID:   930716
- GenomeReviews:   AE005672_GR
- KEGG:   spn:SP_0766
- TIGR:   SP_0766
- GeneTree:   EBGT00050000027651
- OMA:   WDEVARR
- ProtClustDB:   CLSK2393339
- BioCyc:   SPNE170187-1:SP_0766-MONOMER
- BRENDA:   1.15.1.1
- InterPro:   IPR001189
- InterPro:   IPR019833
- InterPro:   IPR019832
- InterPro:   IPR019831
- PANTHER:   PTHR11404
- PIRSF:   PIRSF000349
- PRINTS:   PR01703

Pfam domain/function: PF02777 Sod_Fe_C; PF00081 Sod_Fe_N; SSF46609 SODismutase; SSF54719 SODismutase

EC number: =1.15.1.1

Molecular weight: Translated: 22397; Mature: 22266

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS00088 SOD_MN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIILPELPYAYDALEPYIDAETMHLHHDKHHQTYVNNANAALEKHPEIGEDLEALLADV
CEEEECCCCCHHHHHCCCCCCCEEEECCCCCHHHHHCCCCHHHHCCCCCCHHHHHHHHHH
ESIPADIRQALINNGGGHLNHALFWELMTPEKTAPSAELAAAIDATFGSFEEFQAAFTAA
HHCCHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHH
ATTRFGSGWAWLVVNKEGKLEVTSTANQDTPISEGKKPILGLDVWEHAYYVKYRNVRPDY
HHHCCCCCEEEEEECCCCCEEEEECCCCCCCCCCCCCCEEEEEHHHCEEEEEECCCCHHH
IKAFFSVINWNKVDELYAAAK
HHHHHHHHCCCHHHHHHHCCC
>Mature Secondary Structure 
AIILPELPYAYDALEPYIDAETMHLHHDKHHQTYVNNANAALEKHPEIGEDLEALLADV
EEEECCCCCHHHHHCCCCCCCEEEECCCCCHHHHHCCCCHHHHCCCCCCHHHHHHHHHH
ESIPADIRQALINNGGGHLNHALFWELMTPEKTAPSAELAAAIDATFGSFEEFQAAFTAA
HHCCHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHH
ATTRFGSGWAWLVVNKEGKLEVTSTANQDTPISEGKKPILGLDVWEHAYYVKYRNVRPDY
HHHCCCCCEEEEEECCCCCEEEEECCCCCCCCCCCCCCEEEEEHHHCEEEEEECCCCHHH
IKAFFSVINWNKVDELYAAAK
HHHHHHHHCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10768978; 11463916; 7557308; 9431917; 10517614