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The map label for this gene is pfbA

Identifier: 116515361

GI number: 116515361

Start: 1630597

End: 1632723

Strand: Reverse

Name: pfbA

Synonym: SPD_1617

Alternate gene names: 116515361

Gene position: 1632723-1630597 (Counterclockwise)

Preceding gene: 116516120

Following gene: 116516072

Centisome position: 79.8

GC content: 31.55

Gene sequence:

>2127_bases
ATGAAATATTTTGTTCCTAATGAGGTATTCAGTATTCGTAAATTAAAGGTGGGGACTTGCTCGGTACTATTGGCAATTTC
AATTTTGGGAAGCCAAGGTATTTTATCGGATGAAGTTGTTACTAGTTCTTCACCGATGGCTACAAAAGAGTCTTCTAATG
CAATTACTAATGATTTAGATAATTCACCAACTGTTAATCAGAATCGTTCTGCTGAAATGATTGCCTCTAATTCAACCACT
AATGGTTTAGATAATTCGTTAAGTGTTAATAGTATCAGCTCTAATGGTACTATTCGTTCCAATTCACAATTAGACAACAG
AACAGTTGAATCTACAGTAACATCTACTAATGAAAATAAGAGTTATAAGGAAGATGTTATAAGTGACAGAATTATCAAAA
AAGAATTTGAAGATACTGCTTTAAGTGTAAAAGATTATGGTGCGGTAGGTGATGGGATTCATGATGATCGACAAGCAATT
CAAGATGCAATAGATGCTGCAGCTCAAGGGCTAGGTGGAGGAAATGTATATTTTCCTGAAGGAACTTATTTAGTAAAAGA
AATTGTTTTTTTAAAAAGTCATACACACTTAGAATTGAATGAGAAAGCTACAATTCTAAATGGTATAAATATTAAGAATC
ACCCTTCCATTGTTTTTATGACAGGTTTATTTACGGATGATGGTGCGCAAGTAGAATGGGGCCCAACAGAAGATATTAGT
TATTCTGGTGGTACGATTGATATGAACGGTGCTTTGAATGAAGAAGGAACTAAAGCAAAAAATCTACCACTTATAAATTC
TTCAGGTGCATTTGCTATTGGGAATTCAAATAACGTAACTATAAAAAATGTAACATTCAAGGATAGTTATCAAGGGCATG
CTATTCAAATTGCAGGTTCGAAAAATGTATTAGTTGATAATTCTCGTTTTCTTGGGCAAGCCTTACCCAAAACGATGAAG
GATGGGCAAATCATAAGTAAGGAGAGCATTCAGATTGAACCATTAACTAGAAAAGGTTTTCCTTATGCCTTGAATGATGA
TGGGAAAAAATCTGAAAATGTGACTATTCAAAATTCCTATTTTGGCAAAAGTGATAAATCTGGGGAATTAGTAACAGCAA
TTGGCACACACTATCAAACATTGTCGACACAGAACCCCTCTAATATTAAAATTTTAAATAATCATTTTGATAACATGATG
TATGCAGGTGTACGTTTTACAGGATTCACTGATGTATTAATCAAAGGAAATCGCTTTGATAAGAAAGTTAAAGGAGAGAG
TGTACATTATCGAGAAAGCGGAGCAGCTTTAGTAAATGCTTATAGCTATAAAAACACTAAAGACCTATTAGATTTAAATA
AACAGGTGGTTATCGCCGAAAATATATTTAATATTGCCGATCCTAAAACAAAAGCGATACGAGTTGCAAAAGATAGTGCA
GAATATTTAGGAAAAGTATCAGATATTACTGTAACAAAAAATGTAATTAATAATAATTCTAAGGAAACAGAACAACCAAA
TATTGAATTATTACGAGTTAGTGATAATTTAGTAGTGTCAGAGAATAGTATATTCGGTGGTAAAGAAGGAATTGTTATTG
AGGATTCAAAGGGTAAAATAACCGTTTTAAATAACCAATTTTATAATTTATCCGGTAAGTATATATCATTCATCAAATCT
AATGCAAACGGGAAAGAACCTGTTATACGTGATAGCGATGGTAATTTCAATATTGTAACGGAGAATGGGCTTTACAAAAT
TGTAACAAATAATTTAAGTGATAAAAACGAAAAAGAAAAAAACAAAGAGGAAAAACAATCTAATTCAAATAATGTAATTG
ATAGTAACCAGAAGAACGGAGAGTTTAACTCAAGTAAAGATAATAGACAAATGAATGACAAGATCGACAATAAACAAGAT
AATAAGACAGAAGAAGTAAACTATAAAATAGTTGGAGATGGCAGAGAAACTGAAAATCATATTAATAAATCTAAAGAAAT
AGTAGATGTAAAACAAAAATTACCAAAGACTGGTTCGAACAAGATTATGGAACTATTCTTAACAGTGACAGGAATTGGTT
TACTTTTGACACTAAAAGGGTTGAAGTATTATGGTAAAGATAAATAA

Upstream 100 bases:

>100_bases
GGAAAATATATGATAAAGATAATGACAGCGGTGTCATTCTATCTATTTTAAGAAAAGTAATAATCAATTGTTAAAAATAG
TAAAAAAATTGGAGGTTCTG

Downstream 100 bases:

>100_bases
AATTTGTTCGATACAAGGAAGTTCCGTAGAAAATGAGGATATTGTAGGTTCACAAAATCAGTATTTTTGGATTATTGGTG
GAGCTACAGATTTATATAAT

Product: cell wall surface anchor family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 708; Mature: 708

Protein sequence:

>708_residues
MKYFVPNEVFSIRKLKVGTCSVLLAISILGSQGILSDEVVTSSSPMATKESSNAITNDLDNSPTVNQNRSAEMIASNSTT
NGLDNSLSVNSISSNGTIRSNSQLDNRTVESTVTSTNENKSYKEDVISDRIIKKEFEDTALSVKDYGAVGDGIHDDRQAI
QDAIDAAAQGLGGGNVYFPEGTYLVKEIVFLKSHTHLELNEKATILNGINIKNHPSIVFMTGLFTDDGAQVEWGPTEDIS
YSGGTIDMNGALNEEGTKAKNLPLINSSGAFAIGNSNNVTIKNVTFKDSYQGHAIQIAGSKNVLVDNSRFLGQALPKTMK
DGQIISKESIQIEPLTRKGFPYALNDDGKKSENVTIQNSYFGKSDKSGELVTAIGTHYQTLSTQNPSNIKILNNHFDNMM
YAGVRFTGFTDVLIKGNRFDKKVKGESVHYRESGAALVNAYSYKNTKDLLDLNKQVVIAENIFNIADPKTKAIRVAKDSA
EYLGKVSDITVTKNVINNNSKETEQPNIELLRVSDNLVVSENSIFGGKEGIVIEDSKGKITVLNNQFYNLSGKYISFIKS
NANGKEPVIRDSDGNFNIVTENGLYKIVTNNLSDKNEKEKNKEEKQSNSNNVIDSNQKNGEFNSSKDNRQMNDKIDNKQD
NKTEEVNYKIVGDGRETENHINKSKEIVDVKQKLPKTGSNKIMELFLTVTGIGLLLTLKGLKYYGKDK

Sequences:

>Translated_708_residues
MKYFVPNEVFSIRKLKVGTCSVLLAISILGSQGILSDEVVTSSSPMATKESSNAITNDLDNSPTVNQNRSAEMIASNSTT
NGLDNSLSVNSISSNGTIRSNSQLDNRTVESTVTSTNENKSYKEDVISDRIIKKEFEDTALSVKDYGAVGDGIHDDRQAI
QDAIDAAAQGLGGGNVYFPEGTYLVKEIVFLKSHTHLELNEKATILNGINIKNHPSIVFMTGLFTDDGAQVEWGPTEDIS
YSGGTIDMNGALNEEGTKAKNLPLINSSGAFAIGNSNNVTIKNVTFKDSYQGHAIQIAGSKNVLVDNSRFLGQALPKTMK
DGQIISKESIQIEPLTRKGFPYALNDDGKKSENVTIQNSYFGKSDKSGELVTAIGTHYQTLSTQNPSNIKILNNHFDNMM
YAGVRFTGFTDVLIKGNRFDKKVKGESVHYRESGAALVNAYSYKNTKDLLDLNKQVVIAENIFNIADPKTKAIRVAKDSA
EYLGKVSDITVTKNVINNNSKETEQPNIELLRVSDNLVVSENSIFGGKEGIVIEDSKGKITVLNNQFYNLSGKYISFIKS
NANGKEPVIRDSDGNFNIVTENGLYKIVTNNLSDKNEKEKNKEEKQSNSNNVIDSNQKNGEFNSSKDNRQMNDKIDNKQD
NKTEEVNYKIVGDGRETENHINKSKEIVDVKQKLPKTGSNKIMELFLTVTGIGLLLTLKGLKYYGKDK
>Mature_708_residues
MKYFVPNEVFSIRKLKVGTCSVLLAISILGSQGILSDEVVTSSSPMATKESSNAITNDLDNSPTVNQNRSAEMIASNSTT
NGLDNSLSVNSISSNGTIRSNSQLDNRTVESTVTSTNENKSYKEDVISDRIIKKEFEDTALSVKDYGAVGDGIHDDRQAI
QDAIDAAAQGLGGGNVYFPEGTYLVKEIVFLKSHTHLELNEKATILNGINIKNHPSIVFMTGLFTDDGAQVEWGPTEDIS
YSGGTIDMNGALNEEGTKAKNLPLINSSGAFAIGNSNNVTIKNVTFKDSYQGHAIQIAGSKNVLVDNSRFLGQALPKTMK
DGQIISKESIQIEPLTRKGFPYALNDDGKKSENVTIQNSYFGKSDKSGELVTAIGTHYQTLSTQNPSNIKILNNHFDNMM
YAGVRFTGFTDVLIKGNRFDKKVKGESVHYRESGAALVNAYSYKNTKDLLDLNKQVVIAENIFNIADPKTKAIRVAKDSA
EYLGKVSDITVTKNVINNNSKETEQPNIELLRVSDNLVVSENSIFGGKEGIVIEDSKGKITVLNNQFYNLSGKYISFIKS
NANGKEPVIRDSDGNFNIVTENGLYKIVTNNLSDKNEKEKNKEEKQSNSNNVIDSNQKNGEFNSSKDNRQMNDKIDNKQD
NKTEEVNYKIVGDGRETENHINKSKEIVDVKQKLPKTGSNKIMELFLTVTGIGLLLTLKGLKYYGKDK

Specific function: Acts as a fibronectin-dependent adhesin and invasin. Binds host (in this case human) fibronectin, plasmin, plasminogen, and human serum albumin. Where the bacteria adhere to human cells there is major recruitment of microvilli which seem to fuse to cover

COG id: COG5434

COG function: function code M; Endopolygalacturonase

Gene ontology:

Cell location: Secreted, cell wall; Peptidoglycan-anchor (Probable)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 5 PbH1 repeats

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PFBA_STRR6 (Q8CYC9)

Other databases:

- EMBL:   AE007317
- PIR:   B98078
- RefSeq:   NP_359244.1
- ProteinModelPortal:   Q8CYC9
- SMR:   Q8CYC9
- STRING:   Q8CYC9
- EnsemblBacteria:   EBSTRT00000014826
- GeneID:   933108
- GenomeReviews:   AE007317_GR
- KEGG:   spr:spr1652
- eggNOG:   COG5434
- GeneTree:   EBGT00050000029768
- HOGENOM:   HBG702072
- OMA:   VHYRENG
- ProtClustDB:   CLSK560218
- BioCyc:   SPNE171101:SPR1652-MONOMER
- GO:   GO:0016020
- GO:   GO:0009405
- InterPro:   IPR005877
- InterPro:   IPR006626
- InterPro:   IPR012334
- InterPro:   IPR011050
- Gene3D:   G3DSA:2.160.20.10
- SMART:   SM00710
- TIGRFAMs:   TIGR01168

Pfam domain/function: PF04650 YSIRK_signal; SSF51126 Pectin_lyas_like

EC number: NA

Molecular weight: Translated: 77721; Mature: 77721

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS50847 GRAM_POS_ANCHORING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYFVPNEVFSIRKLKVGTCSVLLAISILGSQGILSDEVVTSSSPMATKESSNAITNDLD
CCCCCCCCCEEEEEEECCHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCCCCCCHHCCCC
NSPTVNQNRSAEMIASNSTTNGLDNSLSVNSISSNGTIRSNSQLDNRTVESTVTSTNENK
CCCCCCCCCCCEEEECCCCCCCCCCCEEEEEECCCCEEECCCCCCCCCHHHHHCCCCCCC
SYKEDVISDRIIKKEFEDTALSVKDYGAVGDGIHDDRQAIQDAIDAAAQGLGGGNVYFPE
HHHHHHHHHHHHHHHHHHHEEEHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEECCC
GTYLVKEIVFLKSHTHLELNEKATILNGINIKNHPSIVFMTGLFTDDGAQVEWGPTEDIS
CHHHHHHHHHHHCCCEEEECCCEEEEECCCCCCCCCEEEEEEEECCCCCEEECCCCCCCC
YSGGTIDMNGALNEEGTKAKNLPLINSSGAFAIGNSNNVTIKNVTFKDSYQGHAIQIAGS
CCCCEEEECCCCCCCCCCCCCCCEEECCCCEEECCCCCEEEEEEEECCCCCCCEEEEECC
KNVLVDNSRFLGQALPKTMKDGQIISKESIQIEPLTRKGFPYALNDDGKKSENVTIQNSY
CCEEEECCHHHHHHHHHHHCCCCEEECCCEEEEEECCCCCCEEECCCCCCCCCEEEEECC
FGKSDKSGELVTAIGTHYQTLSTQNPSNIKILNNHFDNMMYAGVRFTGFTDVLIKGNRFD
CCCCCCCCCEEEEECCCEEEECCCCCCCEEEEECCCCCEEEECEEECCCEEEEEECCCCC
KKVKGESVHYRESGAALVNAYSYKNTKDLLDLNKQVVIAENIFNIADPKTKAIRVAKDSA
CCCCCCCEEEECCCCEEEEEECCCCCHHHHCCCCCEEEEECHHCCCCCCCEEEEEECCCH
EYLGKVSDITVTKNVINNNSKETEQPNIELLRVSDNLVVSENSIFGGKEGIVIEDSKGKI
HHCCCCCCEEEEHHHHCCCCCCCCCCCEEEEEECCCEEEECCCCCCCCCCEEEECCCCEE
TVLNNQFYNLSGKYISFIKSNANGKEPVIRDSDGNFNIVTENGLYKIVTNNLSDKNEKEK
EEEECCEEECCCCEEEEEECCCCCCCCEEECCCCCEEEEECCCEEEEEECCCCCCCHHHH
NKEEKQSNSNNVIDSNQKNGEFNSSKDNRQMNDKIDNKQDNKTEEVNYKIVGDGRETENH
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCEEEEEEEEECCCCHHHH
INKSKEIVDVKQKLPKTGSNKIMELFLTVTGIGLLLTLKGLKYYGKDK
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHEEHHHHHHHCCCCC
>Mature Secondary Structure
MKYFVPNEVFSIRKLKVGTCSVLLAISILGSQGILSDEVVTSSSPMATKESSNAITNDLD
CCCCCCCCCEEEEEEECCHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCCCCCCHHCCCC
NSPTVNQNRSAEMIASNSTTNGLDNSLSVNSISSNGTIRSNSQLDNRTVESTVTSTNENK
CCCCCCCCCCCEEEECCCCCCCCCCCEEEEEECCCCEEECCCCCCCCCHHHHHCCCCCCC
SYKEDVISDRIIKKEFEDTALSVKDYGAVGDGIHDDRQAIQDAIDAAAQGLGGGNVYFPE
HHHHHHHHHHHHHHHHHHHEEEHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEECCC
GTYLVKEIVFLKSHTHLELNEKATILNGINIKNHPSIVFMTGLFTDDGAQVEWGPTEDIS
CHHHHHHHHHHHCCCEEEECCCEEEEECCCCCCCCCEEEEEEEECCCCCEEECCCCCCCC
YSGGTIDMNGALNEEGTKAKNLPLINSSGAFAIGNSNNVTIKNVTFKDSYQGHAIQIAGS
CCCCEEEECCCCCCCCCCCCCCCEEECCCCEEECCCCCEEEEEEEECCCCCCCEEEEECC
KNVLVDNSRFLGQALPKTMKDGQIISKESIQIEPLTRKGFPYALNDDGKKSENVTIQNSY
CCEEEECCHHHHHHHHHHHCCCCEEECCCEEEEEECCCCCCEEECCCCCCCCCEEEEECC
FGKSDKSGELVTAIGTHYQTLSTQNPSNIKILNNHFDNMMYAGVRFTGFTDVLIKGNRFD
CCCCCCCCCEEEEECCCEEEECCCCCCCEEEEECCCCCEEEECEEECCCEEEEEECCCCC
KKVKGESVHYRESGAALVNAYSYKNTKDLLDLNKQVVIAENIFNIADPKTKAIRVAKDSA
CCCCCCCEEEECCCCEEEEEECCCCCHHHHCCCCCEEEEECHHCCCCCCCEEEEEECCCH
EYLGKVSDITVTKNVINNNSKETEQPNIELLRVSDNLVVSENSIFGGKEGIVIEDSKGKI
HHCCCCCCEEEEHHHHCCCCCCCCCCCEEEEEECCCEEEECCCCCCCCCCEEEECCCCEE
TVLNNQFYNLSGKYISFIKSNANGKEPVIRDSDGNFNIVTENGLYKIVTNNLSDKNEKEK
EEEECCEEECCCCEEEEEECCCCCCCCEEECCCCCEEEEECCCEEEEEECCCCCCCHHHH
NKEEKQSNSNNVIDSNQKNGEFNSSKDNRQMNDKIDNKQDNKTEEVNYKIVGDGRETENH
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCEEEEEEEEECCCCHHHH
INKSKEIVDVKQKLPKTGSNKIMELFLTVTGIGLLLTLKGLKYYGKDK
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHEEHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11544234