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The map label for this gene is mutY [H]

Identifier: 116515279

GI number: 116515279

Start: 386287

End: 387318

Strand: Direct

Name: mutY [H]

Synonym: BCc_362

Alternate gene names: 116515279

Gene position: 386287-387318 (Clockwise)

Preceding gene: 116515278

Following gene: 116515280

Centisome position: 92.77

GC content: 18.12

Gene sequence:

>1032_bases
ATGTTCTTTTCACAAAAAATACTTAACTGGTACCATTTTAATGGAAGAAAAAACTTACCTTGGCAAAAAAAAAATATCTA
TTATATTTGGATATCTGAAATTATGTTACAGCAAACACGTGTTCAAACTGTAATTCCATATTTTCAAAAATTTAAAAAAA
AATTTCCTACAATAAAAAAATTAGCTGATTCTAACATTAATAAAGTATTATATTTATGGAGCGGATTAGGATATTATCAA
AGAGCACATAATCTGCATAAAACAGCAAAAATAATAAAAAAAAAATATTATGGAATATTTCCTACAAATATAAATGAGAT
AATAAAATTACCTGGAATCGGAAGATCAACTGCTGGTGCAATTTTATCATTTACCTATAATTATAGATATGCTATTTTAG
ATAGCAATATAAAAAGAGTATTAATTAGATTTCATTTAATAAATATTAATAATTTTAAAAAAAATCAATTAGAAAATAAA
TTATGGAATATTATTGATCAATACATTCCATTACATAATGCTAGAAAATTTAATCAAGCTATGATGGATTTAGGTTCCTT
AATTTGCAAAAATAAAAATCCAAATTGTTTTTCTTGTCCATTAAAAAATAATTGCAATTTTTTTAAAAAAAAAATTATTT
TTTTTAAAAAAAAAGAAAAAAAAAAAAAAATTGGTATATTTTTTTCAATTATAAAATATAAAAATTCAGTAATTTTAATA
AAACAAAAAAATATTTCTATATGGAAAGGATTATTCTATTTTCCGTTAATAACTTTTAAAATATCAAAAAAAAAATGGGA
AAAAATAAAAAAAAAAAATACTTCTAAAACAAAAAAATTATTTTTTACACATTGTTTAAGTCATATAAAATTATTTATTA
TTTGGCAAATTATTAGAGTTAAAAAAAAAAAAAACTATAAAGAAAAAATATGGATGAATATAAATTCAAAAAAAAAAATA
GGAATACCTACTCCAATAAAAAAAATATTATTACAATTAAAAAAAAAAAAAAAAAATGAAAAAAAAACGTAA

Upstream 100 bases:

>100_bases
ATATTAATTTAATTATTAAATATTTAAATAAATATGAATTTTTTTATTTGTATAATTTAATATCTATAAAAATTTATCAA
TAATAAATATTAGGTATACT

Downstream 100 bases:

>100_bases
AATTTTTTGTTCTTTTTTAAAAAAAGAAACGGAAGGATTAGAATATCAATTTTTTCCTGGAAAAATTGGACAACAAATTT
ATGAACAAATATCTAAAAAA

Product: A/G-specific adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MFFSQKILNWYHFNGRKNLPWQKKNIYYIWISEIMLQQTRVQTVIPYFQKFKKKFPTIKKLADSNINKVLYLWSGLGYYQ
RAHNLHKTAKIIKKKYYGIFPTNINEIIKLPGIGRSTAGAILSFTYNYRYAILDSNIKRVLIRFHLININNFKKNQLENK
LWNIIDQYIPLHNARKFNQAMMDLGSLICKNKNPNCFSCPLKNNCNFFKKKIIFFKKKEKKKKIGIFFSIIKYKNSVILI
KQKNISIWKGLFYFPLITFKISKKKWEKIKKKNTSKTKKLFFTHCLSHIKLFIIWQIIRVKKKKNYKEKIWMNINSKKKI
GIPTPIKKILLQLKKKKKNEKKT

Sequences:

>Translated_343_residues
MFFSQKILNWYHFNGRKNLPWQKKNIYYIWISEIMLQQTRVQTVIPYFQKFKKKFPTIKKLADSNINKVLYLWSGLGYYQ
RAHNLHKTAKIIKKKYYGIFPTNINEIIKLPGIGRSTAGAILSFTYNYRYAILDSNIKRVLIRFHLININNFKKNQLENK
LWNIIDQYIPLHNARKFNQAMMDLGSLICKNKNPNCFSCPLKNNCNFFKKKIIFFKKKEKKKKIGIFFSIIKYKNSVILI
KQKNISIWKGLFYFPLITFKISKKKWEKIKKKNTSKTKKLFFTHCLSHIKLFIIWQIIRVKKKKNYKEKIWMNINSKKKI
GIPTPIKKILLQLKKKKKNEKKT
>Mature_343_residues
MFFSQKILNWYHFNGRKNLPWQKKNIYYIWISEIMLQQTRVQTVIPYFQKFKKKFPTIKKLADSNINKVLYLWSGLGYYQ
RAHNLHKTAKIIKKKYYGIFPTNINEIIKLPGIGRSTAGAILSFTYNYRYAILDSNIKRVLIRFHLININNFKKNQLENK
LWNIIDQYIPLHNARKFNQAMMDLGSLICKNKNPNCFSCPLKNNCNFFKKKIIFFKKKEKKKKIGIFFSIIKYKNSVILI
KQKNISIWKGLFYFPLITFKISKKKWEKIKKKNTSKTKKLFFTHCLSHIKLFIIWQIIRVKKKKNYKEKIWMNINSKKKI
GIPTPIKKILLQLKKKKKNEKKT

Specific function: Adenine glycosylase active on G-A and C-A mispairs [H]

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI115298648, Length=218, Percent_Identity=33.4862385321101, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI6912520, Length=218, Percent_Identity=33.4862385321101, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI190358497, Length=321, Percent_Identity=26.1682242990654, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI115298650, Length=218, Percent_Identity=33.4862385321101, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI115298654, Length=218, Percent_Identity=33.4862385321101, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI115298652, Length=218, Percent_Identity=33.4862385321101, Blast_Score=163, Evalue=3e-40,
Organism=Escherichia coli, GI1789331, Length=344, Percent_Identity=39.2441860465116, Blast_Score=275, Evalue=3e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00633 HHH; PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 41308; Mature: 41308

Theoretical pI: Translated: 11.11; Mature: 11.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFFSQKILNWYHFNGRKNLPWQKKNIYYIWISEIMLQQTRVQTVIPYFQKFKKKFPTIKK
CCCHHHHHHHEEECCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
LADSNINKVLYLWSGLGYYQRAHNLHKTAKIIKKKYYGIFPTNINEIIKLPGIGRSTAGA
HHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCCC
ILSFTYNYRYAILDSNIKRVLIRFHLININNFKKNQLENKLWNIIDQYIPLHNARKFNQA
EEEEEEEEEEEEECCHHHHEEHHHEEEECCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHH
MMDLGSLICKNKNPNCFSCPLKNNCNFFKKKIIFFKKKEKKKKIGIFFSIIKYKNSVILI
HHHHHHHHCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEE
KQKNISIWKGLFYFPLITFKISKKKWEKIKKKNTSKTKKLFFTHCLSHIKLFIIWQIIRV
EECCCHHHHHHHHHHHHHEEECHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KKKKNYKEKIWMNINSKKKIGIPTPIKKILLQLKKKKKNEKKT
HHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MFFSQKILNWYHFNGRKNLPWQKKNIYYIWISEIMLQQTRVQTVIPYFQKFKKKFPTIKK
CCCHHHHHHHEEECCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
LADSNINKVLYLWSGLGYYQRAHNLHKTAKIIKKKYYGIFPTNINEIIKLPGIGRSTAGA
HHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCCC
ILSFTYNYRYAILDSNIKRVLIRFHLININNFKKNQLENKLWNIIDQYIPLHNARKFNQA
EEEEEEEEEEEEECCHHHHEEHHHEEEECCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHH
MMDLGSLICKNKNPNCFSCPLKNNCNFFKKKIIFFKKKEKKKKIGIFFSIIKYKNSVILI
HHHHHHHHCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEE
KQKNISIWKGLFYFPLITFKISKKKWEKIKKKNTSKTKKLFFTHCLSHIKLFIIWQIIRV
EECCCHHHHHHHHHHHHHEEECHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KKKKNYKEKIWMNINSKKKIGIPTPIKKILLQLKKKKKNEKKT
HHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12522265 [H]