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The map label for this gene is adk

Identifier: 116515225

GI number: 116515225

Start: 345493

End: 346143

Strand: Direct

Name: adk

Synonym: BCc_303

Alternate gene names: 116515225

Gene position: 345493-346143 (Clockwise)

Preceding gene: 116515224

Following gene: 116515226

Centisome position: 82.98

GC content: 17.67

Gene sequence:

>651_bases
ATGCGTATTATTATGATAGGTCCACCTGGTAGCGGTAAGGGTACACAAACACAATTATTATCAAAATATTTTCATATTCC
TTGCATTTCTACAGGAGAAATACTACGAAAAGAAATAAAAAAAAATAAAAAAACAAAAAAATATATTAAAAAAACAATTA
ATAAAGGTAAATTAATTAAAAATTCTTTTATTATTAAAATAATAGAAAAAAACATAAAAAAAAAAAAATTTTTTAATGGA
TTTATATTAGATGGTTTTCCTAGAAATATTGAACAAGCAAAATCTTTAAGTAAAAAAATAAACATAGAATATATAATATA
TTTAAAAATTAAATATGATGATATTATTAAAAGAATAACAGGAAGATTAATTCATGCATCTTCGGGACGAACATATCATA
AAATATTTAATCCTCCAAAAATAAAAAATAAAGATGATATAACTCAAGAAAAATTATGTTCTAGAAATGATGATAATGAG
AAAACCATAAAAATAAGATTACAAGAATACAAAAAACATACTAATCCATTAATTAAATGGATAAAAAAAAAAAAAAAAAT
AAAATTTATTGAAATACATGCAAATCAATCAATTAAAATTGTAAATAAAAAAATTATTTATAATATAAATAATAATAATA
TAAATAAATAA

Upstream 100 bases:

>100_bases
AAACAATTTCTTTATATCATAAAAATTTTATTTATAAAAATATCACTTATTTAAAATTGATGTATAATAAAATAATTTTT
ATAAAGGAAAATTTTTTATA

Downstream 100 bases:

>100_bases
TTATATATTTTTTTTGCGCTCTACAGGATTCGAACCTGTAACCTACAGCTTAGAAGGCTGTTGCTCTATCCAAATTGAGC
TAAGAGCGCTTAAAAATTAT

Product: hypothetical protein

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 216; Mature: 216

Protein sequence:

>216_residues
MRIIMIGPPGSGKGTQTQLLSKYFHIPCISTGEILRKEIKKNKKTKKYIKKTINKGKLIKNSFIIKIIEKNIKKKKFFNG
FILDGFPRNIEQAKSLSKKINIEYIIYLKIKYDDIIKRITGRLIHASSGRTYHKIFNPPKIKNKDDITQEKLCSRNDDNE
KTIKIRLQEYKKHTNPLIKWIKKKKKIKFIEIHANQSIKIVNKKIIYNINNNNINK

Sequences:

>Translated_216_residues
MRIIMIGPPGSGKGTQTQLLSKYFHIPCISTGEILRKEIKKNKKTKKYIKKTINKGKLIKNSFIIKIIEKNIKKKKFFNG
FILDGFPRNIEQAKSLSKKINIEYIIYLKIKYDDIIKRITGRLIHASSGRTYHKIFNPPKIKNKDDITQEKLCSRNDDNE
KTIKIRLQEYKKHTNPLIKWIKKKKKIKFIEIHANQSIKIVNKKIIYNINNNNINK
>Mature_216_residues
MRIIMIGPPGSGKGTQTQLLSKYFHIPCISTGEILRKEIKKNKKTKKYIKKTINKGKLIKNSFIIKIIEKNIKKKKFFNG
FILDGFPRNIEQAKSLSKKINIEYIIYLKIKYDDIIKRITGRLIHASSGRTYHKIFNPPKIKNKDDITQEKLCSRNDDNE
KTIKIRLQEYKKHTNPLIKWIKKKKKIKFIEIHANQSIKIVNKKIIYNINNNNINK

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI7524346, Length=215, Percent_Identity=41.3953488372093, Blast_Score=183, Evalue=8e-47,
Organism=Homo sapiens, GI4502013, Length=215, Percent_Identity=41.3953488372093, Blast_Score=183, Evalue=1e-46,
Organism=Homo sapiens, GI19923437, Length=184, Percent_Identity=34.7826086956522, Blast_Score=135, Evalue=2e-32,
Organism=Homo sapiens, GI310110345, Length=184, Percent_Identity=33.695652173913, Blast_Score=133, Evalue=1e-31,
Organism=Homo sapiens, GI53832003, Length=184, Percent_Identity=33.695652173913, Blast_Score=133, Evalue=1e-31,
Organism=Homo sapiens, GI8051579, Length=184, Percent_Identity=33.695652173913, Blast_Score=133, Evalue=1e-31,
Organism=Homo sapiens, GI53832001, Length=184, Percent_Identity=33.695652173913, Blast_Score=133, Evalue=1e-31,
Organism=Homo sapiens, GI22749187, Length=178, Percent_Identity=24.1573033707865, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI4502011, Length=210, Percent_Identity=25.2380952380952, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI28144899, Length=186, Percent_Identity=26.8817204301075, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI28144897, Length=186, Percent_Identity=26.8817204301075, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI7706497, Length=214, Percent_Identity=25.2336448598131, Blast_Score=74, Evalue=7e-14,
Organism=Escherichia coli, GI1786680, Length=187, Percent_Identity=43.3155080213904, Blast_Score=185, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17552384, Length=190, Percent_Identity=43.6842105263158, Blast_Score=167, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17537943, Length=189, Percent_Identity=31.7460317460317, Blast_Score=103, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI17567503, Length=209, Percent_Identity=22.9665071770335, Blast_Score=84, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17550688, Length=209, Percent_Identity=24.4019138755981, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17533833, Length=204, Percent_Identity=23.5294117647059, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320432, Length=189, Percent_Identity=42.8571428571429, Blast_Score=169, Evalue=4e-43,
Organism=Saccharomyces cerevisiae, GI6321018, Length=186, Percent_Identity=37.6344086021505, Blast_Score=126, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6322828, Length=216, Percent_Identity=25.9259259259259, Blast_Score=79, Evalue=6e-16,
Organism=Drosophila melanogaster, GI22026816, Length=182, Percent_Identity=43.956043956044, Blast_Score=174, Evalue=4e-44,
Organism=Drosophila melanogaster, GI17737899, Length=183, Percent_Identity=41.5300546448087, Blast_Score=142, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24645822, Length=183, Percent_Identity=41.5300546448087, Blast_Score=142, Evalue=2e-34,
Organism=Drosophila melanogaster, GI17647141, Length=211, Percent_Identity=24.6445497630332, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24663208, Length=211, Percent_Identity=24.6445497630332, Blast_Score=84, Evalue=5e-17,
Organism=Drosophila melanogaster, GI221459597, Length=198, Percent_Identity=25.2525252525253, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21356893, Length=198, Percent_Identity=25.2525252525253, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_BUCCC (Q057D8)

Other databases:

- EMBL:   CP000263
- RefSeq:   YP_802854.1
- ProteinModelPortal:   Q057D8
- SMR:   Q057D8
- STRING:   Q057D8
- EnsemblBacteria:   EBBUCT00000001273
- GeneID:   4440910
- GenomeReviews:   CP000263_GR
- KEGG:   bcc:BCc_303
- eggNOG:   COG0563
- GeneTree:   EBGT00050000007800
- HOGENOM:   HBG630208
- OMA:   CGEGYHD
- BioCyc:   BAPH372461:BCC_303-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR000850
- InterPro:   IPR007862
- PANTHER:   PTHR23359
- PRINTS:   PR00094

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid

EC number: =2.7.4.3

Molecular weight: Translated: 25448; Mature: 25448

Theoretical pI: Translated: 10.98; Mature: 10.98

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIIMIGPPGSGKGTQTQLLSKYFHIPCISTGEILRKEIKKNKKTKKYIKKTINKGKLIK
CEEEEECCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCEEH
NSFIIKIIEKNIKKKKFFNGFILDGFPRNIEQAKSLSKKINIEYIIYLKIKYDDIIKRIT
HHHHHHHHHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHCCEEEEEEEEECHHHHHHHHH
GRLIHASSGRTYHKIFNPPKIKNKDDITQEKLCSRNDDNEKTIKIRLQEYKKHTNPLIKW
HHEEECCCCCEEEECCCCCCCCCCCCCCHHHHHCCCCCCCEEEEEEEHHHHHHHHHHHHH
IKKKKKIKFIEIHANQSIKIVNKKIIYNINNNNINK
HHHHCCEEEEEEECCCEEEEEEEEEEEEECCCCCCC
>Mature Secondary Structure
MRIIMIGPPGSGKGTQTQLLSKYFHIPCISTGEILRKEIKKNKKTKKYIKKTINKGKLIK
CEEEEECCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCEEH
NSFIIKIIEKNIKKKKFFNGFILDGFPRNIEQAKSLSKKINIEYIIYLKIKYDDIIKRIT
HHHHHHHHHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHCCEEEEEEEEECHHHHHHHHH
GRLIHASSGRTYHKIFNPPKIKNKDDITQEKLCSRNDDNEKTIKIRLQEYKKHTNPLIKW
HHEEECCCCCEEEECCCCCCCCCCCCCCHHHHHCCCCCCCEEEEEEEHHHHHHHHHHHHH
IKKKKKIKFIEIHANQSIKIVNKKIIYNINNNNINK
HHHHCCEEEEEEECCCEEEEEEEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA