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The map label for this gene is lon [H]

Identifier: 116515219

GI number: 116515219

Start: 333749

End: 336097

Strand: Direct

Name: lon [H]

Synonym: BCc_295

Alternate gene names: 116515219

Gene position: 333749-336097 (Clockwise)

Preceding gene: 116515218

Following gene: 116515220

Centisome position: 80.15

GC content: 24.14

Gene sequence:

>2349_bases
ATGAATGCTGGGTATTCTAAAAATGTTGATATTCCAATATTACCCTTACGGGATATTGTAATTTATCCGTATATGGTTAC
TCCTTTATTTATTGGTCGAAAAAATTCAATCAAATGTATAGAATTTTCTATGCAAACTAATAAAAAAATACTTTTAATCA
CACAAAAAGAACCAACTATAGAAAATCCAAAAAAAAATGATTTATTTAAAATTGGTACTATAGCAAAAATCTTACAAATA
TTAAATTTGCCAGATGGAACTGTAAAAATTTTAGTTAAGGGAAAAAAAAGAGCAAAAATAGAAAAAATAAAAAAAAATAA
TAATTATTATTTAGCAAATATAAAATTTATTAAGCCTATTAAAATTGAAAAAAAAGAAAAAACAGTACTTATAAAAACAA
CAATAAAACAATTTAAAAAATATATTCAATTAAATAAAAAAATTTCATTAGAAACATTAGATAAATTAAAAAAAATTAAA
GATATTGAAAAATTTAGCGATATATTAGCATATCAAATGCCTTTAAAAACAAAAGATAAACAAAAACTATTAGAAATGTT
TAATACTAATAAACGTTTAGAATTTTTAATAGGAATTATGGAATCAGAAATTGAATTATTAAATATAGAAAAACGCATAA
GAAATAGAATTAAAAAACAAACAGAAAAAAATCAAAGAGAATATTTTTTAACTGAACAAATTAAAGCAATACAAAAAGAA
TTAGGTGATATAGAAAATTCTATTGATGAACATGAAAAATTAAAAAAAAAAATAAATTTAGCAAAAATGCCTAAAGAAGC
AAAAAAAAAAGCACAGAATGAATTAAGAAGATTACGAATGATGTCACCTTTATCAGCTGAATCTACAGTAGTAAGAAATT
ATATTGAATGGATAATACAAATTCCTTGGTGTAAAAAAAGTAAAATAAAAAAAAATATTCATATTGCTCAAAAAATATTA
AATAATGATCATTTTGGACTTAATAATGTCAAAGAAAATATCTTAGAATATTTAGCAGTTCAAAATAGAAAAAGAAAAAT
AAAAGGTCCAATTTTATGTTTAGTTGGTCCTCCAGGAATTGGAAAAACTTCTTTAGGAAAATCTATTGCACGTGCTACAG
GAAGAAAATATATACGTATGGCATTAGGAGGAATTAGAGATGAAGCTGAAATAAGAGGACATAGGAGAACCTATATTGGT
TCCATGCCAGGAAAATTAATGCAAAAAATAGTAAAATCAGGTGTAAAAAACCCTCTTTTTTTACTAGATGAAATAGATAA
AATGGCATTTGATATACGTATTGATCCAGCCGCTGCATTACTAGAAGTACTAGATTCAGAACAAAATAATTCTTTTAATG
ATCATTATTTAGAAATTGACTATGATTTATCAGAAGTTATGTTTATTGCTACATCTAATACTATGAATATACCAACACCA
TTATTAGATCGAATGGAAATTATAAGATTGTCTGGATATACTGAAGAAGAAAAAATAAATATTGCTAAAAAATATTTACA
ACCAAAACAAATGAAACAAAATGCTTTAAAGAAAAAAGAATTATGTATTCAAGATAACGCTTTTACAGATATAATTAGAT
ATTATACTCGAGAATCAGGAGTAAGAAATTTAGAAAGAGCAATTTCAAAAATTTGTCGAAAATCTGTTAAAAAAATATTA
TTAGATACTAAAATTAGTGATATTGTGGTAAATAAAAAAAATTTAAAAAAATATTTAGGTATAAAAAAATATGAATATGG
GAAAACAAATAAAAAAAATCATATTGGACAAGTAGTAGGACTAGCATGGACAGAAATGGGGGGCGATCTATTAACTATTG
AATGTTCATGTGTACCAGGTAAGGGAAAATTGATATACACTGGATCTCTTGGAAAAGTTATGCAAGAGTCTATACAAACA
GCTTTAACAGTTGTTAGATCACAAGCTAATAAATTAAATATTAAAAAAAATTTTTATAATAAAAATGATATACATATACA
TGTACCAGAAGGAGCAACACCAAAAGACGGACCTAGTGCAGGAGTAGCAATGTGTACAGCTATAGTATCCTGTCTTACAA
ATAATCCTGTCTTATCATGTATTGCTATGACTGGAGAAATTACATTAAGAGGAAAAGTATTAAATATTGGTGGACTTAAA
GAAAAATTGTTAGCTGCTCATAGAGGTGGTGTAAAAAAAGTGTTTATTCCTTATGGAAATAAAAAAGATTTATCTGAAAT
ACCTAAAAATATACTCTCTAAATTATATATACATAAAATAAAAAACATAGAAGAAATTTTTATTCTAGCTTTAGAAAAAA
ATCCTTATATAAGACATATAAATAAATAA

Upstream 100 bases:

>100_bases
ATTATATCAATGTATAAAAATATTTTTATAAAGTTAAAATAACATCTATAAAACTATAAAAAGTTTTATATATATTTAAA
ATTCTAATAGAGAGATATAT

Downstream 100 bases:

>100_bases
CAATGTGAAGAAAAAATTGAATAAAGTTTATCTTTATACAACTTAGCTAGTTAGAATACATATTCTTACTAGCTATGAAA
ATTCTATTTTATAAAACTAT

Product: DNA-binding ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 782; Mature: 782

Protein sequence:

>782_residues
MNAGYSKNVDIPILPLRDIVIYPYMVTPLFIGRKNSIKCIEFSMQTNKKILLITQKEPTIENPKKNDLFKIGTIAKILQI
LNLPDGTVKILVKGKKRAKIEKIKKNNNYYLANIKFIKPIKIEKKEKTVLIKTTIKQFKKYIQLNKKISLETLDKLKKIK
DIEKFSDILAYQMPLKTKDKQKLLEMFNTNKRLEFLIGIMESEIELLNIEKRIRNRIKKQTEKNQREYFLTEQIKAIQKE
LGDIENSIDEHEKLKKKINLAKMPKEAKKKAQNELRRLRMMSPLSAESTVVRNYIEWIIQIPWCKKSKIKKNIHIAQKIL
NNDHFGLNNVKENILEYLAVQNRKRKIKGPILCLVGPPGIGKTSLGKSIARATGRKYIRMALGGIRDEAEIRGHRRTYIG
SMPGKLMQKIVKSGVKNPLFLLDEIDKMAFDIRIDPAAALLEVLDSEQNNSFNDHYLEIDYDLSEVMFIATSNTMNIPTP
LLDRMEIIRLSGYTEEEKINIAKKYLQPKQMKQNALKKKELCIQDNAFTDIIRYYTRESGVRNLERAISKICRKSVKKIL
LDTKISDIVVNKKNLKKYLGIKKYEYGKTNKKNHIGQVVGLAWTEMGGDLLTIECSCVPGKGKLIYTGSLGKVMQESIQT
ALTVVRSQANKLNIKKNFYNKNDIHIHVPEGATPKDGPSAGVAMCTAIVSCLTNNPVLSCIAMTGEITLRGKVLNIGGLK
EKLLAAHRGGVKKVFIPYGNKKDLSEIPKNILSKLYIHKIKNIEEIFILALEKNPYIRHINK

Sequences:

>Translated_782_residues
MNAGYSKNVDIPILPLRDIVIYPYMVTPLFIGRKNSIKCIEFSMQTNKKILLITQKEPTIENPKKNDLFKIGTIAKILQI
LNLPDGTVKILVKGKKRAKIEKIKKNNNYYLANIKFIKPIKIEKKEKTVLIKTTIKQFKKYIQLNKKISLETLDKLKKIK
DIEKFSDILAYQMPLKTKDKQKLLEMFNTNKRLEFLIGIMESEIELLNIEKRIRNRIKKQTEKNQREYFLTEQIKAIQKE
LGDIENSIDEHEKLKKKINLAKMPKEAKKKAQNELRRLRMMSPLSAESTVVRNYIEWIIQIPWCKKSKIKKNIHIAQKIL
NNDHFGLNNVKENILEYLAVQNRKRKIKGPILCLVGPPGIGKTSLGKSIARATGRKYIRMALGGIRDEAEIRGHRRTYIG
SMPGKLMQKIVKSGVKNPLFLLDEIDKMAFDIRIDPAAALLEVLDSEQNNSFNDHYLEIDYDLSEVMFIATSNTMNIPTP
LLDRMEIIRLSGYTEEEKINIAKKYLQPKQMKQNALKKKELCIQDNAFTDIIRYYTRESGVRNLERAISKICRKSVKKIL
LDTKISDIVVNKKNLKKYLGIKKYEYGKTNKKNHIGQVVGLAWTEMGGDLLTIECSCVPGKGKLIYTGSLGKVMQESIQT
ALTVVRSQANKLNIKKNFYNKNDIHIHVPEGATPKDGPSAGVAMCTAIVSCLTNNPVLSCIAMTGEITLRGKVLNIGGLK
EKLLAAHRGGVKKVFIPYGNKKDLSEIPKNILSKLYIHKIKNIEEIFILALEKNPYIRHINK
>Mature_782_residues
MNAGYSKNVDIPILPLRDIVIYPYMVTPLFIGRKNSIKCIEFSMQTNKKILLITQKEPTIENPKKNDLFKIGTIAKILQI
LNLPDGTVKILVKGKKRAKIEKIKKNNNYYLANIKFIKPIKIEKKEKTVLIKTTIKQFKKYIQLNKKISLETLDKLKKIK
DIEKFSDILAYQMPLKTKDKQKLLEMFNTNKRLEFLIGIMESEIELLNIEKRIRNRIKKQTEKNQREYFLTEQIKAIQKE
LGDIENSIDEHEKLKKKINLAKMPKEAKKKAQNELRRLRMMSPLSAESTVVRNYIEWIIQIPWCKKSKIKKNIHIAQKIL
NNDHFGLNNVKENILEYLAVQNRKRKIKGPILCLVGPPGIGKTSLGKSIARATGRKYIRMALGGIRDEAEIRGHRRTYIG
SMPGKLMQKIVKSGVKNPLFLLDEIDKMAFDIRIDPAAALLEVLDSEQNNSFNDHYLEIDYDLSEVMFIATSNTMNIPTP
LLDRMEIIRLSGYTEEEKINIAKKYLQPKQMKQNALKKKELCIQDNAFTDIIRYYTRESGVRNLERAISKICRKSVKKIL
LDTKISDIVVNKKNLKKYLGIKKYEYGKTNKKNHIGQVVGLAWTEMGGDLLTIECSCVPGKGKLIYTGSLGKVMQESIQT
ALTVVRSQANKLNIKKNFYNKNDIHIHVPEGATPKDGPSAGVAMCTAIVSCLTNNPVLSCIAMTGEITLRGKVLNIGGLK
EKLLAAHRGGVKKVFIPYGNKKDLSEIPKNILSKLYIHKIKNIEEIFILALEKNPYIRHINK

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=792, Percent_Identity=37.7525252525253, Blast_Score=517, Evalue=1e-146,
Organism=Homo sapiens, GI21396489, Length=664, Percent_Identity=39.0060240963855, Blast_Score=480, Evalue=1e-135,
Organism=Escherichia coli, GI1786643, Length=775, Percent_Identity=64.7741935483871, Blast_Score=1088, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=639, Percent_Identity=40.5320813771518, Blast_Score=486, Evalue=1e-137,
Organism=Caenorhabditis elegans, GI17556486, Length=796, Percent_Identity=33.4170854271357, Blast_Score=404, Evalue=1e-112,
Organism=Saccharomyces cerevisiae, GI6319449, Length=720, Percent_Identity=38.3333333333333, Blast_Score=474, Evalue=1e-134,
Organism=Drosophila melanogaster, GI221513036, Length=676, Percent_Identity=41.2721893491124, Blast_Score=496, Evalue=1e-140,
Organism=Drosophila melanogaster, GI24666867, Length=676, Percent_Identity=41.2721893491124, Blast_Score=496, Evalue=1e-140,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 89578; Mature: 89578

Theoretical pI: Translated: 10.49; Mature: 10.49

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAGYSKNVDIPILPLRDIVIYPYMVTPLFIGRKNSIKCIEFSMQTNKKILLITQKEPTI
CCCCCCCCCCCEEECHHHHHHHHHHHHHEEECCCCCCEEEEEEECCCCEEEEEECCCCCC
ENPKKNDLFKIGTIAKILQILNLPDGTVKILVKGKKRAKIEKIKKNNNYYLANIKFIKPI
CCCCCCCCEEHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHCCCCEEEEEEEEECCE
KIEKKEKTVLIKTTIKQFKKYIQLNKKISLETLDKLKKIKDIEKFSDILAYQMPLKTKDK
EECCCCCEEEHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
QKLLEMFNTNKRLEFLIGIMESEIELLNIEKRIRNRIKKQTEKNQREYFLTEQIKAIQKE
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGDIENSIDEHEKLKKKINLAKMPKEAKKKAQNELRRLRMMSPLSAESTVVRNYIEWIIQ
HHHHHHHHHHHHHHHHHHCHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHEE
IPWCKKSKIKKNIHIAQKILNNDHFGLNNVKENILEYLAVQNRKRKIKGPILCLVGPPGI
CCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCC
GKTSLGKSIARATGRKYIRMALGGIRDEAEIRGHRRTYIGSMPGKLMQKIVKSGVKNPLF
CHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHCCCCCHHHHHHHHHHCCCCCCH
LLDEIDKMAFDIRIDPAAALLEVLDSEQNNSFNDHYLEIDYDLSEVMFIATSNTMNIPTP
HHHHHHHHEEEEEECHHHHHHHHHHCCCCCCCCCCEEEEECCCCCEEEEEECCCCCCCHH
LLDRMEIIRLSGYTEEEKINIAKKYLQPKQMKQNALKKKELCIQDNAFTDIIRYYTRESG
HHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
VRNLERAISKICRKSVKKILLDTKISDIVVNKKNLKKYLGIKKYEYGKTNKKNHIGQVVG
HHHHHHHHHHHHHHHHHHHHHHCCHHHHEECHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
LAWTEMGGDLLTIECSCVPGKGKLIYTGSLGKVMQESIQTALTVVRSQANKLNIKKNFYN
HHHHHCCCCEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHEEEECCCCC
KNDIHIHVPEGATPKDGPSAGVAMCTAIVSCLTNNPVLSCIAMTGEITLRGKVLNIGGLK
CCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECEEEEEEEEEECCCHH
EKLLAAHRGGVKKVFIPYGNKKDLSEIPKNILSKLYIHKIKNIEEIFILALEKNPYIRHI
HHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCC
NK
CC
>Mature Secondary Structure
MNAGYSKNVDIPILPLRDIVIYPYMVTPLFIGRKNSIKCIEFSMQTNKKILLITQKEPTI
CCCCCCCCCCCEEECHHHHHHHHHHHHHEEECCCCCCEEEEEEECCCCEEEEEECCCCCC
ENPKKNDLFKIGTIAKILQILNLPDGTVKILVKGKKRAKIEKIKKNNNYYLANIKFIKPI
CCCCCCCCEEHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHCCCCEEEEEEEEECCE
KIEKKEKTVLIKTTIKQFKKYIQLNKKISLETLDKLKKIKDIEKFSDILAYQMPLKTKDK
EECCCCCEEEHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
QKLLEMFNTNKRLEFLIGIMESEIELLNIEKRIRNRIKKQTEKNQREYFLTEQIKAIQKE
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGDIENSIDEHEKLKKKINLAKMPKEAKKKAQNELRRLRMMSPLSAESTVVRNYIEWIIQ
HHHHHHHHHHHHHHHHHHCHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHEE
IPWCKKSKIKKNIHIAQKILNNDHFGLNNVKENILEYLAVQNRKRKIKGPILCLVGPPGI
CCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCC
GKTSLGKSIARATGRKYIRMALGGIRDEAEIRGHRRTYIGSMPGKLMQKIVKSGVKNPLF
CHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHCCCCCHHHHHHHHHHCCCCCCH
LLDEIDKMAFDIRIDPAAALLEVLDSEQNNSFNDHYLEIDYDLSEVMFIATSNTMNIPTP
HHHHHHHHEEEEEECHHHHHHHHHHCCCCCCCCCCEEEEECCCCCEEEEEECCCCCCCHH
LLDRMEIIRLSGYTEEEKINIAKKYLQPKQMKQNALKKKELCIQDNAFTDIIRYYTRESG
HHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
VRNLERAISKICRKSVKKILLDTKISDIVVNKKNLKKYLGIKKYEYGKTNKKNHIGQVVG
HHHHHHHHHHHHHHHHHHHHHHCCHHHHEECHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
LAWTEMGGDLLTIECSCVPGKGKLIYTGSLGKVMQESIQTALTVVRSQANKLNIKKNFYN
HHHHHCCCCEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHEEEECCCCC
KNDIHIHVPEGATPKDGPSAGVAMCTAIVSCLTNNPVLSCIAMTGEITLRGKVLNIGGLK
CCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECEEEEEEEEEECCCHH
EKLLAAHRGGVKKVFIPYGNKKDLSEIPKNILSKLYIHKIKNIEEIFILALEKNPYIRHI
HHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCC
NK
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12522265 [H]