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The map label for this gene is thrS [H]

Identifier: 116515019

GI number: 116515019

Start: 85506

End: 87434

Strand: Direct

Name: thrS [H]

Synonym: BCc_078

Alternate gene names: 116515019

Gene position: 85506-87434 (Clockwise)

Preceding gene: 116515018

Following gene: 116515020

Centisome position: 20.54

GC content: 19.96

Gene sequence:

>1929_bases
ATGATTATATTATGTAATGGAATTAAAAAAATATATGCAAAACCTACTATTTTGAAAATACTTTTGCAAGATTTTTATCC
TAATCATAATTCTTGTTTTATTGCTGGATTTATAAATAATCAATTATCTGATTTAAATACACTTGTTTCTCATAATTCTA
CTATTGAATTAATTGATGAAAATAATAAAAATTTTTTGTATATGTTAAGATATTCATGTATGCAATTATTGAATTATACA
TTAAAAATTATTTGGCCTAATATAAAAATTGCAGGAGGAAATATAACAGAATCAGGATTTTATTGTGATTTTGATATGCC
ACATATATTAACAAAAAAAGATTTTAATAAAATTTCTCAGAATATGTTAAAAAAAATTTTTAGTTCATATAATATTTTTT
TTAAAAAAATTACTAAAAAAAAAATTTTAGATATTTTAAAAAAAAGAAAAGAAATTTATCAAATTGAAATTTTAAAAAAA
TTTTTTTTTGATACAGATATTATTAATATTTGTTATCATGAGAAATATTATGAATTATCAGTTCATCCGCAATTATCTAA
TATTAGTTTTTGCAAACATTTTTTATTAAATAATGTATCTGGAGCATATTGGAATAATAATAAAAATAATAAAATGTTAC
AAAGAATTCATGTAATTTCTTGGATTTCAAGAAAACAATTATTAGAATTCTTGAAAAAAAAAGAAAAATTAAAATTGTGT
GATCATCGAAAAATTTCAAAATTATTAAGTTTATATCATATTCAAAAAGAATCTCCTGGTATGATTTTTTGGCATAAGAA
TGGATATATTATTTTTAAACAATTAGAAAATTTTCTTCGTAATAAATTATTTCAAAATAATTATATTGAAGTAAAAAGTC
CTATTATTATTGATAAATCATTATGGAAAAAAAGTGGTCATTGGAAACATTATAATCAATCAATTTTTACTACAAAATCT
GAAAATAATCAATATTGTATTAAACCTATGAATTGTCCTGCACACGTTCAAATATTTAAATATGGTTTAAAATCTTATAA
AGATTTACCAATACGTATGGCTGAATTTGGAAGTTGTCATAGACAAGAAACATCAGGTTCTTTACATGGATTATTTCGTG
TAAGAGGATTTACACAAGATGATGCTCATATTTTTTGTACGAAGAAACAAATTAAATCTGAATTAAACCATTGTATACGT
TTATTATTTGATTTGTATCATACTTTTGGTTTTAAGAAAATTTTTATAAAATTTTCTACTAGACCTGAAAATAGAATTGG
AAAAGATGATATTTGGGATCAAGCAGAGAAAGATTTAGAATTAGTTTTAAAAAAAAATAATTTATTTTTTGAGTATCAAA
TTGGAGAAGGTGCATTTTATGGTCCTAAAATTGAAATTGCTTTAGAAGATAATTTAAAGCGTATATGGCAATGTGGTACA
ATTCAATTAGATTTTTATTTATCAAAACAGTTAGATGCTTTTTATATTAACAAAAATAATATTAAAAAAAATCCTATTAT
TATTCATAGAGCATTTTTAGGTTCAATTGAACGGTTTATTGGAATTTTAATTGAAGAATATAATGGTAAATTACCAATAT
GGCTATGTCCAATTCAGGTTGCAATTATTAATGTTTCTGAAAAACATATTTTTTTTATAAAAAATATAGAAAAAAAATTT
TTAAAAAATAATATTCGTTTTATTTCTGATATTAGTAATAATAGTATTAGTTTTAAAATTCGTTTTTATCTTGAGCAAAA
AGTACCATATATAATAATTATTGGAGATAAAGAAGTAAAAAATAATTACATAACAATAAGAAATAGATTTAATAATATTC
AATATAAACAAAATATCAATTTTTTTATTAAAAAAATTATTAATAATGTTAATAGTTTTAGTATACAAGATTGTAATATG
GAGGATTAG

Upstream 100 bases:

>100_bases
TAATTTTATAAAAAAAATATTTTTTATAAATTTCATTTATTATAAAAGATATTATATGTATTACTTTTAATATAAATATT
TTTAGGGATTAAATACACCT

Downstream 100 bases:

>100_bases
AGTATTAAAGGCAGAAAAAAAAATCAATTATTACGTTCTCATCGTATTAATAATGAGATTCGTTCTACAGAAGTTCGATT
AATGGGTTTAAAAGGTGAAC

Product: hypothetical protein

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS [H]

Number of amino acids: Translated: 642; Mature: 642

Protein sequence:

>642_residues
MIILCNGIKKIYAKPTILKILLQDFYPNHNSCFIAGFINNQLSDLNTLVSHNSTIELIDENNKNFLYMLRYSCMQLLNYT
LKIIWPNIKIAGGNITESGFYCDFDMPHILTKKDFNKISQNMLKKIFSSYNIFFKKITKKKILDILKKRKEIYQIEILKK
FFFDTDIINICYHEKYYELSVHPQLSNISFCKHFLLNNVSGAYWNNNKNNKMLQRIHVISWISRKQLLEFLKKKEKLKLC
DHRKISKLLSLYHIQKESPGMIFWHKNGYIIFKQLENFLRNKLFQNNYIEVKSPIIIDKSLWKKSGHWKHYNQSIFTTKS
ENNQYCIKPMNCPAHVQIFKYGLKSYKDLPIRMAEFGSCHRQETSGSLHGLFRVRGFTQDDAHIFCTKKQIKSELNHCIR
LLFDLYHTFGFKKIFIKFSTRPENRIGKDDIWDQAEKDLELVLKKNNLFFEYQIGEGAFYGPKIEIALEDNLKRIWQCGT
IQLDFYLSKQLDAFYINKNNIKKNPIIIHRAFLGSIERFIGILIEEYNGKLPIWLCPIQVAIINVSEKHIFFIKNIEKKF
LKNNIRFISDISNNSISFKIRFYLEQKVPYIIIIGDKEVKNNYITIRNRFNNIQYKQNINFFIKKIINNVNSFSIQDCNM
ED

Sequences:

>Translated_642_residues
MIILCNGIKKIYAKPTILKILLQDFYPNHNSCFIAGFINNQLSDLNTLVSHNSTIELIDENNKNFLYMLRYSCMQLLNYT
LKIIWPNIKIAGGNITESGFYCDFDMPHILTKKDFNKISQNMLKKIFSSYNIFFKKITKKKILDILKKRKEIYQIEILKK
FFFDTDIINICYHEKYYELSVHPQLSNISFCKHFLLNNVSGAYWNNNKNNKMLQRIHVISWISRKQLLEFLKKKEKLKLC
DHRKISKLLSLYHIQKESPGMIFWHKNGYIIFKQLENFLRNKLFQNNYIEVKSPIIIDKSLWKKSGHWKHYNQSIFTTKS
ENNQYCIKPMNCPAHVQIFKYGLKSYKDLPIRMAEFGSCHRQETSGSLHGLFRVRGFTQDDAHIFCTKKQIKSELNHCIR
LLFDLYHTFGFKKIFIKFSTRPENRIGKDDIWDQAEKDLELVLKKNNLFFEYQIGEGAFYGPKIEIALEDNLKRIWQCGT
IQLDFYLSKQLDAFYINKNNIKKNPIIIHRAFLGSIERFIGILIEEYNGKLPIWLCPIQVAIINVSEKHIFFIKNIEKKF
LKNNIRFISDISNNSISFKIRFYLEQKVPYIIIIGDKEVKNNYITIRNRFNNIQYKQNINFFIKKIINNVNSFSIQDCNM
ED
>Mature_642_residues
MIILCNGIKKIYAKPTILKILLQDFYPNHNSCFIAGFINNQLSDLNTLVSHNSTIELIDENNKNFLYMLRYSCMQLLNYT
LKIIWPNIKIAGGNITESGFYCDFDMPHILTKKDFNKISQNMLKKIFSSYNIFFKKITKKKILDILKKRKEIYQIEILKK
FFFDTDIINICYHEKYYELSVHPQLSNISFCKHFLLNNVSGAYWNNNKNNKMLQRIHVISWISRKQLLEFLKKKEKLKLC
DHRKISKLLSLYHIQKESPGMIFWHKNGYIIFKQLENFLRNKLFQNNYIEVKSPIIIDKSLWKKSGHWKHYNQSIFTTKS
ENNQYCIKPMNCPAHVQIFKYGLKSYKDLPIRMAEFGSCHRQETSGSLHGLFRVRGFTQDDAHIFCTKKQIKSELNHCIR
LLFDLYHTFGFKKIFIKFSTRPENRIGKDDIWDQAEKDLELVLKKNNLFFEYQIGEGAFYGPKIEIALEDNLKRIWQCGT
IQLDFYLSKQLDAFYINKNNIKKNPIIIHRAFLGSIERFIGILIEEYNGKLPIWLCPIQVAIINVSEKHIFFIKNIEKKF
LKNNIRFISDISNNSISFKIRFYLEQKVPYIIIIGDKEVKNNYITIRNRFNNIQYKQNINFFIKKIINNVNSFSIQDCNM
ED

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI38570111, Length=598, Percent_Identity=34.4481605351171, Blast_Score=348, Evalue=8e-96,
Organism=Homo sapiens, GI38202255, Length=596, Percent_Identity=34.0604026845638, Blast_Score=346, Evalue=3e-95,
Organism=Homo sapiens, GI20070344, Length=620, Percent_Identity=29.8387096774194, Blast_Score=308, Evalue=1e-83,
Organism=Escherichia coli, GI1788013, Length=636, Percent_Identity=45.9119496855346, Blast_Score=654, Evalue=0.0,
Organism=Escherichia coli, GI1786392, Length=145, Percent_Identity=26.8965517241379, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71984192, Length=598, Percent_Identity=33.1103678929766, Blast_Score=343, Evalue=2e-94,
Organism=Caenorhabditis elegans, GI71984184, Length=598, Percent_Identity=33.1103678929766, Blast_Score=343, Evalue=2e-94,
Organism=Saccharomyces cerevisiae, GI6322112, Length=614, Percent_Identity=32.8990228013029, Blast_Score=327, Evalue=3e-90,
Organism=Saccharomyces cerevisiae, GI6322654, Length=403, Percent_Identity=37.2208436724566, Blast_Score=275, Evalue=2e-74,
Organism=Drosophila melanogaster, GI24583842, Length=609, Percent_Identity=33.3333333333333, Blast_Score=352, Evalue=3e-97,
Organism=Drosophila melanogaster, GI28574141, Length=609, Percent_Identity=33.3333333333333, Blast_Score=352, Evalue=3e-97,
Organism=Drosophila melanogaster, GI24583839, Length=609, Percent_Identity=33.3333333333333, Blast_Score=352, Evalue=4e-97,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD [H]

EC number: =6.1.1.3 [H]

Molecular weight: Translated: 76412; Mature: 76412

Theoretical pI: Translated: 10.03; Mature: 10.03

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIILCNGIKKIYAKPTILKILLQDFYPNHNSCFIAGFINNQLSDLNTLVSHNSTIELIDE
CEEEECCHHHHHCCHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHCCCCEEEEEEC
NNKNFLYMLRYSCMQLLNYTLKIIWPNIKIAGGNITESGFYCDFDMPHILTKKDFNKISQ
CCCCEEEEHHHHHHHHHCCEEEEEECCEEEECCCEECCCEEECCCCCCCCCHHHHHHHHH
NMLKKIFSSYNIFFKKITKKKILDILKKRKEIYQIEILKKFFFDTDIINICYHEKYYELS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCEEEEEE
VHPQLSNISFCKHFLLNNVSGAYWNNNKNNKMLQRIHVISWISRKQLLEFLKKKEKLKLC
ECCCCCCHHHHHHHHHCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DHRKISKLLSLYHIQKESPGMIFWHKNGYIIFKQLENFLRNKLFQNNYIEVKSPIIIDKS
HHHHHHHHHHHHHHCCCCCCEEEEECCCEEEHHHHHHHHHHHHHCCCCEEECCCEEEEHH
LWKKSGHWKHYNQSIFTTKSENNQYCIKPMNCPAHVQIFKYGLKSYKDLPIRMAEFGSCH
HHCCCCCCCCCCCCEEEEECCCCEEEEEECCCCCHHHHHHHHHHHCCCCCEEHHHHCCCC
RQETSGSLHGLFRVRGFTQDDAHIFCTKKQIKSELNHCIRLLFDLYHTFGFKKIFIKFST
CCCCCCCCEEEEEEECCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEC
RPENRIGKDDIWDQAEKDLELVLKKNNLFFEYQIGEGAFYGPKIEIALEDNLKRIWQCGT
CCCCCCCCCHHHHHHHHCCEEEEECCCEEEEEEECCCCEECCEEEEEEECCHHHHHCCCC
IQLDFYLSKQLDAFYINKNNIKKNPIIIHRAFLGSIERFIGILIEEYNGKLPIWLCPIQV
EEEEEEEECCCCEEEEECCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCEEECCEEE
AIINVSEKHIFFIKNIEKKFLKNNIRFISDISNNSISFKIRFYLEQKVPYIIIIGDKEVK
EEEEECCCEEEEEEHHHHHHHHCCCEEEEECCCCEEEEEEEEEEECCCCEEEEECCCCCC
NNYITIRNRFNNIQYKQNINFFIKKIINNVNSFSIQDCNMED
CCEEEEEECCCCCEEECCHHHHHHHHHCCCCCEEEECCCCCC
>Mature Secondary Structure
MIILCNGIKKIYAKPTILKILLQDFYPNHNSCFIAGFINNQLSDLNTLVSHNSTIELIDE
CEEEECCHHHHHCCHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHCCCCEEEEEEC
NNKNFLYMLRYSCMQLLNYTLKIIWPNIKIAGGNITESGFYCDFDMPHILTKKDFNKISQ
CCCCEEEEHHHHHHHHHCCEEEEEECCEEEECCCEECCCEEECCCCCCCCCHHHHHHHHH
NMLKKIFSSYNIFFKKITKKKILDILKKRKEIYQIEILKKFFFDTDIINICYHEKYYELS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCEEEEEE
VHPQLSNISFCKHFLLNNVSGAYWNNNKNNKMLQRIHVISWISRKQLLEFLKKKEKLKLC
ECCCCCCHHHHHHHHHCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DHRKISKLLSLYHIQKESPGMIFWHKNGYIIFKQLENFLRNKLFQNNYIEVKSPIIIDKS
HHHHHHHHHHHHHHCCCCCCEEEEECCCEEEHHHHHHHHHHHHHCCCCEEECCCEEEEHH
LWKKSGHWKHYNQSIFTTKSENNQYCIKPMNCPAHVQIFKYGLKSYKDLPIRMAEFGSCH
HHCCCCCCCCCCCCEEEEECCCCEEEEEECCCCCHHHHHHHHHHHCCCCCEEHHHHCCCC
RQETSGSLHGLFRVRGFTQDDAHIFCTKKQIKSELNHCIRLLFDLYHTFGFKKIFIKFST
CCCCCCCCEEEEEEECCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEC
RPENRIGKDDIWDQAEKDLELVLKKNNLFFEYQIGEGAFYGPKIEIALEDNLKRIWQCGT
CCCCCCCCCHHHHHHHHCCEEEEECCCEEEEEEECCCCEECCEEEEEEECCHHHHHCCCC
IQLDFYLSKQLDAFYINKNNIKKNPIIIHRAFLGSIERFIGILIEEYNGKLPIWLCPIQV
EEEEEEEECCCCEEEEECCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCEEECCEEE
AIINVSEKHIFFIKNIEKKFLKNNIRFISDISNNSISFKIRFYLEQKVPYIIIIGDKEVK
EEEEECCCEEEEEEHHHHHHHHCCCEEEEECCCCEEEEEEEEEEECCCCEEEEECCCCCC
NNYITIRNRFNNIQYKQNINFFIKKIINNVNSFSIQDCNMED
CCEEEEEECCCCCEEECCHHHHHHHHHCCCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7766160; 12089438 [H]