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The map label for this gene is gyrB [H]

Identifier: 116514952

GI number: 116514952

Start: 1981

End: 4374

Strand: Reverse

Name: gyrB [H]

Synonym: BCc_002

Alternate gene names: 116514952

Gene position: 4374-1981 (Counterclockwise)

Preceding gene: 116514953

Following gene: NA

Centisome position: 1.05

GC content: 22.14

Gene sequence:

>2394_bases
ATGTCAGATTTATATACTTCATCAAATATAAAAATTTTAAAAGGATTAGATGCAGTTAGAAAAAGACCTGGAATGTATAT
TGGAGATACAGATGATGGAACCGGTTTACATCATATGGTTTTTGAAGTAGTTGATAATTCAATAGATGAAGCTTTAGCTG
GATTTTGTAATACAATAAATGTAAAAATACATTCTGATAATTCTGTATCCATCAGTGATAATGGAAGAGGTATACCGATA
GATATACATCCAGAAGCAGGAATATCAGCAGCAGAAGTTATAATGACAGTTTTACATGCAGGAGGAAAATTTGATGAAAA
TTCATATAAAGTTTCAGGAGGATTGCATGGAGTAGGAATCTCAGTTGTTAATGCATTATCAAAAAAACTAAAACTTTATA
TTTATAGAAATAGCAAAATTCGACAAATATATTTCCATGGAAATCCTAAAGAATCTTTATTATGTATAGGAAAAACAAAA
AAACAAGGTACAAAAATTAGATTTTGGCCGAACGAAAAAATTTTTACAAATCAAAATAATTTTCAGTCTGAAATTTTACA
AAAAAGATTACAAGAATTATCATTTTTAAATTCTAATTTGTTAATCAAATTAACAGATATGAGAAATAAAATATATTTTC
AATACTTAAATAAAGGTGGTATAAAAAATTTTATAAAATTTTTAAATAATTCAAAAATACCTATACATAATAAAATTTTT
ATTTTTAAAAAAAAAAAAAAAAATATTGAAGTAAATATTGCTATGCAATGGAATTCAACATTTCAAGAAAAAATTTTATG
TTTTACTAATAATATACCCCAGCAAGACGGAGGTAGTCATTTATCTGGTTTTCGTGCCGCATTAACAAGAACATTAAATA
ACTTTTCTGATCGAGAAAAATCAAATAAAAAAAACAAAATTACAATTACTGGAGATGACACAAGAGAAGGATTAATAGCA
TTAATTTCAATAAAAATGTTTAATCCAAAATTTTCGTCACAAACTAAAGAAAAATTAGTATCTTCAGAAGTAAAGTCAGT
TGTCGAAACATTATTAAATGAACATTTAATGAATTTTTTATTAGAAAACCCAAAAGAATCTAAACCTATAATTACTAAAA
TCATACAATCAGCTCGATCAAGAGAAGCAGCTAAAAAAGCTAGAGAAATAACAAGAAAAAAGGGAACAATTGAAAGCACA
AACCTTTCAGGAAAATTATCAGATTGCCAAGAAAAAGATCCTTTATTTTCAGAAATATATTTAGTTGAAGGAGATTCAGC
TGGGGGGTCTGCTAAACAAGGAAGGAATAGAAGAAACCAAGCAATTTTGCCTTTAAAAGGAAAAATTTTAAATATAGAAA
AAGCACGATTAGAAAAAATAATTAATTCTTCTGAATTAGTAACATTAATAACTGTATTAGGTTGCGGATTTGGAAAAGAA
GAATATGATCTTAAAAAATTAAGATATAATTATATAATAATTATGACAGATGCTGATGTAGATGGATTACATATTAGAAC
TTTATTATTAACATTTTTTTTTCGACAAATGCCTGAAATTATAAAAAAAGGACACATATATATTGCTCAACCTCCTTTAT
ATAAAATAAAAGAAGGAAAAAAAGAAAAATATTTAACAGATACTAATGAATTATATAAATATCAATATCAATTAATACAA
AAAAAATGTTATTTAGTATATAAAATAAAACAAGAAAAAAAAGAAGAAACTTTCTCTAAAATAATTTTTCAATATAATAA
AATTAATAAATTATTTTTAAAAAAAAAATATATAATACCAAGTTTTATTTTTAAAATAATGATCTATATAATTCCATTAA
AAAATTTACAAAAAAAAAACAAAGTAAAAAATTGGATAAAATTATTAATAAAAAATTTACAAAAAAAAGAAAAAAAAAAG
ATATATTCATATCAAATAAAAAAAAATCAAAAAAACTATGAACCAATATTAAATATTAGTAGTAATAATAATTTTTATTC
TTATCATCTAAAAAATGAATTTTTATTAACAAAAAAATATAAAAAATTTATTAAATTTATATTAAAAATTAATTTTTTAA
TTCAACATAATGCGTATATAAAACTGAATAATAAAAAATTTATATTTAATAATATAGATAAAATTATTACATTATTAATT
AAAGAAACAAACGATTTTTTGAATATACAAAGATACAAAGGATTAGGAGAAATGAATCCTGAACAATTATGGATGACTAC
AATGAATCCAAAAACTAGAAAAATGCTACAAGTTACTATGAATGATGCTAAATCCGCCGATCAATTATTTAGTATATTAA
TGGGAGATTTAGTAGAACCAAGAAGAAATTTTATTAAAAAAAATGCTTTATATGCAAAAAATATAGATATTTAG

Upstream 100 bases:

>100_bases
CATATCTTAAAATTATTAATTTATAAAAATCTCTTTTTTAAAAGAGATTTAAATAAAAATCTTATAAAACAAAAAATTTT
TTTATAAAAAAGGAAATTTT

Downstream 100 bases:

>100_bases
AAAAAACATTAAAAATATTTACTTTCGGCAGGTATTAACGTTTTTAAACCTGCCAAAAAACGAAAAATAAAATATTTATT
TTTTAAAATAAAACTTTTTT

Product: DNA gyrase subunit B

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 797; Mature: 796

Protein sequence:

>797_residues
MSDLYTSSNIKILKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNSIDEALAGFCNTINVKIHSDNSVSISDNGRGIPI
DIHPEAGISAAEVIMTVLHAGGKFDENSYKVSGGLHGVGISVVNALSKKLKLYIYRNSKIRQIYFHGNPKESLLCIGKTK
KQGTKIRFWPNEKIFTNQNNFQSEILQKRLQELSFLNSNLLIKLTDMRNKIYFQYLNKGGIKNFIKFLNNSKIPIHNKIF
IFKKKKKNIEVNIAMQWNSTFQEKILCFTNNIPQQDGGSHLSGFRAALTRTLNNFSDREKSNKKNKITITGDDTREGLIA
LISIKMFNPKFSSQTKEKLVSSEVKSVVETLLNEHLMNFLLENPKESKPIITKIIQSARSREAAKKAREITRKKGTIEST
NLSGKLSDCQEKDPLFSEIYLVEGDSAGGSAKQGRNRRNQAILPLKGKILNIEKARLEKIINSSELVTLITVLGCGFGKE
EYDLKKLRYNYIIIMTDADVDGLHIRTLLLTFFFRQMPEIIKKGHIYIAQPPLYKIKEGKKEKYLTDTNELYKYQYQLIQ
KKCYLVYKIKQEKKEETFSKIIFQYNKINKLFLKKKYIIPSFIFKIMIYIIPLKNLQKKNKVKNWIKLLIKNLQKKEKKK
IYSYQIKKNQKNYEPILNISSNNNFYSYHLKNEFLLTKKYKKFIKFILKINFLIQHNAYIKLNNKKFIFNNIDKIITLLI
KETNDFLNIQRYKGLGEMNPEQLWMTTMNPKTRKMLQVTMNDAKSADQLFSILMGDLVEPRRNFIKKNALYAKNIDI

Sequences:

>Translated_797_residues
MSDLYTSSNIKILKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNSIDEALAGFCNTINVKIHSDNSVSISDNGRGIPI
DIHPEAGISAAEVIMTVLHAGGKFDENSYKVSGGLHGVGISVVNALSKKLKLYIYRNSKIRQIYFHGNPKESLLCIGKTK
KQGTKIRFWPNEKIFTNQNNFQSEILQKRLQELSFLNSNLLIKLTDMRNKIYFQYLNKGGIKNFIKFLNNSKIPIHNKIF
IFKKKKKNIEVNIAMQWNSTFQEKILCFTNNIPQQDGGSHLSGFRAALTRTLNNFSDREKSNKKNKITITGDDTREGLIA
LISIKMFNPKFSSQTKEKLVSSEVKSVVETLLNEHLMNFLLENPKESKPIITKIIQSARSREAAKKAREITRKKGTIEST
NLSGKLSDCQEKDPLFSEIYLVEGDSAGGSAKQGRNRRNQAILPLKGKILNIEKARLEKIINSSELVTLITVLGCGFGKE
EYDLKKLRYNYIIIMTDADVDGLHIRTLLLTFFFRQMPEIIKKGHIYIAQPPLYKIKEGKKEKYLTDTNELYKYQYQLIQ
KKCYLVYKIKQEKKEETFSKIIFQYNKINKLFLKKKYIIPSFIFKIMIYIIPLKNLQKKNKVKNWIKLLIKNLQKKEKKK
IYSYQIKKNQKNYEPILNISSNNNFYSYHLKNEFLLTKKYKKFIKFILKINFLIQHNAYIKLNNKKFIFNNIDKIITLLI
KETNDFLNIQRYKGLGEMNPEQLWMTTMNPKTRKMLQVTMNDAKSADQLFSILMGDLVEPRRNFIKKNALYAKNIDI
>Mature_796_residues
SDLYTSSNIKILKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNSIDEALAGFCNTINVKIHSDNSVSISDNGRGIPID
IHPEAGISAAEVIMTVLHAGGKFDENSYKVSGGLHGVGISVVNALSKKLKLYIYRNSKIRQIYFHGNPKESLLCIGKTKK
QGTKIRFWPNEKIFTNQNNFQSEILQKRLQELSFLNSNLLIKLTDMRNKIYFQYLNKGGIKNFIKFLNNSKIPIHNKIFI
FKKKKKNIEVNIAMQWNSTFQEKILCFTNNIPQQDGGSHLSGFRAALTRTLNNFSDREKSNKKNKITITGDDTREGLIAL
ISIKMFNPKFSSQTKEKLVSSEVKSVVETLLNEHLMNFLLENPKESKPIITKIIQSARSREAAKKAREITRKKGTIESTN
LSGKLSDCQEKDPLFSEIYLVEGDSAGGSAKQGRNRRNQAILPLKGKILNIEKARLEKIINSSELVTLITVLGCGFGKEE
YDLKKLRYNYIIIMTDADVDGLHIRTLLLTFFFRQMPEIIKKGHIYIAQPPLYKIKEGKKEKYLTDTNELYKYQYQLIQK
KCYLVYKIKQEKKEETFSKIIFQYNKINKLFLKKKYIIPSFIFKIMIYIIPLKNLQKKNKVKNWIKLLIKNLQKKEKKKI
YSYQIKKNQKNYEPILNISSNNNFYSYHLKNEFLLTKKYKKFIKFILKINFLIQHNAYIKLNNKKFIFNNIDKIITLLIK
ETNDFLNIQRYKGLGEMNPEQLWMTTMNPKTRKMLQVTMNDAKSADQLFSILMGDLVEPRRNFIKKNALYAKNIDI

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type II topoisomerase family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=563, Percent_Identity=24.3339253996448, Blast_Score=113, Evalue=7e-25,
Organism=Homo sapiens, GI19913408, Length=586, Percent_Identity=24.2320819112628, Blast_Score=111, Evalue=3e-24,
Organism=Escherichia coli, GI48994957, Length=804, Percent_Identity=56.9651741293532, Blast_Score=935, Evalue=0.0,
Organism=Escherichia coli, GI1789408, Length=566, Percent_Identity=36.7491166077738, Blast_Score=371, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI212645845, Length=521, Percent_Identity=24.9520153550864, Blast_Score=119, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI17535065, Length=537, Percent_Identity=24.0223463687151, Blast_Score=115, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI212645657, Length=199, Percent_Identity=29.1457286432161, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=562, Percent_Identity=24.9110320284698, Blast_Score=114, Evalue=6e-26,
Organism=Drosophila melanogaster, GI17136538, Length=518, Percent_Identity=26.6409266409266, Blast_Score=121, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011557
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 92327; Mature: 92196

Theoretical pI: Translated: 10.46; Mature: 10.46

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDLYTSSNIKILKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNSIDEALAGFCNTIN
CCCCCCCCCCEEECCCHHHHHCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEE
VKIHSDNSVSISDNGRGIPIDIHPEAGISAAEVIMTVLHAGGKFDENSYKVSGGLHGVGI
EEEECCCEEEECCCCCCCEEEECCCCCCCHHHHHHHHHHCCCCCCCCCEEECCCCCHHHH
SVVNALSKKLKLYIYRNSKIRQIYFHGNPKESLLCIGKTKKQGTKIRFWPNEKIFTNQNN
HHHHHHHHCEEEEEEECCCEEEEEEECCCCCCEEEEECCCCCCCEEEECCCCCEEECCCC
FQSEILQKRLQELSFLNSNLLIKLTDMRNKIYFQYLNKGGIKNFIKFLNNSKIPIHNKIF
HHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEHHHHCCCCHHHHHHHHCCCCCCCCCEEE
IFKKKKKNIEVNIAMQWNSTFQEKILCFTNNIPQQDGGSHLSGFRAALTRTLNNFSDREK
EEEECCCCEEEEEEEEECCCHHHEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
SNKKNKITITGDDTREGLIALISIKMFNPKFSSQTKEKLVSSEVKSVVETLLNEHLMNFL
CCCCCEEEEECCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LENPKESKPIITKIIQSARSREAAKKAREITRKKGTIESTNLSGKLSDCQEKDPLFSEIY
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEE
LVEGDSAGGSAKQGRNRRNQAILPLKGKILNIEKARLEKIINSSELVTLITVLGCGFGKE
EEECCCCCCCCHHCCCCCCCEEEECCCCEECCHHHHHHHHHCCHHHHHHHHHHHCCCCCC
EYDLKKLRYNYIIIMTDADVDGLHIRTLLLTFFFRQMPEIIKKGHIYIAQPPLYKIKEGK
HHHHHHEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHCCCC
KEKYLTDTNELYKYQYQLIQKKCYLVYKIKQEKKEETFSKIIFQYNKINKLFLKKKYIIP
CCCCCCCHHHHHHHHHHHHHHHHEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SFIFKIMIYIIPLKNLQKKNKVKNWIKLLIKNLQKKEKKKIYSYQIKKNQKNYEPILNIS
HHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCEEEEE
SNNNFYSYHLKNEFLLTKKYKKFIKFILKINFLIQHNAYIKLNNKKFIFNNIDKIITLLI
CCCCEEEEEECCCEEHHHHHHHHHHHHHHHHEEEEECCEEEECCCEEEHHHHHHHHHHHH
KETNDFLNIQRYKGLGEMNPEQLWMTTMNPKTRKMLQVTMNDAKSADQLFSILMGDLVEP
HCCCCCEEHHHHCCCCCCCHHHEEEECCCCHHHHHHEEEHHCCCCHHHHHHHHHHHHHHH
RRNFIKKNALYAKNIDI
HHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SDLYTSSNIKILKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNSIDEALAGFCNTIN
CCCCCCCCCEEECCCHHHHHCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEE
VKIHSDNSVSISDNGRGIPIDIHPEAGISAAEVIMTVLHAGGKFDENSYKVSGGLHGVGI
EEEECCCEEEECCCCCCCEEEECCCCCCCHHHHHHHHHHCCCCCCCCCEEECCCCCHHHH
SVVNALSKKLKLYIYRNSKIRQIYFHGNPKESLLCIGKTKKQGTKIRFWPNEKIFTNQNN
HHHHHHHHCEEEEEEECCCEEEEEEECCCCCCEEEEECCCCCCCEEEECCCCCEEECCCC
FQSEILQKRLQELSFLNSNLLIKLTDMRNKIYFQYLNKGGIKNFIKFLNNSKIPIHNKIF
HHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEHHHHCCCCHHHHHHHHCCCCCCCCCEEE
IFKKKKKNIEVNIAMQWNSTFQEKILCFTNNIPQQDGGSHLSGFRAALTRTLNNFSDREK
EEEECCCCEEEEEEEEECCCHHHEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
SNKKNKITITGDDTREGLIALISIKMFNPKFSSQTKEKLVSSEVKSVVETLLNEHLMNFL
CCCCCEEEEECCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LENPKESKPIITKIIQSARSREAAKKAREITRKKGTIESTNLSGKLSDCQEKDPLFSEIY
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEE
LVEGDSAGGSAKQGRNRRNQAILPLKGKILNIEKARLEKIINSSELVTLITVLGCGFGKE
EEECCCCCCCCHHCCCCCCCEEEECCCCEECCHHHHHHHHHCCHHHHHHHHHHHCCCCCC
EYDLKKLRYNYIIIMTDADVDGLHIRTLLLTFFFRQMPEIIKKGHIYIAQPPLYKIKEGK
HHHHHHEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHCCCC
KEKYLTDTNELYKYQYQLIQKKCYLVYKIKQEKKEETFSKIIFQYNKINKLFLKKKYIIP
CCCCCCCHHHHHHHHHHHHHHHHEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SFIFKIMIYIIPLKNLQKKNKVKNWIKLLIKNLQKKEKKKIYSYQIKKNQKNYEPILNIS
HHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCEEEEE
SNNNFYSYHLKNEFLLTKKYKKFIKFILKINFLIQHNAYIKLNNKKFIFNNIDKIITLLI
CCCCEEEEEECCCEEHHHHHHHHHHHHHHHHEEEEECCEEEECCCEEEHHHHHHHHHHHH
KETNDFLNIQRYKGLGEMNPEQLWMTTMNPKTRKMLQVTMNDAKSADQLFSILMGDLVEP
HCCCCCEEHHHHCCCCCCCHHHEEEECCCCHHHHHHEEEHHCCCCHHHHHHHHHHHHHHH
RRNFIKKNALYAKNIDI
HHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9516544; 12089438; 1572539 [H]