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The map label for this gene is yfhQ [H]

Identifier: 116494237

GI number: 116494237

Start: 690176

End: 691279

Strand: Direct

Name: yfhQ [H]

Synonym: LSEI_0689

Alternate gene names: 116494237

Gene position: 690176-691279 (Clockwise)

Preceding gene: 116494235

Following gene: 116494238

Centisome position: 23.84

GC content: 50.72

Gene sequence:

>1104_bases
ATGACAAACAAATTAATGAACTGGCCGCCGGAAAAAGTGGCGGCTTTTCAAAAGGCCTTATTGAATTGGTATGATCAACA
TGCGCGTCAATTGCCGTGGCGCGAGGATCATGATCCTTATCATGTCATGGTTAGTGAGCTCATGCTGCAGCAAACGCAAG
TGCAGACGGTGATTCCTTATTATGAACGGTTTATGAATCAATTCCCGACCGTGGGAGCCTTAGCGAAGGCGCCAGAAGCA
GAGGTTCTGAAGGCGTGGGAGGGCTTGGGTTATTATTCCCGCGCACGCCGTCTGCAACAGGCAGCCAAGCAGATTGTTGC
CGATTATGGCGGCGTTTGGCCGCAGACCTCAGAAACACTGCAGACATTGTCTGGCATCGGGCCTTACACAGCCGGAGCGA
TTGCGTCAATTAGTTTCGGGGAACCTGTGCCTGCCATTGACGGTAACGCTTTTCGAGTTTTCGCTCGGTTGTTTAAAGTG
GATGCGGATATTGCCCGGCCACAAACGCGTCAGATCTTTTTTGACTTGATTCAGCCACTGATGCCAAAAGATCGACCTGG
TGATTTTAATCAGGCCGTCATGGATCTTGGCTCAAGTTACATGTCGGCGAATCACCCAGACCCTGCACATTCTCCGGTGC
GAGATTTTGATGCCAGTTATCGAGATGGGGTGGTTTCGGCTTATCCGGTTAAAACGAAAAAGCCACGGCCGGTGGTGCAT
CGTTACTTTGCGTTAGTCATTCGGTCAGAGAAAGGCTATTTACTTGAACAGCGGCCAAGTACTGGCTTGCTGGCTGATTT
GTGGATGTTTCCGCTCGTTGACATGGCAGATCTTGAAAGTACCATGATGAGTGCGCAGTTAGATGAGGTCAGCACGTTGT
TTGCGGCATCATCAGGGATGCAGCTGACGTTTGCGGATCTTGGCGCGAAAACGGTTAAGCATACTTTTACGCATCAGCAA
TGGCAGTTGACGTTGATTGGGGTCGAAACTGCGGCGAGCGATCTCAGCTTTTTACCAGCACGGTGGGTGAAAGCGGATCA
TTTTAGTGAGCTGGCGTTGCCGACGGTGCAGAAGAAGTTGAATGCAGCGCTGGGGATGAATTAG

Upstream 100 bases:

>100_bases
CTTGCTCGCGCGTTTCAGCTTGCAACAAGGATTCCAACTCATCAACTAAAGCAGTTCAATATTTCCCGTTTTTCAAGTCC
ATGGTAAGCTAGTGGTTATG

Downstream 100 bases:

>100_bases
AAATTGGTATTGGGTGAGTGGCTTAGTGATTTTGAAAAATGTTCATCAGCTCAGAAACTGGGCCGTCTCACCCGCTGGCT
GAAACGTGCGAACAGGCGCA

Product: A/G-specific DNA glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 367; Mature: 366

Protein sequence:

>367_residues
MTNKLMNWPPEKVAAFQKALLNWYDQHARQLPWREDHDPYHVMVSELMLQQTQVQTVIPYYERFMNQFPTVGALAKAPEA
EVLKAWEGLGYYSRARRLQQAAKQIVADYGGVWPQTSETLQTLSGIGPYTAGAIASISFGEPVPAIDGNAFRVFARLFKV
DADIARPQTRQIFFDLIQPLMPKDRPGDFNQAVMDLGSSYMSANHPDPAHSPVRDFDASYRDGVVSAYPVKTKKPRPVVH
RYFALVIRSEKGYLLEQRPSTGLLADLWMFPLVDMADLESTMMSAQLDEVSTLFAASSGMQLTFADLGAKTVKHTFTHQQ
WQLTLIGVETAASDLSFLPARWVKADHFSELALPTVQKKLNAALGMN

Sequences:

>Translated_367_residues
MTNKLMNWPPEKVAAFQKALLNWYDQHARQLPWREDHDPYHVMVSELMLQQTQVQTVIPYYERFMNQFPTVGALAKAPEA
EVLKAWEGLGYYSRARRLQQAAKQIVADYGGVWPQTSETLQTLSGIGPYTAGAIASISFGEPVPAIDGNAFRVFARLFKV
DADIARPQTRQIFFDLIQPLMPKDRPGDFNQAVMDLGSSYMSANHPDPAHSPVRDFDASYRDGVVSAYPVKTKKPRPVVH
RYFALVIRSEKGYLLEQRPSTGLLADLWMFPLVDMADLESTMMSAQLDEVSTLFAASSGMQLTFADLGAKTVKHTFTHQQ
WQLTLIGVETAASDLSFLPARWVKADHFSELALPTVQKKLNAALGMN
>Mature_366_residues
TNKLMNWPPEKVAAFQKALLNWYDQHARQLPWREDHDPYHVMVSELMLQQTQVQTVIPYYERFMNQFPTVGALAKAPEAE
VLKAWEGLGYYSRARRLQQAAKQIVADYGGVWPQTSETLQTLSGIGPYTAGAIASISFGEPVPAIDGNAFRVFARLFKVD
ADIARPQTRQIFFDLIQPLMPKDRPGDFNQAVMDLGSSYMSANHPDPAHSPVRDFDASYRDGVVSAYPVKTKKPRPVVHR
YFALVIRSEKGYLLEQRPSTGLLADLWMFPLVDMADLESTMMSAQLDEVSTLFAASSGMQLTFADLGAKTVKHTFTHQQW
QLTLIGVETAASDLSFLPARWVKADHFSELALPTVQKKLNAALGMN

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8- oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal effici

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HhH domain [H]

Homologues:

Organism=Homo sapiens, GI6912520, Length=408, Percent_Identity=35.7843137254902, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI115298654, Length=408, Percent_Identity=35.7843137254902, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI115298652, Length=408, Percent_Identity=35.7843137254902, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI190358497, Length=408, Percent_Identity=35.7843137254902, Blast_Score=212, Evalue=3e-55,
Organism=Homo sapiens, GI115298648, Length=408, Percent_Identity=35.7843137254902, Blast_Score=212, Evalue=3e-55,
Organism=Homo sapiens, GI115298650, Length=408, Percent_Identity=35.7843137254902, Blast_Score=212, Evalue=4e-55,
Organism=Escherichia coli, GI1789331, Length=310, Percent_Identity=39.6774193548387, Blast_Score=208, Evalue=4e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 41171; Mature: 41039

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNKLMNWPPEKVAAFQKALLNWYDQHARQLPWREDHDPYHVMVSELMLQQTQVQTVIPY
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
YERFMNQFPTVGALAKAPEAEVLKAWEGLGYYSRARRLQQAAKQIVADYGGVWPQTSETL
HHHHHHHCCCCHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
QTLSGIGPYTAGAIASISFGEPVPAIDGNAFRVFARLFKVDADIARPQTRQIFFDLIQPL
HHHHCCCCHHHHHHEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
MPKDRPGDFNQAVMDLGSSYMSANHPDPAHSPVRDFDASYRDGVVSAYPVKTKKPRPVVH
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCHHHCCCCEECCCCCCCCCHHHH
RYFALVIRSEKGYLLEQRPSTGLLADLWMFPLVDMADLESTMMSAQLDEVSTLFAASSGM
HHHHHHHCCCCCCEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
QLTFADLGAKTVKHTFTHQQWQLTLIGVETAASDLSFLPARWVKADHFSELALPTVQKKL
EEEHHHHCHHHHHHHHCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NAALGMN
HHHHCCC
>Mature Secondary Structure 
TNKLMNWPPEKVAAFQKALLNWYDQHARQLPWREDHDPYHVMVSELMLQQTQVQTVIPY
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
YERFMNQFPTVGALAKAPEAEVLKAWEGLGYYSRARRLQQAAKQIVADYGGVWPQTSETL
HHHHHHHCCCCHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
QTLSGIGPYTAGAIASISFGEPVPAIDGNAFRVFARLFKVDADIARPQTRQIFFDLIQPL
HHHHCCCCHHHHHHEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
MPKDRPGDFNQAVMDLGSSYMSANHPDPAHSPVRDFDASYRDGVVSAYPVKTKKPRPVVH
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCHHHCCCCEECCCCCCCCCHHHH
RYFALVIRSEKGYLLEQRPSTGLLADLWMFPLVDMADLESTMMSAQLDEVSTLFAASSGM
HHHHHHHCCCCCCEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
QLTFADLGAKTVKHTFTHQQWQLTLIGVETAASDLSFLPARWVKADHFSELALPTVQKKL
EEEHHHHCHHHHHHHHCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NAALGMN
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8946165; 9384377 [H]