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The map label for this gene is manY [C]

Identifier: 116494117

GI number: 116494117

Start: 552459

End: 553325

Strand: Direct

Name: manY [C]

Synonym: LSEI_0561

Alternate gene names: 116494117

Gene position: 552459-553325 (Clockwise)

Preceding gene: 116494116

Following gene: 116494118

Centisome position: 19.08

GC content: 45.21

Gene sequence:

>867_bases
ATGACAATTAGTTGGTTTCAAGCAGCTATTTTAGGTGTTTTCGCTTGCTTATGTTCCAACTCATGTATGGCTGGTCAAGC
GGTTGGTAATTATACCATTGGCCGTCCATTGGTTGGGGGTCTTGTCTGTGGCATTATTCTAGGTAATCTTCAGTTAGGGA
TTGCCTGCGGGGTTGCGATGCAGTTGGTTTATATCGCATTGGTTACCCCAGGTGGTACTGTTTCTGCCGATGTTCGTGCT
ATTTCTTATATTGGGATCCCTCTAGCAATGGTTGCAATTTCTTCGCAAGGATTGAATCCGCTGGGTGGCGGTGCTGCTAA
CTTGGCTAAGTCAGTTGGGACATTAGTCGGAACTGTCGGGACGGTTTTGTACTACGCTGTTGCAACAATGAACCTAGTTT
GGCAGTCCTTTGGTTGGAAAGACGTTCATAATGGCAAGCTTGATAAATTAACAGCTGTTAACTTTGGCTGGCCTTGGATC
TCACATGCATTGTTCTCATTTTTACCAACAATGTTACTCACATACTACGGTGCTACGGCGGTTACAGCTTTGCGTAGTGC
CTTACCAATGGACGGCATTGCCATGAAGACACTGTTCACGGTCGGCGGCATGCTGCCATGTGTCGGGATTGCGATTCTGC
TTCGGCAAATTGTTGGTAAAGCAGCTGATTTCATTCCGTTCTTAGTTGGGTTCACACTTGCTGCTTCACTACACTTGAAC
TTAGTCTCAGTCACAGTTGTATCGTTACTGTTTGCGGTTATTATTTATGAAATTGAGATGTCTGGTTCTAACAACACACC
TTCAAAAGGTAGTGCAGCACCAGCAGATGGACCAAGTGATGATGACGATGATGAGGAGGATATTTGA

Upstream 100 bases:

>100_bases
TTGCCAGATCAGCGGATTGGTAGTTGGGACAAATTCAAGTCACGCTTTGGGTATTAATGGTTGAACAATAACGCGCTCGC
AAAAAAGGAAGGTAAGAAAA

Downstream 100 bases:

>100_bases
TCATGGAAACGACAAATGATATGAAAAAGCTTGATCACAAAACACTGACAAAATCTTTTCATCGTTGGTTCTGGGGTGCG
TTGACCTGCTTCTCACAAGA

Product: phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC

Products: protein histidine; sugar phosphate; D-glucosamine-6-phosphate [Cytoplasm]; pyruvate; glucose-6-phosphate [Cytoplasm]; N-acetyl-D-glucosamine-6-phosphate [Cytoplasm]; mannose-6-phosphate [Cytoplasm]; fructose-6-phosphate [Cytoplasm] [C]

Alternate protein names: PTS System IIC Component; PTS System Mannose-Specific IIC Component; PTS System; PTS System Sorbose-Specific Transporter Subunit IIC; PTS System Protein; Phosphotransferase System; PTS System Fructose(Mannose)-Specific IIC; PTS System Mannose/Fructose Family Transporter Subunit IIC

Number of amino acids: Translated: 288; Mature: 287

Protein sequence:

>288_residues
MTISWFQAAILGVFACLCSNSCMAGQAVGNYTIGRPLVGGLVCGIILGNLQLGIACGVAMQLVYIALVTPGGTVSADVRA
ISYIGIPLAMVAISSQGLNPLGGGAANLAKSVGTLVGTVGTVLYYAVATMNLVWQSFGWKDVHNGKLDKLTAVNFGWPWI
SHALFSFLPTMLLTYYGATAVTALRSALPMDGIAMKTLFTVGGMLPCVGIAILLRQIVGKAADFIPFLVGFTLAASLHLN
LVSVTVVSLLFAVIIYEIEMSGSNNTPSKGSAAPADGPSDDDDDEEDI

Sequences:

>Translated_288_residues
MTISWFQAAILGVFACLCSNSCMAGQAVGNYTIGRPLVGGLVCGIILGNLQLGIACGVAMQLVYIALVTPGGTVSADVRA
ISYIGIPLAMVAISSQGLNPLGGGAANLAKSVGTLVGTVGTVLYYAVATMNLVWQSFGWKDVHNGKLDKLTAVNFGWPWI
SHALFSFLPTMLLTYYGATAVTALRSALPMDGIAMKTLFTVGGMLPCVGIAILLRQIVGKAADFIPFLVGFTLAASLHLN
LVSVTVVSLLFAVIIYEIEMSGSNNTPSKGSAAPADGPSDDDDDEEDI
>Mature_287_residues
TISWFQAAILGVFACLCSNSCMAGQAVGNYTIGRPLVGGLVCGIILGNLQLGIACGVAMQLVYIALVTPGGTVSADVRAI
SYIGIPLAMVAISSQGLNPLGGGAANLAKSVGTLVGTVGTVLYYAVATMNLVWQSFGWKDVHNGKLDKLTAVNFGWPWIS
HALFSFLPTMLLTYYGATAVTALRSALPMDGIAMKTLFTVGGMLPCVGIAILLRQIVGKAADFIPFLVGFTLAASLHLNL
VSVTVVSLLFAVIIYEIEMSGSNNTPSKGSAAPADGPSDDDDDEEDI

Specific function: This Is A Component Of The Phosphoenolpyruvate-Dependent Sugar Phosphotransferase System (Pts), A Major Carbohydrate Active -Transport System. The IIcd Domains Contain The Sugar Binding Site And The Transmembrane Channel; The IIa Domain Contains The Prim

COG id: COG3715

COG function: function code G; Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC

Gene ontology:

Cell location: Integral Membrane Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1788121, Length=287, Percent_Identity=24.0418118466899, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 29855; Mature: 29724

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS51106 PTS_EIIC_TYPE_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TISWFQAAILGVFACLCSNSCMAGQAVGNYTIGRPLVGGLVCGIILGNLQLGIACGVAM
CHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
QLVYIALVTPGGTVSADVRAISYIGIPLAMVAISSQGLNPLGGGAANLAKSVGTLVGTVG
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
TVLYYAVATMNLVWQSFGWKDVHNGKLDKLTAVNFGWPWISHALFSFLPTMLLTYYGATA
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
VTALRSALPMDGIAMKTLFTVGGMLPCVGIAILLRQIVGKAADFIPFLVGFTLAASLHLN
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVSVTVVSLLFAVIIYEIEMSGSNNTPSKGSAAPADGPSDDDDDEEDI
HHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: protein N p -phosphohistidine; sugar; phosphoenolpyruvate; glucosamine [Periplasm]; phosphoenolpyruvate; beta-D-glucose [Periplasm]; N-acetyl-D-glucosamine [Periplasm]; mannose [Periplasm]; fructose [Periplasm] [C]

Specific reaction: protein N p -phosphohistidine + sugar = protein histidine + sugar phosphate phosphoenolpyruvate + glucosamine [Periplasm] = D-glucosamine-6-phosphate [Cytoplasm] + pyruvate phosphoenolpyruvate + beta-D-glucose [Periplasm] = glucose-6-phosphate [Cytoplasm]

General reaction: Transferring phosphorus-containing groups; Phosphotransferases with an alcohol group as acceptor [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA