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The map label for this gene is manD [H]

Identifier: 116493482

GI number: 116493482

Start: 1728893

End: 1730038

Strand: Reverse

Name: manD [H]

Synonym: PEPE_1754

Alternate gene names: 116493482

Gene position: 1730038-1728893 (Counterclockwise)

Preceding gene: 116493483

Following gene: 116493479

Centisome position: 94.41

GC content: 41.19

Gene sequence:

>1146_bases
TTGGAATATTATATTCATGCAGAAAAATTCTTTTTAGGTAGTAATGTAGAAATGGGAGGTTATCTCCAAGTTGTTGATGG
TAAATTTGGTAGATATCAAAAAAATCAACCAGATGGAGATATCGTAGAATATAGTGATAAATGGATAGCTCCTGGGCTAG
TGGATACCCATATTCATGGCTTGTTGAATCACGATGTGATGGATGCAAGTGCTGAAGGAATTGAGGCCATGGCTAATGGG
CTACTAAAATGTGGGGTAACTTCGTGGCTGCCAACGACTTTAACGGCTAGTTCAGAACAGTTGAAAGAAGTGGTTCAAGT
AATTAGCAAGAACCTTGATCACTTTGAAGGGGCTAAAGTTCAAGGTATTCACTTTGAAGGACCATATTATACTGAAAAAC
ATAAAGGGGCTCAAAATCCGAAATACTTCGAAAACCCTAGTATTGAAGAATTTCACGAATGGCAAGCAGCAGCTAATGGC
ATGATTCGTAAAATTTCGATTGCACCAGAGCGTGATGGTGCAGTAGAATTTACGGCTCAAATTAGCTCTGAAGGGGTTAC
GGTAGCTTTAGGACACAGTGATGCAACCTTTGAACAGGCCAAGGCTTGTGTTGAGGCTGGGGCAACCATGTTCACTCACA
CATTTAATGGGATGAGTGGATTAGATCATCGCGAACCTGGTATGGCAGGTGCAGCTCTAAGCTTACAAGGTGTAACAGAT
GAATTAATTTGTGATGGGCACCATGTGAATCCATATGTAGTCAAGATTCTACTGGATGCCAAAACTCCTAGTAAGGTAGC
TTTAGTTACGGACTGTATGAAAGCTGGTTTAATGCCAGATGGCGACTATATTTTAGGAGAATTTCCAGTTATTGTGCAAA
ACGGTACGGCTCGTTTGAAAGATAGCAGTCATAGTTTAGCAGGCAGTATCTTACTATTAAAAGACGCCATAAAGAACGTG
GTTGATTGGAATGTAGTTACTCCTGAACAAGCTATACAGATGGCCACCGCAAATGCGGCCGATAGCGCAGGAATTGGGAG
CAAATGTGGACACATTTTACCAGGCCGCGATGCTGATTTTATTGTGTTAGACCGAGAAATGAAGCTAGATAAGACATACC
TAAATGGCGAAAAAGTGGTTGGATAA

Upstream 100 bases:

>100_bases
AGGTTAAGAATACACCGGACACTCCTTCAGCAACGGGGACAGTTAACCGAGTAGTAAAAGGTGTAACAATTCACGATTTT
GAAGGATAGGAGCGAGAAGT

Downstream 100 bases:

>100_bases
TAATTATTACAAAGACGTAGTAGAGGATAACCCAAACCTCTTCTACGTCTTTTTGATTGTTTAGGGGTGTAGGAAGTTTT
TTAATAAATGAAGTAATAAC

Product: N-acetylglucosamine 6-phosphate deacetylase

Products: NA

Alternate protein names: GlcNAc 6-P deacetylase [H]

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MEYYIHAEKFFLGSNVEMGGYLQVVDGKFGRYQKNQPDGDIVEYSDKWIAPGLVDTHIHGLLNHDVMDASAEGIEAMANG
LLKCGVTSWLPTTLTASSEQLKEVVQVISKNLDHFEGAKVQGIHFEGPYYTEKHKGAQNPKYFENPSIEEFHEWQAAANG
MIRKISIAPERDGAVEFTAQISSEGVTVALGHSDATFEQAKACVEAGATMFTHTFNGMSGLDHREPGMAGAALSLQGVTD
ELICDGHHVNPYVVKILLDAKTPSKVALVTDCMKAGLMPDGDYILGEFPVIVQNGTARLKDSSHSLAGSILLLKDAIKNV
VDWNVVTPEQAIQMATANAADSAGIGSKCGHILPGRDADFIVLDREMKLDKTYLNGEKVVG

Sequences:

>Translated_381_residues
MEYYIHAEKFFLGSNVEMGGYLQVVDGKFGRYQKNQPDGDIVEYSDKWIAPGLVDTHIHGLLNHDVMDASAEGIEAMANG
LLKCGVTSWLPTTLTASSEQLKEVVQVISKNLDHFEGAKVQGIHFEGPYYTEKHKGAQNPKYFENPSIEEFHEWQAAANG
MIRKISIAPERDGAVEFTAQISSEGVTVALGHSDATFEQAKACVEAGATMFTHTFNGMSGLDHREPGMAGAALSLQGVTD
ELICDGHHVNPYVVKILLDAKTPSKVALVTDCMKAGLMPDGDYILGEFPVIVQNGTARLKDSSHSLAGSILLLKDAIKNV
VDWNVVTPEQAIQMATANAADSAGIGSKCGHILPGRDADFIVLDREMKLDKTYLNGEKVVG
>Mature_381_residues
MEYYIHAEKFFLGSNVEMGGYLQVVDGKFGRYQKNQPDGDIVEYSDKWIAPGLVDTHIHGLLNHDVMDASAEGIEAMANG
LLKCGVTSWLPTTLTASSEQLKEVVQVISKNLDHFEGAKVQGIHFEGPYYTEKHKGAQNPKYFENPSIEEFHEWQAAANG
MIRKISIAPERDGAVEFTAQISSEGVTVALGHSDATFEQAKACVEAGATMFTHTFNGMSGLDHREPGMAGAALSLQGVTD
ELICDGHHVNPYVVKILLDAKTPSKVALVTDCMKAGLMPDGDYILGEFPVIVQNGTARLKDSSHSLAGSILLLKDAIKNV
VDWNVVTPEQAIQMATANAADSAGIGSKCGHILPGRDADFIVLDREMKLDKTYLNGEKVVG

Specific function: N-acetylglucosamine utilization. [C]

COG id: COG1820

COG function: function code G; N-acetylglucosamine-6-phosphate deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nagA family [H]

Homologues:

Organism=Homo sapiens, GI21361513, Length=372, Percent_Identity=28.494623655914, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI224922791, Length=372, Percent_Identity=28.2258064516129, Blast_Score=140, Evalue=2e-33,
Organism=Escherichia coli, GI1786892, Length=338, Percent_Identity=29.8816568047337, Blast_Score=150, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17553768, Length=345, Percent_Identity=29.5652173913043, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI19920392, Length=341, Percent_Identity=31.6715542521994, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI281361140, Length=355, Percent_Identity=30.9859154929577, Blast_Score=150, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR003764
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.1.25 [H]

Molecular weight: Translated: 41236; Mature: 41236

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEYYIHAEKFFLGSNVEMGGYLQVVDGKFGRYQKNQPDGDIVEYSDKWIAPGLVDTHIHG
CCEEEEEEEEEECCCCCCCCEEEEECCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHH
LLNHDVMDASAEGIEAMANGLLKCGVTSWLPTTLTASSEQLKEVVQVISKNLDHFEGAKV
HHCCCHHCCCHHHHHHHHHHHHHCCHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEE
QGIHFEGPYYTEKHKGAQNPKYFENPSIEEFHEWQAAANGMIRKISIAPERDGAVEFTAQ
EEEEECCCEECHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCEEEEEE
ISSEGVTVALGHSDATFEQAKACVEAGATMFTHTFNGMSGLDHREPGMAGAALSLQGVTD
ECCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCEEEECCCCH
ELICDGHHVNPYVVKILLDAKTPSKVALVTDCMKAGLMPDGDYILGEFPVIVQNGTARLK
HHEECCCCCCCEEEEEEEECCCCCCHHHHHHHHHHCCCCCCCEEEECCCEEEECCCCEEC
DSSHSLAGSILLLKDAIKNVVDWNVVTPEQAIQMATANAADSAGIGSKCGHILPGRDADF
CCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCE
IVLDREMKLDKTYLNGEKVVG
EEECCCCCCCCEECCCCCCCC
>Mature Secondary Structure
MEYYIHAEKFFLGSNVEMGGYLQVVDGKFGRYQKNQPDGDIVEYSDKWIAPGLVDTHIHG
CCEEEEEEEEEECCCCCCCCEEEEECCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHH
LLNHDVMDASAEGIEAMANGLLKCGVTSWLPTTLTASSEQLKEVVQVISKNLDHFEGAKV
HHCCCHHCCCHHHHHHHHHHHHHCCHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEE
QGIHFEGPYYTEKHKGAQNPKYFENPSIEEFHEWQAAANGMIRKISIAPERDGAVEFTAQ
EEEEECCCEECHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCEEEEEE
ISSEGVTVALGHSDATFEQAKACVEAGATMFTHTFNGMSGLDHREPGMAGAALSLQGVTD
ECCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCEEEECCCCH
ELICDGHHVNPYVVKILLDAKTPSKVALVTDCMKAGLMPDGDYILGEFPVIVQNGTARLK
HHEECCCCCCCEEEEEEEECCCCCCHHHHHHHHHHCCCCCCCEEEECCCEEEECCCCEEC
DSSHSLAGSILLLKDAIKNVVDWNVVTPEQAIQMATANAADSAGIGSKCGHILPGRDADF
CCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCE
IVLDREMKLDKTYLNGEKVVG
EEECCCCCCCCEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969210 [H]