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The map label for this gene is nox [H]

Identifier: 116493369

GI number: 116493369

Start: 1625024

End: 1626370

Strand: Reverse

Name: nox [H]

Synonym: PEPE_1641

Alternate gene names: 116493369

Gene position: 1626370-1625024 (Counterclockwise)

Preceding gene: 116493371

Following gene: 116493368

Centisome position: 88.76

GC content: 37.94

Gene sequence:

>1347_bases
ATGAAAGTAGCAATCATCGGGTGTACCCATGCTGGTACAGCAGCAGTGAGAGAAATCTTACGACAAAATCCGGATACGGA
GGTAGATATTTATGAACGTAATAATAATATCTCTTTCTTATCATGTGGAATCGCATTGTATCTGAATGGACGCGTAAAAC
GGCTAGAAGACATGATGTATGATGATGCAGAGGATCTCCGTTCAGAAAAAATTCGGGTGAACCTGCGACATGATGTTCTA
AAAATTGACCGAAATCAAAAAGAGATTTTGGTACAAAACATGGAAGACTATAGTATTCGTCGTGAACATTACGATAAATT
AGTGATGTGCACGGGTTCAGCAGTGACCTTACCTCCAATTAAAGGCATTAATCATAAACGAGTAATGCTATGTAAAAACT
ATGAACAAGCGCAGACTTTACACCAAGTTTTAAAACCCCACCAGCGAGTTGCATTAATTGGTGGAGGATATGTTAACGCA
GAGTTAGCAGAAAGCTTGTCTGATTTAGGTTGTCAAGTAACCTTATACCATAGTCATGATGTGATTTTAAATAATTACGT
GGATGTACAGCTGAGCAAAATGTTAGTTGAAATCCTGGAAGATCACGGGGTCAAAGTTAAACTTAATAGTAAAGTCGCAT
CATTCACGGATCAAAAGGACTCCTTACTGGTTACTACCATTCATGATCAAAATGAAGAAGTTGACGTAGCGATTGTTTCA
AAAGGCTTCATCCCGGTAACTAATTTGTTAGAGGGGCAGGTTAAAATGAGTCGTAATGGTGCAATTTTAACTAACGAATA
TGGACAAACTTCTGATCCGGATATTTACGCGGCAGGAGATGCTCGTACTGTACATTACAATCCGACGGATACAGATAGCT
ATATCCCATTGGCGACGAATGCAATTCGCCAAGGTAAATTAGTTGGTATTAATATTTTCGGTAATCGTTGGCCTGAAATA
GGTTCGCAAGGAACATCAGGCTTACAATTGTTTGGTTATACATTAGCTACTACCGGTTTAACCTATCAACGAGCTTTAGA
TGCTGGTTTAAAGGTCAAATATATCAGCTATGAGGACAATTATCGTCCAGAATTTATGCCGACAACGGAAAAAATAAACA
GTATAATTGTTTATGAACAGGACAGTTTAAAAGTTCTGGGGGCCCAATTCTTTAGTGAACATAATGTTTCTCAATTGGCT
AATACAATGTCTTTAGCAATTCAGAATCAAAATACGCTGAAAGATTTAGCATTTGTGGATATGTTATTCCAACCATACTA
CGATCGACCATTTAATTTTATTAACTTGGTAGCGCAGGCAGGGTTGCAACAAGAAGGGCTAATTTAA

Upstream 100 bases:

>100_bases
ACAAAGTCTTAATCCAGTCTAAAATTAAAATATAAAGCATCTGGAATCGTGTAAAAAATTCTTAACAAGTAAGTCCAGTA
TAAAACAAGTAGGAGGCAAA

Downstream 100 bases:

>100_bases
AGAAGGAAGCGCGTAAATATGACAAGAACTGAACGAGAAAAAATGACTGCTGGAGAACCTTACCAGCAGTTTGATGCTGA
ATTAATTGGTCGTCGAAAGT

Product: NAD(FAD)-dependent dehydrogenase

Products: NA

Alternate protein names: NOXase [H]

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MKVAIIGCTHAGTAAVREILRQNPDTEVDIYERNNNISFLSCGIALYLNGRVKRLEDMMYDDAEDLRSEKIRVNLRHDVL
KIDRNQKEILVQNMEDYSIRREHYDKLVMCTGSAVTLPPIKGINHKRVMLCKNYEQAQTLHQVLKPHQRVALIGGGYVNA
ELAESLSDLGCQVTLYHSHDVILNNYVDVQLSKMLVEILEDHGVKVKLNSKVASFTDQKDSLLVTTIHDQNEEVDVAIVS
KGFIPVTNLLEGQVKMSRNGAILTNEYGQTSDPDIYAAGDARTVHYNPTDTDSYIPLATNAIRQGKLVGINIFGNRWPEI
GSQGTSGLQLFGYTLATTGLTYQRALDAGLKVKYISYEDNYRPEFMPTTEKINSIIVYEQDSLKVLGAQFFSEHNVSQLA
NTMSLAIQNQNTLKDLAFVDMLFQPYYDRPFNFINLVAQAGLQQEGLI

Sequences:

>Translated_448_residues
MKVAIIGCTHAGTAAVREILRQNPDTEVDIYERNNNISFLSCGIALYLNGRVKRLEDMMYDDAEDLRSEKIRVNLRHDVL
KIDRNQKEILVQNMEDYSIRREHYDKLVMCTGSAVTLPPIKGINHKRVMLCKNYEQAQTLHQVLKPHQRVALIGGGYVNA
ELAESLSDLGCQVTLYHSHDVILNNYVDVQLSKMLVEILEDHGVKVKLNSKVASFTDQKDSLLVTTIHDQNEEVDVAIVS
KGFIPVTNLLEGQVKMSRNGAILTNEYGQTSDPDIYAAGDARTVHYNPTDTDSYIPLATNAIRQGKLVGINIFGNRWPEI
GSQGTSGLQLFGYTLATTGLTYQRALDAGLKVKYISYEDNYRPEFMPTTEKINSIIVYEQDSLKVLGAQFFSEHNVSQLA
NTMSLAIQNQNTLKDLAFVDMLFQPYYDRPFNFINLVAQAGLQQEGLI
>Mature_448_residues
MKVAIIGCTHAGTAAVREILRQNPDTEVDIYERNNNISFLSCGIALYLNGRVKRLEDMMYDDAEDLRSEKIRVNLRHDVL
KIDRNQKEILVQNMEDYSIRREHYDKLVMCTGSAVTLPPIKGINHKRVMLCKNYEQAQTLHQVLKPHQRVALIGGGYVNA
ELAESLSDLGCQVTLYHSHDVILNNYVDVQLSKMLVEILEDHGVKVKLNSKVASFTDQKDSLLVTTIHDQNEEVDVAIVS
KGFIPVTNLLEGQVKMSRNGAILTNEYGQTSDPDIYAAGDARTVHYNPTDTDSYIPLATNAIRQGKLVGINIFGNRWPEI
GSQGTSGLQLFGYTLATTGLTYQRALDAGLKVKYISYEDNYRPEFMPTTEKINSIIVYEQDSLKVLGAQFFSEHNVSQLA
NTMSLAIQNQNTLKDLAFVDMLFQPYYDRPFNFINLVAQAGLQQEGLI

Specific function: Catalyzes the four-electron reduction of molecular oxygen to water [H]

COG id: COG0446

COG function: function code R; Uncharacterized NAD(FAD)-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI65787454, Length=287, Percent_Identity=21.602787456446, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI21389617, Length=287, Percent_Identity=21.602787456446, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI226437568, Length=287, Percent_Identity=21.602787456446, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1789065, Length=217, Percent_Identity=28.5714285714286, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1788892, Length=199, Percent_Identity=25.1256281407035, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1789765, Length=340, Percent_Identity=23.2352941176471, Blast_Score=62, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17559934, Length=269, Percent_Identity=24.5353159851301, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24639257, Length=284, Percent_Identity=22.887323943662, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI281359715, Length=284, Percent_Identity=22.887323943662, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI281359713, Length=284, Percent_Identity=22.887323943662, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24639250, Length=284, Percent_Identity=22.887323943662, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI18543267, Length=284, Percent_Identity=22.887323943662, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24639252, Length=284, Percent_Identity=22.887323943662, Blast_Score=84, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.6.99.3 [H]

Molecular weight: Translated: 50372; Mature: 50372

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVAIIGCTHAGTAAVREILRQNPDTEVDIYERNNNISFLSCGIALYLNGRVKRLEDMMY
CEEEEEEECCCCHHHHHHHHHCCCCCEEEEEEECCCEEEEEEEEEEEECCHHHHHHHHHC
DDAEDLRSEKIRVNLRHDVLKIDRNQKEILVQNMEDYSIRREHYDKLVMCTGSAVTLPPI
CCHHHHCCCEEEEEEEEEEEEECCCCHHHHHHCCHHHHHHHHHCCEEEEEECCEEECCCC
KGINHKRVMLCKNYEQAQTLHQVLKPHQRVALIGGGYVNAELAESLSDLGCQVTLYHSHD
CCCCCCEEEEECCCHHHHHHHHHHCCCCEEEEEECCEECHHHHHHHHHCCCEEEEEECCC
VILNNYVDVQLSKMLVEILEDHGVKVKLNSKVASFTDQKDSLLVTTIHDQNEEVDVAIVS
EEEECEEHHHHHHHHHHHHHCCCEEEEECCCEECCCCCCCCEEEEEEECCCCCEEEEEEE
KGFIPVTNLLEGQVKMSRNGAILTNEYGQTSDPDIYAAGDARTVHYNPTDTDSYIPLATN
CCCCCHHHHHCCCEEECCCCCEEECCCCCCCCCCEEECCCEEEEEECCCCCCCCCEEEHH
AIRQGKLVGINIFGNRWPEIGSQGTSGLQLFGYTLATTGLTYQRALDAGLKVKYISYEDN
HHCCCCEEEEEECCCCCCCCCCCCCCCEEEEEEEEHHCCCHHHHHHCCCCEEEEEEECCC
YRPEFMPTTEKINSIIVYEQDSLKVLGAQFFSEHNVSQLANTMSLAIQNQNTLKDLAFVD
CCCCCCCCHHHCCEEEEEECCCHHHHHHHHHCCCCHHHHHHHHEEEECCCCHHHHHHHHH
MLFQPYYDRPFNFINLVAQAGLQQEGLI
HHHCCCCCCCHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MKVAIIGCTHAGTAAVREILRQNPDTEVDIYERNNNISFLSCGIALYLNGRVKRLEDMMY
CEEEEEEECCCCHHHHHHHHHCCCCCEEEEEEECCCEEEEEEEEEEEECCHHHHHHHHHC
DDAEDLRSEKIRVNLRHDVLKIDRNQKEILVQNMEDYSIRREHYDKLVMCTGSAVTLPPI
CCHHHHCCCEEEEEEEEEEEEECCCCHHHHHHCCHHHHHHHHHCCEEEEEECCEEECCCC
KGINHKRVMLCKNYEQAQTLHQVLKPHQRVALIGGGYVNAELAESLSDLGCQVTLYHSHD
CCCCCCEEEEECCCHHHHHHHHHHCCCCEEEEEECCEECHHHHHHHHHCCCEEEEEECCC
VILNNYVDVQLSKMLVEILEDHGVKVKLNSKVASFTDQKDSLLVTTIHDQNEEVDVAIVS
EEEECEEHHHHHHHHHHHHHCCCEEEEECCCEECCCCCCCCEEEEEEECCCCCEEEEEEE
KGFIPVTNLLEGQVKMSRNGAILTNEYGQTSDPDIYAAGDARTVHYNPTDTDSYIPLATN
CCCCCHHHHHCCCEEECCCCCEEECCCCCCCCCCEEECCCEEEEEECCCCCCCCCEEEHH
AIRQGKLVGINIFGNRWPEIGSQGTSGLQLFGYTLATTGLTYQRALDAGLKVKYISYEDN
HHCCCCEEEEEECCCCCCCCCCCCCCCEEEEEEEEHHCCCHHHHHHCCCCEEEEEEECCC
YRPEFMPTTEKINSIIVYEQDSLKVLGAQFFSEHNVSQLANTMSLAIQNQNTLKDLAFVD
CCCCCCCCHHHCCEEEEEECCCHHHHHHHHHCCCCHHHHHHHHEEEECCCCHHHHHHHHH
MLFQPYYDRPFNFINLVAQAGLQQEGLI
HHHCCCCCCCHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1404382; 12663927; 2511195; 8262333 [H]