Click here to switch to the map view.

The map label for this gene is rnz

Identifier: 116492893

GI number: 116492893

Start: 1131581

End: 1132507

Strand: Reverse

Name: rnz

Synonym: PEPE_1132

Alternate gene names: 116492893

Gene position: 1132507-1131581 (Counterclockwise)

Preceding gene: 116492895

Following gene: 116492892

Centisome position: 61.81

GC content: 36.46

Gene sequence:

>927_bases
ATGCAACTTGAATTTTTAGGAACTGGAGCCGGAAGTCCCGGTAAATTCCGTAATGTTACTAGTGTAGCATTAAAATTATT
AGATGAAAGTAATGAAGTTTGGCTTTTTGACTGTGGTGAAGCAACCCAGCATCAAATCTTAAAAACTAATATAAAACCCC
GTAAAATTGATAAAATATTTATTACCCATCTTCATGGTGATCATATTTTTGGTTTGCCAGGTTTCTTAAGTAGTCGTTCT
AATCAGGGGGGTAGCGAAGAACTTACTATCTTCGGGCCAACTGGCATTAAAGACTTTGTGATGACCTCATTGCGCATTTC
AGAGTCAAAACTTTCATATCGAATAAAATTTGTTGAAATAGCTCAAGAGGGCGTTTTATTTGAAGATCAAAATTATATTG
TTAACGTTGCTGAGTTAGATCATCGAATTAAAAGTTACGGTTTTCGGGTAAAGGAAAAAGACCATCCAGGTGAACTTTTA
GTCGATAAGCTAAAAGAATTAGCGATACCTTCAGGACCTATTTATGGTCAGATTAAGCAAGGTAAAGAAGTTACTTTAGA
TGACGGTAGAGTTATTAACGGGCAAGATTTCATTGGAAAACCTCAACCAGGTCGAGTAGTCACAGTTTTGGGCGACACAC
GACAAACGCCTAATATCGAACTTTTAGCTAAAGATGCGGATGCCTTGGTCCACGAAAGTACTTTTGGAAAACAAGAGGGA
AGCTTGGCACGTAATTATTATCATTCAACTAATATTCAAGCTGCGAAAATTGCTAAGCAAGCTAATGCTCGGCAATTATT
GCTAACCCATATTTCAGCTCGTTATACGGGAAAGCTCAGTAAGCAACTTGAAAGTGATGCAAAGGAAATTTTTAGTAATA
GTAAAGTTGTTCGTGATTTTGACATAATTGATATTCCATTACCTTAA

Upstream 100 bases:

>100_bases
ACTTATATAGCAAGGATATCTTAGAATTATAGTCGATGCTAGTGATACAATTAAAAGTATTGTAAAATGGATTGTTAAGT
CAATAGATATAGGTGAAAAT

Downstream 100 bases:

>100_bases
AAGTAGGAGTGATTTTAATGACAACGGCAGTAATTACTGGAGCAGGCAGCGGTTTAGGGCAAAAGATTGCAATTTTGAAT
AGCACTCGCTATGATAATTT

Product: beta-lactamase superfamily hydrolase

Products: NA

Alternate protein names: RNase Z; tRNA 3 endonuclease; tRNase Z

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MQLEFLGTGAGSPGKFRNVTSVALKLLDESNEVWLFDCGEATQHQILKTNIKPRKIDKIFITHLHGDHIFGLPGFLSSRS
NQGGSEELTIFGPTGIKDFVMTSLRISESKLSYRIKFVEIAQEGVLFEDQNYIVNVAELDHRIKSYGFRVKEKDHPGELL
VDKLKELAIPSGPIYGQIKQGKEVTLDDGRVINGQDFIGKPQPGRVVTVLGDTRQTPNIELLAKDADALVHESTFGKQEG
SLARNYYHSTNIQAAKIAKQANARQLLLTHISARYTGKLSKQLESDAKEIFSNSKVVRDFDIIDIPLP

Sequences:

>Translated_308_residues
MQLEFLGTGAGSPGKFRNVTSVALKLLDESNEVWLFDCGEATQHQILKTNIKPRKIDKIFITHLHGDHIFGLPGFLSSRS
NQGGSEELTIFGPTGIKDFVMTSLRISESKLSYRIKFVEIAQEGVLFEDQNYIVNVAELDHRIKSYGFRVKEKDHPGELL
VDKLKELAIPSGPIYGQIKQGKEVTLDDGRVINGQDFIGKPQPGRVVTVLGDTRQTPNIELLAKDADALVHESTFGKQEG
SLARNYYHSTNIQAAKIAKQANARQLLLTHISARYTGKLSKQLESDAKEIFSNSKVVRDFDIIDIPLP
>Mature_308_residues
MQLEFLGTGAGSPGKFRNVTSVALKLLDESNEVWLFDCGEATQHQILKTNIKPRKIDKIFITHLHGDHIFGLPGFLSSRS
NQGGSEELTIFGPTGIKDFVMTSLRISESKLSYRIKFVEIAQEGVLFEDQNYIVNVAELDHRIKSYGFRVKEKDHPGELL
VDKLKELAIPSGPIYGQIKQGKEVTLDDGRVINGQDFIGKPQPGRVVTVLGDTRQTPNIELLAKDADALVHESTFGKQEG
SLARNYYHSTNIQAAKIAKQANARQLLLTHISARYTGKLSKQLESDAKEIFSNSKVVRDFDIIDIPLP

Specific function: Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA

COG id: COG1234

COG function: function code R; Metal-dependent hydrolases of the beta-lactamase superfamily III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase Z family

Homologues:

Organism=Homo sapiens, GI8922122, Length=366, Percent_Identity=35.792349726776, Blast_Score=219, Evalue=2e-57,
Organism=Escherichia coli, GI87082078, Length=306, Percent_Identity=43.7908496732026, Blast_Score=274, Evalue=6e-75,
Organism=Drosophila melanogaster, GI24652403, Length=201, Percent_Identity=27.363184079602, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNZ_PEDPA (Q03F36)

Other databases:

- EMBL:   CP000422
- RefSeq:   YP_804628.1
- ProteinModelPortal:   Q03F36
- SMR:   Q03F36
- STRING:   Q03F36
- GeneID:   4417101
- GenomeReviews:   CP000422_GR
- KEGG:   ppe:PEPE_1132
- NMPDR:   fig|278197.10.peg.994
- eggNOG:   COG1234
- HOGENOM:   HBG648406
- OMA:   HSTSTMA
- PhylomeDB:   Q03F36
- BioCyc:   PPEN278197:PEPE_1132-MONOMER
- HAMAP:   MF_01818
- InterPro:   IPR001279
- InterPro:   IPR013471
- SMART:   SM00849
- TIGRFAMs:   TIGR02651

Pfam domain/function: PF00753 Lactamase_B

EC number: =3.1.26.11

Molecular weight: Translated: 34272; Mature: 34272

Theoretical pI: Translated: 7.84; Mature: 7.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLEFLGTGAGSPGKFRNVTSVALKLLDESNEVWLFDCGEATQHQILKTNIKPRKIDKIF
CEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHCCCCCCEEEEEE
ITHLHGDHIFGLPGFLSSRSNQGGSEELTIFGPTGIKDFVMTSLRISESKLSYRIKFVEI
EEEECCCEEECCCCHHHCCCCCCCCCEEEEECCCCHHHHHHHHHEECCCCCEEEEEEEEE
AQEGVLFEDQNYIVNVAELDHRIKSYGFRVKEKDHPGELLVDKLKELAIPSGPIYGQIKQ
CCCCCEEECCCCEEEHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHCCCCCCCEEEECC
GKEVTLDDGRVINGQDFIGKPQPGRVVTVLGDTRQTPNIELLAKDADALVHESTFGKQEG
CCEEEECCCEEECCCCCCCCCCCCEEEEEECCCCCCCCEEEEECCHHHHHHHHHCCCCCC
SLARNYYHSTNIQAAKIAKQANARQLLLTHISARYTGKLSKQLESDAKEIFSNSKVVRDF
CHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
DIIDIPLP
EEEEECCC
>Mature Secondary Structure
MQLEFLGTGAGSPGKFRNVTSVALKLLDESNEVWLFDCGEATQHQILKTNIKPRKIDKIF
CEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHCCCCCCEEEEEE
ITHLHGDHIFGLPGFLSSRSNQGGSEELTIFGPTGIKDFVMTSLRISESKLSYRIKFVEI
EEEECCCEEECCCCHHHCCCCCCCCCEEEEECCCCHHHHHHHHHEECCCCCEEEEEEEEE
AQEGVLFEDQNYIVNVAELDHRIKSYGFRVKEKDHPGELLVDKLKELAIPSGPIYGQIKQ
CCCCCEEECCCCEEEHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHCCCCCCCEEEECC
GKEVTLDDGRVINGQDFIGKPQPGRVVTVLGDTRQTPNIELLAKDADALVHESTFGKQEG
CCEEEECCCEEECCCCCCCCCCCCEEEEEECCCCCCCCEEEEECCHHHHHHHHHCCCCCC
SLARNYYHSTNIQAAKIAKQANARQLLLTHISARYTGKLSKQLESDAKEIFSNSKVVRDF
CHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
DIIDIPLP
EEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA