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The map label for this gene is rnr1 [H]

Identifier: 116492266

GI number: 116492266

Start: 517279

End: 519624

Strand: Direct

Name: rnr1 [H]

Synonym: PEPE_0464

Alternate gene names: 116492266

Gene position: 517279-519624 (Clockwise)

Preceding gene: 116492265

Following gene: 116492267

Centisome position: 28.23

GC content: 38.15

Gene sequence:

>2346_bases
ATGGAAATAAACAAATTACAAGCTTTAATTATTAATTATCTGCAACAACGACCAACCCAAAAGTTAACTGCTGAGGAACT
TTTTAAGGGTTTAAATTTAGAAGGGGCCAGTGTGTTTAACACCTTAGTTAAGGAATTGGCATTAATGGAACGTTCTAAAA
AAGTTGAAATAACGGAAGATGGCAAATTTAAAATTGCTCGTCCTAAAAATCAATTATTAGTTCATGGTGTGTTCCATGCT
AATGATCGTGGTTTCGGATTTGTTTCAGTAGAAGAGGATGAAATTCCTGACATTTATATTAGTGAAGATCATACAGCGTA
TGCTTTAAATATGGATGAAGTTGATGTAAAAATTACTCGTCCATCTAAGAAGGGTGACGATCGCGGACCAGAAGGAATTG
TTAAGAAGATTACAAGTCGCCACTTTACCCAAGCGGTGGGGGTTTTTGAATTTGCTCCTGAACCACAGAAGAATGTTTTA
GGTCATATCAATTTGAAAGACAAGAAAATGTCTTCATATCAATTCGATGTTCTAGAAGGCGGAATTCAACCAACTGACGG
TTCAGTGATCACGGCCCAAGTTACGCAATATCCTAAGCCTAATTCTCCTAAGTTAATTGCCGGGGTTGCTGAAAAGACGG
TTGGTCATAAGGATGATCCAGGAGTGGACATCTTAGAAGTGGTTTATCAACATGAGTTACCAACTGAATTTCCAGATGAT
GTCAAAGCAGAGATTGCTTCGATTCCAGACTATGTAACAGATGCAGAGAAAAAAGGACGCGTTGATTTAACTAATGAAGT
AGTGGTCACAATCGATGGGGATGATTCCAAAGATTTTGATGATGCTGTAGGTCTTAAAAAACTAGATAATGGAAATTACC
GTTTATTAGTTAACATTGCGGATGTTTCTCACTATGTTAAAGAAGGTTCTCCTTTAGATAAAGAAGCATATCGTCGAAGT
ACAAGTGTTTACTTGACTGACCGAGTAATTCCAATGTTGCCACGTAAGCTTTCTAACGGAATTTGTTCATTAAACCCTAA
TGTTGAACGGCTTTCGATGACTTGTGAAATGGAAATTACGCCTGAAGGAGACGTAGTTAACCATAAGATTTACCCAAGTG
TAATTGAATCAGATGCTCGAATGACATATAACGATGTTAATAAGATTTTGGAATCTAAAGACGAAAAAACTATGGCACGT
TATGAAAAATTAGTGCCTATGTTTGAAATGATGGGCGAACTTCACAAAATCTTGCTTAAGAAGCGTAAGCAACGTGGAGC
AATTGAATTTAGCGATAAAGAAGCCCAAATCATCGTTGATGAAACCGGACATCCAATTGACATTAAATTACGGACGCGTG
GGACTTCAGAACGTATGATTGAATCATTCATGTTGGCAGCTAATGAAACGGTTGCTGAGCACTACTATAAGGCTCATGTG
CCATTCTTATATCGTATTCATGAAACTCCCGATAGCGAAAGAATGTTAACCTTCTTTGAATTCCTATCTGTATTTGGACA
CGTAGTTAAAGGAAGCACCAAGGATCTGAAGCCTAAGATGCTGCAAAGCGTGCTTAAGAAGATTGCTGGGACTCCAGAAG
AAGCAATGATTTCAGTAATGATGCTTCGTAGTATGCGCCAAGCTAAGTATGATGCTCAATCATTAGGTCATTTTGGATTG
GCTGCTGAGTATTATACGCATTTCACTTCACCAATTCGCCGTTATCCGGACTTATTTGTGCACCGCTTAATTCGTCATTA
TGCCGAAAATGGTACTGGTGAAGCAGCACAAGCGAAATATGTTGAAAGCATTCCAGAAATTGCCGATCATACTTCCAAGT
TAGAACGTCGAGCAATCGACACAGAACGTGATGTTGATGGAATGAAGAAGGCTGAATTTATGGCTGACCATGTGGGAGAA
GAATTCCATGCGGTAGTTAGTTCAGTAATGAAGTTTGGTTTATTCGTTGAATTGGAAAATACGGTTGAAGGACTAATTCA
TATTAGTACCATGAAGGATGACTACTATGAATATGTTGAAAAACAGATGGCCTTGGTCGGACGGAATACCCACCGTACAT
TCCAAATTGGTCAAGAAGTTGAGATTAAATTAATGCGAGTGGATAAGGATCAATCTGAAGTTGATTTTGAATTATTGCAT
CCAGAAAAAACACCTAAGAGTGATATTCAACTTCCACCGCGTCAACAATTTAACCGTGGTCCGCGTCGTAACGGTCAAAA
GCCTAGCGGAAAGAACAACAATAAATCAGGAAATCGAAACGGAAAACCATTTTACAAAGATAAAACGGTCAAGAAGTTTT
CTAAAAATACTTCTCATAAGAAATAA

Upstream 100 bases:

>100_bases
TCTGAAATTTAGATTTCGGAATCATTAGGAACGGCTAAAGACGAAATTAGTTTTGTCTTTAGCTTTTTTATTTAATAAAT
ACAAAAATATGAGGTAAGAA

Downstream 100 bases:

>100_bases
GAGGAGGTTATGTTATGGCTAAGAAACCAAAGTCCAATGATAAAGCACTTGCCCAAAATAAAAAGGCGCGTCATGATTAT
TCCATATTAAGTACGATGGA

Product: exoribonuclease R

Products: NA

Alternate protein names: RNase R 1; VacB protein homolog 1 [H]

Number of amino acids: Translated: 781; Mature: 781

Protein sequence:

>781_residues
MEINKLQALIINYLQQRPTQKLTAEELFKGLNLEGASVFNTLVKELALMERSKKVEITEDGKFKIARPKNQLLVHGVFHA
NDRGFGFVSVEEDEIPDIYISEDHTAYALNMDEVDVKITRPSKKGDDRGPEGIVKKITSRHFTQAVGVFEFAPEPQKNVL
GHINLKDKKMSSYQFDVLEGGIQPTDGSVITAQVTQYPKPNSPKLIAGVAEKTVGHKDDPGVDILEVVYQHELPTEFPDD
VKAEIASIPDYVTDAEKKGRVDLTNEVVVTIDGDDSKDFDDAVGLKKLDNGNYRLLVNIADVSHYVKEGSPLDKEAYRRS
TSVYLTDRVIPMLPRKLSNGICSLNPNVERLSMTCEMEITPEGDVVNHKIYPSVIESDARMTYNDVNKILESKDEKTMAR
YEKLVPMFEMMGELHKILLKKRKQRGAIEFSDKEAQIIVDETGHPIDIKLRTRGTSERMIESFMLAANETVAEHYYKAHV
PFLYRIHETPDSERMLTFFEFLSVFGHVVKGSTKDLKPKMLQSVLKKIAGTPEEAMISVMMLRSMRQAKYDAQSLGHFGL
AAEYYTHFTSPIRRYPDLFVHRLIRHYAENGTGEAAQAKYVESIPEIADHTSKLERRAIDTERDVDGMKKAEFMADHVGE
EFHAVVSSVMKFGLFVELENTVEGLIHISTMKDDYYEYVEKQMALVGRNTHRTFQIGQEVEIKLMRVDKDQSEVDFELLH
PEKTPKSDIQLPPRQQFNRGPRRNGQKPSGKNNNKSGNRNGKPFYKDKTVKKFSKNTSHKK

Sequences:

>Translated_781_residues
MEINKLQALIINYLQQRPTQKLTAEELFKGLNLEGASVFNTLVKELALMERSKKVEITEDGKFKIARPKNQLLVHGVFHA
NDRGFGFVSVEEDEIPDIYISEDHTAYALNMDEVDVKITRPSKKGDDRGPEGIVKKITSRHFTQAVGVFEFAPEPQKNVL
GHINLKDKKMSSYQFDVLEGGIQPTDGSVITAQVTQYPKPNSPKLIAGVAEKTVGHKDDPGVDILEVVYQHELPTEFPDD
VKAEIASIPDYVTDAEKKGRVDLTNEVVVTIDGDDSKDFDDAVGLKKLDNGNYRLLVNIADVSHYVKEGSPLDKEAYRRS
TSVYLTDRVIPMLPRKLSNGICSLNPNVERLSMTCEMEITPEGDVVNHKIYPSVIESDARMTYNDVNKILESKDEKTMAR
YEKLVPMFEMMGELHKILLKKRKQRGAIEFSDKEAQIIVDETGHPIDIKLRTRGTSERMIESFMLAANETVAEHYYKAHV
PFLYRIHETPDSERMLTFFEFLSVFGHVVKGSTKDLKPKMLQSVLKKIAGTPEEAMISVMMLRSMRQAKYDAQSLGHFGL
AAEYYTHFTSPIRRYPDLFVHRLIRHYAENGTGEAAQAKYVESIPEIADHTSKLERRAIDTERDVDGMKKAEFMADHVGE
EFHAVVSSVMKFGLFVELENTVEGLIHISTMKDDYYEYVEKQMALVGRNTHRTFQIGQEVEIKLMRVDKDQSEVDFELLH
PEKTPKSDIQLPPRQQFNRGPRRNGQKPSGKNNNKSGNRNGKPFYKDKTVKKFSKNTSHKK
>Mature_781_residues
MEINKLQALIINYLQQRPTQKLTAEELFKGLNLEGASVFNTLVKELALMERSKKVEITEDGKFKIARPKNQLLVHGVFHA
NDRGFGFVSVEEDEIPDIYISEDHTAYALNMDEVDVKITRPSKKGDDRGPEGIVKKITSRHFTQAVGVFEFAPEPQKNVL
GHINLKDKKMSSYQFDVLEGGIQPTDGSVITAQVTQYPKPNSPKLIAGVAEKTVGHKDDPGVDILEVVYQHELPTEFPDD
VKAEIASIPDYVTDAEKKGRVDLTNEVVVTIDGDDSKDFDDAVGLKKLDNGNYRLLVNIADVSHYVKEGSPLDKEAYRRS
TSVYLTDRVIPMLPRKLSNGICSLNPNVERLSMTCEMEITPEGDVVNHKIYPSVIESDARMTYNDVNKILESKDEKTMAR
YEKLVPMFEMMGELHKILLKKRKQRGAIEFSDKEAQIIVDETGHPIDIKLRTRGTSERMIESFMLAANETVAEHYYKAHV
PFLYRIHETPDSERMLTFFEFLSVFGHVVKGSTKDLKPKMLQSVLKKIAGTPEEAMISVMMLRSMRQAKYDAQSLGHFGL
AAEYYTHFTSPIRRYPDLFVHRLIRHYAENGTGEAAQAKYVESIPEIADHTSKLERRAIDTERDVDGMKKAEFMADHVGE
EFHAVVSSVMKFGLFVELENTVEGLIHISTMKDDYYEYVEKQMALVGRNTHRTFQIGQEVEIKLMRVDKDQSEVDFELLH
PEKTPKSDIQLPPRQQFNRGPRRNGQKPSGKNNNKSGNRNGKPFYKDKTVKKFSKNTSHKK

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014623, Length=378, Percent_Identity=32.5396825396825, Blast_Score=193, Evalue=7e-49,
Organism=Homo sapiens, GI190014625, Length=378, Percent_Identity=32.5396825396825, Blast_Score=192, Evalue=7e-49,
Organism=Homo sapiens, GI134288890, Length=362, Percent_Identity=33.7016574585635, Blast_Score=187, Evalue=4e-47,
Organism=Homo sapiens, GI19115966, Length=382, Percent_Identity=29.5811518324607, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI219521928, Length=382, Percent_Identity=29.5811518324607, Blast_Score=132, Evalue=1e-30,
Organism=Escherichia coli, GI87082383, Length=740, Percent_Identity=35.5405405405405, Blast_Score=429, Evalue=1e-121,
Organism=Escherichia coli, GI1787542, Length=597, Percent_Identity=26.8006700167504, Blast_Score=158, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17553506, Length=507, Percent_Identity=29.1913214990138, Blast_Score=173, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI212645896, Length=345, Percent_Identity=32.463768115942, Blast_Score=162, Evalue=6e-40,
Organism=Saccharomyces cerevisiae, GI6324552, Length=339, Percent_Identity=34.5132743362832, Blast_Score=169, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6320499, Length=328, Percent_Identity=25.3048780487805, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323943, Length=428, Percent_Identity=22.6635514018692, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24649634, Length=479, Percent_Identity=30.8977035490605, Blast_Score=209, Evalue=9e-54,
Organism=Drosophila melanogaster, GI24654592, Length=406, Percent_Identity=29.3103448275862, Blast_Score=154, Evalue=3e-37,
Organism=Drosophila melanogaster, GI19922976, Length=406, Percent_Identity=29.3103448275862, Blast_Score=153, Evalue=4e-37,
Organism=Drosophila melanogaster, GI24654597, Length=406, Percent_Identity=29.3103448275862, Blast_Score=153, Evalue=4e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805 [H]

Pfam domain/function: PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 88809; Mature: 88809

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS50126 S1 ; PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEINKLQALIINYLQQRPTQKLTAEELFKGLNLEGASVFNTLVKELALMERSKKVEITED
CCHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECC
GKFKIARPKNQLLVHGVFHANDRGFGFVSVEEDEIPDIYISEDHTAYALNMDEVDVKITR
CCEEEECCCCCEEEEEEEECCCCCCEEEEECCCCCCEEEECCCCEEEEEECCCEEEEEEC
PSKKGDDRGPEGIVKKITSRHFTQAVGVFEFAPEPQKNVLGHINLKDKKMSSYQFDVLEG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCEEECCCCCCCCCCEEEHHHHC
GIQPTDGSVITAQVTQYPKPNSPKLIAGVAEKTVGHKDDPGVDILEVVYQHELPTEFPDD
CCCCCCCCEEEEEEECCCCCCCCCEEEEHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCH
VKAEIASIPDYVTDAEKKGRVDLTNEVVVTIDGDDSKDFDDAVGLKKLDNGNYRLLVNIA
HHHHHHHCCHHHCCCCCCCCEEECCCEEEEECCCCCCCHHHHCCCCEECCCCEEEEEEEH
DVSHYVKEGSPLDKEAYRRSTSVYLTDRVIPMLPRKLSNGICSLNPNVERLSMTCEMEIT
HHHHHHHCCCCCCHHHHHCCCCEEEECCHHHHHHHHHCCCEEECCCCHHHEEEEEEEEEC
PEGDVVNHKIYPSVIESDARMTYNDVNKILESKDEKTMARYEKLVPMFEMMGELHKILLK
CCCCEECCCCCHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KRKQRGAIEFSDKEAQIIVDETGHPIDIKLRTRGTSERMIESFMLAANETVAEHYYKAHV
HHHHCCCEEECCCCCEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCC
PFLYRIHETPDSERMLTFFEFLSVFGHVVKGSTKDLKPKMLQSVLKKIAGTPEEAMISVM
CEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHH
MLRSMRQAKYDAQSLGHFGLAAEYYTHFTSPIRRYPDLFVHRLIRHYAENGTGEAAQAKY
HHHHHHHHHHCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
VESIPEIADHTSKLERRAIDTERDVDGMKKAEFMADHVGEEFHAVVSSVMKFGLFVELEN
HHHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECC
TVEGLIHISTMKDDYYEYVEKQMALVGRNTHRTFQIGQEVEIKLMRVDKDQSEVDFELLH
HHCCEEEEEHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEEEEEEECCCCCCCCEEEEC
PEKTPKSDIQLPPRQQFNRGPRRNGQKPSGKNNNKSGNRNGKPFYKDKTVKKFSKNTSHK
CCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCC
K
C
>Mature Secondary Structure
MEINKLQALIINYLQQRPTQKLTAEELFKGLNLEGASVFNTLVKELALMERSKKVEITED
CCHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECC
GKFKIARPKNQLLVHGVFHANDRGFGFVSVEEDEIPDIYISEDHTAYALNMDEVDVKITR
CCEEEECCCCCEEEEEEEECCCCCCEEEEECCCCCCEEEECCCCEEEEEECCCEEEEEEC
PSKKGDDRGPEGIVKKITSRHFTQAVGVFEFAPEPQKNVLGHINLKDKKMSSYQFDVLEG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCEEECCCCCCCCCCEEEHHHHC
GIQPTDGSVITAQVTQYPKPNSPKLIAGVAEKTVGHKDDPGVDILEVVYQHELPTEFPDD
CCCCCCCCEEEEEEECCCCCCCCCEEEEHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCH
VKAEIASIPDYVTDAEKKGRVDLTNEVVVTIDGDDSKDFDDAVGLKKLDNGNYRLLVNIA
HHHHHHHCCHHHCCCCCCCCEEECCCEEEEECCCCCCCHHHHCCCCEECCCCEEEEEEEH
DVSHYVKEGSPLDKEAYRRSTSVYLTDRVIPMLPRKLSNGICSLNPNVERLSMTCEMEIT
HHHHHHHCCCCCCHHHHHCCCCEEEECCHHHHHHHHHCCCEEECCCCHHHEEEEEEEEEC
PEGDVVNHKIYPSVIESDARMTYNDVNKILESKDEKTMARYEKLVPMFEMMGELHKILLK
CCCCEECCCCCHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KRKQRGAIEFSDKEAQIIVDETGHPIDIKLRTRGTSERMIESFMLAANETVAEHYYKAHV
HHHHCCCEEECCCCCEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCC
PFLYRIHETPDSERMLTFFEFLSVFGHVVKGSTKDLKPKMLQSVLKKIAGTPEEAMISVM
CEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHH
MLRSMRQAKYDAQSLGHFGLAAEYYTHFTSPIRRYPDLFVHRLIRHYAENGTGEAAQAKY
HHHHHHHHHHCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
VESIPEIADHTSKLERRAIDTERDVDGMKKAEFMADHVGEEFHAVVSSVMKFGLFVELEN
HHHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECC
TVEGLIHISTMKDDYYEYVEKQMALVGRNTHRTFQIGQEVEIKLMRVDKDQSEVDFELLH
HHCCEEEEEHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEEEEEEECCCCCCCCEEEEC
PEKTPKSDIQLPPRQQFNRGPRRNGQKPSGKNNNKSGNRNGKPFYKDKTVKKFSKNTSHK
CCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCC
K
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]