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The map label for this gene is pgcA [H]

Identifier: 116492249

GI number: 116492249

Start: 495032

End: 496756

Strand: Direct

Name: pgcA [H]

Synonym: PEPE_0446

Alternate gene names: 116492249

Gene position: 495032-496756 (Clockwise)

Preceding gene: 116492248

Following gene: 116492250

Centisome position: 27.02

GC content: 38.03

Gene sequence:

>1725_bases
ATGAGTTGGGAAGATTCTGTCAAAGAATGGCAAGATTATGCAGATTTAGATTTTAATTTAAAAAAAGAATTAGCAACTTT
AGCTGAAGATAAAGATGCTTTAAAAGAAGCCTTTTATGCTCCAATGGAATTTGGTACAGCAGGAATGCGTGGCGTAATGG
GCCCTGGTATCAACCGGATGAATATCTATACGGTTCGTCAAGCAACAGAAGGTTTAGCTAATTTTATGGATACCTTGGAT
TTTACTGATAAGAAACGGGGAGTGGCGATCAGTTTTGATTCCCGCTATCACTCACAAGAGTTTGCTTTAGCAGCAGCTGG
TGTTTTAGGTAAGCATGGTATTCCAAGTTTTGTTTTTGATAGTATGCGTCCCACTCCAGAATTATCATATACAGTACGTG
AGTTAAACACTTATGCTGGAATCATGATTACTGCTAGTCATAATCCTAAACAATATAATGGATATAAGATTTATGGTCCT
GATGGCGGACAAATGCCACCAATGGAATCTGATAAGATTACAGAATATATTCGCCAAGTAACTGACATCTTTGGTGTTGA
AACTCTTACTCAAAGTGAATTAAGAGCTAAGGGCTTAATGACCATTATTGGTGAAGACATTGACCTCAAGTATCTTGAGG
AAGTTAAGACGGTATCAATTAATCATGAACTAATCCAACGCTTTGGTGCAGACATGAAGTTGATCTACTCACCATTACAT
GGTACTGGAAAAGTAGTTGGTGGACGTGCGTTAGAAAATGCTGGTTTTAAGGATTACACTATGGTCCCTGAACAAGCAAT
TGCTGACCCAGAATTTATTACAACGCCATTCCCTAACCCAGAATTCCCACAAACTTTTGATTTGGCTATTGAATTAGGTA
AAAAGCAAGATGCTGACCTTTTGATTGCCACTGATCCGGATGCCGATCGTTTGGGAGCTGCCGTTCGTTTACCAAATGGT
GACTACAAATTATTGACAGGAAATCAAATTGCAGCCCTGATGTTAGAATACATCTTAACTGCGCATGATGCAGCGGGTGA
CTTGCCAAGTAATGCAGCTGCCGTTAAATCAATTGTTTCTAGTGAACTAGCAACCAGAATTGCCGAAGCCCATCATGTAG
AAATGATTAACGTTCTAACTGGGTTTAAGTACATTGCTGACCAAATTAAACATTACGAAGAAAATGGCGACCATACCTTT
ATGTTTGGTTTCGAAGAAAGTTATGGCTATCTTGTTCGGCCATTTGTTCGCGATAAAGATGCCATCCAAGGAATTGTCCT
ATTGGCTGAAATTGCTGCTTATTATCGTAGTAAGGGGCAAACCTTATATGACGGTCTTCAAAACTTATTTACTACTTACG
GATATCATGAAGAAAAGACCATTTCAAAAGATTTCCCTGGAGTTGACGGTAAAGAAAAAATGGCTGCCATTATGGAAAAG
GTTCGTGAAGAACGCCCAAGTCAATTTGATCAGTACAAGGTATTAGAAACTGAAGACTTCTTAGCTCAAACTAAGTATGA
AGCAGACGGATCTACCCAAGCTATCAAATTACCAAAAGCGGATGTTTTGAAATTTACATTAGATGATGGTACTTGGATTG
CAATTCGCCCTTCTGGAACAGAACCAAAAATTAAATTCTATATTGGTACAGTTGGCGAAGATGAAAAAGATGCTTTGAAT
AAGATTGATGTTTTTGAAACAGCTATTAATGAACTTATAAAATAA

Upstream 100 bases:

>100_bases
GTGATTGGTCTATACCTAAAATTAAAAAAACGCTTTCTGGTATTCCATGGGTATTGTATAATGAAAGTAACTATAAGTTA
CATCATAGGAGGATTTTTGA

Downstream 100 bases:

>100_bases
TATTTAAAGAACTATGACGGAGCTCAAATTGAATGGTTATGCGCGATTCAGTTGGGCTTTTGGAGCATAGTTCTTTTTTA
TTCTAATTAAGTGAATCGGA

Product: alpha-phosphoglucomutase

Products: NA

Alternate protein names: PGM; Alpha-phosphoglucomutase; Glucose phosphomutase [H]

Number of amino acids: Translated: 574; Mature: 573

Protein sequence:

>574_residues
MSWEDSVKEWQDYADLDFNLKKELATLAEDKDALKEAFYAPMEFGTAGMRGVMGPGINRMNIYTVRQATEGLANFMDTLD
FTDKKRGVAISFDSRYHSQEFALAAAGVLGKHGIPSFVFDSMRPTPELSYTVRELNTYAGIMITASHNPKQYNGYKIYGP
DGGQMPPMESDKITEYIRQVTDIFGVETLTQSELRAKGLMTIIGEDIDLKYLEEVKTVSINHELIQRFGADMKLIYSPLH
GTGKVVGGRALENAGFKDYTMVPEQAIADPEFITTPFPNPEFPQTFDLAIELGKKQDADLLIATDPDADRLGAAVRLPNG
DYKLLTGNQIAALMLEYILTAHDAAGDLPSNAAAVKSIVSSELATRIAEAHHVEMINVLTGFKYIADQIKHYEENGDHTF
MFGFEESYGYLVRPFVRDKDAIQGIVLLAEIAAYYRSKGQTLYDGLQNLFTTYGYHEEKTISKDFPGVDGKEKMAAIMEK
VREERPSQFDQYKVLETEDFLAQTKYEADGSTQAIKLPKADVLKFTLDDGTWIAIRPSGTEPKIKFYIGTVGEDEKDALN
KIDVFETAINELIK

Sequences:

>Translated_574_residues
MSWEDSVKEWQDYADLDFNLKKELATLAEDKDALKEAFYAPMEFGTAGMRGVMGPGINRMNIYTVRQATEGLANFMDTLD
FTDKKRGVAISFDSRYHSQEFALAAAGVLGKHGIPSFVFDSMRPTPELSYTVRELNTYAGIMITASHNPKQYNGYKIYGP
DGGQMPPMESDKITEYIRQVTDIFGVETLTQSELRAKGLMTIIGEDIDLKYLEEVKTVSINHELIQRFGADMKLIYSPLH
GTGKVVGGRALENAGFKDYTMVPEQAIADPEFITTPFPNPEFPQTFDLAIELGKKQDADLLIATDPDADRLGAAVRLPNG
DYKLLTGNQIAALMLEYILTAHDAAGDLPSNAAAVKSIVSSELATRIAEAHHVEMINVLTGFKYIADQIKHYEENGDHTF
MFGFEESYGYLVRPFVRDKDAIQGIVLLAEIAAYYRSKGQTLYDGLQNLFTTYGYHEEKTISKDFPGVDGKEKMAAIMEK
VREERPSQFDQYKVLETEDFLAQTKYEADGSTQAIKLPKADVLKFTLDDGTWIAIRPSGTEPKIKFYIGTVGEDEKDALN
KIDVFETAINELIK
>Mature_573_residues
SWEDSVKEWQDYADLDFNLKKELATLAEDKDALKEAFYAPMEFGTAGMRGVMGPGINRMNIYTVRQATEGLANFMDTLDF
TDKKRGVAISFDSRYHSQEFALAAAGVLGKHGIPSFVFDSMRPTPELSYTVRELNTYAGIMITASHNPKQYNGYKIYGPD
GGQMPPMESDKITEYIRQVTDIFGVETLTQSELRAKGLMTIIGEDIDLKYLEEVKTVSINHELIQRFGADMKLIYSPLHG
TGKVVGGRALENAGFKDYTMVPEQAIADPEFITTPFPNPEFPQTFDLAIELGKKQDADLLIATDPDADRLGAAVRLPNGD
YKLLTGNQIAALMLEYILTAHDAAGDLPSNAAAVKSIVSSELATRIAEAHHVEMINVLTGFKYIADQIKHYEENGDHTFM
FGFEESYGYLVRPFVRDKDAIQGIVLLAEIAAYYRSKGQTLYDGLQNLFTTYGYHEEKTISKDFPGVDGKEKMAAIMEKV
REERPSQFDQYKVLETEDFLAQTKYEADGSTQAIKLPKADVLKFTLDDGTWIAIRPSGTEPKIKFYIGTVGEDEKDALNK
IDVFETAINELIK

Specific function: Catalyzes the interconversion between glucose-6- phosphate and alpha-glucose-1-phosphate. This is the first step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the predominant glycolipid found in B.subtilis membrane, which is also used

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI63055049, Length=609, Percent_Identity=32.3481116584565, Blast_Score=281, Evalue=8e-76,
Organism=Homo sapiens, GI31377548, Length=545, Percent_Identity=33.5779816513761, Blast_Score=266, Evalue=5e-71,
Organism=Escherichia coli, GI1786904, Length=545, Percent_Identity=25.5045871559633, Blast_Score=83, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI71993870, Length=582, Percent_Identity=32.3024054982818, Blast_Score=246, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI71993878, Length=316, Percent_Identity=36.3924050632911, Blast_Score=163, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6323934, Length=577, Percent_Identity=32.5823223570191, Blast_Score=226, Evalue=1e-59,
Organism=Drosophila melanogaster, GI20129809, Length=573, Percent_Identity=29.8429319371728, Blast_Score=258, Evalue=7e-69,
Organism=Drosophila melanogaster, GI24651977, Length=442, Percent_Identity=32.579185520362, Blast_Score=234, Evalue=9e-62,
Organism=Drosophila melanogaster, GI24653722, Length=560, Percent_Identity=29.2857142857143, Blast_Score=214, Evalue=9e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2 [H]

Molecular weight: Translated: 64116; Mature: 63985

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSWEDSVKEWQDYADLDFNLKKELATLAEDKDALKEAFYAPMEFGTAGMRGVMGPGINRM
CCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCE
NIYTVRQATEGLANFMDTLDFTDKKRGVAISFDSRYHSQEFALAAAGVLGKHGIPSFVFD
EEEEHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCHHHHH
SMRPTPELSYTVRELNTYAGIMITASHNPKQYNGYKIYGPDGGQMPPMESDKITEYIRQV
CCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHH
TDIFGVETLTQSELRAKGLMTIIGEDIDLKYLEEVKTVSINHELIQRFGADMKLIYSPLH
HHHHHHHHHHHHHHHHHCCHHEECCCCCHHHHHHHHHEECCHHHHHHHCCCEEEEEECCC
GTGKVVGGRALENAGFKDYTMVPEQAIADPEFITTPFPNPEFPQTFDLAIELGKKQDADL
CCCCEECCCHHHCCCCCCCCCCCHHHCCCCCEEECCCCCCCCCCHHHHHEEECCCCCCCE
LIATDPDADRLGAAVRLPNGDYKLLTGNQIAALMLEYILTAHDAAGDLPSNAAAVKSIVS
EEEECCCHHHCCCEEECCCCCEEEEECCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
SELATRIAEAHHVEMINVLTGFKYIADQIKHYEENGDHTFMFGFEESYGYLVRPFVRDKD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCEEECHHCCHH
AIQGIVLLAEIAAYYRSKGQTLYDGLQNLFTTYGYHEEKTISKDFPGVDGKEKMAAIMEK
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHH
VREERPSQFDQYKVLETEDFLAQTKYEADGSTQAIKLPKADVLKFTLDDGTWIAIRPSGT
HHHHCCCCCCCEEEECHHHHHHHCCCCCCCCCEEEECCCCCEEEEEECCCEEEEEECCCC
EPKIKFYIGTVGEDEKDALNKIDVFETAINELIK
CCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SWEDSVKEWQDYADLDFNLKKELATLAEDKDALKEAFYAPMEFGTAGMRGVMGPGINRM
CCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCE
NIYTVRQATEGLANFMDTLDFTDKKRGVAISFDSRYHSQEFALAAAGVLGKHGIPSFVFD
EEEEHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCHHHHH
SMRPTPELSYTVRELNTYAGIMITASHNPKQYNGYKIYGPDGGQMPPMESDKITEYIRQV
CCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHH
TDIFGVETLTQSELRAKGLMTIIGEDIDLKYLEEVKTVSINHELIQRFGADMKLIYSPLH
HHHHHHHHHHHHHHHHHCCHHEECCCCCHHHHHHHHHEECCHHHHHHHCCCEEEEEECCC
GTGKVVGGRALENAGFKDYTMVPEQAIADPEFITTPFPNPEFPQTFDLAIELGKKQDADL
CCCCEECCCHHHCCCCCCCCCCCHHHCCCCCEEECCCCCCCCCCHHHHHEEECCCCCCCE
LIATDPDADRLGAAVRLPNGDYKLLTGNQIAALMLEYILTAHDAAGDLPSNAAAVKSIVS
EEEECCCHHHCCCEEECCCCCEEEEECCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
SELATRIAEAHHVEMINVLTGFKYIADQIKHYEENGDHTFMFGFEESYGYLVRPFVRDKD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCEEECHHCCHH
AIQGIVLLAEIAAYYRSKGQTLYDGLQNLFTTYGYHEEKTISKDFPGVDGKEKMAAIMEK
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHH
VREERPSQFDQYKVLETEDFLAQTKYEADGSTQAIKLPKADVLKFTLDDGTWIAIRPSGT
HHHHCCCCCCCEEEECHHHHHHHCCCCCCCCCEEEECCCCCEEEEEECCCEEEEEECCCC
EPKIKFYIGTVGEDEKDALNKIDVFETAINELIK
CCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 2127799 [H]