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The map label for this gene is trxB [H]

Identifier: 116492248

GI number: 116492248

Start: 493949

End: 494875

Strand: Direct

Name: trxB [H]

Synonym: PEPE_0445

Alternate gene names: 116492248

Gene position: 493949-494875 (Clockwise)

Preceding gene: 116492247

Following gene: 116492249

Centisome position: 26.96

GC content: 42.39

Gene sequence:

>927_bases
ATGACAAAACAATATGATGTTGTTATTATTGGGGCCGGCCCAGCCGGAATGACAGCGGCCTTATATGCTTCCCGTGCAAA
CCTATCGGTAGTGATGCTAGATCGTGGAATCTATGGTGGTCAAATGAATAATACTGCTGATATTGAAAACTTTCCTGGCT
TTAAATCTGTTTTAGGACCGGATTTATCAAAAGATATGTACGAAAGTTCAACTCAGTTCGGCGCTGAATATGCTTACGGC
AGTGTCGAATCCATTCGAGATGACGGAGCTACTAAACTCGTCAAAACTGATATGGGTGACGAGTTCGAAGCTAAAGTAGT
TATTATTGGTACTGGTTCTGAATATAAGAAATTAGGTGTACCAGGCGAAGAAGATTTTAGCGGACGGGGCGTTTCGTACT
GTGCGGTCTGTGATGGAGCCTTTTTTAAAGGGACAGATGTTGTAGTGGTCGGTGGCGGAGACTCTGCTATTGAAGAAGGT
TTATACCTAACACAATTAGCTTCTAAGGTTACCGTGATTCATCGTCGTGACCAACTACGGGCTCAAAAAATTATCCAAGA
TCGTGCTTTTGCCAATCCTAAGATGGAATTTGTCTGGAACAGTAATGTTACAGAAGTAGTTGGTGAAGGTAAGGTCACGG
GCGTTAAAGTTAATAATAACCAAACTGGCGAAGATTCATTTATTGAAGCAGCCGGAATATTCATTTACGTAGGGGTAAAA
CCCATGACGGCCGCCTTTGCGGACTTAGGTATTTTGGATGAACAAGGTTGGATTCCAACTGATGACCATATGCATACTAA
GGTTCCTGGAATTCTAGCTGTTGGTGATGTACGTAAGAAAGATTTACGTCAAATCACAACGGCCGTAGGTGACGGTGGCG
TCGCTGGACAACAAGCGTATGAATATATTCAAGCTTTAAATGATTAA

Upstream 100 bases:

>100_bases
TTGACCGGATCGTTTGATTTTTTATATAAAACAAAATGATAGACAGTTATTAAAAGTAAGTGTATAGTGAATGCATTATT
AAAAGTGTGGAGGAAAGAGA

Downstream 100 bases:

>100_bases
AGTCAAAATAAGCCGCGGTGAAAACCGGGGCTTTTCTTTTTGCCAAAATTCAAAAAGTGATTGGTCTATACCTAAAATTA
AAAAAACGCTTTCTGGTATT

Product: thioredoxin reductase

Products: NA

Alternate protein names: TRXR; General stress protein 35; GSP35 [H]

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MTKQYDVVIIGAGPAGMTAALYASRANLSVVMLDRGIYGGQMNNTADIENFPGFKSVLGPDLSKDMYESSTQFGAEYAYG
SVESIRDDGATKLVKTDMGDEFEAKVVIIGTGSEYKKLGVPGEEDFSGRGVSYCAVCDGAFFKGTDVVVVGGGDSAIEEG
LYLTQLASKVTVIHRRDQLRAQKIIQDRAFANPKMEFVWNSNVTEVVGEGKVTGVKVNNNQTGEDSFIEAAGIFIYVGVK
PMTAAFADLGILDEQGWIPTDDHMHTKVPGILAVGDVRKKDLRQITTAVGDGGVAGQQAYEYIQALND

Sequences:

>Translated_308_residues
MTKQYDVVIIGAGPAGMTAALYASRANLSVVMLDRGIYGGQMNNTADIENFPGFKSVLGPDLSKDMYESSTQFGAEYAYG
SVESIRDDGATKLVKTDMGDEFEAKVVIIGTGSEYKKLGVPGEEDFSGRGVSYCAVCDGAFFKGTDVVVVGGGDSAIEEG
LYLTQLASKVTVIHRRDQLRAQKIIQDRAFANPKMEFVWNSNVTEVVGEGKVTGVKVNNNQTGEDSFIEAAGIFIYVGVK
PMTAAFADLGILDEQGWIPTDDHMHTKVPGILAVGDVRKKDLRQITTAVGDGGVAGQQAYEYIQALND
>Mature_307_residues
TKQYDVVIIGAGPAGMTAALYASRANLSVVMLDRGIYGGQMNNTADIENFPGFKSVLGPDLSKDMYESSTQFGAEYAYGS
VESIRDDGATKLVKTDMGDEFEAKVVIIGTGSEYKKLGVPGEEDFSGRGVSYCAVCDGAFFKGTDVVVVGGGDSAIEEGL
YLTQLASKVTVIHRRDQLRAQKIIQDRAFANPKMEFVWNSNVTEVVGEGKVTGVKVNNNQTGEDSFIEAAGIFIYVGVKP
MTAAFADLGILDEQGWIPTDDHMHTKVPGILAVGDVRKKDLRQITTAVGDGGVAGQQAYEYIQALND

Specific function: Unknown

COG id: COG0492

COG function: function code O; Thioredoxin reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI21389617, Length=325, Percent_Identity=25.5384615384615, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI65787454, Length=325, Percent_Identity=25.5384615384615, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI226437568, Length=325, Percent_Identity=25.5384615384615, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1787114, Length=319, Percent_Identity=38.871473354232, Blast_Score=209, Evalue=2e-55,
Organism=Escherichia coli, GI87081763, Length=310, Percent_Identity=32.258064516129, Blast_Score=149, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6320560, Length=315, Percent_Identity=38.7301587301587, Blast_Score=199, Evalue=4e-52,
Organism=Saccharomyces cerevisiae, GI6321898, Length=315, Percent_Identity=35.8730158730159, Blast_Score=186, Evalue=3e-48,
Organism=Drosophila melanogaster, GI21358499, Length=329, Percent_Identity=26.1398176291793, Blast_Score=68, Evalue=8e-12,

Paralogues:

None

Copy number: 808 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR008255
- InterPro:   IPR001327
- InterPro:   IPR000103
- InterPro:   IPR005982 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: =1.8.1.9 [H]

Molecular weight: Translated: 32984; Mature: 32852

Theoretical pI: Translated: 4.45; Mature: 4.45

Prosite motif: PS00573 PYRIDINE_REDOX_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKQYDVVIIGAGPAGMTAALYASRANLSVVMLDRGIYGGQMNNTADIENFPGFKSVLGP
CCCCEEEEEEECCCCCHHHHEEECCCCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHCC
DLSKDMYESSTQFGAEYAYGSVESIRDDGATKLVKTDMGDEFEAKVVIIGTGSEYKKLGV
CCHHHHHHHHHHCCHHHCCCCHHHHHCCCCEEEEECCCCCCCEEEEEEEECCCCHHCCCC
PGEEDFSGRGVSYCAVCDGAFFKGTDVVVVGGGDSAIEEGLYLTQLASKVTVIHRRDQLR
CCCCCCCCCCEEEEEEECCCEECCCCEEEECCCCHHHHCCCHHHHHHHHHHEEHHHHHHH
AQKIIQDRAFANPKMEFVWNSNVTEVVGEGKVTGVKVNNNQTGEDSFIEAAGIFIYVGVK
HHHHHHHHHCCCCCEEEEECCCHHHHHCCCEEEEEEECCCCCCCHHHEEECCEEEEECCC
PMTAAFADLGILDEQGWIPTDDHMHTKVPGILAVGDVRKKDLRQITTAVGDGGVAGQQAY
HHHHHHHHCCEECCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHCCCCCCHHHHH
EYIQALND
HHHHHHCC
>Mature Secondary Structure 
TKQYDVVIIGAGPAGMTAALYASRANLSVVMLDRGIYGGQMNNTADIENFPGFKSVLGP
CCCEEEEEEECCCCCHHHHEEECCCCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHCC
DLSKDMYESSTQFGAEYAYGSVESIRDDGATKLVKTDMGDEFEAKVVIIGTGSEYKKLGV
CCHHHHHHHHHHCCHHHCCCCHHHHHCCCCEEEEECCCCCCCEEEEEEEECCCCHHCCCC
PGEEDFSGRGVSYCAVCDGAFFKGTDVVVVGGGDSAIEEGLYLTQLASKVTVIHRRDQLR
CCCCCCCCCCEEEEEEECCCEECCCCEEEECCCCHHHHCCCHHHHHHHHHHEEHHHHHHH
AQKIIQDRAFANPKMEFVWNSNVTEVVGEGKVTGVKVNNNQTGEDSFIEAAGIFIYVGVK
HHHHHHHHHCCCCCEEEEECCCHHHHHCCCEEEEEEECCCCCCCHHHEEECCEEEEECCC
PMTAAFADLGILDEQGWIPTDDHMHTKVPGILAVGDVRKKDLRQITTAVGDGGVAGQQAY
HHHHHHHHCCEECCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHCCCCCCHHHHH
EYIQALND
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 9298659 [H]