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The map label for this gene is gpsA

Identifier: 116492246

GI number: 116492246

Start: 491897

End: 492913

Strand: Direct

Name: gpsA

Synonym: PEPE_0443

Alternate gene names: 116492246

Gene position: 491897-492913 (Clockwise)

Preceding gene: 116492245

Following gene: 116492247

Centisome position: 26.84

GC content: 40.61

Gene sequence:

>1017_bases
ATGGTAAAAAAAGTTGCAGTGTTAGGAGCCGGATCATGGGGCAGTATTTTAGCTAACATGCTTGTCCAAAATGGCAATGA
TGTAGTTGCATGGACGAACATGGAGGAACAAGCTAAAGAACTTAACGAGCAGCACTCCAATGAACATTACGTTCCCGGTT
TTAAGTATGACGAACGTTTAGTAGCAACAACCGACTTAGAAGTAGCGTTGAAGGATGTTGATGCGGTATTGTTTGTTGTA
CCAACCAAGGTAATGCGATTAGTTGCCCAACAAATGGTTGAAGTTTTAAAGAAAACTGGTCAAAAGCCAATTATTGTTCA
TGCAAGTAAAGGTTTGGAACTTGGAACGCATAAGCGTTTGTCAGAAGTATTAGCGGAAGAAATTCCTAGTGAATTACGTC
AAGCAATTGTAGTTCTTTCAGGTCCAAGTCATGCTGAAGAAGTTGCTAAGCAAGATTTAACGCTTGTTACAGCAGCTAGC
TCAGATTTAGCAAGTGCTGAAGCAGTTCAAAAATTATTTATGAATAATTACTTCCGCGTATATACTAATGACGATATTGT
CGGAGTTGAAATGGGTGCCGCACTTAAAAATGTAATTGCAATTGGAGCCGGAGCATTACATGGCTTGGGTTACGGCGATG
ACGCTAAGGCAGCTTTAATCACACGTGGTTTAGCTGAAATTTCTCGTTTAGGAGTAGCCTTTGGGGCAAACCCACTCACT
TTCATCGGTTTATCTGGTGTAGGTGATTTGATTGTTACGGCAACTAGTGTGCATTCACGAAACTGGCGTGCGGGTAACGA
ACTTGGCCAAGGTATGAAACTAGACGAAGTTATTGATACAATGGGAATGGTGATTGAAGGAGTTCCTTCAACTAAAGCCG
CCTATGAATTAGCTCAACAAAAAAATATCGAAATGCCAATTACTGAAGCTATCTATGATGTATTGTATAATGAAAAGGGT
GTCAAGGAAGCAATCGACGAATTGATGCATCGTGACGGTAGGTCAGAATTAGAGTAA

Upstream 100 bases:

>100_bases
TCAGCTTTCACCAAAATGAACTTGAGTAAAGTACCTTTGTATACGATAATAGAAAGGTACATAAATTATTTTTAAATTTA
AGATTGTAAGGGGATTAACT

Downstream 100 bases:

>100_bases
AAATTTTTGGAGGTTAGGTATTCATGAAAAAAGTACGTAAAGCAATTATTCCTGCAGCAGGATTAGGAACTAGATTTTTA
CCAGTAACCAAAGCTTCACC

Product: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Products: NA

Alternate protein names: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MVKKVAVLGAGSWGSILANMLVQNGNDVVAWTNMEEQAKELNEQHSNEHYVPGFKYDERLVATTDLEVALKDVDAVLFVV
PTKVMRLVAQQMVEVLKKTGQKPIIVHASKGLELGTHKRLSEVLAEEIPSELRQAIVVLSGPSHAEEVAKQDLTLVTAAS
SDLASAEAVQKLFMNNYFRVYTNDDIVGVEMGAALKNVIAIGAGALHGLGYGDDAKAALITRGLAEISRLGVAFGANPLT
FIGLSGVGDLIVTATSVHSRNWRAGNELGQGMKLDEVIDTMGMVIEGVPSTKAAYELAQQKNIEMPITEAIYDVLYNEKG
VKEAIDELMHRDGRSELE

Sequences:

>Translated_338_residues
MVKKVAVLGAGSWGSILANMLVQNGNDVVAWTNMEEQAKELNEQHSNEHYVPGFKYDERLVATTDLEVALKDVDAVLFVV
PTKVMRLVAQQMVEVLKKTGQKPIIVHASKGLELGTHKRLSEVLAEEIPSELRQAIVVLSGPSHAEEVAKQDLTLVTAAS
SDLASAEAVQKLFMNNYFRVYTNDDIVGVEMGAALKNVIAIGAGALHGLGYGDDAKAALITRGLAEISRLGVAFGANPLT
FIGLSGVGDLIVTATSVHSRNWRAGNELGQGMKLDEVIDTMGMVIEGVPSTKAAYELAQQKNIEMPITEAIYDVLYNEKG
VKEAIDELMHRDGRSELE
>Mature_338_residues
MVKKVAVLGAGSWGSILANMLVQNGNDVVAWTNMEEQAKELNEQHSNEHYVPGFKYDERLVATTDLEVALKDVDAVLFVV
PTKVMRLVAQQMVEVLKKTGQKPIIVHASKGLELGTHKRLSEVLAEEIPSELRQAIVVLSGPSHAEEVAKQDLTLVTAAS
SDLASAEAVQKLFMNNYFRVYTNDDIVGVEMGAALKNVIAIGAGALHGLGYGDDAKAALITRGLAEISRLGVAFGANPLT
FIGLSGVGDLIVTATSVHSRNWRAGNELGQGMKLDEVIDTMGMVIEGVPSTKAAYELAQQKNIEMPITEAIYDVLYNEKG
VKEAIDELMHRDGRSELE

Specific function: De novo phospholipid biosynthesis; glycerol-3 phosphate formation. [C]

COG id: COG0240

COG function: function code C; Glycerol-3-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family

Homologues:

Organism=Homo sapiens, GI33695088, Length=353, Percent_Identity=31.1614730878187, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI24307999, Length=347, Percent_Identity=28.8184438040346, Blast_Score=135, Evalue=4e-32,
Organism=Escherichia coli, GI1790037, Length=334, Percent_Identity=41.6167664670659, Blast_Score=248, Evalue=5e-67,
Organism=Caenorhabditis elegans, GI32564399, Length=347, Percent_Identity=28.8184438040346, Blast_Score=120, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI193210136, Length=353, Percent_Identity=28.328611898017, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI32564403, Length=353, Percent_Identity=28.328611898017, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17507425, Length=350, Percent_Identity=27.1428571428571, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI193210134, Length=345, Percent_Identity=26.3768115942029, Blast_Score=89, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6320181, Length=365, Percent_Identity=29.3150684931507, Blast_Score=125, Evalue=8e-30,
Organism=Saccharomyces cerevisiae, GI6324513, Length=365, Percent_Identity=27.6712328767123, Blast_Score=119, Evalue=6e-28,
Organism=Drosophila melanogaster, GI17136200, Length=344, Percent_Identity=30.5232558139535, Blast_Score=120, Evalue=9e-28,
Organism=Drosophila melanogaster, GI17136202, Length=344, Percent_Identity=30.5232558139535, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI17136204, Length=344, Percent_Identity=30.5232558139535, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI22026922, Length=345, Percent_Identity=21.7391304347826, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI281362270, Length=269, Percent_Identity=27.8810408921933, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI45551945, Length=238, Percent_Identity=27.7310924369748, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24648969, Length=190, Percent_Identity=28.9473684210526, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GPDA_PEDPA (Q03GY3)

Other databases:

- EMBL:   CP000422
- RefSeq:   YP_803981.1
- ProteinModelPortal:   Q03GY3
- SMR:   Q03GY3
- STRING:   Q03GY3
- GeneID:   4418374
- GenomeReviews:   CP000422_GR
- KEGG:   ppe:PEPE_0443
- NMPDR:   fig|278197.10.peg.411
- eggNOG:   COG0240
- HOGENOM:   HBG586392
- OMA:   NVAKGIE
- PhylomeDB:   Q03GY3
- ProtClustDB:   PRK00094
- BioCyc:   PPEN278197:PEPE_0443-MONOMER
- HAMAP:   MF_00394
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR006168
- InterPro:   IPR006109
- InterPro:   IPR011128
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR11728
- PIRSF:   PIRSF000114
- PRINTS:   PR00077

Pfam domain/function: PF07479 NAD_Gly3P_dh_C; PF01210 NAD_Gly3P_dh_N; SSF48179 6DGDH_C_like

EC number: =1.1.1.94

Molecular weight: Translated: 36493; Mature: 36493

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS00957 NAD_G3PDH

Important sites: ACT_SITE 196-196 BINDING 110-110 BINDING 110-110 BINDING 145-145 BINDING 260-260 BINDING 286-286

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKKVAVLGAGSWGSILANMLVQNGNDVVAWTNMEEQAKELNEQHSNEHYVPGFKYDERL
CCCEEEEEECCCHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCEE
VATTDLEVALKDVDAVLFVVPTKVMRLVAQQMVEVLKKTGQKPIIVHASKGLELGTHKRL
EEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHH
SEVLAEEIPSELRQAIVVLSGPSHAEEVAKQDLTLVTAASSDLASAEAVQKLFMNNYFRV
HHHHHHHHHHHHHHHEEEECCCCHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHCCCEEE
YTNDDIVGVEMGAALKNVIAIGAGALHGLGYGDDAKAALITRGLAEISRLGVAFGANPLT
EECCCEEEEHHHHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEE
FIGLSGVGDLIVTATSVHSRNWRAGNELGQGMKLDEVIDTMGMVIEGVPSTKAAYELAQQ
EEECCCCCCHHEEEEHHCCCCCCCHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHH
KNIEMPITEAIYDVLYNEKGVKEAIDELMHRDGRSELE
CCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MVKKVAVLGAGSWGSILANMLVQNGNDVVAWTNMEEQAKELNEQHSNEHYVPGFKYDERL
CCCEEEEEECCCHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCEE
VATTDLEVALKDVDAVLFVVPTKVMRLVAQQMVEVLKKTGQKPIIVHASKGLELGTHKRL
EEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHH
SEVLAEEIPSELRQAIVVLSGPSHAEEVAKQDLTLVTAASSDLASAEAVQKLFMNNYFRV
HHHHHHHHHHHHHHHEEEECCCCHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHCCCEEE
YTNDDIVGVEMGAALKNVIAIGAGALHGLGYGDDAKAALITRGLAEISRLGVAFGANPLT
EECCCEEEEHHHHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEE
FIGLSGVGDLIVTATSVHSRNWRAGNELGQGMKLDEVIDTMGMVIEGVPSTKAAYELAQQ
EEECCCCCCHHEEEEHHCCCCCCCHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHH
KNIEMPITEAIYDVLYNEKGVKEAIDELMHRDGRSELE
CCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA