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The map label for this gene is helD [H]

Identifier: 116492207

GI number: 116492207

Start: 449829

End: 452126

Strand: Direct

Name: helD [H]

Synonym: PEPE_0404

Alternate gene names: 116492207

Gene position: 449829-452126 (Clockwise)

Preceding gene: 116492203

Following gene: 116492208

Centisome position: 24.55

GC content: 37.9

Gene sequence:

>2298_bases
TTGGCAGAGGGAATTTTTGAATACGAAAATAGACATTTAGATGAAGTTTTAGATAAGGTGGATACTGCAATTGCCAAAGC
AGAAAACGACGCCGATAATGCCGAAAAAGATCGTAGTGCGATTGATAAGAATTTTTACAACGATGTTCGAATTAACACTT
CCAGTTATTCAGGTATGATGGATACTGCAATTTCAATCCGTCAACAACAGCAATTATTATCTGAACGCGAAAATAGTTGG
CAACACGCTAATAAACGTTTAACCACGTTTAAAGAAATGAAAAAGCGGCCCTATTTTGCACGAATTGATTTTCACGAAAA
AGGTGAAAAGAAGGATGAAACCATCTATATTGGTTTAGCTTCATTTTCGGACACGGCCGATCATTTTTTGATTTATGATT
GGCGGGCTCCCATTTCTAGTGTTTACTATGACGGAAAAATGGGCGATGTGGAATATGCAACGCCAGATGGCACGCAAACG
GTAGACTTGAAGTTAAAACGGCAATTTACTATTGAAGATGGTAAATTGATTTCAGTTTACGATACGGACGAAACTATCGG
AGATCAAATGCTACTAAACGCGTTGGGTTCTCAATCCGATGTTAAGATGAAAAGTATTGTTTCAACCATCCAAAGAGAAC
AGAATAAAATTATTCGAAATACCGCAGCCGATTTACTATTCGTTCAAGGTGCAGCTGGATCGGGAAAGACCGCTGCGATT
TTACAGCGGGTCGCTTTCTTGCTTTACCGTTACCGCGGAAATTTAAATGCTGGACAAGTCATCATGTTTTCACCTAATCA
ATTGTTTAATGATTATGTTGATCAAGTTTTACCCGAACTGGGCGAACAAAACATGATTCAGATGACCTATTATCAATTTA
CTAGACGACGGATTCCAAACATCGACGTTGAAAACTTGCAACAACGTTTTGATAAGAAGCTCACGGATGCGGAACGTAAA
ATCGAACAATTCAAAGGAAGCTTGCAATTTTTCAAAGCTACTACTAAATATGCGAAATATCTTGGGACGGCAGGTATGCG
ATTCCGCAATATCATGTTCCAAGGTCAACCGTTTGCTACTAAGGAAAAAATTAAAGACATCTATTATTCATTTAATACTA
CCTATAATTTGGGTAACCGAATTGAAGGAACTCGGGAAGCCTTGATCCGCCAATTGAACCAAAAAGTAGGTAGTGAATTG
AGAACTAAGTGGGTGGAAGAAGCGGTCCAAAACCTTAGCCAAGAAGAATTACACAACCTATTTAAAAACGAGCCCCGTGA
ATTTAAGGATAATGATGAAGAATTTAAATTCCTTGCTCGTCAAATCGTAATGAAAGAACTTAAACCGGTTCGAAATGCGA
TTATGCGTAATCGCTTCTTAAGCATTAATGCCCAATATGTCCAAATGCTACGTTCGTTCCCCAAATGGTACGATTTAAAG
AAAGTTGGGGTAACAGAAGCAGAATGGGATAACCATGTGGATAAAGTGGTAAATGGACTTAAGGAGCATCAGTTAACCAT
GGTAGATACAACCGCTTATTTATACTTGTATGATTTAATTACGGGTAAAAAAGGTGATCGTTCCATGCGTTATGCATTTA
TTGATGAAATCCAAGATTATAATGCTTTCCAACTAGCTTATATTCGGTTCAATTTTCCTCGAGCAAAATTCACACTTTTA
GGAGATTTAAATCAATCAATTTACGCCAATGAAACTAGTGATACTTTATTAGCAGAGTTATCAACAATGTTTGATCCAGA
AAAGACGGAAGTAGTTCAACTATCTAAGTCTTATCGTTCAACACAACAAATTACAGACTTTACTAAGGAAATCTTGGTCA
AAGGTGAAGCAATTGAATCCTTTAATCGCGCGGGTGAATTACCAACGGTTTCAATTAATAGTAGTCATCAAGGAATGGTT
GAGGCGGTGATCGAACAGCTTCATCGCGATCGCCAAGATCATGAGACTAGCGCCATTATTGGGCGTAGCTATGCTGAATG
TGAACAAATCGCGGATGAATTAAAAGCAGCTGGCGAGCAAGTAACGCTAATCCGAACTGAAAATCAGCGTTTGGTGGAAG
GTACCATCGTTGTTCCATCTTTCTTAGCCAAGGGATTGGAATTTGATTCAGTAATCGTGTGGAATACTTCAGCGAAGATT
TATCAAACTAATCGGGATGAACAGTTATTATATACAATTTGTTCACGGGCAATGCATCGACTCTTAATCGTTGCTGAGAA
TGATCTTAGTCCGTTAATTACTAAGATTCCTGAAAATTTATATATTAAAAAAGCTTAA

Upstream 100 bases:

>100_bases
ATTCTATCATATATCCCGTGTACCAAATTAGCTAAATCTTTGTGAAAACGCATAAAAAGGAGTAAAATTTATGTCTAACA
AAACTGAGAGGTGATTCACA

Downstream 100 bases:

>100_bases
TAACTTAAAATACAACACAAAGAGCTTAAAATAAGATACTTTTTTATTAAGCTCTTTTTATTATATTTTGATATAGTTAA
CTATGTAATCACTTTCAAAA

Product: superfamily I DNA/RNA helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 765; Mature: 764

Protein sequence:

>765_residues
MAEGIFEYENRHLDEVLDKVDTAIAKAENDADNAEKDRSAIDKNFYNDVRINTSSYSGMMDTAISIRQQQQLLSERENSW
QHANKRLTTFKEMKKRPYFARIDFHEKGEKKDETIYIGLASFSDTADHFLIYDWRAPISSVYYDGKMGDVEYATPDGTQT
VDLKLKRQFTIEDGKLISVYDTDETIGDQMLLNALGSQSDVKMKSIVSTIQREQNKIIRNTAADLLFVQGAAGSGKTAAI
LQRVAFLLYRYRGNLNAGQVIMFSPNQLFNDYVDQVLPELGEQNMIQMTYYQFTRRRIPNIDVENLQQRFDKKLTDAERK
IEQFKGSLQFFKATTKYAKYLGTAGMRFRNIMFQGQPFATKEKIKDIYYSFNTTYNLGNRIEGTREALIRQLNQKVGSEL
RTKWVEEAVQNLSQEELHNLFKNEPREFKDNDEEFKFLARQIVMKELKPVRNAIMRNRFLSINAQYVQMLRSFPKWYDLK
KVGVTEAEWDNHVDKVVNGLKEHQLTMVDTTAYLYLYDLITGKKGDRSMRYAFIDEIQDYNAFQLAYIRFNFPRAKFTLL
GDLNQSIYANETSDTLLAELSTMFDPEKTEVVQLSKSYRSTQQITDFTKEILVKGEAIESFNRAGELPTVSINSSHQGMV
EAVIEQLHRDRQDHETSAIIGRSYAECEQIADELKAAGEQVTLIRTENQRLVEGTIVVPSFLAKGLEFDSVIVWNTSAKI
YQTNRDEQLLYTICSRAMHRLLIVAENDLSPLITKIPENLYIKKA

Sequences:

>Translated_765_residues
MAEGIFEYENRHLDEVLDKVDTAIAKAENDADNAEKDRSAIDKNFYNDVRINTSSYSGMMDTAISIRQQQQLLSERENSW
QHANKRLTTFKEMKKRPYFARIDFHEKGEKKDETIYIGLASFSDTADHFLIYDWRAPISSVYYDGKMGDVEYATPDGTQT
VDLKLKRQFTIEDGKLISVYDTDETIGDQMLLNALGSQSDVKMKSIVSTIQREQNKIIRNTAADLLFVQGAAGSGKTAAI
LQRVAFLLYRYRGNLNAGQVIMFSPNQLFNDYVDQVLPELGEQNMIQMTYYQFTRRRIPNIDVENLQQRFDKKLTDAERK
IEQFKGSLQFFKATTKYAKYLGTAGMRFRNIMFQGQPFATKEKIKDIYYSFNTTYNLGNRIEGTREALIRQLNQKVGSEL
RTKWVEEAVQNLSQEELHNLFKNEPREFKDNDEEFKFLARQIVMKELKPVRNAIMRNRFLSINAQYVQMLRSFPKWYDLK
KVGVTEAEWDNHVDKVVNGLKEHQLTMVDTTAYLYLYDLITGKKGDRSMRYAFIDEIQDYNAFQLAYIRFNFPRAKFTLL
GDLNQSIYANETSDTLLAELSTMFDPEKTEVVQLSKSYRSTQQITDFTKEILVKGEAIESFNRAGELPTVSINSSHQGMV
EAVIEQLHRDRQDHETSAIIGRSYAECEQIADELKAAGEQVTLIRTENQRLVEGTIVVPSFLAKGLEFDSVIVWNTSAKI
YQTNRDEQLLYTICSRAMHRLLIVAENDLSPLITKIPENLYIKKA
>Mature_764_residues
AEGIFEYENRHLDEVLDKVDTAIAKAENDADNAEKDRSAIDKNFYNDVRINTSSYSGMMDTAISIRQQQQLLSERENSWQ
HANKRLTTFKEMKKRPYFARIDFHEKGEKKDETIYIGLASFSDTADHFLIYDWRAPISSVYYDGKMGDVEYATPDGTQTV
DLKLKRQFTIEDGKLISVYDTDETIGDQMLLNALGSQSDVKMKSIVSTIQREQNKIIRNTAADLLFVQGAAGSGKTAAIL
QRVAFLLYRYRGNLNAGQVIMFSPNQLFNDYVDQVLPELGEQNMIQMTYYQFTRRRIPNIDVENLQQRFDKKLTDAERKI
EQFKGSLQFFKATTKYAKYLGTAGMRFRNIMFQGQPFATKEKIKDIYYSFNTTYNLGNRIEGTREALIRQLNQKVGSELR
TKWVEEAVQNLSQEELHNLFKNEPREFKDNDEEFKFLARQIVMKELKPVRNAIMRNRFLSINAQYVQMLRSFPKWYDLKK
VGVTEAEWDNHVDKVVNGLKEHQLTMVDTTAYLYLYDLITGKKGDRSMRYAFIDEIQDYNAFQLAYIRFNFPRAKFTLLG
DLNQSIYANETSDTLLAELSTMFDPEKTEVVQLSKSYRSTQQITDFTKEILVKGEAIESFNRAGELPTVSINSSHQGMVE
AVIEQLHRDRQDHETSAIIGRSYAECEQIADELKAAGEQVTLIRTENQRLVEGTIVVPSFLAKGLEFDSVIVWNTSAKIY
QTNRDEQLLYTICSRAMHRLLIVAENDLSPLITKIPENLYIKKA

Specific function: Catalyzes the unwinding of duplex DNA in the 3' to 5' direction; this reaction is dependent on the hydrolysis of ATP [H]

COG id: COG3973

COG function: function code R; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase ATP-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 88420; Mature: 88289

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEGIFEYENRHLDEVLDKVDTAIAKAENDADNAEKDRSAIDKNFYNDVRINTSSYSGMM
CCCCCHHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCCHH
DTAISIRQQQQLLSERENSWQHANKRLTTFKEMKKRPYFARIDFHEKGEKKDETIYIGLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHCCCCCCCEEEEEEE
SFSDTADHFLIYDWRAPISSVYYDGKMGDVEYATPDGTQTVDLKLKRQFTIEDGKLISVY
CCCCCCCCEEEEECCCCHHHHEECCCCCCCEECCCCCCEEEEEEEEEEEEECCCCEEEEE
DTDETIGDQMLLNALGSQSDVKMKSIVSTIQREQNKIIRNTAADLLFVQGAAGSGKTAAI
CCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHH
LQRVAFLLYRYRGNLNAGQVIMFSPNQLFNDYVDQVLPELGEQNMIQMTYYQFTRRRIPN
HHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHCCCC
IDVENLQQRFDKKLTDAERKIEQFKGSLQFFKATTKYAKYLGTAGMRFRNIMFQGQPFAT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHEECCCCCCH
KEKIKDIYYSFNTTYNLGNRIEGTREALIRQLNQKVGSELRTKWVEEAVQNLSQEELHNL
HHHHHHHHHHCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
FKNEPREFKDNDEEFKFLARQIVMKELKPVRNAIMRNRFLSINAQYVQMLRSFPKWYDLK
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHCHH
KVGVTEAEWDNHVDKVVNGLKEHQLTMVDTTAYLYLYDLITGKKGDRSMRYAFIDEIQDY
HCCCCHHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCC
NAFQLAYIRFNFPRAKFTLLGDLNQSIYANETSDTLLAELSTMFDPEKTEVVQLSKSYRS
CCEEEEEEEEECCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHH
TQQITDFTKEILVKGEAIESFNRAGELPTVSINSSHQGMVEAVIEQLHRDRQDHETSAII
HHHHHHHHHHHHHCCHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHCHHHHHHHHHH
GRSYAECEQIADELKAAGEQVTLIRTENQRLVEGTIVVPSFLAKGLEFDSVIVWNTSAKI
CCCHHHHHHHHHHHHHCCCEEEEEEECCCEEEEEEEEHHHHHHCCCCCCEEEEEECCCEE
YQTNRDEQLLYTICSRAMHRLLIVAENDLSPLITKIPENLYIKKA
EECCCCHHHHHHHHHHHHHHEEEEECCCCCHHHHHCCCCCEEECC
>Mature Secondary Structure 
AEGIFEYENRHLDEVLDKVDTAIAKAENDADNAEKDRSAIDKNFYNDVRINTSSYSGMM
CCCCHHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCCHH
DTAISIRQQQQLLSERENSWQHANKRLTTFKEMKKRPYFARIDFHEKGEKKDETIYIGLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHCCCCCCCEEEEEEE
SFSDTADHFLIYDWRAPISSVYYDGKMGDVEYATPDGTQTVDLKLKRQFTIEDGKLISVY
CCCCCCCCEEEEECCCCHHHHEECCCCCCCEECCCCCCEEEEEEEEEEEEECCCCEEEEE
DTDETIGDQMLLNALGSQSDVKMKSIVSTIQREQNKIIRNTAADLLFVQGAAGSGKTAAI
CCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHH
LQRVAFLLYRYRGNLNAGQVIMFSPNQLFNDYVDQVLPELGEQNMIQMTYYQFTRRRIPN
HHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHCCCC
IDVENLQQRFDKKLTDAERKIEQFKGSLQFFKATTKYAKYLGTAGMRFRNIMFQGQPFAT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHEECCCCCCH
KEKIKDIYYSFNTTYNLGNRIEGTREALIRQLNQKVGSELRTKWVEEAVQNLSQEELHNL
HHHHHHHHHHCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
FKNEPREFKDNDEEFKFLARQIVMKELKPVRNAIMRNRFLSINAQYVQMLRSFPKWYDLK
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHCHH
KVGVTEAEWDNHVDKVVNGLKEHQLTMVDTTAYLYLYDLITGKKGDRSMRYAFIDEIQDY
HCCCCHHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCC
NAFQLAYIRFNFPRAKFTLLGDLNQSIYANETSDTLLAELSTMFDPEKTEVVQLSKSYRS
CCEEEEEEEEECCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHH
TQQITDFTKEILVKGEAIESFNRAGELPTVSINSSHQGMVEAVIEQLHRDRQDHETSAII
HHHHHHHHHHHHHCCHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHCHHHHHHHHHH
GRSYAECEQIADELKAAGEQVTLIRTENQRLVEGTIVVPSFLAKGLEFDSVIVWNTSAKI
CCCHHHHHHHHHHHHHCCCEEEEEEECCCEEEEEEEEHHHHHHCCCCCCEEEEEECCCEE
YQTNRDEQLLYTICSRAMHRLLIVAENDLSPLITKIPENLYIKKA
EECCCCHHHHHHHHHHHHHHEEEEECCCCCHHHHHCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]