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The map label for this gene is gmk [H]

Identifier: 116492188

GI number: 116492188

Start: 432400

End: 432981

Strand: Direct

Name: gmk [H]

Synonym: PEPE_0385

Alternate gene names: 116492188

Gene position: 432400-432981 (Clockwise)

Preceding gene: 116492186

Following gene: 116492189

Centisome position: 23.6

GC content: 38.32

Gene sequence:

>582_bases
ATGGATAAAGTTATTGTGATTGCTGGACCAACTGGATCGGGAAAAACGACGATTGCCGATTACCTTTACCAAAAATATGG
AGTGATTAAGGTAATTACCCACACTACGAGACCAAAAAGAAAAAATGAGCAATCAGGAATCGATTATTACTTTGAAACAG
ACGAGACATTTGATGATAACCATTACTTAGAACAGGTGCAGTATTCTTACTATCGATATGGTTCTTCGTATGAGGGCCTT
CGACGTGCTTGGTCAAAAAATTCAATTGCTAGTATTGTATTAGACACAGCTGGAGCAATAACTTACCTTAAAGAGTTAGG
GGCACAGGTGGAAATCTTATTTTTACGGGTAAACGAAGAAAAAACTTTGAAGGATCGATTGTTAAAACGTGGTGATAGCT
TAGAGGCAATCCAAAAAAGAATTGACAGTCCCGAATATCGACGCGACATGCAGTTGCCAGAAGAGCTTCAAGGGCGGGCG
ACGGTCATTAATAACGATGATTGGGAGCACACCAAACAAAAAATTGATCAATTTTATCAAAGAGTTAAAGAAGCAACCAA
AAAGATACCAAATGAAGGTTAA

Upstream 100 bases:

>100_bases
GTATTTTAGAAAGCTTTGAAAAGCGCTTTCATTTGTTAGGATACTTTAATTTACAATATTTTTGGAAAAAATGCAACTAT
TTTGAATTGAGGAGTTAAAA

Downstream 100 bases:

>100_bases
TTATGGTAGGGTAAAACGTAATGATTACTATTTAGAGGTGCAGATTTTTGAACAAAACTAGTAAAGAAATTGCGGTAAAA
ATTTTAAAAGCTAATAACTA

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 193; Mature: 193

Protein sequence:

>193_residues
MDKVIVIAGPTGSGKTTIADYLYQKYGVIKVITHTTRPKRKNEQSGIDYYFETDETFDDNHYLEQVQYSYYRYGSSYEGL
RRAWSKNSIASIVLDTAGAITYLKELGAQVEILFLRVNEEKTLKDRLLKRGDSLEAIQKRIDSPEYRRDMQLPEELQGRA
TVINNDDWEHTKQKIDQFYQRVKEATKKIPNEG

Sequences:

>Translated_193_residues
MDKVIVIAGPTGSGKTTIADYLYQKYGVIKVITHTTRPKRKNEQSGIDYYFETDETFDDNHYLEQVQYSYYRYGSSYEGL
RRAWSKNSIASIVLDTAGAITYLKELGAQVEILFLRVNEEKTLKDRLLKRGDSLEAIQKRIDSPEYRRDMQLPEELQGRA
TVINNDDWEHTKQKIDQFYQRVKEATKKIPNEG
>Mature_193_residues
MDKVIVIAGPTGSGKTTIADYLYQKYGVIKVITHTTRPKRKNEQSGIDYYFETDETFDDNHYLEQVQYSYYRYGSSYEGL
RRAWSKNSIASIVLDTAGAITYLKELGAQVEILFLRVNEEKTLKDRLLKRGDSLEAIQKRIDSPEYRRDMQLPEELQGRA
TVINNDDWEHTKQKIDQFYQRVKEATKKIPNEG

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874831, Length=192, Percent_Identity=29.6875, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI226874833, Length=192, Percent_Identity=29.6875, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI4504221, Length=192, Percent_Identity=29.6875, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6320662, Length=187, Percent_Identity=28.3422459893048, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21356141, Length=193, Percent_Identity=26.4248704663212, Blast_Score=67, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 22473; Mature: 22473

Theoretical pI: Translated: 7.71; Mature: 7.71

Prosite motif: PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKVIVIAGPTGSGKTTIADYLYQKYGVIKVITHTTRPKRKNEQSGIDYYFETDETFDDN
CCCEEEEECCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCEEECCCCCCCCH
HYLEQVQYSYYRYGSSYEGLRRAWSKNSIASIVLDTAGAITYLKELGAQVEILFLRVNEE
HHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCC
KTLKDRLLKRGDSLEAIQKRIDSPEYRRDMQLPEELQGRATVINNDDWEHTKQKIDQFYQ
HHHHHHHHHCCCCHHHHHHHCCCHHHHHHCCCCHHHCCCEEEECCCCHHHHHHHHHHHHH
RVKEATKKIPNEG
HHHHHHHCCCCCC
>Mature Secondary Structure
MDKVIVIAGPTGSGKTTIADYLYQKYGVIKVITHTTRPKRKNEQSGIDYYFETDETFDDN
CCCEEEEECCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCEEECCCCCCCCH
HYLEQVQYSYYRYGSSYEGLRRAWSKNSIASIVLDTAGAITYLKELGAQVEILFLRVNEE
HHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCC
KTLKDRLLKRGDSLEAIQKRIDSPEYRRDMQLPEELQGRATVINNDDWEHTKQKIDQFYQ
HHHHHHHHHCCCCHHHHHHHCCCHHHHHHCCCCHHHCCCEEEECCCCHHHHHHHHHHHHH
RVKEATKKIPNEG
HHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12663928 [H]