Click here to switch to the map view.

The map label for this gene is pbuG [H]

Identifier: 116492184

GI number: 116492184

Start: 428628

End: 429974

Strand: Direct

Name: pbuG [H]

Synonym: PEPE_0381

Alternate gene names: 116492184

Gene position: 428628-429974 (Clockwise)

Preceding gene: 116492180

Following gene: 116492186

Centisome position: 23.39

GC content: 40.24

Gene sequence:

>1347_bases
ATGGATCAAAAATTGGATGATAATGCTTCATATGGATTATTAGACCGAACGTTTCATCTTACAGAACAACATACTACGGT
TAAAAGAGAAATTTTAGCCGGTTTAACGACTTTTGTTTCAATGGCATACATTTTGTTTGTTAATCCTACAATCCTAGGGC
AAGCCGGGATGGATAAAGGAGCGGTTTTCACAGCAACGGCCATTTCAGCAATTATCGGCTGTGCGTTGATGGCTTTTCTT
GCAAATTATCCGATTGCGATTGCGCCTGGATTGGGTGACAATGCCTTTTTCACTTTCTCAGTTGTTTTAGGAATGGGAAT
TCCATGGGAAAAGGCGATGGCCGGAGTATTTATTGCTTCTGTTTTATTCACAATTTTATCCTTCCTCAAAGTACGTGAAA
TTGTGATTGATTCAATTTCTAAAGATCTCAAATTAGCTATGGCGGCTGGGATTGGGATCTTCATTGCGTTTATCGGGCTG
CAAGGCGGTGGATTAGTTACAGCAAGTAAGACCTCATTAGTTGAGATGGGTTCCTTGTCCGTTCCCACAACGTGGTTAAC
CATTTTTGGAATTTTTGTAATCGCGATTTTAATGGCGAAAAAAGTGCCAGGTTCAATCTTTATCGGTTTAGTTTCCACTG
CGATTTTAGGGTTGGTGACAGGTTTGATTAAAATGCCGGAGCATTTGATTTCCCTTGCTCCTAGTATGAAACCAACATTT
GGAGTGGGAATTGCTCATTTGCCTTCAATCGCTGACCCTGAGATGTGGGCCGTAGTTTTAATCTTATTGCTAGTTGCGTT
TTTTGATACCGCTGGTACTTTAATTGGGTTAGCTCAACAAGCTGGAATTATGAAAAACAATAAAATGCCACGAATTGGAC
AGGCTCTAATGGCAGATTCAATTTCAATGTTAGCTGGATCAGTAATGGGAACTACACCCACAGCAACTTATGTGGAATCA
TCTGCCGGTATTGCAGTTGGTGGACGAACAGGACTGACTTCTCTAACCGTTGGAATCTTGTTTGTATTTAGTATGTTTTT
CTCACCACTTTTAACAGTCGTTACAACGCAAGTAACTGCACCAGCTCTAATCGTGGTTGGGGTATTGATGGCTTCTGCGC
TTCGTGAAATTAATTGGGATAAATTTGAAATTGCTATGCCAGCCTTCCTCACCATTATTGGAATGCCATTGACTTACAAT
ATTTCCTACGGAATGGCATTTGGATTCTTAACTTATCCAATCTTAATGACCGTTGCTGGTCGCCGTAAGGAAGTTAATTA
CGTTGTTTGGATTTTAATGGTCGCTTTCGCACTAATGCTATATGTGCTTAATAAACTTCCAAATTAG

Upstream 100 bases:

>100_bases
TTATAAGCATCTATAAACGAACATTAGGTGTTGAAAACAACATTAAAGTATGGAATAATATGGAAGTTGATAAAAAAGAT
TTTGATGGGGGAACGAAATA

Downstream 100 bases:

>100_bases
TATGAAATAAATTAAAAGAGTTGTGATTAAAGACATTTGCCTTTATCACAACTCTTTTTTTATTGGGCCAGTTTACTATG
ATGAATTCCATAACTAAAGT

Product: xanthine/uracil/vitamin C permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MDQKLDDNASYGLLDRTFHLTEQHTTVKREILAGLTTFVSMAYILFVNPTILGQAGMDKGAVFTATAISAIIGCALMAFL
ANYPIAIAPGLGDNAFFTFSVVLGMGIPWEKAMAGVFIASVLFTILSFLKVREIVIDSISKDLKLAMAAGIGIFIAFIGL
QGGGLVTASKTSLVEMGSLSVPTTWLTIFGIFVIAILMAKKVPGSIFIGLVSTAILGLVTGLIKMPEHLISLAPSMKPTF
GVGIAHLPSIADPEMWAVVLILLLVAFFDTAGTLIGLAQQAGIMKNNKMPRIGQALMADSISMLAGSVMGTTPTATYVES
SAGIAVGGRTGLTSLTVGILFVFSMFFSPLLTVVTTQVTAPALIVVGVLMASALREINWDKFEIAMPAFLTIIGMPLTYN
ISYGMAFGFLTYPILMTVAGRRKEVNYVVWILMVAFALMLYVLNKLPN

Sequences:

>Translated_448_residues
MDQKLDDNASYGLLDRTFHLTEQHTTVKREILAGLTTFVSMAYILFVNPTILGQAGMDKGAVFTATAISAIIGCALMAFL
ANYPIAIAPGLGDNAFFTFSVVLGMGIPWEKAMAGVFIASVLFTILSFLKVREIVIDSISKDLKLAMAAGIGIFIAFIGL
QGGGLVTASKTSLVEMGSLSVPTTWLTIFGIFVIAILMAKKVPGSIFIGLVSTAILGLVTGLIKMPEHLISLAPSMKPTF
GVGIAHLPSIADPEMWAVVLILLLVAFFDTAGTLIGLAQQAGIMKNNKMPRIGQALMADSISMLAGSVMGTTPTATYVES
SAGIAVGGRTGLTSLTVGILFVFSMFFSPLLTVVTTQVTAPALIVVGVLMASALREINWDKFEIAMPAFLTIIGMPLTYN
ISYGMAFGFLTYPILMTVAGRRKEVNYVVWILMVAFALMLYVLNKLPN
>Mature_448_residues
MDQKLDDNASYGLLDRTFHLTEQHTTVKREILAGLTTFVSMAYILFVNPTILGQAGMDKGAVFTATAISAIIGCALMAFL
ANYPIAIAPGLGDNAFFTFSVVLGMGIPWEKAMAGVFIASVLFTILSFLKVREIVIDSISKDLKLAMAAGIGIFIAFIGL
QGGGLVTASKTSLVEMGSLSVPTTWLTIFGIFVIAILMAKKVPGSIFIGLVSTAILGLVTGLIKMPEHLISLAPSMKPTF
GVGIAHLPSIADPEMWAVVLILLLVAFFDTAGTLIGLAQQAGIMKNNKMPRIGQALMADSISMLAGSVMGTTPTATYVES
SAGIAVGGRTGLTSLTVGILFVFSMFFSPLLTVVTTQVTAPALIVVGVLMASALREINWDKFEIAMPAFLTIIGMPLTYN
ISYGMAFGFLTYPILMTVAGRRKEVNYVVWILMVAFALMLYVLNKLPN

Specific function: Involved in the uptake of the purine bases hypoxanthine and guanine [H]

COG id: COG2252

COG function: function code R; Permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. AzgA purine transporter (TC 2.A.1.40) subfamily [H]

Homologues:

Organism=Escherichia coli, GI87082309, Length=445, Percent_Identity=39.7752808988764, Blast_Score=329, Evalue=2e-91,
Organism=Escherichia coli, GI1790150, Length=444, Percent_Identity=38.963963963964, Blast_Score=308, Evalue=5e-85,
Organism=Escherichia coli, GI1790499, Length=435, Percent_Identity=35.1724137931034, Blast_Score=218, Evalue=5e-58,
Organism=Escherichia coli, GI48994909, Length=438, Percent_Identity=34.9315068493151, Blast_Score=202, Evalue=3e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 47609; Mature: 47609

Theoretical pI: Translated: 8.86; Mature: 8.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQKLDDNASYGLLDRTFHLTEQHTTVKREILAGLTTFVSMAYILFVNPTILGQAGMDKG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCC
AVFTATAISAIIGCALMAFLANYPIAIAPGLGDNAFFTFSVVLGMGIPWEKAMAGVFIAS
CCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHH
VLFTILSFLKVREIVIDSISKDLKLAMAAGIGIFIAFIGLQGGGLVTASKTSLVEMGSLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHCCCCC
VPTTWLTIFGIFVIAILMAKKVPGSIFIGLVSTAILGLVTGLIKMPEHLISLAPSMKPTF
CCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GVGIAHLPSIADPEMWAVVLILLLVAFFDTAGTLIGLAQQAGIMKNNKMPRIGQALMADS
CCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHCCCCCCHHHHHHHHHH
ISMLAGSVMGTTPTATYVESSAGIAVGGRTGLTSLTVGILFVFSMFFSPLLTVVTTQVTA
HHHHHHHHCCCCCCHHHEECCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PALIVVGVLMASALREINWDKFEIAMPAFLTIIGMPLTYNISYGMAFGFLTYPILMTVAG
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHHHCC
RRKEVNYVVWILMVAFALMLYVLNKLPN
CCCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDQKLDDNASYGLLDRTFHLTEQHTTVKREILAGLTTFVSMAYILFVNPTILGQAGMDKG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCC
AVFTATAISAIIGCALMAFLANYPIAIAPGLGDNAFFTFSVVLGMGIPWEKAMAGVFIAS
CCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHH
VLFTILSFLKVREIVIDSISKDLKLAMAAGIGIFIAFIGLQGGGLVTASKTSLVEMGSLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHCCCCC
VPTTWLTIFGIFVIAILMAKKVPGSIFIGLVSTAILGLVTGLIKMPEHLISLAPSMKPTF
CCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GVGIAHLPSIADPEMWAVVLILLLVAFFDTAGTLIGLAQQAGIMKNNKMPRIGQALMADS
CCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHCCCCCCHHHHHHHHHH
ISMLAGSVMGTTPTATYVESSAGIAVGGRTGLTSLTVGILFVFSMFFSPLLTVVTTQVTA
HHHHHHHHCCCCCCHHHEECCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PALIVVGVLMASALREINWDKFEIAMPAFLTIIGMPLTYNISYGMAFGFLTYPILMTVAG
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHHHCC
RRKEVNYVVWILMVAFALMLYVLNKLPN
CCCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969499; 9384377; 11591660 [H]