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The map label for this gene is map [H]

Identifier: 116492178

GI number: 116492178

Start: 420992

End: 421774

Strand: Direct

Name: map [H]

Synonym: PEPE_0375

Alternate gene names: 116492178

Gene position: 420992-421774 (Clockwise)

Preceding gene: 116492177

Following gene: 116492180

Centisome position: 22.98

GC content: 40.49

Gene sequence:

>783_bases
ATGATTACATTAAAGTCAGAACGAGAAATTGAAGGAATGAGAAAGGCCGGTGCAGTACTTGCTGGTATGCATATCGGACT
TCGTGACATTATTAAACCAGGTATCTCAAGCTGGGAAATTGAAAAGTTTGCATTAAAATACTTAGACAAAAACGGTGCTG
TTCCTGAAGAAAAGGGATTTGAAGGCTACGAATATGCAACCTGTGTAAGTGTTAATAATGAAGTTTGTCATGGCTTTCCA
CGTAAGGGTTTAATCCTTAAAGAAGGCGACTTAGTTAAGGTTGATACAGTTGTTAGTGTGGATGGCTACATGTCTGACTC
ATGCTGGGCTTTTGCTGTTGGCGAAGTTAGCGATGAAGTTAAAAAATTAATGGAAGTTACTAAAAAGGCTTTATATCTTG
GGATTGACCAAGCTGTAGAAGGCAACCGAATTGGTGATATTGGTCATGCAATTCAATCATATGTTGAAGATGAAATGGGT
TATGGCGATGTTCGTGAATTCGTGGGACATGGTATCCAACCTACAATGCATGAAGATCCAATGGTCCCAGGATACGGTGA
AGCTGGACATGGTCCTCGCTTGAAGAATGGTATGACGATTACAATTGAACCCATGGTTAATGTTGGGGGATGGCAATGTG
ATACTTCCGCTCCAGATGGTTGGACTGTTACTACAATGGATGGTAGTCTCTCTTGTCAATACGAACACACACTAGTAATC
ACACCAGACGGTCCTAAGATTTTAACATCTCAAGATCCTGTTGAAGATGCTAAGTATTTGTAG

Upstream 100 bases:

>100_bases
CGTATGTAGGTACTTATACTGGTAGTAAAGCGATTGGACTAATTTGGTCGCCAAAATTGTGATAGTATAGACGTTAGTTA
TTAAGAAACGGGTGGATAGA

Downstream 100 bases:

>100_bases
AAGCAAAAAAGGAAGCCTTGACTTTTTTAGTCGAGACTTCCTTTTGTTTTTGATGCTAAAATGGTTACATCCTAATCATT
ATTTTAGTAATTAGCGATTT

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 260; Mature: 260

Protein sequence:

>260_residues
MITLKSEREIEGMRKAGAVLAGMHIGLRDIIKPGISSWEIEKFALKYLDKNGAVPEEKGFEGYEYATCVSVNNEVCHGFP
RKGLILKEGDLVKVDTVVSVDGYMSDSCWAFAVGEVSDEVKKLMEVTKKALYLGIDQAVEGNRIGDIGHAIQSYVEDEMG
YGDVREFVGHGIQPTMHEDPMVPGYGEAGHGPRLKNGMTITIEPMVNVGGWQCDTSAPDGWTVTTMDGSLSCQYEHTLVI
TPDGPKILTSQDPVEDAKYL

Sequences:

>Translated_260_residues
MITLKSEREIEGMRKAGAVLAGMHIGLRDIIKPGISSWEIEKFALKYLDKNGAVPEEKGFEGYEYATCVSVNNEVCHGFP
RKGLILKEGDLVKVDTVVSVDGYMSDSCWAFAVGEVSDEVKKLMEVTKKALYLGIDQAVEGNRIGDIGHAIQSYVEDEMG
YGDVREFVGHGIQPTMHEDPMVPGYGEAGHGPRLKNGMTITIEPMVNVGGWQCDTSAPDGWTVTTMDGSLSCQYEHTLVI
TPDGPKILTSQDPVEDAKYL
>Mature_260_residues
MITLKSEREIEGMRKAGAVLAGMHIGLRDIIKPGISSWEIEKFALKYLDKNGAVPEEKGFEGYEYATCVSVNNEVCHGFP
RKGLILKEGDLVKVDTVVSVDGYMSDSCWAFAVGEVSDEVKKLMEVTKKALYLGIDQAVEGNRIGDIGHAIQSYVEDEMG
YGDVREFVGHGIQPTMHEDPMVPGYGEAGHGPRLKNGMTITIEPMVNVGGWQCDTSAPDGWTVTTMDGSLSCQYEHTLVI
TPDGPKILTSQDPVEDAKYL

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=250, Percent_Identity=37.2, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI40385867, Length=248, Percent_Identity=31.4516129032258, Blast_Score=127, Evalue=8e-30,
Organism=Escherichia coli, GI1786364, Length=249, Percent_Identity=41.3654618473896, Blast_Score=184, Evalue=7e-48,
Organism=Caenorhabditis elegans, GI71996291, Length=255, Percent_Identity=33.3333333333333, Blast_Score=132, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6323273, Length=258, Percent_Identity=34.1085271317829, Blast_Score=146, Evalue=3e-36,
Organism=Drosophila melanogaster, GI21355531, Length=250, Percent_Identity=34.8, Blast_Score=139, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24583427, Length=246, Percent_Identity=33.3333333333333, Blast_Score=134, Evalue=5e-32,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 28407; Mature: 28407

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITLKSEREIEGMRKAGAVLAGMHIGLRDIIKPGISSWEIEKFALKYLDKNGAVPEEKGF
CEECCCHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCC
EGYEYATCVSVNNEVCHGFPRKGLILKEGDLVKVDTVVSVDGYMSDSCWAFAVGEVSDEV
CCCCEEEEEECCCHHHCCCCCCCEEEECCCEEEEEEEEEECCCCCCCEEEEEEHHHHHHH
KKLMEVTKKALYLGIDQAVEGNRIGDIGHAIQSYVEDEMGYGDVREFVGHGIQPTMHEDP
HHHHHHHHHHHHHCCHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCC
MVPGYGEAGHGPRLKNGMTITIEPMVNVGGWQCDTSAPDGWTVTTMDGSLSCQYEHTLVI
CCCCCCCCCCCCCCCCCEEEEEEEEECCCCEEECCCCCCCEEEEEECCCEEEEEEEEEEE
TPDGPKILTSQDPVEDAKYL
CCCCCEEECCCCCCHHCCCC
>Mature Secondary Structure
MITLKSEREIEGMRKAGAVLAGMHIGLRDIIKPGISSWEIEKFALKYLDKNGAVPEEKGF
CEECCCHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCC
EGYEYATCVSVNNEVCHGFPRKGLILKEGDLVKVDTVVSVDGYMSDSCWAFAVGEVSDEV
CCCCEEEEEECCCHHHCCCCCCCEEEECCCEEEEEEEEEECCCCCCCEEEEEEHHHHHHH
KKLMEVTKKALYLGIDQAVEGNRIGDIGHAIQSYVEDEMGYGDVREFVGHGIQPTMHEDP
HHHHHHHHHHHHHCCHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCC
MVPGYGEAGHGPRLKNGMTITIEPMVNVGGWQCDTSAPDGWTVTTMDGSLSCQYEHTLVI
CCCCCCCCCCCCCCCCCEEEEEEEEECCCCEEECCCCCCCEEEEEECCCEEEEEEEEEEE
TPDGPKILTSQDPVEDAKYL
CCCCCEEECCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]