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The map label for this gene is mvaA [H]

Identifier: 116492062

GI number: 116492062

Start: 307018

End: 308250

Strand: Direct

Name: mvaA [H]

Synonym: PEPE_0258

Alternate gene names: 116492062

Gene position: 307018-308250 (Clockwise)

Preceding gene: 116492061

Following gene: 116492063

Centisome position: 16.76

GC content: 41.85

Gene sequence:

>1233_bases
ATGATAGAAGGCTACCACAAATTAACGCGTCAACAGCAACTCGAGCAATTAGCGCAGGAAACTGACGTTGATTTGTCTGA
ACTAACTGAATTAGCTATGGACTCAATTCATCAACAACAAATTGAAAATTATCTGACTGATTTTAATTTACCAGAAGGAA
TCGCAGTTAATTTAGTAGTTAACGGTCAAGCTTATGTAGTTCCCATGGTAACCGAAGAACCGTCAGTAATAGCGGCGGCT
AGTTATGGAGCTAAAATGGTCCAGCGAGCCGGAGGATTTTCGGCGAATAGTAGACGGATAATGTTGGGCCAGTTATTAAT
TAGCAGTGCGCAACCAGCCCCCATAATCGATTATGTAAAAAAACAAAAATCACATTTATTGAAGGTCGCTAATGCAGCCC
ACCCTTCGATGCAAGCTCGTGGAGGTGGCGCAAAAAATCTACGCATTCGGCAGTTAACCGCCACGAAACTGTCAGTTGAT
TTAATGGTTGATACGCGCGAAGCCATGGGAGCGAATACGATTAATTCCATGGTAGAGGCTGTTAAGAAAGATTTAGTAAC
ACAACAAATCGATGTTGATATGGCAATATTATCTAATTTAGCTGACCAAGCTCTGACAGAAGTTACGTGTCAAATTCCAG
TCAACCAACTGGGAGTAGAAGTGGCTAAAAAGATTAGTTTAGCTAGTGATTATGCACAAATTGACCCATATCGGGCAGCA
ACGCACAATAAAGGGATTATGAATGGAATTGATGCGGTTGTAATGGCGTCTGGTAACGATTGGCGAGCCATTGAGAGCGG
AGCCCACGCTTATGCTGCTCAAAATGGTCAATATCAAGGACTTAGTACGTGGGATGTAGTTGGTGATCAACTAGTTGGCA
GAATGGAATTACCATTACCAGTGGCAACCGTTGGTGGTTCGATTGGGATTAATACTCAAGCTCAGCTGAACTTAAAATTA
ATGCAAATTAAGAACGCTAAACAATTGGCGGAAGTAATTGCTGCGATTGGTTTAGCTCAGAATCTGGCCGCTTTGAGAGC
TATTGTGTCAGAGGGAATTCAATCAGGACATATGCGACTACAGGCTAAATCACTTTTAATAGAACACGGAGCGACTCAAG
CAGAGCTAGGAGATGCGGTTAACCGATTAGTCCAAGCTGAAAGAATTGATGCCAAAAATGCCCAACAAATTATTAAACAG
CTAAGAAAGAAGGATAATGATGAGCAAAGTTGA

Upstream 100 bases:

>100_bases
TACAAATGATTGACGCTGATCGAGTAATTTTTTCTGAAAGTGGCGTTCGGGAAGGAATCATTTCGGAGTACATCAATTTT
AGAAAAGAGGAATAGTTTTA

Downstream 100 bases:

>100_bases
AGTAAATGATACAGTAAAATCGCTTCTTGAAGAAGTTAATGCAAGTTTTCCAGGAGAAGTACGGATTGGTTTTGGTGAAG
AACAGGCCGGTTTTGTGCGT

Product: 3-hydroxy-3-methylglutaryl-coenzyme A reductase

Products: NA

Alternate protein names: HMG-CoA reductase [H]

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MIEGYHKLTRQQQLEQLAQETDVDLSELTELAMDSIHQQQIENYLTDFNLPEGIAVNLVVNGQAYVVPMVTEEPSVIAAA
SYGAKMVQRAGGFSANSRRIMLGQLLISSAQPAPIIDYVKKQKSHLLKVANAAHPSMQARGGGAKNLRIRQLTATKLSVD
LMVDTREAMGANTINSMVEAVKKDLVTQQIDVDMAILSNLADQALTEVTCQIPVNQLGVEVAKKISLASDYAQIDPYRAA
THNKGIMNGIDAVVMASGNDWRAIESGAHAYAAQNGQYQGLSTWDVVGDQLVGRMELPLPVATVGGSIGINTQAQLNLKL
MQIKNAKQLAEVIAAIGLAQNLAALRAIVSEGIQSGHMRLQAKSLLIEHGATQAELGDAVNRLVQAERIDAKNAQQIIKQ
LRKKDNDEQS

Sequences:

>Translated_410_residues
MIEGYHKLTRQQQLEQLAQETDVDLSELTELAMDSIHQQQIENYLTDFNLPEGIAVNLVVNGQAYVVPMVTEEPSVIAAA
SYGAKMVQRAGGFSANSRRIMLGQLLISSAQPAPIIDYVKKQKSHLLKVANAAHPSMQARGGGAKNLRIRQLTATKLSVD
LMVDTREAMGANTINSMVEAVKKDLVTQQIDVDMAILSNLADQALTEVTCQIPVNQLGVEVAKKISLASDYAQIDPYRAA
THNKGIMNGIDAVVMASGNDWRAIESGAHAYAAQNGQYQGLSTWDVVGDQLVGRMELPLPVATVGGSIGINTQAQLNLKL
MQIKNAKQLAEVIAAIGLAQNLAALRAIVSEGIQSGHMRLQAKSLLIEHGATQAELGDAVNRLVQAERIDAKNAQQIIKQ
LRKKDNDEQS
>Mature_410_residues
MIEGYHKLTRQQQLEQLAQETDVDLSELTELAMDSIHQQQIENYLTDFNLPEGIAVNLVVNGQAYVVPMVTEEPSVIAAA
SYGAKMVQRAGGFSANSRRIMLGQLLISSAQPAPIIDYVKKQKSHLLKVANAAHPSMQARGGGAKNLRIRQLTATKLSVD
LMVDTREAMGANTINSMVEAVKKDLVTQQIDVDMAILSNLADQALTEVTCQIPVNQLGVEVAKKISLASDYAQIDPYRAA
THNKGIMNGIDAVVMASGNDWRAIESGAHAYAAQNGQYQGLSTWDVVGDQLVGRMELPLPVATVGGSIGINTQAQLNLKL
MQIKNAKQLAEVIAAIGLAQNLAALRAIVSEGIQSGHMRLQAKSLLIEHGATQAELGDAVNRLVQAERIDAKNAQQIIKQ
LRKKDNDEQS

Specific function: P.mevalonii can use mevalonate as sole carbon source. With this enzyme mevalonate is deacetylated to HMG-CoA [H]

COG id: COG1257

COG function: function code I; Hydroxymethylglutaryl-CoA reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA reductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002202
- InterPro:   IPR004553
- InterPro:   IPR023074
- InterPro:   IPR023076
- InterPro:   IPR009023
- InterPro:   IPR009029 [H]

Pfam domain/function: PF00368 HMG-CoA_red [H]

EC number: =1.1.1.88 [H]

Molecular weight: Translated: 44284; Mature: 44284

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS50065 HMG_COA_REDUCTASE_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEGYHKLTRQQQLEQLAQETDVDLSELTELAMDSIHQQQIENYLTDFNLPEGIAVNLVV
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEE
NGQAYVVPMVTEEPSVIAAASYGAKMVQRAGGFSANSRRIMLGQLLISSAQPAPIIDYVK
CCCEEEEEEECCCCCEEEEHHHHHHHHHHCCCCCCCCCEEHHHHHHHCCCCCCHHHHHHH
KQKSHLLKVANAAHPSMQARGGGAKNLRIRQLTATKLSVDLMVDTREAMGANTINSMVEA
HHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEHHEEEEEEEEECHHHHCCHHHHHHHHH
VKKDLVTQQIDVDMAILSNLADQALTEVTCQIPVNQLGVEVAKKISLASDYAQIDPYRAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHH
THNKGIMNGIDAVVMASGNDWRAIESGAHAYAAQNGQYQGLSTWDVVGDQLVGRMELPLP
CCCCCHHCCCCEEEEECCCCCHHHHCCCHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCC
VATVGGSIGINTQAQLNLKLMQIKNAKQLAEVIAAIGLAQNLAALRAIVSEGIQSGHMRL
HHHCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHH
QAKSLLIEHGATQAELGDAVNRLVQAERIDAKNAQQIIKQLRKKDNDEQS
HHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MIEGYHKLTRQQQLEQLAQETDVDLSELTELAMDSIHQQQIENYLTDFNLPEGIAVNLVV
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEE
NGQAYVVPMVTEEPSVIAAASYGAKMVQRAGGFSANSRRIMLGQLLISSAQPAPIIDYVK
CCCEEEEEEECCCCCEEEEHHHHHHHHHHCCCCCCCCCEEHHHHHHHCCCCCCHHHHHHH
KQKSHLLKVANAAHPSMQARGGGAKNLRIRQLTATKLSVDLMVDTREAMGANTINSMVEA
HHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEHHEEEEEEEEECHHHHCCHHHHHHHHH
VKKDLVTQQIDVDMAILSNLADQALTEVTCQIPVNQLGVEVAKKISLASDYAQIDPYRAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHH
THNKGIMNGIDAVVMASGNDWRAIESGAHAYAAQNGQYQGLSTWDVVGDQLVGRMELPLP
CCCCCHHCCCCEEEEECCCCCHHHHCCCHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCC
VATVGGSIGINTQAQLNLKLMQIKNAKQLAEVIAAIGLAQNLAALRAIVSEGIQSGHMRL
HHHCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHH
QAKSLLIEHGATQAELGDAVNRLVQAERIDAKNAQQIIKQLRKKDNDEQS
HHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2656635; 2477360; 2123872; 1634543; 10377386 [H]