Click here to switch to the map view.

The map label for this gene is fabG [C]

Identifier: 116332533

GI number: 116332533

Start: 112008

End: 112763

Strand: Direct

Name: fabG [C]

Synonym: LBJ_4097

Alternate gene names: 116332533

Gene position: 112008-112763 (Clockwise)

Preceding gene: 116332530

Following gene: 116332536

Centisome position: 37.37

GC content: 42.46

Gene sequence:

>756_bases
TTGTCTCCGAAAAATCAGGAAACGAACAAAAAAAGAAATGTGATCCTTACCGGAGGAAGCGGAGGTTTGGGAAGAGCCGT
CGCTGAATCTCTTGTATTCGAAGGATATTCCGTGACCAATTTAGATATTCAAGTTCCGAAGGAAATTTTGTCGGGAGAAC
TTTTTCTGAATACGGATCTTACGAAAGATGAAGAACTTATTTCCTCGCTTTCCGAATGGGAAAATACGATTTCTACCCAA
AATCAAATTCCGTACGGTTTTGTTCACTGTGCCGGATATGGAGGGCCTTATCATAAAATCACTCAAGTCAGTCTGGAGGA
ATGGGATCGTATTTTTTCGATAAATATTCGTTCCTCTTTTCAGATTGCGAAGTTTCTTTTGCCTATATTCAAAAATTTGC
AATTAGGAAGATTGGTATTTATCGCCTCTTCTTTATCGCTGATCGGTTCTGCAAATTCAGTCGCGTATTCCTCATCGAAA
CACGCTTTGATCGGCTTTGTAAAATCTCTTGCGGATGAATGGGGCCCTTTCGGAATTACTGCGAATGCGGTCAGTCCGGG
TTATATGGAAACGTCGATGGGAATTCAGGAAGATCAAGTTTCCGATCATAGACAAAAAATCATTACCATGACTCCGTCCG
GCAAAATAGCGCATCCTTGCGAAATCGCGAGGGTCGTTGCTTTTATGTTGAACGAAAACTCCTCCTATATCAACGGTGCA
AACTGGGTCGTTGACGGGGGGATCACTGCGGTTTGA

Upstream 100 bases:

>100_bases
TCTTTCCAAAAGTTTTTCCATGAGAAACAAAAGAATCCTTGTGTCTTCCTCTGTCATCTAGAAATAGAGAGTAATAGATT
GCCTACTATGAGGTTATAGA

Downstream 100 bases:

>100_bases
AGAATTTGAAATTTAGGATATTTTCATATAAGAACCCGTCGAGCGCCAATAGAAGCGAGACGCTTTAGTTACCGCTTGAT
CTTTCTGATAAAGCAGAAAA

Product: Short chain dehydrogenase

Products: 3-oxoacyl-[acyl-carrier protein]; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 251; Mature: 250

Protein sequence:

>251_residues
MSPKNQETNKKRNVILTGGSGGLGRAVAESLVFEGYSVTNLDIQVPKEILSGELFLNTDLTKDEELISSLSEWENTISTQ
NQIPYGFVHCAGYGGPYHKITQVSLEEWDRIFSINIRSSFQIAKFLLPIFKNLQLGRLVFIASSLSLIGSANSVAYSSSK
HALIGFVKSLADEWGPFGITANAVSPGYMETSMGIQEDQVSDHRQKIITMTPSGKIAHPCEIARVVAFMLNENSSYINGA
NWVVDGGITAV

Sequences:

>Translated_251_residues
MSPKNQETNKKRNVILTGGSGGLGRAVAESLVFEGYSVTNLDIQVPKEILSGELFLNTDLTKDEELISSLSEWENTISTQ
NQIPYGFVHCAGYGGPYHKITQVSLEEWDRIFSINIRSSFQIAKFLLPIFKNLQLGRLVFIASSLSLIGSANSVAYSSSK
HALIGFVKSLADEWGPFGITANAVSPGYMETSMGIQEDQVSDHRQKIITMTPSGKIAHPCEIARVVAFMLNENSSYINGA
NWVVDGGITAV
>Mature_250_residues
SPKNQETNKKRNVILTGGSGGLGRAVAESLVFEGYSVTNLDIQVPKEILSGELFLNTDLTKDEELISSLSEWENTISTQN
QIPYGFVHCAGYGGPYHKITQVSLEEWDRIFSINIRSSFQIAKFLLPIFKNLQLGRLVFIASSLSLIGSANSVAYSSSKH
ALIGFVKSLADEWGPFGITANAVSPGYMETSMGIQEDQVSDHRQKIITMTPSGKIAHPCEIARVVAFMLNENSSYINGAN
WVVDGGITAV

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI15277342, Length=270, Percent_Identity=28.5185185185185, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI40254992, Length=237, Percent_Identity=29.957805907173, Blast_Score=84, Evalue=8e-17,
Organism=Homo sapiens, GI59889578, Length=207, Percent_Identity=25.1207729468599, Blast_Score=81, Evalue=9e-16,
Organism=Homo sapiens, GI32483357, Length=257, Percent_Identity=25.6809338521401, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI7705925, Length=239, Percent_Identity=26.7782426778243, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI66933014, Length=167, Percent_Identity=27.5449101796407, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI126723750, Length=261, Percent_Identity=24.5210727969349, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI4503817, Length=243, Percent_Identity=26.7489711934156, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI5031737, Length=261, Percent_Identity=26.8199233716475, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI10190704, Length=251, Percent_Identity=22.7091633466135, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1787335, Length=243, Percent_Identity=30.4526748971193, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI87082160, Length=258, Percent_Identity=26.7441860465116, Blast_Score=95, Evalue=3e-21,
Organism=Escherichia coli, GI1789208, Length=241, Percent_Identity=27.8008298755187, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI87082100, Length=254, Percent_Identity=25.9842519685039, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1786812, Length=246, Percent_Identity=26.4227642276423, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1789378, Length=250, Percent_Identity=26, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI2367365, Length=254, Percent_Identity=24.0157480314961, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1788459, Length=148, Percent_Identity=31.7567567567568, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1787905, Length=245, Percent_Identity=27.3469387755102, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1790717, Length=251, Percent_Identity=22.3107569721116, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI2367175, Length=253, Percent_Identity=25.6916996047431, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1787526, Length=247, Percent_Identity=24.6963562753036, Blast_Score=62, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI115534694, Length=258, Percent_Identity=29.0697674418605, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17561402, Length=265, Percent_Identity=26.7924528301887, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17555706, Length=244, Percent_Identity=27.0491803278689, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI25147288, Length=247, Percent_Identity=24.2914979757085, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17538182, Length=256, Percent_Identity=27.734375, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17560676, Length=165, Percent_Identity=28.4848484848485, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17559104, Length=267, Percent_Identity=28.4644194756554, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17560332, Length=272, Percent_Identity=31.25, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71994604, Length=249, Percent_Identity=28.1124497991968, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17562910, Length=270, Percent_Identity=28.8888888888889, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17508651, Length=263, Percent_Identity=22.8136882129278, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17562906, Length=272, Percent_Identity=30.5147058823529, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17551412, Length=265, Percent_Identity=27.9245283018868, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17562908, Length=272, Percent_Identity=29.7794117647059, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17536651, Length=255, Percent_Identity=25.8823529411765, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71994600, Length=249, Percent_Identity=26.5060240963855, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=251, Percent_Identity=22.7091633466135, Blast_Score=73, Evalue=5e-14,
Organism=Drosophila melanogaster, GI23397609, Length=247, Percent_Identity=28.3400809716599, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24639444, Length=245, Percent_Identity=26.9387755102041, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI21355319, Length=250, Percent_Identity=28.8, Blast_Score=94, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24643142, Length=241, Percent_Identity=28.6307053941909, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI28571526, Length=252, Percent_Identity=26.984126984127, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI17737361, Length=252, Percent_Identity=26.1904761904762, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24644337, Length=156, Percent_Identity=31.4102564102564, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI21357041, Length=152, Percent_Identity=26.9736842105263, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100

Molecular weight: Translated: 27366; Mature: 27235

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPKNQETNKKRNVILTGGSGGLGRAVAESLVFEGYSVTNLDIQVPKEILSGELFLNTDL
CCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCEEEEEEEECCHHHHCCEEEEECCC
TKDEELISSLSEWENTISTQNQIPYGFVHCAGYGGPYHKITQVSLEEWDRIFSINIRSSF
CCHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHEEECHHHCCEEEEEEECCHH
QIAKFLLPIFKNLQLGRLVFIASSLSLIGSANSVAYSSSKHALIGFVKSLADEWGPFGIT
HHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHCCCCCEE
ANAVSPGYMETSMGIQEDQVSDHRQKIITMTPSGKIAHPCEIARVVAFMLNENSSYINGA
ECCCCCCCCHHCCCCCHHHHHHHHCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCEECCC
NWVVDGGITAV
CEEECCCEECC
>Mature Secondary Structure 
SPKNQETNKKRNVILTGGSGGLGRAVAESLVFEGYSVTNLDIQVPKEILSGELFLNTDL
CCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCEEEEEEEECCHHHHCCEEEEECCC
TKDEELISSLSEWENTISTQNQIPYGFVHCAGYGGPYHKITQVSLEEWDRIFSINIRSSF
CCHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHEEECHHHCCEEEEEEECCHH
QIAKFLLPIFKNLQLGRLVFIASSLSLIGSANSVAYSSSKHALIGFVKSLADEWGPFGIT
HHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHCCCCCEE
ANAVSPGYMETSMGIQEDQVSDHRQKIITMTPSGKIAHPCEIARVVAFMLNENSSYINGA
ECCCCCCCCHHCCCCCHHHHHHHHCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCEECCC
NWVVDGGITAV
CEEECCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (3R)-3-hydroxyacyl-[acyl-carrier protein]; NADP+

Specific reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8796346; 9163424 [H]