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The map label for this gene is hisG [H]

Identifier: 116328721

GI number: 116328721

Start: 2454499

End: 2455116

Strand: Reverse

Name: hisG [H]

Synonym: LBL_2095

Alternate gene names: 116328721

Gene position: 2455116-2454499 (Counterclockwise)

Preceding gene: 116328722

Following gene: 116328720

Centisome position: 67.93

GC content: 47.9

Gene sequence:

>618_bases
ATGCTTACTCTGGCTTTGCCCAAAGGAAGACTAGCCGAAGAAAGCATCGATTTGATGATTTCCAAGGGATGGCTTTCCGC
AAAGCCCGATCCGGATTCTAAAGAGCTCATTTATAATGACCCCCTAGGAAAAATTCGGATTCTTCTTGTGCGTTCGCAAG
ACGTGGCGACTTACGTGGAACAATGTGCGGCGGATGCGGGGATCAGCGGCTGGGACGTCCTTAAGGAAGGCGGTTACGAT
TTGGCCACCCCTCTGGATTTGGGGATTGGAAAATGCAGACTTTCCCTCGCCGCTCCTGAAGGTTATACATTGGAAGCACG
TCATCGTAAGATCCGTGTTGCGACCAAGTATCCGAACTTAGCGAGAGAATTCTTTTTTCATAAAGGGTTGTCTTGCGAGA
TTTTTAAACTCTACGGAAGCATAGAACTGGCGCCGCTTGTCGGTCTTTCCGATTGTATCGTGGATTTGGTTTCGACCGGT
GGGACTCTTAAGGCTAACGGCCTCAAAGAGCTGAATATAATCTTAGAATCTTCCGCCAGATTGGTTTTCAACCGGTCTTC
TCTCTACGGAAAACGGAAGGAAGCTGCGGAGTTTATGGATTCTCTCTCCAAAATCTAA

Upstream 100 bases:

>100_bases
AAAAGGTATTGGATCAGGAAATCAAAACCCCGGCGAGAGATTACAACACCGTCAAACAATACGCTACGTTTTTACTTATA
CAACTCAATCAAAAAGGCTA

Downstream 100 bases:

>100_bases
AACAGACCATAAGAAGTATTTTGTTCAAAGTTCCACACGACTGTTTTTCTAGCGAAGAGCCCGTCTCAAAACCTTAGGAA
TATAAGAGCTTACAATGTAG

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 205; Mature: 205

Protein sequence:

>205_residues
MLTLALPKGRLAEESIDLMISKGWLSAKPDPDSKELIYNDPLGKIRILLVRSQDVATYVEQCAADAGISGWDVLKEGGYD
LATPLDLGIGKCRLSLAAPEGYTLEARHRKIRVATKYPNLAREFFFHKGLSCEIFKLYGSIELAPLVGLSDCIVDLVSTG
GTLKANGLKELNIILESSARLVFNRSSLYGKRKEAAEFMDSLSKI

Sequences:

>Translated_205_residues
MLTLALPKGRLAEESIDLMISKGWLSAKPDPDSKELIYNDPLGKIRILLVRSQDVATYVEQCAADAGISGWDVLKEGGYD
LATPLDLGIGKCRLSLAAPEGYTLEARHRKIRVATKYPNLAREFFFHKGLSCEIFKLYGSIELAPLVGLSDCIVDLVSTG
GTLKANGLKELNIILESSARLVFNRSSLYGKRKEAAEFMDSLSKI
>Mature_205_residues
MLTLALPKGRLAEESIDLMISKGWLSAKPDPDSKELIYNDPLGKIRILLVRSQDVATYVEQCAADAGISGWDVLKEGGYD
LATPLDLGIGKCRLSLAAPEGYTLEARHRKIRVATKYPNLAREFFFHKGLSCEIFKLYGSIELAPLVGLSDCIVDLVSTG
GTLKANGLKELNIILESSARLVFNRSSLYGKRKEAAEFMDSLSKI

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=193, Percent_Identity=38.860103626943, Blast_Score=96, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6320896, Length=194, Percent_Identity=26.2886597938144, Blast_Score=71, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198 [H]

Pfam domain/function: PF01634 HisG [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 22479; Mature: 22479

Theoretical pI: Translated: 7.92; Mature: 7.92

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTLALPKGRLAEESIDLMISKGWLSAKPDPDSKELIYNDPLGKIRILLVRSQDVATYVE
CEEEECCCCCCCHHHHHEEEECCCCCCCCCCCCCCEEEECCCCEEEEEEEECCHHHHHHH
QCAADAGISGWDVLKEGGYDLATPLDLGIGKCRLSLAAPEGYTLEARHRKIRVATKYPNL
HHHHHCCCCHHHHHHCCCCCCCCCHHCCCCEEEEEEECCCCCEEECCCCEEEEEECCCHH
AREFFFHKGLSCEIFKLYGSIELAPLVGLSDCIVDLVSTGGTLKANGLKELNIILESSAR
HHHHHHHCCCCEEEEEEECCEEEEHHCCHHHHHHHHHHCCCEEEECCCEEEEEEEECCCE
LVFNRSSLYGKRKEAAEFMDSLSKI
EEEECHHHCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MLTLALPKGRLAEESIDLMISKGWLSAKPDPDSKELIYNDPLGKIRILLVRSQDVATYVE
CEEEECCCCCCCHHHHHEEEECCCCCCCCCCCCCCEEEECCCCEEEEEEEECCHHHHHHH
QCAADAGISGWDVLKEGGYDLATPLDLGIGKCRLSLAAPEGYTLEARHRKIRVATKYPNL
HHHHHCCCCHHHHHHCCCCCCCCCHHCCCCEEEEEEECCCCCEEECCCCEEEEEECCCHH
AREFFFHKGLSCEIFKLYGSIELAPLVGLSDCIVDLVSTGGTLKANGLKELNIILESSAR
HHHHHHHCCCCEEEEEEECCEEEEHHCCHHHHHHHHHHCCCEEEECCCEEEEEEEECCCE
LVFNRSSLYGKRKEAAEFMDSLSKI
EEEECHHHCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA