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The map label for this gene is mpg1 [H]

Identifier: 116327929

GI number: 116327929

Start: 1430843

End: 1431556

Strand: Direct

Name: mpg1 [H]

Synonym: LBL_1215

Alternate gene names: 116327929

Gene position: 1430843-1431556 (Clockwise)

Preceding gene: 116327928

Following gene: 116327930

Centisome position: 39.59

GC content: 36.55

Gene sequence:

>714_bases
ATGTCTAAACGCGCGGTTATTCTAGCAGGTGGTAAAGGGACACGATTACGTCCTTATACTACTGTATTTCCTAAGCCATT
GATGCCTATTGGAGAATACCCTATCCTAGAAGTTATTGTTAAACAACTGGTAAAATCTGGATTTTCTCATATTACTTTGG
CTGTAAATCATCAAGCTCAATTGATCCAAGCTTTTTTCCAAGATGGAAGTAGGTGGAATACGAAGATTGATTATTCTTTA
GAGGATAAACCGTTGGGCACGATGGGACCGTTAAAGTTGATTTCTGATCTGCCAAATGATTTTTTAGTAATGAACGGAGA
CGTACTTACGGATATAGACTTTGCTAATTTTTATCAAGTGCATGTTCAATCGAAATCTATCTTTACTATATCATCCAAAA
AAAGACAACAGATGATTGATTATGGAGTCTTAGAAACAGATAACGATGGACTTCTAAGCGGTTTTCGAGAAAAGCCTGCG
CAAAGTTATGAAGTAAGCATGGGTGTGTATATGGTAAGCCAGGCAGCTCTAAATTTTATTCCTGAAGATAGCGTTTTTGG
ATTTGATAACCTAATGCTAAAATTAATTGAATTAGATAAACCTGTTTCAGTTCGACCGCATGAGGGCTATTGGTTAGACA
TTGGACGCCCAGACGATTATGAGAAAGCGATCGATGAATTTGAAATAATGAAAGATACCTTATTTCATGATTGA

Upstream 100 bases:

>100_bases
GCCTACAGTGGGTTAGAAGGATTTAAACGCGGTCTTACTGAAACTATTGAGTGGTTTCGATATCCTGAAAACTTAAAGAG
TTATAAGGCAGAAGTCTACA

Downstream 100 bases:

>100_bases
TGTACTGGTTTCCGGCGCCTCCGGATTTATCGGTAAACCTTTGATCGAAAAATTTCGAAATCAAGGTTTATCCGTTTTAG
CGCTCGATCGAAAGATGGGG

Product: nucleoside-diphosphate-sugar pyrophosphorylase

Products: NA

Alternate protein names: ATP-mannose-1-phosphate guanylyltransferase; GDP-mannose pyrophosphorylase; NDP-hexose pyrophosphorylase [H]

Number of amino acids: Translated: 237; Mature: 236

Protein sequence:

>237_residues
MSKRAVILAGGKGTRLRPYTTVFPKPLMPIGEYPILEVIVKQLVKSGFSHITLAVNHQAQLIQAFFQDGSRWNTKIDYSL
EDKPLGTMGPLKLISDLPNDFLVMNGDVLTDIDFANFYQVHVQSKSIFTISSKKRQQMIDYGVLETDNDGLLSGFREKPA
QSYEVSMGVYMVSQAALNFIPEDSVFGFDNLMLKLIELDKPVSVRPHEGYWLDIGRPDDYEKAIDEFEIMKDTLFHD

Sequences:

>Translated_237_residues
MSKRAVILAGGKGTRLRPYTTVFPKPLMPIGEYPILEVIVKQLVKSGFSHITLAVNHQAQLIQAFFQDGSRWNTKIDYSL
EDKPLGTMGPLKLISDLPNDFLVMNGDVLTDIDFANFYQVHVQSKSIFTISSKKRQQMIDYGVLETDNDGLLSGFREKPA
QSYEVSMGVYMVSQAALNFIPEDSVFGFDNLMLKLIELDKPVSVRPHEGYWLDIGRPDDYEKAIDEFEIMKDTLFHD
>Mature_236_residues
SKRAVILAGGKGTRLRPYTTVFPKPLMPIGEYPILEVIVKQLVKSGFSHITLAVNHQAQLIQAFFQDGSRWNTKIDYSLE
DKPLGTMGPLKLISDLPNDFLVMNGDVLTDIDFANFYQVHVQSKSIFTISSKKRQQMIDYGVLETDNDGLLSGFREKPAQ
SYEVSMGVYMVSQAALNFIPEDSVFGFDNLMLKLIELDKPVSVRPHEGYWLDIGRPDDYEKAIDEFEIMKDTLFHD

Specific function: Catalyzes The Formation Of Dtdp-Glucose, From Dttp And Glucose 1-Phosphate, As Well As Its Pyrophosphorolysis. [C]

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=225, Percent_Identity=33.3333333333333, Blast_Score=114, Evalue=5e-26,
Organism=Homo sapiens, GI11761619, Length=225, Percent_Identity=33.3333333333333, Blast_Score=114, Evalue=6e-26,
Organism=Homo sapiens, GI31881779, Length=192, Percent_Identity=29.6875, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI45447090, Length=192, Percent_Identity=29.6875, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI1788351, Length=229, Percent_Identity=27.0742358078603, Blast_Score=65, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI133931050, Length=240, Percent_Identity=34.1666666666667, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17509979, Length=186, Percent_Identity=32.7956989247312, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17509981, Length=173, Percent_Identity=30.635838150289, Blast_Score=73, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320148, Length=226, Percent_Identity=30.0884955752212, Blast_Score=108, Evalue=1e-24,
Organism=Drosophila melanogaster, GI21355443, Length=230, Percent_Identity=32.6086956521739, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24644084, Length=230, Percent_Identity=32.6086956521739, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24653912, Length=189, Percent_Identity=32.2751322751323, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.13 [H]

Molecular weight: Translated: 26875; Mature: 26744

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKRAVILAGGKGTRLRPYTTVFPKPLMPIGEYPILEVIVKQLVKSGFSHITLAVNHQAQ
CCCCEEEEECCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCHHH
LIQAFFQDGSRWNTKIDYSLEDKPLGTMGPLKLISDLPNDFLVMNGDVLTDIDFANFYQV
HHHHHHHCCCCCCCEEEEEECCCCCCCCCHHHHHHHCCCCEEEECCCEEEECCCCCEEEE
HVQSKSIFTISSKKRQQMIDYGVLETDNDGLLSGFREKPAQSYEVSMGVYMVSQAALNFI
EEECCEEEEECCHHHHHHHHCCCEECCCCHHHHHHHHCCCCCEEHHHHHHHHHHHHHHCC
PEDSVFGFDNLMLKLIELDKPVSVRPHEGYWLDIGRPDDYEKAIDEFEIMKDTLFHD
CCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SKRAVILAGGKGTRLRPYTTVFPKPLMPIGEYPILEVIVKQLVKSGFSHITLAVNHQAQ
CCCEEEEECCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCHHH
LIQAFFQDGSRWNTKIDYSLEDKPLGTMGPLKLISDLPNDFLVMNGDVLTDIDFANFYQV
HHHHHHHCCCCCCCEEEEEECCCCCCCCCHHHHHHHCCCCEEEECCCEEEECCCCCEEEE
HVQSKSIFTISSKKRQQMIDYGVLETDNDGLLSGFREKPAQSYEVSMGVYMVSQAALNFI
EEECCEEEEECCHHHHHHHHCCCEECCCCHHHHHHHHCCCCCEEHHHHHHHHHHHHHHCC
PEDSVFGFDNLMLKLIELDKPVSVRPHEGYWLDIGRPDDYEKAIDEFEIMKDTLFHD
CCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8334170 [H]