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The map label for this gene is csdB [H]

Identifier: 116327453

GI number: 116327453

Start: 747931

End: 749172

Strand: Direct

Name: csdB [H]

Synonym: LBL_0669

Alternate gene names: 116327453

Gene position: 747931-749172 (Clockwise)

Preceding gene: 116327452

Following gene: 116327454

Centisome position: 20.69

GC content: 45.97

Gene sequence:

>1242_bases
ATGAATTTCTCAGCCGAAAGAATTAGAACCGATTTCCCGATTTTGGGAACAATGATGAACGGAAAACCGCTCGTTTTTTT
GGACAGTGCGGCTAGTTCGCAAAAACCCTTTACGGTCATCGATAGAATCGAAAAGTATTATAGAGAAGAAAACGCAAATA
TACATCGTGGGATTTATTATCTTTCTCAAAAAGCCACGGAAAAATACGAGCTGAGTAGAATTCGTCTTTCCCGATTTATC
GGAGCCCAGTGTGCGAAGGTTTGTATCTTTACGAGAAACGCGACCGAATCGATCAATTTAGTCGCTCAGACTTGGGGAAG
GACTCAAGTCGAAGAAGGGGATGAGATCGTTTTGAACGAACTCGAACACCATTCCAACATCGTACCTTGGCAGATGCTCG
CTCAGGAAAAAAAAGCGGTATTAAGATTCATTCCGTTAAACGAAGACGGCACGTTGGATCTGAGCAATTTGGATGAGATC
ATCACGACTAAGACAAAGTTAGTCGCTGTTGCTCAGATGTCGAACGTGACCGGAACGATTCACGATCTTGCTTCGATTCA
AAAAAGAGCGAAAGAAGTAGGGGCTAAGGTTCTTGTGGACGGGGCTCAGGGGGTTTGTCATCTCCCTGTCAATATGAAGG
AAATGGATTATGATTTCTACGTATTCTCCGCGCATAAGATGCTCGGCCCGACCGGAGTCGGAGTTCTTTACGCAAAAGAA
GAAATTTTAGAGGAGATGCCTCCTTGGATGGGCGGAGGGGATATGATCGCTCACGTTTATAAGGAAAGATCCACGTATGC
GGAACTTCCTTCCAAACTCGAGGCGGGAACTCCCAACATTGCGGGAGTGATCGGTTTCGAATCTGCGATCGAATATCTCG
AAACGATCGGAATGCAGGAAGTCAGAAATCACGAAGTGGAACTTCTCGCTTATGCACTCGATCGATTGGACGATTTCGGC
GGATTGGAACTTTATGGAACGAGGGATTTATCCAAAAGAGGAGGAGTCATTTCCTTCAACTTTCCGGGAGTGCATCCGCA
CGATGTCGGAACGATTCTCGACGAAGAGGGAATTGCGATCCGGGTCGGACATCACTGTGCTCAACCTTTTATGGCGTTTA
AGAACATACCGGGGACCTGCCGCGCGAGCCTCTATCTTTACAATACAAAAGGTGACATCGATCGATTGATCGAGGGTCTA
ATTAAGGTAAAGGAAATATTCTCCCGTGTCCTTAAGCGATAG

Upstream 100 bases:

>100_bases
CCGGAAAGGCGCTTTGTATGCCCGCCGTGGAAGATCTCCCCGTATATCCCGTGAGAATCGTAGGTGACTCCATTGAAGTG
GATTTGGAGGATTGAAATAC

Downstream 100 bases:

>100_bases
TCTCTATAAAGAAGTTATACTCGATCACTATCAAAATCCGAGATTTCGGGGTAAACTCGAACCGGCGGATTTATCTGAAC
ATGGGATCAATCCTCTATGC

Product: selenocysteine lyase

Products: NA

Alternate protein names: Selenocysteine beta-lyase; SCL; Selenocysteine lyase; Selenocysteine reductase [H]

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MNFSAERIRTDFPILGTMMNGKPLVFLDSAASSQKPFTVIDRIEKYYREENANIHRGIYYLSQKATEKYELSRIRLSRFI
GAQCAKVCIFTRNATESINLVAQTWGRTQVEEGDEIVLNELEHHSNIVPWQMLAQEKKAVLRFIPLNEDGTLDLSNLDEI
ITTKTKLVAVAQMSNVTGTIHDLASIQKRAKEVGAKVLVDGAQGVCHLPVNMKEMDYDFYVFSAHKMLGPTGVGVLYAKE
EILEEMPPWMGGGDMIAHVYKERSTYAELPSKLEAGTPNIAGVIGFESAIEYLETIGMQEVRNHEVELLAYALDRLDDFG
GLELYGTRDLSKRGGVISFNFPGVHPHDVGTILDEEGIAIRVGHHCAQPFMAFKNIPGTCRASLYLYNTKGDIDRLIEGL
IKVKEIFSRVLKR

Sequences:

>Translated_413_residues
MNFSAERIRTDFPILGTMMNGKPLVFLDSAASSQKPFTVIDRIEKYYREENANIHRGIYYLSQKATEKYELSRIRLSRFI
GAQCAKVCIFTRNATESINLVAQTWGRTQVEEGDEIVLNELEHHSNIVPWQMLAQEKKAVLRFIPLNEDGTLDLSNLDEI
ITTKTKLVAVAQMSNVTGTIHDLASIQKRAKEVGAKVLVDGAQGVCHLPVNMKEMDYDFYVFSAHKMLGPTGVGVLYAKE
EILEEMPPWMGGGDMIAHVYKERSTYAELPSKLEAGTPNIAGVIGFESAIEYLETIGMQEVRNHEVELLAYALDRLDDFG
GLELYGTRDLSKRGGVISFNFPGVHPHDVGTILDEEGIAIRVGHHCAQPFMAFKNIPGTCRASLYLYNTKGDIDRLIEGL
IKVKEIFSRVLKR
>Mature_413_residues
MNFSAERIRTDFPILGTMMNGKPLVFLDSAASSQKPFTVIDRIEKYYREENANIHRGIYYLSQKATEKYELSRIRLSRFI
GAQCAKVCIFTRNATESINLVAQTWGRTQVEEGDEIVLNELEHHSNIVPWQMLAQEKKAVLRFIPLNEDGTLDLSNLDEI
ITTKTKLVAVAQMSNVTGTIHDLASIQKRAKEVGAKVLVDGAQGVCHLPVNMKEMDYDFYVFSAHKMLGPTGVGVLYAKE
EILEEMPPWMGGGDMIAHVYKERSTYAELPSKLEAGTPNIAGVIGFESAIEYLETIGMQEVRNHEVELLAYALDRLDDFG
GLELYGTRDLSKRGGVISFNFPGVHPHDVGTILDEEGIAIRVGHHCAQPFMAFKNIPGTCRASLYLYNTKGDIDRLIEGL
IKVKEIFSRVLKR

Specific function: Cysteine desulfurases mobilize the sulfur from L- cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under speci

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=218, Percent_Identity=26.605504587156, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI156713448, Length=327, Percent_Identity=24.4648318042813, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1787970, Length=408, Percent_Identity=50.4901960784314, Blast_Score=430, Evalue=1e-122,
Organism=Escherichia coli, GI1789175, Length=408, Percent_Identity=41.421568627451, Blast_Score=336, Evalue=1e-93,
Organism=Escherichia coli, GI48994898, Length=231, Percent_Identity=25.5411255411255, Blast_Score=92, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI25143064, Length=230, Percent_Identity=27.8260869565217, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI193211090, Length=382, Percent_Identity=25.3926701570681, Blast_Score=89, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6319831, Length=233, Percent_Identity=26.1802575107296, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI20129463, Length=251, Percent_Identity=27.8884462151394, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7; =4.4.1.16 [H]

Molecular weight: Translated: 46291; Mature: 46291

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFSAERIRTDFPILGTMMNGKPLVFLDSAASSQKPFTVIDRIEKYYREENANIHRGIYY
CCCCHHHHCCCCCEEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHH
LSQKATEKYELSRIRLSRFIGAQCAKVCIFTRNATESINLVAQTWGRTQVEEGDEIVLNE
HHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHCCCCCCCCCCHHHHHH
LEHHSNIVPWQMLAQEKKAVLRFIPLNEDGTLDLSNLDEIITTKTKLVAVAQMSNVTGTI
HHHCCCCCCHHHHHHHHHHEEEEEECCCCCCEEHHHHHHHHHHHHHHHEEEHHHCCCHHH
HDLASIQKRAKEVGAKVLVDGAQGVCHLPVNMKEMDYDFYVFSAHKMLGPTGVGVLYAKE
HHHHHHHHHHHHCCCEEEEECCCCEEECCCCHHHCCCEEEEEEHHHHCCCCCCEEEEEHH
EILEEMPPWMGGGDMIAHVYKERSTYAELPSKLEAGTPNIAGVIGFESAIEYLETIGMQE
HHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHCCCCCCCEEEECHHHHHHHHHHHCHHH
VRNHEVELLAYALDRLDDFGGLELYGTRDLSKRGGVISFNFPGVHPHDVGTILDEEGIAI
HHCCHHHHHHHHHHHHCCCCCEEEEECCCHHHCCCEEEECCCCCCCCCCHHHCCCCCCEE
RVGHHCAQPFMAFKNIPGTCRASLYLYNTKGDIDRLIEGLIKVKEIFSRVLKR
EECHHHHHHHHHHHCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNFSAERIRTDFPILGTMMNGKPLVFLDSAASSQKPFTVIDRIEKYYREENANIHRGIYY
CCCCHHHHCCCCCEEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHH
LSQKATEKYELSRIRLSRFIGAQCAKVCIFTRNATESINLVAQTWGRTQVEEGDEIVLNE
HHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHCCCCCCCCCCHHHHHH
LEHHSNIVPWQMLAQEKKAVLRFIPLNEDGTLDLSNLDEIITTKTKLVAVAQMSNVTGTI
HHHCCCCCCHHHHHHHHHHEEEEEECCCCCCEEHHHHHHHHHHHHHHHEEEHHHCCCHHH
HDLASIQKRAKEVGAKVLVDGAQGVCHLPVNMKEMDYDFYVFSAHKMLGPTGVGVLYAKE
HHHHHHHHHHHHCCCEEEEECCCCEEECCCCHHHCCCEEEEEEHHHHCCCCCCEEEEEHH
EILEEMPPWMGGGDMIAHVYKERSTYAELPSKLEAGTPNIAGVIGFESAIEYLETIGMQE
HHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHCCCCCCCEEEECHHHHHHHHHHHCHHH
VRNHEVELLAYALDRLDDFGGLELYGTRDLSKRGGVISFNFPGVHPHDVGTILDEEGIAI
HHCCHHHHHHHHHHHHCCCCCEEEEECCCHHHCCCEEEECCCCCCCCCCHHHCCCCCCEE
RVGHHCAQPFMAFKNIPGTCRASLYLYNTKGDIDRLIEGLIKVKEIFSRVLKR
EECHHHHHHHHHHHCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA