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The map label for this gene is proC [H]

Identifier: 116249181

GI number: 116249181

Start: 562265

End: 563059

Strand: Reverse

Name: proC [H]

Synonym: pRL120517

Alternate gene names: 116249181

Gene position: 563059-562265 (Counterclockwise)

Preceding gene: 116249182

Following gene: 116249180

Centisome position: 64.72

GC content: 63.14

Gene sequence:

>795_bases
ATGAGCGTTTCCTTGAGGATCGGTATCATTGGCGGCGGAGGCTGGCTTGGCGGAGCAATCGCCGGCTCGATCCTTGATGC
CGGCCTGGTCGAACCTCGAAATCTCTCCCTTTCCTATCGCAGTGAGCAGCCGCGCCGCTTCCCGAATTCTTTCTTGACCA
CCGACAATCAGGCGCTTGCCGACCGTTCGGACGTGATCCTTCTCTCCGTCCGTCCTGATGACTGGCATGCTCTCGATGTC
GATGCCGGCGGCAAGCTCATCATCTCGGTCATGGCGGGCATCCGCCTGGACGCGCTTTCCGAGCGCCACAACACCGGTCG
CGTCATCCGCGCTTTGCCGAACGCCGCCGCCGAAGTGGCCAAGTCCTATACGCCGTGGATTGGCGCGCGCGATGTCACCG
AAGACGACCGGGCACTCGTCCGCGCGATTTTTCAGGCATGCGGATCTGAGGACGAGGTCGCAAGGGAAAGCGACATCGAT
TACCTCACCGGTCTTTCCGGTTCCGGACCGGCTTTCCCGGCACTGCTCGCGGCAGCCATGATGCGCGACGCCGTCGCAAA
CGGCCTGCCGGCGGAGATTGCGCGCCGCGCCGTCAACACGGTGATCACAGGCGCCGGCCGCCTGCTGGAGCGCCACGACG
AATGTCCCGATGACGTCGTTGAAACCTTTGTCGGCTATCGCGGCACGACTGCGGCAGCCATCGAAGGCATGCGCGTTGCC
GGGTTCGACGCTTCGGTCGCGAAGGGACTATCGGCGGCATTCAAGAAATCGGTGAGTATGGGAGACGCTTCCTGA

Upstream 100 bases:

>100_bases
CCGAATATATCGCGATCTACACCGGCGAAGTGCCGCAGCAGAGGGAGCTCGATCGCTTCTTCTCCCGGCATGGCTACAGG
CCGGGTTAGGGAAGGCCGGG

Downstream 100 bases:

>100_bases
CAACCGTTGGAGTGGGTCCTGCGGCGCCCCGCTCAGCAAAACCGGCCGCTAAACAGAGGGAACGAGAATGAAAAAACTAT
TCGCATCGACATGTCTGATG

Product: putative pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 264; Mature: 263

Protein sequence:

>264_residues
MSVSLRIGIIGGGGWLGGAIAGSILDAGLVEPRNLSLSYRSEQPRRFPNSFLTTDNQALADRSDVILLSVRPDDWHALDV
DAGGKLIISVMAGIRLDALSERHNTGRVIRALPNAAAEVAKSYTPWIGARDVTEDDRALVRAIFQACGSEDEVARESDID
YLTGLSGSGPAFPALLAAAMMRDAVANGLPAEIARRAVNTVITGAGRLLERHDECPDDVVETFVGYRGTTAAAIEGMRVA
GFDASVAKGLSAAFKKSVSMGDAS

Sequences:

>Translated_264_residues
MSVSLRIGIIGGGGWLGGAIAGSILDAGLVEPRNLSLSYRSEQPRRFPNSFLTTDNQALADRSDVILLSVRPDDWHALDV
DAGGKLIISVMAGIRLDALSERHNTGRVIRALPNAAAEVAKSYTPWIGARDVTEDDRALVRAIFQACGSEDEVARESDID
YLTGLSGSGPAFPALLAAAMMRDAVANGLPAEIARRAVNTVITGAGRLLERHDECPDDVVETFVGYRGTTAAAIEGMRVA
GFDASVAKGLSAAFKKSVSMGDAS
>Mature_263_residues
SVSLRIGIIGGGGWLGGAIAGSILDAGLVEPRNLSLSYRSEQPRRFPNSFLTTDNQALADRSDVILLSVRPDDWHALDVD
AGGKLIISVMAGIRLDALSERHNTGRVIRALPNAAAEVAKSYTPWIGARDVTEDDRALVRAIFQACGSEDEVARESDIDY
LTGLSGSGPAFPALLAAAMMRDAVANGLPAEIARRAVNTVITGAGRLLERHDECPDDVVETFVGYRGTTAAAIEGMRVAG
FDASVAKGLSAAFKKSVSMGDAS

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=258, Percent_Identity=27.5193798449612, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI21361454, Length=253, Percent_Identity=25.296442687747, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI24797097, Length=200, Percent_Identity=26.5, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI24797095, Length=200, Percent_Identity=26.5, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1786585, Length=265, Percent_Identity=29.0566037735849, Blast_Score=85, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17569021, Length=274, Percent_Identity=23.7226277372263, Blast_Score=64, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6320861, Length=211, Percent_Identity=25.5924170616114, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21358587, Length=260, Percent_Identity=30.3846153846154, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24648116, Length=275, Percent_Identity=23.6363636363636, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24647700, Length=162, Percent_Identity=30.2469135802469, Blast_Score=75, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 27754; Mature: 27622

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVSLRIGIIGGGGWLGGAIAGSILDAGLVEPRNLSLSYRSEQPRRFPNSFLTTDNQALA
CCEEEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCHHHCCCCHHHC
DRSDVILLSVRPDDWHALDVDAGGKLIISVMAGIRLDALSERHNTGRVIRALPNAAAEVA
CCCCEEEEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
KSYTPWIGARDVTEDDRALVRAIFQACGSEDEVARESDIDYLTGLSGSGPAFPALLAAAM
HHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHCCCHHHHCCCCCCCHHHHHHHHHH
MRDAVANGLPAEIARRAVNTVITGAGRLLERHDECPDDVVETFVGYRGTTAAAIEGMRVA
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHCCCEEE
GFDASVAKGLSAAFKKSVSMGDAS
CCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SVSLRIGIIGGGGWLGGAIAGSILDAGLVEPRNLSLSYRSEQPRRFPNSFLTTDNQALA
CEEEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCHHHCCCCHHHC
DRSDVILLSVRPDDWHALDVDAGGKLIISVMAGIRLDALSERHNTGRVIRALPNAAAEVA
CCCCEEEEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
KSYTPWIGARDVTEDDRALVRAIFQACGSEDEVARESDIDYLTGLSGSGPAFPALLAAAM
HHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHCCCHHHHCCCCCCCHHHHHHHHHH
MRDAVANGLPAEIARRAVNTVITGAGRLLERHDECPDDVVETFVGYRGTTAAAIEGMRVA
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHCCCEEE
GFDASVAKGLSAAFKKSVSMGDAS
CCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]