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The map label for this gene is oxyR [H]

Identifier: 116249030

GI number: 116249030

Start: 390094

End: 391008

Strand: Reverse

Name: oxyR [H]

Synonym: pRL120361

Alternate gene names: 116249030

Gene position: 391008-390094 (Counterclockwise)

Preceding gene: 116249032

Following gene: 116249027

Centisome position: 44.94

GC content: 61.2

Gene sequence:

>915_bases
ATGAAGAACCTTACGCTGAAACAGCTGCGTTATTTTGAAGCGCTGGCAAGAGATGGACGCTTCCGACGCGCGGCCGACGC
CTGTGCGATCTCCCAGCCGGCATTGTCAATGCAGATCAAAGAACTTGAGCAAGAGTTGGGCGGTGAGCTTTTCGAGCGCA
ACGCGCGTGAGGTGAAGCTGACCGCTTTCGGTCAGACCGTCGCTCTCAGGATCCGCGATATCCTGCGTGGCGTGGACGAA
CTGGCGGACCTGGCGCGCGCCGCGCGCGATCCTTTCCTGACGCGGCTGCGCATCGGCATCATCCCGACGATTGCGCCCTA
TCTGTTGCCGGCAATCATCAACGATCTGAACAGGAGCTTTGCAGGCATTCAGATCGAAGTGCGCGAAACGCAGACGTCGA
AGCTGGTTCACGAGCTGGCGCAGGGCCAGCTGGATACGGCAATCGTTGCCTTGCCCGTGTCGGAACCATCCCTCGCAGAA
CTCGAGCTCTTCAAGGAAGAGTTCGTGCTGGTTCGGCGGCCCGAAGACGAGGGTAAGCCGGTGCCCGAACGCGAGGCGTT
GCGCGAAATGCGGTTGTTGCTGCTCGAGGAAGGCCACTGCTTTCGCGATCAGGCCTTGTCGTTCTGCAAGATCGGGCAGG
CCCGTCCCCGGGAAGTCATGGAAGGCAGCTCTCTCTCCACCCTGGTCCAGATGGTCAGTGCCGGTATCGGCATCACCTTG
ATTCCCGAGATGGCCGTTCCCCTCGAAACGCGCTCGGCGCACGTCTCGATCTCCCGTTTTCAGTCTCCGCAGCCGTCGCG
AACGATCGGCATGATCTGGCGCAATTCGACACCGATGGCCAAACAGCTCCAGCAGGTTTCCGAGGCGGTTCGCCGGTCGG
CCGACAGCATGCGCGAACAGTATGCCGCCCGGTGA

Upstream 100 bases:

>100_bases
TGAGCCGAGCTGGCGCCCCACTCTCTCCCTGCAGTCTTCATATCGGAAGCGCTTCATAAATTTAAGTTGGATTTACTGAT
CGCTGCGATAAGCTGAGATT

Downstream 100 bases:

>100_bases
TGGATCTGATATGGCCTCGCCTCAAGATCGCCGTTTGAACGTATGCTCCGCTGCCGGAAACTGTCGCGATCGGACCTCGT
CGGCATAAGCGGCAGCGGCG

Product: putative peroxide-inducible genes transcriptional regulator

Products: NA

Alternate protein names: Morphology and auto-aggregation control protein [H]

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MKNLTLKQLRYFEALARDGRFRRAADACAISQPALSMQIKELEQELGGELFERNAREVKLTAFGQTVALRIRDILRGVDE
LADLARAARDPFLTRLRIGIIPTIAPYLLPAIINDLNRSFAGIQIEVRETQTSKLVHELAQGQLDTAIVALPVSEPSLAE
LELFKEEFVLVRRPEDEGKPVPEREALREMRLLLLEEGHCFRDQALSFCKIGQARPREVMEGSSLSTLVQMVSAGIGITL
IPEMAVPLETRSAHVSISRFQSPQPSRTIGMIWRNSTPMAKQLQQVSEAVRRSADSMREQYAAR

Sequences:

>Translated_304_residues
MKNLTLKQLRYFEALARDGRFRRAADACAISQPALSMQIKELEQELGGELFERNAREVKLTAFGQTVALRIRDILRGVDE
LADLARAARDPFLTRLRIGIIPTIAPYLLPAIINDLNRSFAGIQIEVRETQTSKLVHELAQGQLDTAIVALPVSEPSLAE
LELFKEEFVLVRRPEDEGKPVPEREALREMRLLLLEEGHCFRDQALSFCKIGQARPREVMEGSSLSTLVQMVSAGIGITL
IPEMAVPLETRSAHVSISRFQSPQPSRTIGMIWRNSTPMAKQLQQVSEAVRRSADSMREQYAAR
>Mature_304_residues
MKNLTLKQLRYFEALARDGRFRRAADACAISQPALSMQIKELEQELGGELFERNAREVKLTAFGQTVALRIRDILRGVDE
LADLARAARDPFLTRLRIGIIPTIAPYLLPAIINDLNRSFAGIQIEVRETQTSKLVHELAQGQLDTAIVALPVSEPSLAE
LELFKEEFVLVRRPEDEGKPVPEREALREMRLLLLEEGHCFRDQALSFCKIGQARPREVMEGSSLSTLVQMVSAGIGITL
IPEMAVPLETRSAHVSISRFQSPQPSRTIGMIWRNSTPMAKQLQQVSEAVRRSADSMREQYAAR

Specific function: Hydrogen peroxide sensor. Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS (a regulatory RNA), dps, fur and grxA. OxyR expression is negatively autoregulated by binding to a 43 bp region upstre

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790399, Length=298, Percent_Identity=39.5973154362416, Blast_Score=204, Evalue=6e-54,
Organism=Escherichia coli, GI157672245, Length=246, Percent_Identity=31.3008130081301, Blast_Score=111, Evalue=6e-26,
Organism=Escherichia coli, GI1788748, Length=302, Percent_Identity=29.1390728476821, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI145693105, Length=273, Percent_Identity=28.2051282051282, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1787879, Length=250, Percent_Identity=30, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1788887, Length=284, Percent_Identity=28.169014084507, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI2367136, Length=244, Percent_Identity=31.1475409836066, Blast_Score=81, Evalue=7e-17,
Organism=Escherichia coli, GI1788297, Length=264, Percent_Identity=26.1363636363636, Blast_Score=81, Evalue=9e-17,
Organism=Escherichia coli, GI1787806, Length=273, Percent_Identity=24.1758241758242, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1787601, Length=191, Percent_Identity=27.7486910994764, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1787530, Length=249, Percent_Identity=25.7028112449799, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI87081904, Length=305, Percent_Identity=26.5573770491803, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1789506, Length=246, Percent_Identity=24.7967479674797, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789173, Length=173, Percent_Identity=31.7919075144509, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI145693193, Length=122, Percent_Identity=34.4262295081967, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1788626, Length=256, Percent_Identity=29.296875, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1790262, Length=244, Percent_Identity=26.6393442622951, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1790783, Length=269, Percent_Identity=26.3940520446097, Blast_Score=62, Evalue=6e-11,
Organism=Escherichia coli, GI87082132, Length=246, Percent_Identity=21.9512195121951, Blast_Score=62, Evalue=6e-11,
Organism=Escherichia coli, GI1790208, Length=284, Percent_Identity=24.6478873239437, Blast_Score=61, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34129; Mature: 34129

Theoretical pI: Translated: 8.07; Mature: 8.07

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNLTLKQLRYFEALARDGRFRRAADACAISQPALSMQIKELEQELGGELFERNAREVKL
CCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCHHHHHCCCCEEEE
TAFGQTVALRIRDILRGVDELADLARAARDPFLTRLRIGIIPTIAPYLLPAIINDLNRSF
EEHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGIQIEVRETQTSKLVHELAQGQLDTAIVALPVSEPSLAELELFKEEFVLVRRPEDEGKP
CCEEEEEEHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHEEEECCCCCCCC
VPEREALREMRLLLLEEGHCFRDQALSFCKIGQARPREVMEGSSLSTLVQMVSAGIGITL
CCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHCCCCEEE
IPEMAVPLETRSAHVSISRFQSPQPSRTIGMIWRNSTPMAKQLQQVSEAVRRSADSMREQ
CCCCCCCCCCCCCEEEHHHCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
YAAR
HCCC
>Mature Secondary Structure
MKNLTLKQLRYFEALARDGRFRRAADACAISQPALSMQIKELEQELGGELFERNAREVKL
CCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCHHHHHCCCCEEEE
TAFGQTVALRIRDILRGVDELADLARAARDPFLTRLRIGIIPTIAPYLLPAIINDLNRSF
EEHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGIQIEVRETQTSKLVHELAQGQLDTAIVALPVSEPSLAELELFKEEFVLVRRPEDEGKP
CCEEEEEEHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHEEEECCCCCCCC
VPEREALREMRLLLLEEGHCFRDQALSFCKIGQARPREVMEGSSLSTLVQMVSAGIGITL
CCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHCCCCEEE
IPEMAVPLETRSAHVSISRFQSPQPSRTIGMIWRNSTPMAKQLQQVSEAVRRSADSMREQ
CCCCCCCCCCCCCEEEHHHCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
YAAR
HCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]