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The map label for this gene is kipR [H]

Identifier: 116249001

GI number: 116249001

Start: 356531

End: 357295

Strand: Reverse

Name: kipR [H]

Synonym: pRL120332

Alternate gene names: 116249001

Gene position: 357295-356531 (Counterclockwise)

Preceding gene: 116249011

Following gene: 116248991

Centisome position: 41.07

GC content: 56.99

Gene sequence:

>765_bases
ATGGACAAAAGACAACCATCAAAAAGCGAGATTGTGCAATCTGTTGATGTCTGCATCGACGTATTGCTGAATGTCGCCAA
AAACCCGGATATCAGACTGACTGAGGTGGCGCAGAACCTCGGGGAAACCAAACCGAGAATTTTGCGCATGTTACGCACAC
TGGAACGGCGCGGCCTGGTGCGGAAGAGCGATACGGGCACTTACCGGCTGGGGACGACTGCGATCATTCTCGGGACCGCT
GCCTCGACACAGGTTGATCTGGTGCGAATAGCCAATCCTATTCTTGAAGAAGTCGGCCAGAAGGCGAACGAAACGACCCA
GCTCAGGATCATCGACAATGGGGAATCCCTGTGTATTGCAAAGTTCGAACCGATGCGCGACTTGCGAGTGCAGGCGATGA
TCGGTCGAAGACGGCCGCTCACGGCCGGCTCGTACAAGGTGCTTCTCGCCTATCTCCACCCCCAGGTGCAGTTGCAAATG
ATCCCGGAGACTTTGCCGCGGCTGACCAAGCGCACGATCACGGATCGCAGCAAGCTGGTGGCTGAATTGGATAAAATCCG
CCGCCAGGGATTTTGTGTGAGTTACGGTGAAGTCAGCGAGCAACTCGTCTCCGTCTCGGTGCCGGTTCTGGCTTTCGACG
GATCCGTGATCGCCGCGGTGAATGTCGGCGCCCCGGCCTTCCGCACGCAAAAAAGCGACGTCGACCGCTTCATCGTTCTG
CTGAAGGAGGCCTCCAGCAAGATATCGGCCCGGCTGGGATGGTAG

Upstream 100 bases:

>100_bases
CTCAAGGGGGCTGTCAAACGGAAAACAAGCGCGTTACGATAGGCGTAACTTGAGACTACGCCAATCCTTCAGCCCTGGTC
GCGGAGAAAATTCTGGTCCC

Downstream 100 bases:

>100_bases
AGCGTTCTGCGCCATATCGGGCCTTGTCTCTTCGGCTCGACGCCCATCGAGGCGAGCCAACGCAGGTTGTTTCGTGACAA
GCCCGCTCTTTGAGCAAACT

Product: IclR family transcriptional regulator

Products: NA

Alternate protein names: Kip operon repressor protein [H]

Number of amino acids: Translated: 254; Mature: 254

Protein sequence:

>254_residues
MDKRQPSKSEIVQSVDVCIDVLLNVAKNPDIRLTEVAQNLGETKPRILRMLRTLERRGLVRKSDTGTYRLGTTAIILGTA
ASTQVDLVRIANPILEEVGQKANETTQLRIIDNGESLCIAKFEPMRDLRVQAMIGRRRPLTAGSYKVLLAYLHPQVQLQM
IPETLPRLTKRTITDRSKLVAELDKIRRQGFCVSYGEVSEQLVSVSVPVLAFDGSVIAAVNVGAPAFRTQKSDVDRFIVL
LKEASSKISARLGW

Sequences:

>Translated_254_residues
MDKRQPSKSEIVQSVDVCIDVLLNVAKNPDIRLTEVAQNLGETKPRILRMLRTLERRGLVRKSDTGTYRLGTTAIILGTA
ASTQVDLVRIANPILEEVGQKANETTQLRIIDNGESLCIAKFEPMRDLRVQAMIGRRRPLTAGSYKVLLAYLHPQVQLQM
IPETLPRLTKRTITDRSKLVAELDKIRRQGFCVSYGEVSEQLVSVSVPVLAFDGSVIAAVNVGAPAFRTQKSDVDRFIVL
LKEASSKISARLGW
>Mature_254_residues
MDKRQPSKSEIVQSVDVCIDVLLNVAKNPDIRLTEVAQNLGETKPRILRMLRTLERRGLVRKSDTGTYRLGTTAIILGTA
ASTQVDLVRIANPILEEVGQKANETTQLRIIDNGESLCIAKFEPMRDLRVQAMIGRRRPLTAGSYKVLLAYLHPQVQLQM
IPETLPRLTKRTITDRSKLVAELDKIRRQGFCVSYGEVSEQLVSVSVPVLAFDGSVIAAVNVGAPAFRTQKSDVDRFIVL
LKEASSKISARLGW

Specific function: Transcriptional repressor of the kip gene-containing operon [H]

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI1788131, Length=255, Percent_Identity=31.3725490196078, Blast_Score=110, Evalue=7e-26,
Organism=Escherichia coli, GI1786468, Length=249, Percent_Identity=27.710843373494, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI1789999, Length=260, Percent_Identity=27.6923076923077, Blast_Score=88, Evalue=7e-19,
Organism=Escherichia coli, GI87082359, Length=248, Percent_Identity=25, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1786715, Length=227, Percent_Identity=26.431718061674, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1788581, Length=250, Percent_Identity=28, Blast_Score=69, Evalue=3e-13,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 28220; Mature: 28220

Theoretical pI: Translated: 10.42; Mature: 10.42

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKRQPSKSEIVQSVDVCIDVLLNVAKNPDIRLTEVAQNLGETKPRILRMLRTLERRGLV
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHCCCCHHHHHHHHHHHHCCCC
RKSDTGTYRLGTTAIILGTAASTQVDLVRIANPILEEVGQKANETTQLRIIDNGESLCIA
EECCCCCEEECCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEEE
KFEPMRDLRVQAMIGRRRPLTAGSYKVLLAYLHPQVQLQMIPETLPRLTKRTITDRSKLV
ECCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHH
AELDKIRRQGFCVSYGEVSEQLVSVSVPVLAFDGSVIAAVNVGAPAFRTQKSDVDRFIVL
HHHHHHHHCCCEEEHHHHHHHHHHHCCCEEEECCCEEEEEECCCCCHHCCHHHHHHHHHH
LKEASSKISARLGW
HHHHHHHHHHCCCC
>Mature Secondary Structure
MDKRQPSKSEIVQSVDVCIDVLLNVAKNPDIRLTEVAQNLGETKPRILRMLRTLERRGLV
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHCCCCHHHHHHHHHHHHCCCC
RKSDTGTYRLGTTAIILGTAASTQVDLVRIANPILEEVGQKANETTQLRIIDNGESLCIA
EECCCCCEEECCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEEE
KFEPMRDLRVQAMIGRRRPLTAGSYKVLLAYLHPQVQLQMIPETLPRLTKRTITDRSKLV
ECCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHH
AELDKIRRQGFCVSYGEVSEQLVSVSVPVLAFDGSVIAAVNVGAPAFRTQKSDVDRFIVL
HHHHHHHHCCCEEEHHHHHHHHHHHCCCEEEECCCEEEEEECCCCCHHCCHHHHHHHHHH
LKEASSKISARLGW
HHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]