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The map label for this gene is copS [H]

Identifier: 114798801

GI number: 114798801

Start: 2283140

End: 2284495

Strand: Direct

Name: copS [H]

Synonym: HNE_2189

Alternate gene names: 114798801

Gene position: 2283140-2284495 (Clockwise)

Preceding gene: 114800395

Following gene: 114800040

Centisome position: 61.62

GC content: 62.02

Gene sequence:

>1356_bases
ATGAAAGGACGCTCGATCGCGCTCCACCTTGCCGTGATGTTTGGTCTCTCGGTCGCCATCGTCTCTTCGGTCGCTGGCGT
TGCGATCAATATCTTTCAAGCCGACGAATTGCGACGCCACAAGATGGAGGAACTTACAGGTCGGTACGCACTCGTGGAGC
GGATCGCCGAGTCCCTGTCCCGCGATGACTGGGACATCATGATTGACAAGCTGCGGGCTTTCACGCCGGCCGATGACAGT
TTGAGGTTTATTATCGAAAGCCCGGAGCCTGCGTTCGCGTATGGACTGGATTTTCTCGAGGCGGCGCAGTTCGACAGGCC
CGAGGAAGGGTTCGGGACCGCCCGGACACAATCGCGGCCCTATGTGACTCTGTCGCGATACATCGAGCCGCTGGGTACGC
GGCCACGTGTACGCCTGACCGTCGCGCTCGGCACGTCCGATATCGAGCAGGCGCAGGCCGTCCTCGCGATCGGCGTCGTC
GTGATTTCAGCCCTGGCGATCCTTGCCGTCTCCCTGCTGGGCTGGCTGATCGCGCGCCGCGGTCTTGCGCCCGTGGGCGC
GCTCTCTGCACATGCGCGGCTGCTCGGGGAAGGCGATCTCTCGCAGCGGCTGCCGGCCGAGCGCCTGCCGTCAGAACTGG
AGGGCCTGGTTTTCTCTCTCAACCAGGCGCTGGGCCGGGTTCAGACGACGTATCAGAAACTTTCCGCCTTTAACGCCGAT
GTCGCTCATGAACTGCGCACACCGGTCAGCAATCTGATCGGTGAAACACAGGTTGCGCTGTCTCGCCAACGCTCCGCGAG
CGATCTGGAGGCGGTTCTGCAATCCAATCTCGAAGAGCTGGAACGGCTGAAGTCGATCATCAACGACATGCTCTTTCTGG
CGCGCGCCGATGAGGGAGACCTTGCCGGAAACCTGATCGATTGTTCGCTTGCGGAGGAAACACGCAAGAGTGCAGACTTT
ATGGAGCTCGCTTTCGAAGAGGCGGGCACGGTCCTGGAGATATGCGGCGACGCCCGCGCCCGGATCAACCAATCGCTCTA
TCGGCGTGCGATCACGAACCTGCTCGACAATGCAATCCGGCATGGGACGAATGGTCATGTGGGTGTATCCATCACGGAGC
GGGGGGGTCAGATTGAAATCACGTCTGAAAATGACGCAGCGCCCCTTCCCCCCGACGTCCTGGACCGGCTGTTCGACCGG
TTCTTTCGGGGCGATCCTGCCAGGACGGGCAGCGAGCACACCCATGGGCTGGGGCTCGCCATCGTCAAAGCAATTGCCAG
GATGCATGGCGGCGAGGTGTTCGCCCGGCAGGCGGCCGGCCGGATCCGGATCGGATTGACCCTGCCGGTACGGTGA

Upstream 100 bases:

>100_bases
AACGCCTGCGGAGCAAACTCGAAGAGCCAGGCGAAATCAGGCTCCTCCATACGGTGAGGGGTATGGGATATGTGCTGGAG
CTACGCGAGGAAGGCGGGCT

Downstream 100 bases:

>100_bases
ACACAAAGCCCCGACAAACGCGTTCGCCAGGCGCCCCATGGGCCCGACGGCCGGGGCCCTGCAAACCGCGCCGCGCGGTG
TACCTTTGAACCCGGCAGCC

Product: heavy metal sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MKGRSIALHLAVMFGLSVAIVSSVAGVAINIFQADELRRHKMEELTGRYALVERIAESLSRDDWDIMIDKLRAFTPADDS
LRFIIESPEPAFAYGLDFLEAAQFDRPEEGFGTARTQSRPYVTLSRYIEPLGTRPRVRLTVALGTSDIEQAQAVLAIGVV
VISALAILAVSLLGWLIARRGLAPVGALSAHARLLGEGDLSQRLPAERLPSELEGLVFSLNQALGRVQTTYQKLSAFNAD
VAHELRTPVSNLIGETQVALSRQRSASDLEAVLQSNLEELERLKSIINDMLFLARADEGDLAGNLIDCSLAEETRKSADF
MELAFEEAGTVLEICGDARARINQSLYRRAITNLLDNAIRHGTNGHVGVSITERGGQIEITSENDAAPLPPDVLDRLFDR
FFRGDPARTGSEHTHGLGLAIVKAIARMHGGEVFARQAAGRIRIGLTLPVR

Sequences:

>Translated_451_residues
MKGRSIALHLAVMFGLSVAIVSSVAGVAINIFQADELRRHKMEELTGRYALVERIAESLSRDDWDIMIDKLRAFTPADDS
LRFIIESPEPAFAYGLDFLEAAQFDRPEEGFGTARTQSRPYVTLSRYIEPLGTRPRVRLTVALGTSDIEQAQAVLAIGVV
VISALAILAVSLLGWLIARRGLAPVGALSAHARLLGEGDLSQRLPAERLPSELEGLVFSLNQALGRVQTTYQKLSAFNAD
VAHELRTPVSNLIGETQVALSRQRSASDLEAVLQSNLEELERLKSIINDMLFLARADEGDLAGNLIDCSLAEETRKSADF
MELAFEEAGTVLEICGDARARINQSLYRRAITNLLDNAIRHGTNGHVGVSITERGGQIEITSENDAAPLPPDVLDRLFDR
FFRGDPARTGSEHTHGLGLAIVKAIARMHGGEVFARQAAGRIRIGLTLPVR
>Mature_451_residues
MKGRSIALHLAVMFGLSVAIVSSVAGVAINIFQADELRRHKMEELTGRYALVERIAESLSRDDWDIMIDKLRAFTPADDS
LRFIIESPEPAFAYGLDFLEAAQFDRPEEGFGTARTQSRPYVTLSRYIEPLGTRPRVRLTVALGTSDIEQAQAVLAIGVV
VISALAILAVSLLGWLIARRGLAPVGALSAHARLLGEGDLSQRLPAERLPSELEGLVFSLNQALGRVQTTYQKLSAFNAD
VAHELRTPVSNLIGETQVALSRQRSASDLEAVLQSNLEELERLKSIINDMLFLARADEGDLAGNLIDCSLAEETRKSADF
MELAFEEAGTVLEICGDARARINQSLYRRAITNLLDNAIRHGTNGHVGVSITERGGQIEITSENDAAPLPPDVLDRLFDR
FFRGDPARTGSEHTHGLGLAIVKAIARMHGGEVFARQAAGRIRIGLTLPVR

Specific function: Member of the two-component regulatory system CopS/CopR. Involved in the activation of copper resistance gene operon copABCD. Specifically recognizes or transduces a signal only in response to copper. This would lead to phosphorylation of CopR in the cyto

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=293, Percent_Identity=39.2491467576792, Blast_Score=199, Evalue=4e-52,
Organism=Escherichia coli, GI1788279, Length=332, Percent_Identity=31.0240963855422, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI1790346, Length=274, Percent_Identity=31.7518248175182, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1789403, Length=293, Percent_Identity=31.0580204778157, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1788393, Length=281, Percent_Identity=29.1814946619217, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI1787894, Length=321, Percent_Identity=26.1682242990654, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1786600, Length=219, Percent_Identity=26.9406392694064, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1787374, Length=291, Percent_Identity=26.4604810996564, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI1786912, Length=250, Percent_Identity=25.2, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789808, Length=344, Percent_Identity=25.8720930232558, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789149, Length=231, Percent_Identity=27.7056277056277, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790436, Length=224, Percent_Identity=29.4642857142857, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1790551, Length=234, Percent_Identity=26.9230769230769, Blast_Score=65, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR006290
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49176; Mature: 49176

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGRSIALHLAVMFGLSVAIVSSVAGVAINIFQADELRRHKMEELTGRYALVERIAESLS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
RDDWDIMIDKLRAFTPADDSLRFIIESPEPAFAYGLDFLEAAQFDRPEEGFGTARTQSRP
CCCHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
YVTLSRYIEPLGTRPRVRLTVALGTSDIEQAQAVLAIGVVVISALAILAVSLLGWLIARR
CEEHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GLAPVGALSAHARLLGEGDLSQRLPAERLPSELEGLVFSLNQALGRVQTTYQKLSAFNAD
CCCCHHHHHHHHHHHCCCCHHHCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHH
VAHELRTPVSNLIGETQVALSRQRSASDLEAVLQSNLEELERLKSIINDMLFLARADEGD
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
LAGNLIDCSLAEETRKSADFMELAFEEAGTVLEICGDARARINQSLYRRAITNLLDNAIR
CCCCEEECHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
HGTNGHVGVSITERGGQIEITSENDAAPLPPDVLDRLFDRFFRGDPARTGSEHTHGLGLA
CCCCCCEEEEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHH
IVKAIARMHGGEVFARQAAGRIRIGLTLPVR
HHHHHHHHCCCHHHHHHCCCEEEEEEEECCC
>Mature Secondary Structure
MKGRSIALHLAVMFGLSVAIVSSVAGVAINIFQADELRRHKMEELTGRYALVERIAESLS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
RDDWDIMIDKLRAFTPADDSLRFIIESPEPAFAYGLDFLEAAQFDRPEEGFGTARTQSRP
CCCHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
YVTLSRYIEPLGTRPRVRLTVALGTSDIEQAQAVLAIGVVVISALAILAVSLLGWLIARR
CEEHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GLAPVGALSAHARLLGEGDLSQRLPAERLPSELEGLVFSLNQALGRVQTTYQKLSAFNAD
CCCCHHHHHHHHHHHCCCCHHHCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHH
VAHELRTPVSNLIGETQVALSRQRSASDLEAVLQSNLEELERLKSIINDMLFLARADEGD
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
LAGNLIDCSLAEETRKSADFMELAFEEAGTVLEICGDARARINQSLYRRAITNLLDNAIR
CCCCEEECHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
HGTNGHVGVSITERGGQIEITSENDAAPLPPDVLDRLFDRFFRGDPARTGSEHTHGLGLA
CCCCCCEEEEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHH
IVKAIARMHGGEVFARQAAGRIRIGLTLPVR
HHHHHHHHCCCHHHHHHCCCEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8449873 [H]