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The map label for this gene is yngJ [H]

Identifier: 114800342

GI number: 114800342

Start: 3524229

End: 3525929

Strand: Reverse

Name: yngJ [H]

Synonym: HNE_3379

Alternate gene names: 114800342

Gene position: 3525929-3524229 (Counterclockwise)

Preceding gene: 114799744

Following gene: 114798755

Centisome position: 95.17

GC content: 63.26

Gene sequence:

>1701_bases
ATGGGTGACGTGAGCACGCTGGAAAACGGGCAGGGCACGGTTTTTGACGGTCTGGTGCCGGCGCTGGCGGAGGCTGTTGC
CGCGCTCGATACGTATGCCGCTGCGGCGCTGGCAGGCGCGCGCAAGCAGCTGGCCGGACCCGACGGCCGGCCAGATCGCG
CCGCTTTTGAGCGTGACCAGCACCTGGCTCACGGCCTCTCCTGGCTGGTTACCTATGTCGAGACGCTGCGCCAGGTTTCC
GAATGGACCGGGCGTCTTCAGGATGAAGGCAAGTTCGGTGAGGCCGAAGCGCTGCTGGCGCAGATTCTGTTCAGCGAATA
CTGCGCCCAGATCATCGGTGGCATTCCAATGAATCAGGGCGAAACGATCCGCCCGCATGAGCTCGGCAGTCTCGAGGCGG
CAGACGCGCTGTTTGCGGTGCCGGTGATCCGCAAGCTGATCGTTGAGGGCAAGACGCAGGCTGTAATGACCGCGGCGGCA
AATCTGCTGCCGGACTCGCTCTCGCGCCATACGGTGGAAGCCACGGGCCTGGACGAGACCATGGACATGGTGCGCGAGCA
GTTTGCGAAATTTGCCGCCGACCGTATCCGTCCGTATGCCCATGGCTGGCATCTGCGCAATGATTACATCCCCATGGAGG
TCGTCGACGAGATGGCCGAACTGGGCGTCTTTGGTCTGACGATCCCCGAAGAGTTCGGCGGCCTCGGTATGGGCAAGACG
GCGATGTGCGTGGTCACCGAAGAACTTTCGCGCGGCTATATCGGCACGGGGTCTCTGGGCACGCGGTCGGAGATTGCTGC
TGAGCTGATCCTGATCGGCGGCACGCCGGAGCAGAAGGCAAAATGGCTGCCGGTCATCGCCAGCGGCGAGATCCTGCCCA
CGGCCGTGTTCACCGAGCCCAACACCGGGTCTGACCTTGGCTCGCTGCGTACCCGCGCGGTGAAGTCCGCAGATGGCACC
CATTATGCCGTCACCGGCAACAAGACCTGGATCACGCATCCGGTGCGCGCAGACCTGATGACCCTTATGGCGCGGACCGA
TCCGGCCACGAACAATTTCTCAGGCCTGTCGATGCTGCTGGCCGAGAAGCCGCGCGGAACGGATGCCGAGCCATTCCCGG
CTGAAGGCATGACCGGCGGCGAGATCGAAGTGCTCGGTTATCGCGGCATGAAGGAATTTGAAATCGGGTTCGACAATTTC
AAGGTCAAGTCTGAGAACCTGCTCGGCGGTGTCGAAGGGCAGGGGTTCAAGCAGCTGATGGCGACGTTTGAAAGCGCCCG
CATCCAGACGGCCGCCCGCGCCGTTGGGGTGGCGCAGAACGCGCTTGAGGTGGGCCTGCGTTACGCGCTGGACCGCCAGC
AGTTTGGCCAGGCGATCTTCAAGTTTCCGCGCGTCTCCAACAAGCTGGTGATGATGGCGGCTGAACTGGTCGGTATGCGT
CAGCTGACCTATTTCTCCGCGCGCCAGAAAGACAATGGCAAGCGCTGTGATCTTGAAGCAGGCATGGCGAAACTACTGGC
CGCGCGCGCGGCCTGGGCTGCGGCCGACAACGCGGTGCAGATCCACGGCGGCAACGGTTTTGCGCTGGAGTATCCCATCA
GCCGTATCCTGCAGGACGCCCGCATCCTGAACATCTTCGAGGGTGCAGGCGAAGTGCAGGCGATGGTCATCGCCCGCCGC
CTGGTCGAGGGCGGTAACTGA

Upstream 100 bases:

>100_bases
GGGCGCGATGTTGCGCCGCACAACATGAATATGTCAGAAAGCGCTTGCCGCCCTATCCTTACTGGCAACATGAGGCGGTA
GATATTCAAGGGAGCAGAGC

Downstream 100 bases:

>100_bases
GCCGCGCCCTTGCCGTAACACTTCGGTTGCGAGATCGGACTATAAGTTAGCCCTGCCGGGGCGGACCTTCTCGGACGAGG
ACGGGATATGACCGATATTG

Product: isobutyryl-CoA dehydrogenase

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 566; Mature: 565

Protein sequence:

>566_residues
MGDVSTLENGQGTVFDGLVPALAEAVAALDTYAAAALAGARKQLAGPDGRPDRAAFERDQHLAHGLSWLVTYVETLRQVS
EWTGRLQDEGKFGEAEALLAQILFSEYCAQIIGGIPMNQGETIRPHELGSLEAADALFAVPVIRKLIVEGKTQAVMTAAA
NLLPDSLSRHTVEATGLDETMDMVREQFAKFAADRIRPYAHGWHLRNDYIPMEVVDEMAELGVFGLTIPEEFGGLGMGKT
AMCVVTEELSRGYIGTGSLGTRSEIAAELILIGGTPEQKAKWLPVIASGEILPTAVFTEPNTGSDLGSLRTRAVKSADGT
HYAVTGNKTWITHPVRADLMTLMARTDPATNNFSGLSMLLAEKPRGTDAEPFPAEGMTGGEIEVLGYRGMKEFEIGFDNF
KVKSENLLGGVEGQGFKQLMATFESARIQTAARAVGVAQNALEVGLRYALDRQQFGQAIFKFPRVSNKLVMMAAELVGMR
QLTYFSARQKDNGKRCDLEAGMAKLLAARAAWAAADNAVQIHGGNGFALEYPISRILQDARILNIFEGAGEVQAMVIARR
LVEGGN

Sequences:

>Translated_566_residues
MGDVSTLENGQGTVFDGLVPALAEAVAALDTYAAAALAGARKQLAGPDGRPDRAAFERDQHLAHGLSWLVTYVETLRQVS
EWTGRLQDEGKFGEAEALLAQILFSEYCAQIIGGIPMNQGETIRPHELGSLEAADALFAVPVIRKLIVEGKTQAVMTAAA
NLLPDSLSRHTVEATGLDETMDMVREQFAKFAADRIRPYAHGWHLRNDYIPMEVVDEMAELGVFGLTIPEEFGGLGMGKT
AMCVVTEELSRGYIGTGSLGTRSEIAAELILIGGTPEQKAKWLPVIASGEILPTAVFTEPNTGSDLGSLRTRAVKSADGT
HYAVTGNKTWITHPVRADLMTLMARTDPATNNFSGLSMLLAEKPRGTDAEPFPAEGMTGGEIEVLGYRGMKEFEIGFDNF
KVKSENLLGGVEGQGFKQLMATFESARIQTAARAVGVAQNALEVGLRYALDRQQFGQAIFKFPRVSNKLVMMAAELVGMR
QLTYFSARQKDNGKRCDLEAGMAKLLAARAAWAAADNAVQIHGGNGFALEYPISRILQDARILNIFEGAGEVQAMVIARR
LVEGGN
>Mature_565_residues
GDVSTLENGQGTVFDGLVPALAEAVAALDTYAAAALAGARKQLAGPDGRPDRAAFERDQHLAHGLSWLVTYVETLRQVSE
WTGRLQDEGKFGEAEALLAQILFSEYCAQIIGGIPMNQGETIRPHELGSLEAADALFAVPVIRKLIVEGKTQAVMTAAAN
LLPDSLSRHTVEATGLDETMDMVREQFAKFAADRIRPYAHGWHLRNDYIPMEVVDEMAELGVFGLTIPEEFGGLGMGKTA
MCVVTEELSRGYIGTGSLGTRSEIAAELILIGGTPEQKAKWLPVIASGEILPTAVFTEPNTGSDLGSLRTRAVKSADGTH
YAVTGNKTWITHPVRADLMTLMARTDPATNNFSGLSMLLAEKPRGTDAEPFPAEGMTGGEIEVLGYRGMKEFEIGFDNFK
VKSENLLGGVEGQGFKQLMATFESARIQTAARAVGVAQNALEVGLRYALDRQQFGQAIFKFPRVSNKLVMMAAELVGMRQ
LTYFSARQKDNGKRCDLEAGMAKLLAARAAWAAADNAVQIHGGNGFALEYPISRILQDARILNIFEGAGEVQAMVIARRL
VEGGN

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI21361497, Length=355, Percent_Identity=37.1830985915493, Blast_Score=224, Evalue=2e-58,
Organism=Homo sapiens, GI4557233, Length=396, Percent_Identity=35.6060606060606, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI4557231, Length=380, Percent_Identity=34.2105263157895, Blast_Score=200, Evalue=3e-51,
Organism=Homo sapiens, GI187960098, Length=380, Percent_Identity=34.2105263157895, Blast_Score=200, Evalue=3e-51,
Organism=Homo sapiens, GI76496475, Length=392, Percent_Identity=32.9081632653061, Blast_Score=192, Evalue=6e-49,
Organism=Homo sapiens, GI4557235, Length=392, Percent_Identity=32.9081632653061, Blast_Score=192, Evalue=6e-49,
Organism=Homo sapiens, GI226958412, Length=392, Percent_Identity=32.1428571428571, Blast_Score=189, Evalue=9e-48,
Organism=Homo sapiens, GI226958414, Length=353, Percent_Identity=32.8611898016997, Blast_Score=177, Evalue=3e-44,
Organism=Homo sapiens, GI4501859, Length=392, Percent_Identity=31.6326530612245, Blast_Score=173, Evalue=4e-43,
Organism=Homo sapiens, GI7656849, Length=406, Percent_Identity=28.8177339901478, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI4503943, Length=384, Percent_Identity=29.4270833333333, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI4501857, Length=383, Percent_Identity=26.8929503916449, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI7669494, Length=385, Percent_Identity=29.6103896103896, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI38505218, Length=360, Percent_Identity=24.7222222222222, Blast_Score=96, Evalue=8e-20,
Organism=Homo sapiens, GI48976061, Length=298, Percent_Identity=26.510067114094, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI211971008, Length=298, Percent_Identity=26.510067114094, Blast_Score=89, Evalue=1e-17,
Organism=Escherichia coli, GI1786223, Length=365, Percent_Identity=31.5068493150685, Blast_Score=151, Evalue=1e-37,
Organism=Escherichia coli, GI87081958, Length=358, Percent_Identity=27.3743016759777, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI87082384, Length=272, Percent_Identity=23.5294117647059, Blast_Score=62, Evalue=1e-10,
Organism=Caenorhabditis elegans, GI71985184, Length=365, Percent_Identity=36.986301369863, Blast_Score=215, Evalue=5e-56,
Organism=Caenorhabditis elegans, GI17569725, Length=393, Percent_Identity=34.8600508905852, Blast_Score=204, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17534899, Length=393, Percent_Identity=34.3511450381679, Blast_Score=202, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI17570075, Length=401, Percent_Identity=32.1695760598504, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17538396, Length=414, Percent_Identity=30.6763285024155, Blast_Score=188, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI17506239, Length=403, Percent_Identity=30.272952853598, Blast_Score=180, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17508101, Length=372, Percent_Identity=30.6451612903226, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI71985192, Length=312, Percent_Identity=34.9358974358974, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17533517, Length=405, Percent_Identity=29.3827160493827, Blast_Score=155, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI17505929, Length=412, Percent_Identity=25.9708737864078, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17551932, Length=405, Percent_Identity=26.4197530864197, Blast_Score=131, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17534353, Length=374, Percent_Identity=28.0748663101604, Blast_Score=129, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI71990804, Length=297, Percent_Identity=30.976430976431, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI32563615, Length=240, Percent_Identity=30.4166666666667, Blast_Score=115, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI17562446, Length=453, Percent_Identity=24.2825607064018, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI71982178, Length=288, Percent_Identity=25, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI281363737, Length=346, Percent_Identity=34.971098265896, Blast_Score=200, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24660351, Length=429, Percent_Identity=32.4009324009324, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI21356377, Length=414, Percent_Identity=32.1256038647343, Blast_Score=188, Evalue=8e-48,
Organism=Drosophila melanogaster, GI24666513, Length=426, Percent_Identity=31.4553990610329, Blast_Score=183, Evalue=3e-46,
Organism=Drosophila melanogaster, GI21355753, Length=389, Percent_Identity=32.3907455012853, Blast_Score=179, Evalue=5e-45,
Organism=Drosophila melanogaster, GI24646207, Length=382, Percent_Identity=30.6282722513089, Blast_Score=164, Evalue=2e-40,
Organism=Drosophila melanogaster, GI19920834, Length=383, Percent_Identity=27.4151436031332, Blast_Score=119, Evalue=6e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 60952; Mature: 60821

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGDVSTLENGQGTVFDGLVPALAEAVAALDTYAAAALAGARKQLAGPDGRPDRAAFERDQ
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
HLAHGLSWLVTYVETLRQVSEWTGRLQDEGKFGEAEALLAQILFSEYCAQIIGGIPMNQG
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
ETIRPHELGSLEAADALFAVPVIRKLIVEGKTQAVMTAAANLLPDSLSRHTVEATGLDET
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHCEEECCCCHHH
MDMVREQFAKFAADRIRPYAHGWHLRNDYIPMEVVDEMAELGVFGLTIPEEFGGLGMGKT
HHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCHHHHHHHHHCCEEEEECCHHHCCCCCCCC
AMCVVTEELSRGYIGTGSLGTRSEIAAELILIGGTPEQKAKWLPVIASGEILPTAVFTEP
EEEEEEHHHHCCCCCCCCCCCHHHHHEEEEEECCCCCCCCCCCEEEECCCEECEEEEECC
NTGSDLGSLRTRAVKSADGTHYAVTGNKTWITHPVRADLMTLMARTDPATNNFSGLSMLL
CCCCHHHHHHHHHHHCCCCCEEEEECCCEEEECCHHHHHHHHHHHCCCCCCCCCHHHHHH
AEKPRGTDAEPFPAEGMTGGEIEVLGYRGMKEFEIGFDNFKVKSENLLGGVEGQGFKQLM
HCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCEECCCCCEEEECCCCCCCCCCCCHHHHH
ATFESARIQTAARAVGVAQNALEVGLRYALDRQQFGQAIFKFPRVSNKLVMMAAELVGMR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
QLTYFSARQKDNGKRCDLEAGMAKLLAARAAWAAADNAVQIHGGNGFALEYPISRILQDA
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEECCCHHHHHHHH
RILNIFEGAGEVQAMVIARRLVEGGN
HHHHHHHCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
GDVSTLENGQGTVFDGLVPALAEAVAALDTYAAAALAGARKQLAGPDGRPDRAAFERDQ
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
HLAHGLSWLVTYVETLRQVSEWTGRLQDEGKFGEAEALLAQILFSEYCAQIIGGIPMNQG
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
ETIRPHELGSLEAADALFAVPVIRKLIVEGKTQAVMTAAANLLPDSLSRHTVEATGLDET
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHCEEECCCCHHH
MDMVREQFAKFAADRIRPYAHGWHLRNDYIPMEVVDEMAELGVFGLTIPEEFGGLGMGKT
HHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCHHHHHHHHHCCEEEEECCHHHCCCCCCCC
AMCVVTEELSRGYIGTGSLGTRSEIAAELILIGGTPEQKAKWLPVIASGEILPTAVFTEP
EEEEEEHHHHCCCCCCCCCCCHHHHHEEEEEECCCCCCCCCCCEEEECCCEECEEEEECC
NTGSDLGSLRTRAVKSADGTHYAVTGNKTWITHPVRADLMTLMARTDPATNNFSGLSMLL
CCCCHHHHHHHHHHHCCCCCEEEEECCCEEEECCHHHHHHHHHHHCCCCCCCCCHHHHHH
AEKPRGTDAEPFPAEGMTGGEIEVLGYRGMKEFEIGFDNFKVKSENLLGGVEGQGFKQLM
HCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCEECCCCCEEEECCCCCCCCCCCCHHHHH
ATFESARIQTAARAVGVAQNALEVGLRYALDRQQFGQAIFKFPRVSNKLVMMAAELVGMR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
QLTYFSARQKDNGKRCDLEAGMAKLLAARAAWAAADNAVQIHGGNGFALEYPISRILQDA
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEECCCHHHHHHHH
RILNIFEGAGEVQAMVIARRLVEGGN
HHHHHHHCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]