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The map label for this gene is moaA1 [H]

Identifier: 114800233

GI number: 114800233

Start: 1074829

End: 1075860

Strand: Reverse

Name: moaA1 [H]

Synonym: HNE_1069

Alternate gene names: 114800233

Gene position: 1075860-1074829 (Counterclockwise)

Preceding gene: 114800035

Following gene: 114799467

Centisome position: 29.04

GC content: 66.47

Gene sequence:

>1032_bases
ATGGCTGACGGACTGGGACGCGCCCCGCCCCCACCCCTCACAGACGCTTTCGGGCGCAACGTCACCTATCTGCGCCTCTC
GGTGACAGACCGCTGCGATCTGCGGTGCACCTACTGCATGGCCGAACAGATGACCTTCCTGCCGAAAAAGGATCTTCTGA
CGCTGGAAGAACTCGAAAGCGTCGCCGATGCCTTCATCCGCCGGGGCGTCACCAAAATCCGCATCACCGGCGGCGAGCCC
CTCGTGCGCCGCGACATCGGAACCCTGTTTGACCGTCTGGGCAGCCGCCTCGGCCACGGCCTGGACGAACTCACCCTCAC
CACAAACGCCACCCTGCTCACCACCCACGCCGCCCGCCTCTACGCCGCCGGCGTCCGCCGCGTGAACATCTCGCTGGACA
CGCTCGACGCCGACACCTTCAAAGCCATCACCCGGCGCGGTGATCTTGCCCAGACCCTCGCCGGCATCGCCGCTGCAAAA
GCCGCCGGCCTCAAGGTCAAGATCAACACCGTCGCCCTCAAACACCAGAATGCCGAGGAAATCCCCGGCATGATCGCCTG
GGCACATGATCAGGGCTTTGACATCACCCTCATCGAAGTCATGCCCCTCGGGCTGACCGGCGAAGACCGGTATGACCAGT
ACATTCCCCTGTTCGAGATCCGCGACCGGCTGGAACAGAAATGGACGCTCACGGACGATACCGCGCGCGCCGCCGATGCC
GGCCCGTCCCGCTATGCCAGGGTTGCCGAAACCGGCGGCCGGGTCGGCTTCATCACCCCGCTGACCAATAATTTCTGCGC
CGGCTGCAACCGCGTCCGCGTCACCTGCACCGGCCGCATCTACATGTGCCTCGGCCATGACGATCACGTCGATCTGCGCA
GCGCCCTTCGCGATACCGCAGACCCCGCCGCCGCCCTCAACGCCGCGCTGGACCGCGCCCTGCGCGGCAAGCCGGAAAAA
CACGCCTTCGGCATCCGCGCCCGCGCCGAAACCCCGGCCCTGCCCCGTCACATGTCGGTCACGGGCGGCTGA

Upstream 100 bases:

>100_bases
TTTCATTCTCTGCCGGGCGGCGTCACAGTCTCTCTGGATACGGCCCACGCCTTTGACATAGACACGACGGATGATCTTCG
GCTTGCACAGGAATTAGCCA

Downstream 100 bases:

>100_bases
CCCATGGCTCAGCTTCTGTTCTTCGGCCGCCTGGCCGATCTCGTCGATCCGCCCAGCCAGGCCGTCCAGCTGCCCGGCGA
CATCCAGGACACCCTCGCCC

Product: molybdenum cofactor biosynthesis protein MoaA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 343; Mature: 342

Protein sequence:

>343_residues
MADGLGRAPPPPLTDAFGRNVTYLRLSVTDRCDLRCTYCMAEQMTFLPKKDLLTLEELESVADAFIRRGVTKIRITGGEP
LVRRDIGTLFDRLGSRLGHGLDELTLTTNATLLTTHAARLYAAGVRRVNISLDTLDADTFKAITRRGDLAQTLAGIAAAK
AAGLKVKINTVALKHQNAEEIPGMIAWAHDQGFDITLIEVMPLGLTGEDRYDQYIPLFEIRDRLEQKWTLTDDTARAADA
GPSRYARVAETGGRVGFITPLTNNFCAGCNRVRVTCTGRIYMCLGHDDHVDLRSALRDTADPAAALNAALDRALRGKPEK
HAFGIRARAETPALPRHMSVTGG

Sequences:

>Translated_343_residues
MADGLGRAPPPPLTDAFGRNVTYLRLSVTDRCDLRCTYCMAEQMTFLPKKDLLTLEELESVADAFIRRGVTKIRITGGEP
LVRRDIGTLFDRLGSRLGHGLDELTLTTNATLLTTHAARLYAAGVRRVNISLDTLDADTFKAITRRGDLAQTLAGIAAAK
AAGLKVKINTVALKHQNAEEIPGMIAWAHDQGFDITLIEVMPLGLTGEDRYDQYIPLFEIRDRLEQKWTLTDDTARAADA
GPSRYARVAETGGRVGFITPLTNNFCAGCNRVRVTCTGRIYMCLGHDDHVDLRSALRDTADPAAALNAALDRALRGKPEK
HAFGIRARAETPALPRHMSVTGG
>Mature_342_residues
ADGLGRAPPPPLTDAFGRNVTYLRLSVTDRCDLRCTYCMAEQMTFLPKKDLLTLEELESVADAFIRRGVTKIRITGGEPL
VRRDIGTLFDRLGSRLGHGLDELTLTTNATLLTTHAARLYAAGVRRVNISLDTLDADTFKAITRRGDLAQTLAGIAAAKA
AGLKVKINTVALKHQNAEEIPGMIAWAHDQGFDITLIEVMPLGLTGEDRYDQYIPLFEIRDRLEQKWTLTDDTARAADAG
PSRYARVAETGGRVGFITPLTNNFCAGCNRVRVTCTGRIYMCLGHDDHVDLRSALRDTADPAAALNAALDRALRGKPEKH
AFGIRARAETPALPRHMSVTGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=326, Percent_Identity=34.0490797546012, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI22027536, Length=326, Percent_Identity=34.0490797546012, Blast_Score=183, Evalue=2e-46,
Organism=Escherichia coli, GI1786999, Length=337, Percent_Identity=34.4213649851632, Blast_Score=186, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI32566331, Length=335, Percent_Identity=34.3283582089552, Blast_Score=204, Evalue=6e-53,
Organism=Caenorhabditis elegans, GI32566329, Length=336, Percent_Identity=34.5238095238095, Blast_Score=201, Evalue=5e-52,
Organism=Caenorhabditis elegans, GI17561210, Length=335, Percent_Identity=34.3283582089552, Blast_Score=193, Evalue=1e-49,
Organism=Drosophila melanogaster, GI28574488, Length=318, Percent_Identity=38.9937106918239, Blast_Score=200, Evalue=1e-51,
Organism=Drosophila melanogaster, GI28574490, Length=318, Percent_Identity=38.9937106918239, Blast_Score=199, Evalue=2e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 37452; Mature: 37321

Theoretical pI: Translated: 8.29; Mature: 8.29

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADGLGRAPPPPLTDAFGRNVTYLRLSVTDRCDLRCTYCMAEQMTFLPKKDLLTLEELES
CCCCCCCCCCCCCHHHHCCCEEEEEEEECCCCCCEEEHHHHHHHHCCCCHHCCCHHHHHH
VADAFIRRGVTKIRITGGEPLVRRDIGTLFDRLGSRLGHGLDELTLTTNATLLTTHAARL
HHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCHHEEEECCCEEEEHHHHHH
YAAGVRRVNISLDTLDADTFKAITRRGDLAQTLAGIAAAKAAGLKVKINTVALKHQNAEE
HHHCEEEEEEEEEECCCHHHHHHHHCCHHHHHHHHHHHHHHCCEEEEEEEEEEECCCHHH
IPGMIAWAHDQGFDITLIEVMPLGLTGEDRYDQYIPLFEIRDRLEQKWTLTDDTARAADA
CCCEEEEECCCCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHCCC
GPSRYARVAETGGRVGFITPLTNNFCAGCNRVRVTCTGRIYMCLGHDDHVDLRSALRDTA
CHHHHHHHHHCCCCEEEECCCCCCHHCCCCEEEEEEEEEEEEEECCCCCHHHHHHHHCCC
DPAAALNAALDRALRGKPEKHAFGIRARAETPALPRHMSVTGG
CHHHHHHHHHHHHHCCCCCHHEEEEEECCCCCCCCCCEECCCC
>Mature Secondary Structure 
ADGLGRAPPPPLTDAFGRNVTYLRLSVTDRCDLRCTYCMAEQMTFLPKKDLLTLEELES
CCCCCCCCCCCCHHHHCCCEEEEEEEECCCCCCEEEHHHHHHHHCCCCHHCCCHHHHHH
VADAFIRRGVTKIRITGGEPLVRRDIGTLFDRLGSRLGHGLDELTLTTNATLLTTHAARL
HHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCHHEEEECCCEEEEHHHHHH
YAAGVRRVNISLDTLDADTFKAITRRGDLAQTLAGIAAAKAAGLKVKINTVALKHQNAEE
HHHCEEEEEEEEEECCCHHHHHHHHCCHHHHHHHHHHHHHHCCEEEEEEEEEEECCCHHH
IPGMIAWAHDQGFDITLIEVMPLGLTGEDRYDQYIPLFEIRDRLEQKWTLTDDTARAADA
CCCEEEEECCCCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHCCC
GPSRYARVAETGGRVGFITPLTNNFCAGCNRVRVTCTGRIYMCLGHDDHVDLRSALRDTA
CHHHHHHHHHCCCCEEEECCCCCCHHCCCCEEEEEEEEEEEEEECCCCCHHHHHHHHCCC
DPAAALNAALDRALRGKPEKHAFGIRARAETPALPRHMSVTGG
CHHHHHHHHHHHHHCCCCCHHEEEEEECCCCCCCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA