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The map label for this gene is rdgB [C]

Identifier: 114800076

GI number: 114800076

Start: 3465806

End: 3466462

Strand: Reverse

Name: rdgB [C]

Synonym: HNE_3310

Alternate gene names: 114800076

Gene position: 3466462-3465806 (Counterclockwise)

Preceding gene: 114798422

Following gene: 114797411

Centisome position: 93.56

GC content: 61.04

Gene sequence:

>657_bases
ATGCATTCGCGCATAAAGCAAGAATGGAGCCACATTACTGTGAATAATGCTACGGCTATGCCCCGCCTTGTGCCCGGAAA
ACTCGTGGCAGCTACACACAACAGAGGCAAGGTGTCCGAACTGAAAGATCTGTTCGCGCCCCATGGTTTTGAGGTTGTTT
CTGCCCTTGAGCTTGATCTGGACGAACCTGAAGAAACCGAGGATAGTTTTTCTGGCAACGCCTTGTTGAAGGCGCGGGCG
GCTGCCCTGGCGACGGGTCTGCCGGCGCTGTCAGATGATTCGGGGCTGGCGGTGACCGCGCTGGGCGGTCAACCGGGCAT
CTATTCGGCGCGCTGGGCCGGAGAGCCGCGGGACTTCTACAAGGCGATGGAGAAGGTGGAGGCTGAACTCAAGGCATCGG
GCTCGCAGGACCGCTCCGCCAAATTTGTCTGCGCGCTGGCAGTTGTGTGGCCCGATGGGACGCAAGCCGTGTATGAGGGC
GAGGTGCACGGAACCCTCGTCTGGCCCCCCAGGGGTGATAAGGGGTTTGGCTATGATCCCGTATTTGTTGCCGAGGGCGA
GACGATGACGTTTGGTGAAATGGACCCCGCGCGCAAACACGCGATGAGCCACCGGGCCCGCGCGGTCGAGAAGCTGCGCG
CGGCGCTGCTCGCATGA

Upstream 100 bases:

>100_bases
CCTGTCTTTGTCATACCCGGCCTTTTCACCCTGCTTGGTTGATGGTTTATGAAGAGGAACTTTGCCAGTGCGCTGTCCCG
TTATTACCGAATAACGATAT

Downstream 100 bases:

>100_bases
CCCAGGTTTTTGCGCCTTTCGGCCCGCATTTCGGCTTCGGCCTGTATATCCATTGGCCCTATTGCACGCGGGTCTGCCCT
TATTGCGACTTCAACGTCTA

Product: non-canonical purine NTP pyrophosphatase

Products: NA

Alternate protein names: Nucleoside triphosphate phosphohydrolase; NTPase [H]

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MHSRIKQEWSHITVNNATAMPRLVPGKLVAATHNRGKVSELKDLFAPHGFEVVSALELDLDEPEETEDSFSGNALLKARA
AALATGLPALSDDSGLAVTALGGQPGIYSARWAGEPRDFYKAMEKVEAELKASGSQDRSAKFVCALAVVWPDGTQAVYEG
EVHGTLVWPPRGDKGFGYDPVFVAEGETMTFGEMDPARKHAMSHRARAVEKLRAALLA

Sequences:

>Translated_218_residues
MHSRIKQEWSHITVNNATAMPRLVPGKLVAATHNRGKVSELKDLFAPHGFEVVSALELDLDEPEETEDSFSGNALLKARA
AALATGLPALSDDSGLAVTALGGQPGIYSARWAGEPRDFYKAMEKVEAELKASGSQDRSAKFVCALAVVWPDGTQAVYEG
EVHGTLVWPPRGDKGFGYDPVFVAEGETMTFGEMDPARKHAMSHRARAVEKLRAALLA
>Mature_218_residues
MHSRIKQEWSHITVNNATAMPRLVPGKLVAATHNRGKVSELKDLFAPHGFEVVSALELDLDEPEETEDSFSGNALLKARA
AALATGLPALSDDSGLAVTALGGQPGIYSARWAGEPRDFYKAMEKVEAELKASGSQDRSAKFVCALAVVWPDGTQAVYEG
EVHGTLVWPPRGDKGFGYDPVFVAEGETMTFGEMDPARKHAMSHRARAVEKLRAALLA

Specific function: Hydrolyzes non-standard nucleotides such as XTP and dITP/ITP. Might exclude non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions [H]

COG id: COG0127

COG function: function code F; Xanthosine triphosphate pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAM1 NTPase family [H]

Homologues:

Organism=Homo sapiens, GI15626999, Length=193, Percent_Identity=32.1243523316062, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI31657144, Length=161, Percent_Identity=33.5403726708075, Blast_Score=76, Evalue=3e-14,
Organism=Escherichia coli, GI1789324, Length=192, Percent_Identity=43.75, Blast_Score=142, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17556833, Length=188, Percent_Identity=36.1702127659575, Blast_Score=85, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6322529, Length=199, Percent_Identity=26.6331658291457, Blast_Score=62, Evalue=7e-11,
Organism=Drosophila melanogaster, GI19920712, Length=189, Percent_Identity=29.6296296296296, Blast_Score=78, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002637
- InterPro:   IPR020922 [H]

Pfam domain/function: PF01725 Ham1p_like [H]

EC number: =3.6.1.15 [H]

Molecular weight: Translated: 23485; Mature: 23485

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHSRIKQEWSHITVNNATAMPRLVPGKLVAATHNRGKVSELKDLFAPHGFEVVSALELDL
CCCHHHHHHCEEEECCCCCCCEECCCEEEEEECCCCCHHHHHHHHCCCCHHHHHHEECCC
DEPEETEDSFSGNALLKARAAALATGLPALSDDSGLAVTALGGQPGIYSARWAGEPRDFY
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHH
KAMEKVEAELKASGSQDRSAKFVCALAVVWPDGTQAVYEGEVHGTLVWPPRGDKGFGYDP
HHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCCEEEECCCCEEEEECCCCCCCCCCCC
VFVAEGETMTFGEMDPARKHAMSHRARAVEKLRAALLA
EEEECCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MHSRIKQEWSHITVNNATAMPRLVPGKLVAATHNRGKVSELKDLFAPHGFEVVSALELDL
CCCHHHHHHCEEEECCCCCCCEECCCEEEEEECCCCCHHHHHHHHCCCCHHHHHHEECCC
DEPEETEDSFSGNALLKARAAALATGLPALSDDSGLAVTALGGQPGIYSARWAGEPRDFY
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHH
KAMEKVEAELKASGSQDRSAKFVCALAVVWPDGTQAVYEGEVHGTLVWPPRGDKGFGYDP
HHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCCEEEECCCCEEEEECCCCCCCCCCCC
VFVAEGETMTFGEMDPARKHAMSHRARAVEKLRAALLA
EEEECCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA