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The map label for this gene is metA

Identifier: 114799570

GI number: 114799570

Start: 3445416

End: 3446333

Strand: Reverse

Name: metA

Synonym: HNE_3283

Alternate gene names: 114799570

Gene position: 3446333-3445416 (Counterclockwise)

Preceding gene: 114800473

Following gene: 114797258

Centisome position: 93.02

GC content: 59.48

Gene sequence:

>918_bases
ATGCCGATCCGGATTCCTGATACGCTGCCTGCGCGTGAGACGCTGCTGAAAGAGGGCGTGGCCGTGATGACGGAGACTGA
TGCCGTGCGCCAGGACATCCGCCCGCTGCAGATCGCGCTTTTGAACCTCATGCCCAACAAGATCCGCACCGAGACGCAGA
TCGCCCGGCTGATCGGCGCCTCGCCCTTGCAGGTGGAGCTGACGCTCGTGCGCGTGGGCGGGCACACGCCGAAGAATACC
TCGCAGGAACATCTGATAAGCTTTTACCAGACCTGGGAAGAAATCCGGGAGCGGAAGTTTGATGGCTTCATCATCACCGG
CGCGCCGATTGAGCAGATGCCGTTTGAAGAGGTGAATTATTGGGAAGAGCTGACCCAGATATTCGACTGGACGCAGACGA
ACGTGCATTCGCCTTTCTATATCTGCTGGGGCGCGATGGCGGCGGCGTATCATTTCCATGGCCTGCCGAAATACCAACTT
GAAGCGAAAGCTTTCGGCGTGTTTCGCCACCGGAATCTTGATCTGGCCTCGCCCTATCTCTCGGGCTTTTCCGATGATTT
TGCCATTCCCGTTTCGCGCTGGACCGAAGTGCGCCGCGCCGACGTTCTGGAGCGCCAGTCCCTCCGCCTGCTGATCGACA
GTGATGACACAGGCCCCTGCCTGCTGGAAGACCGCGCGCGGCGCAGCCTCTATATGTTCAACCATGTCGAGTATGACTCC
TTCTCCCTGAAGGAGGAGTTTGAGCGCGACCGGGAAGCGGGCAAGCAGATCCAGGTGCCGTTTGGTTACTATCCCGGTGA
TGACCCCGCGCGCCAGCCGCTCAACCGCTGGCGCAGCCATGCCCATCTCCTGTTCGGTAACTGGATCAACCAGACGTACC
AGTCGACACCGTTCAGCCTTGACGAAATCGGGCAATAG

Upstream 100 bases:

>100_bases
GCCGAGATGCAGGAAACCCCGGCTTTCCGGGCCTGCCTTTCCCCCTCCGTTGCGGACGTGTTTATTGGACCTGAAGCGGG
CCGATGAGGATGTTTGAGCC

Downstream 100 bases:

>100_bases
ACCAGAACTGAGGCATGACCAGTTTTGCCGCAGAACCTGAGCACGTAACAGAGATCCGCCGCCAGCTTGCCCGCTGGGTG
GCCGAGAAGATGCCGCGCGA

Product: homoserine O-succinyltransferase

Products: NA

Alternate protein names: Homoserine O-transsuccinylase; HTS

Number of amino acids: Translated: 305; Mature: 304

Protein sequence:

>305_residues
MPIRIPDTLPARETLLKEGVAVMTETDAVRQDIRPLQIALLNLMPNKIRTETQIARLIGASPLQVELTLVRVGGHTPKNT
SQEHLISFYQTWEEIRERKFDGFIITGAPIEQMPFEEVNYWEELTQIFDWTQTNVHSPFYICWGAMAAAYHFHGLPKYQL
EAKAFGVFRHRNLDLASPYLSGFSDDFAIPVSRWTEVRRADVLERQSLRLLIDSDDTGPCLLEDRARRSLYMFNHVEYDS
FSLKEEFERDREAGKQIQVPFGYYPGDDPARQPLNRWRSHAHLLFGNWINQTYQSTPFSLDEIGQ

Sequences:

>Translated_305_residues
MPIRIPDTLPARETLLKEGVAVMTETDAVRQDIRPLQIALLNLMPNKIRTETQIARLIGASPLQVELTLVRVGGHTPKNT
SQEHLISFYQTWEEIRERKFDGFIITGAPIEQMPFEEVNYWEELTQIFDWTQTNVHSPFYICWGAMAAAYHFHGLPKYQL
EAKAFGVFRHRNLDLASPYLSGFSDDFAIPVSRWTEVRRADVLERQSLRLLIDSDDTGPCLLEDRARRSLYMFNHVEYDS
FSLKEEFERDREAGKQIQVPFGYYPGDDPARQPLNRWRSHAHLLFGNWINQTYQSTPFSLDEIGQ
>Mature_304_residues
PIRIPDTLPARETLLKEGVAVMTETDAVRQDIRPLQIALLNLMPNKIRTETQIARLIGASPLQVELTLVRVGGHTPKNTS
QEHLISFYQTWEEIRERKFDGFIITGAPIEQMPFEEVNYWEELTQIFDWTQTNVHSPFYICWGAMAAAYHFHGLPKYQLE
AKAFGVFRHRNLDLASPYLSGFSDDFAIPVSRWTEVRRADVLERQSLRLLIDSDDTGPCLLEDRARRSLYMFNHVEYDSF
SLKEEFERDREAGKQIQVPFGYYPGDDPARQPLNRWRSHAHLLFGNWINQTYQSTPFSLDEIGQ

Specific function: Methionine biosynthesis; HTS variant; first step. [C]

COG id: COG1897

COG function: function code E; Homoserine trans-succinylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HTS family

Homologues:

Organism=Escherichia coli, GI1790443, Length=301, Percent_Identity=40.8637873754153, Blast_Score=250, Evalue=1e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): META_HYPNA (Q0BX37)

Other databases:

- EMBL:   CP000158
- RefSeq:   YP_761956.1
- ProteinModelPortal:   Q0BX37
- SMR:   Q0BX37
- STRING:   Q0BX37
- GeneID:   4288555
- GenomeReviews:   CP000158_GR
- KEGG:   hne:HNE_3283
- NMPDR:   fig|228405.5.peg.3144
- TIGR:   HNE_3283
- eggNOG:   COG1897
- HOGENOM:   HBG362506
- OMA:   QAGLYYH
- PhylomeDB:   Q0BX37
- ProtClustDB:   PRK05368
- BioCyc:   HNEP81032:HNE_3283-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00295
- InterPro:   IPR005697
- PANTHER:   PTHR20919
- PIRSF:   PIRSF000450
- ProDom:   PD037892
- TIGRFAMs:   TIGR01001

Pfam domain/function: PF04204 HTS

EC number: =2.3.1.46

Molecular weight: Translated: 35436; Mature: 35304

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: NA

Important sites: ACT_SITE 142-142

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIRIPDTLPARETLLKEGVAVMTETDAVRQDIRPLQIALLNLMPNKIRTETQIARLIGA
CCCCCCCCCCHHHHHHHCCCCEEECCHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHCC
SPLQVELTLVRVGGHTPKNTSQEHLISFYQTWEEIRERKFDGFIITGAPIEQMPFEEVNY
CCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHH
WEELTQIFDWTQTNVHSPFYICWGAMAAAYHFHGLPKYQLEAKAFGVFRHRNLDLASPYL
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCHHH
SGFSDDFAIPVSRWTEVRRADVLERQSLRLLIDSDDTGPCLLEDRARRSLYMFNHVEYDS
CCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHEEEEECCCCCC
FSLKEEFERDREAGKQIQVPFGYYPGDDPARQPLNRWRSHAHLLFGNWINQTYQSTPFSL
CHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
DEIGQ
HHCCC
>Mature Secondary Structure 
PIRIPDTLPARETLLKEGVAVMTETDAVRQDIRPLQIALLNLMPNKIRTETQIARLIGA
CCCCCCCCCHHHHHHHCCCCEEECCHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHCC
SPLQVELTLVRVGGHTPKNTSQEHLISFYQTWEEIRERKFDGFIITGAPIEQMPFEEVNY
CCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHH
WEELTQIFDWTQTNVHSPFYICWGAMAAAYHFHGLPKYQLEAKAFGVFRHRNLDLASPYL
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCHHH
SGFSDDFAIPVSRWTEVRRADVLERQSLRLLIDSDDTGPCLLEDRARRSLYMFNHVEYDS
CCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHEEEEECCCCCC
FSLKEEFERDREAGKQIQVPFGYYPGDDPARQPLNRWRSHAHLLFGNWINQTYQSTPFSL
CHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
DEIGQ
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA