Click here to switch to the map view.

The map label for this gene is fmt [H]

Identifier: 114799265

GI number: 114799265

Start: 506427

End: 507386

Strand: Direct

Name: fmt [H]

Synonym: HNE_0513

Alternate gene names: 114799265

Gene position: 506427-507386 (Clockwise)

Preceding gene: 114800420

Following gene: 114798503

Centisome position: 13.67

GC content: 67.6

Gene sequence:

>960_bases
ATGCCAGACCAAATAACCCCGCCTCTCCGCATTGCCTTCATGGGCAGCCCCGGCATCGCGCTTGGCGTGCTCGAAGCGCT
GATCGCGGCCGGGCATGAGATCGCCTGCGTCTATTCCCAGCCGCCCCGGCCCTCCGGGCGCGGCCAGAAACTGACGCCAA
CGCCGGTGCATGCTTTTGCGCAGGCGCGTGGCCTCGAAGTGCGCACGCCAAAGTCCCTGAAAAAGCCCGAAGAGCAGGCG
GCCTTTGCGGCGCTGAACCTCGATGCGGCAGTTGTGGTCGCCTATGGCCTGATCCTGCCGCAGGCGGTGCTGAACGCCCC
GCGCCTCGGCTGCCTCAACATGCACGCCTCCATCCTGCCGCGCTGGCGGGGCGCCGCGCCGATCCAGCGCGCCATCATGG
CGGGCGACACCGAAACGGGCGTGGACGCCATGATGATGGAAGCCGGCCTCGACACCGGCCCCGTCTTGGAATCCGTCCGC
ACACCCATCACACCACAGGACACCGCCGGCACCCTGCATGACCGCCTGGCCGCGCTCGCCGCCGAGCTGGCGCCGCGCGC
GCTGGCGGGTCTGGCAGACGGCAGCCTGAAGCCTGTGCCCCAGACAGAAGAGGGCATGACCTACGCTCAGAAAATCAGCG
CCGAAGATCAGCGTATCGACTGGACGAAACCGGCCGCTGAAGTCGATTGCCAGATACGCGGTCTCGCGCCTGCGTCGGGC
GCATGGTGTGAAGCCGATCTGGGGCAGGGGCCGGTACGGCTCAAGGTTCTCTTCAGTGAGCTGACGGACCTCTGGAACCC
GGCCCCTCCCGGCACGCTCATCGACGACCGCCTCGCCGTGGCCTGCGGCGATGGCCGCGCCGTGCGTCTGATGAGGCTTC
AGAAGCCGGGCGGAAAGGCGCTGGAGGCGCGAGATTTCCTTGCCGGAAATCACCTTCCCGCAGGCAAGATCTTCAGCTGA

Upstream 100 bases:

>100_bases
AAGGTGAAGAAGGCCAAGATCCGCGCCATCCGCGAAGACGCCAACTGATCGGCCACTGCCGTCTCGACCCGCAGGCGGCG
AGAGACTATGAGGCTGGCCT

Downstream 100 bases:

>100_bases
TGGACATCTGGATACGCCCGTTCCGCCCGGAATATCTTGACGCCATCGTGGCGGTGAACGATGCGGCTTTCGGTGGCCCG
GATGAGGGCGCCATCACGCG

Product: methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 319; Mature: 318

Protein sequence:

>319_residues
MPDQITPPLRIAFMGSPGIALGVLEALIAAGHEIACVYSQPPRPSGRGQKLTPTPVHAFAQARGLEVRTPKSLKKPEEQA
AFAALNLDAAVVVAYGLILPQAVLNAPRLGCLNMHASILPRWRGAAPIQRAIMAGDTETGVDAMMMEAGLDTGPVLESVR
TPITPQDTAGTLHDRLAALAAELAPRALAGLADGSLKPVPQTEEGMTYAQKISAEDQRIDWTKPAAEVDCQIRGLAPASG
AWCEADLGQGPVRLKVLFSELTDLWNPAPPGTLIDDRLAVACGDGRAVRLMRLQKPGGKALEARDFLAGNHLPAGKIFS

Sequences:

>Translated_319_residues
MPDQITPPLRIAFMGSPGIALGVLEALIAAGHEIACVYSQPPRPSGRGQKLTPTPVHAFAQARGLEVRTPKSLKKPEEQA
AFAALNLDAAVVVAYGLILPQAVLNAPRLGCLNMHASILPRWRGAAPIQRAIMAGDTETGVDAMMMEAGLDTGPVLESVR
TPITPQDTAGTLHDRLAALAAELAPRALAGLADGSLKPVPQTEEGMTYAQKISAEDQRIDWTKPAAEVDCQIRGLAPASG
AWCEADLGQGPVRLKVLFSELTDLWNPAPPGTLIDDRLAVACGDGRAVRLMRLQKPGGKALEARDFLAGNHLPAGKIFS
>Mature_318_residues
PDQITPPLRIAFMGSPGIALGVLEALIAAGHEIACVYSQPPRPSGRGQKLTPTPVHAFAQARGLEVRTPKSLKKPEEQAA
FAALNLDAAVVVAYGLILPQAVLNAPRLGCLNMHASILPRWRGAAPIQRAIMAGDTETGVDAMMMEAGLDTGPVLESVRT
PITPQDTAGTLHDRLAALAAELAPRALAGLADGSLKPVPQTEEGMTYAQKISAEDQRIDWTKPAAEVDCQIRGLAPASGA
WCEADLGQGPVRLKVLFSELTDLWNPAPPGTLIDDRLAVACGDGRAVRLMRLQKPGGKALEARDFLAGNHLPAGKIFS

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family [H]

Homologues:

Organism=Homo sapiens, GI21614513, Length=322, Percent_Identity=27.9503105590062, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI238814322, Length=318, Percent_Identity=27.6729559748428, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI164663775, Length=328, Percent_Identity=30.1829268292683, Blast_Score=98, Evalue=1e-20,
Organism=Escherichia coli, GI1789683, Length=306, Percent_Identity=48.3660130718954, Blast_Score=266, Evalue=2e-72,
Organism=Escherichia coli, GI1788589, Length=274, Percent_Identity=31.021897810219, Blast_Score=123, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI133930964, Length=304, Percent_Identity=29.2763157894737, Blast_Score=98, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6319458, Length=360, Percent_Identity=27.7777777777778, Blast_Score=86, Evalue=8e-18,
Organism=Drosophila melanogaster, GI45550868, Length=227, Percent_Identity=32.15859030837, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI28571984, Length=227, Percent_Identity=32.15859030837, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24585660, Length=320, Percent_Identity=28.4375, Blast_Score=86, Evalue=5e-17,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR015518 [H]

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N [H]

EC number: =2.1.2.9 [H]

Molecular weight: Translated: 33608; Mature: 33477

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDQITPPLRIAFMGSPGIALGVLEALIAAGHEIACVYSQPPRPSGRGQKLTPTPVHAFA
CCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCHHHHHH
QARGLEVRTPKSLKKPEEQAAFAALNLDAAVVVAYGLILPQAVLNAPRLGCLNMHASILP
HHCCCEEECCHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCC
RWRGAAPIQRAIMAGDTETGVDAMMMEAGLDTGPVLESVRTPITPQDTAGTLHDRLAALA
CCCCCCHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHH
AELAPRALAGLADGSLKPVPQTEEGMTYAQKISAEDQRIDWTKPAAEVDCQIRGLAPASG
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCC
AWCEADLGQGPVRLKVLFSELTDLWNPAPPGTLIDDRLAVACGDGRAVRLMRLQKPGGKA
CEEECCCCCCCEEEHHHHHHHHHHCCCCCCCCEECCCEEEEECCCCEEEEEEEECCCCCC
LEARDFLAGNHLPAGKIFS
CHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
PDQITPPLRIAFMGSPGIALGVLEALIAAGHEIACVYSQPPRPSGRGQKLTPTPVHAFA
CCCCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCHHHHHH
QARGLEVRTPKSLKKPEEQAAFAALNLDAAVVVAYGLILPQAVLNAPRLGCLNMHASILP
HHCCCEEECCHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCC
RWRGAAPIQRAIMAGDTETGVDAMMMEAGLDTGPVLESVRTPITPQDTAGTLHDRLAALA
CCCCCCHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHH
AELAPRALAGLADGSLKPVPQTEEGMTYAQKISAEDQRIDWTKPAAEVDCQIRGLAPASG
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCC
AWCEADLGQGPVRLKVLFSELTDLWNPAPPGTLIDDRLAVACGDGRAVRLMRLQKPGGKA
CEEECCCCCCCEEEHHHHHHHHHHCCCCCCCCEECCCEEEEECCCCEEEEEEEECCCCCC
LEARDFLAGNHLPAGKIFS
CHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA