Click here to switch to the map view.

The map label for this gene is gbd [H]

Identifier: 114798252

GI number: 114798252

Start: 162628

End: 163761

Strand: Direct

Name: gbd [H]

Synonym: HNE_0174

Alternate gene names: 114798252

Gene position: 162628-163761 (Clockwise)

Preceding gene: 114799790

Following gene: 114797489

Centisome position: 4.39

GC content: 60.14

Gene sequence:

>1134_bases
ATGCCGGTCATGAATTTTCTTACTCAGTGCGTCTTCGATTCGGGTGCGCTGAAGCAGCTTGCCAAACTCGCAAAGGCGCG
CGGCATAACGCGCCCGTTCATTGTGACCGATGCTGGCATCAAGGCTTCAGGTATCCTGGCGAAGGTGGAGGACGCACTCG
GTGTAGCGCCGGCGGGCGTCTTCGCGGAGACGGTTCCCAATCCAACGGAAGCACAGACGAAGGTGGCGACCGCACTCTAC
AAGGAGTCCGGCGCAGACGGGATTATCGCGGTGGGCGGGGGCTCGTCCATGGATCATGCGAAGGCAATCGGTCTGATGGC
CAGCCATGACGAGCCCCTGGAAACCTATGCTGCCATCATCGGTGGGTCCAAGCTGGTCGGCAAGATCCCGCCGCTGATTG
CGATTCCCACAACCGCCGGTACGGGTTCGGAAGTCTCCATCGGTATGGTCATCATTATGGAAAATGGGCGCAAGGAAACC
TTTGCGTCGCCCAACCTTATTCCGCTGGTTGCGCTTTGTGACCCTGATCTGACGATCGGTCTCCCAGCGGGCCTCACGGC
GGCAACGGGTATGGATGCCCTGACCCACTGTATCGAGGCGATCCTCACGCCTGCCATCAATCCGCCTGCGGAGGGGATCG
GTTACGATGGCGCTCGCCGGGCATTTGGCATGGATATGTTGAAGCGGGCCGTGAGGGATGGATCAGACGAGGAGGCGCGT
TGGCATATGATGATGGCCAGCTATGAGGGCGCGCTTGCCTTCGTGAAGGGCCTTGGCGGCGTTCATGCGCTCAGCCATGC
GGCCGGGCGCTTGCATGACAAGAAGCTGCACCATGGGACGCTGAACGCAGTTTTCCTTCCGCACATCCTGCGCTTTCACA
ATGGTGCTGCCGACGAAAAGTATGCCCGGCTGCGCGAGGCGATGGGGCTCAAGGCAAACGCCGATCTCGCCGATGCCATT
CAGGACCTCAACGATGCGATCGGCATTCCCAAGACACTCAGCGCCATGGGCCTTTCTGCGTCGGACGGTCCAGGAATTGT
TGAGTATGCCCTGGTGGATCTTGCCCATGCAGGAAATCCACGTCCGATGAGCGCGGATGATTATGCGGCGGTATATGAGA
CCGCGCTCGGCTGA

Upstream 100 bases:

>100_bases
CTAAGCCCGCCGGACTGCGTCACGCTGACCTTGGGAAAGGCTTGCCTTGGGGCAAGTGAGCGGGGAACATGTCTTCAGTC
CCTTTCCGCTGGAGTGCTCA

Downstream 100 bases:

>100_bases
GGAAGAACCATGAAGCGCCGCTTCGCTCCCATACTCAAGATGGCCGCCAGCCATCATGGTGGGGAAGAGGCGGCGCTTGC
AAAATCGGTGAACGCCCATT

Product: 4-hydroxybutyrate dehydrogenase, NAD-dependent

Products: NA

Alternate protein names: Propanediol oxidoreductase [H]

Number of amino acids: Translated: 377; Mature: 376

Protein sequence:

>377_residues
MPVMNFLTQCVFDSGALKQLAKLAKARGITRPFIVTDAGIKASGILAKVEDALGVAPAGVFAETVPNPTEAQTKVATALY
KESGADGIIAVGGGSSMDHAKAIGLMASHDEPLETYAAIIGGSKLVGKIPPLIAIPTTAGTGSEVSIGMVIIMENGRKET
FASPNLIPLVALCDPDLTIGLPAGLTAATGMDALTHCIEAILTPAINPPAEGIGYDGARRAFGMDMLKRAVRDGSDEEAR
WHMMMASYEGALAFVKGLGGVHALSHAAGRLHDKKLHHGTLNAVFLPHILRFHNGAADEKYARLREAMGLKANADLADAI
QDLNDAIGIPKTLSAMGLSASDGPGIVEYALVDLAHAGNPRPMSADDYAAVYETALG

Sequences:

>Translated_377_residues
MPVMNFLTQCVFDSGALKQLAKLAKARGITRPFIVTDAGIKASGILAKVEDALGVAPAGVFAETVPNPTEAQTKVATALY
KESGADGIIAVGGGSSMDHAKAIGLMASHDEPLETYAAIIGGSKLVGKIPPLIAIPTTAGTGSEVSIGMVIIMENGRKET
FASPNLIPLVALCDPDLTIGLPAGLTAATGMDALTHCIEAILTPAINPPAEGIGYDGARRAFGMDMLKRAVRDGSDEEAR
WHMMMASYEGALAFVKGLGGVHALSHAAGRLHDKKLHHGTLNAVFLPHILRFHNGAADEKYARLREAMGLKANADLADAI
QDLNDAIGIPKTLSAMGLSASDGPGIVEYALVDLAHAGNPRPMSADDYAAVYETALG
>Mature_376_residues
PVMNFLTQCVFDSGALKQLAKLAKARGITRPFIVTDAGIKASGILAKVEDALGVAPAGVFAETVPNPTEAQTKVATALYK
ESGADGIIAVGGGSSMDHAKAIGLMASHDEPLETYAAIIGGSKLVGKIPPLIAIPTTAGTGSEVSIGMVIIMENGRKETF
ASPNLIPLVALCDPDLTIGLPAGLTAATGMDALTHCIEAILTPAINPPAEGIGYDGARRAFGMDMLKRAVRDGSDEEARW
HMMMASYEGALAFVKGLGGVHALSHAAGRLHDKKLHHGTLNAVFLPHILRFHNGAADEKYARLREAMGLKANADLADAIQ
DLNDAIGIPKTLSAMGLSASDGPGIVEYALVDLAHAGNPRPMSADDYAAVYETALG

Specific function: Fucose metabolism; fourth step. [C]

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=365, Percent_Identity=29.3150684931507, Blast_Score=92, Evalue=7e-19,
Organism=Escherichia coli, GI1789163, Length=379, Percent_Identity=34.3007915567282, Blast_Score=189, Evalue=3e-49,
Organism=Escherichia coli, GI87082107, Length=368, Percent_Identity=35.054347826087, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI48994951, Length=367, Percent_Identity=35.4223433242507, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI1787493, Length=375, Percent_Identity=28.2666666666667, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1789386, Length=356, Percent_Identity=26.685393258427, Blast_Score=90, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17537053, Length=419, Percent_Identity=25.7756563245823, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6321181, Length=378, Percent_Identity=34.6560846560847, Blast_Score=183, Evalue=4e-47,
Organism=Drosophila melanogaster, GI24657991, Length=368, Percent_Identity=27.7173913043478, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211
- InterPro:   IPR013460 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.77 [H]

Molecular weight: Translated: 39048; Mature: 38917

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS00913 ADH_IRON_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVMNFLTQCVFDSGALKQLAKLAKARGITRPFIVTDAGIKASGILAKVEDALGVAPAGV
CCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHCCCCCCH
FAETVPNPTEAQTKVATALYKESGADGIIAVGGGSSMDHAKAIGLMASHDEPLETYAAII
HHHCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHCCCCCHHHHHHHHH
GGSKLVGKIPPLIAIPTTAGTGSEVSIGMVIIMENGRKETFASPNLIPLVALCDPDLTIG
CCCHHHHCCCCEEEECCCCCCCCCEEEEEEEEEECCCCCCCCCCCCEEEEEECCCCCEEE
LPAGLTAATGMDALTHCIEAILTPAINPPAEGIGYDGARRAFGMDMLKRAVRDGSDEEAR
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHH
WHMMMASYEGALAFVKGLGGVHALSHAAGRLHDKKLHHGTLNAVFLPHILRFHNGAADEK
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHH
YARLREAMGLKANADLADAIQDLNDAIGIPKTLSAMGLSASDGPGIVEYALVDLAHAGNP
HHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHCCCC
RPMSADDYAAVYETALG
CCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
PVMNFLTQCVFDSGALKQLAKLAKARGITRPFIVTDAGIKASGILAKVEDALGVAPAGV
CHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHCCCCCCH
FAETVPNPTEAQTKVATALYKESGADGIIAVGGGSSMDHAKAIGLMASHDEPLETYAAII
HHHCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHCCCCCHHHHHHHHH
GGSKLVGKIPPLIAIPTTAGTGSEVSIGMVIIMENGRKETFASPNLIPLVALCDPDLTIG
CCCHHHHCCCCEEEECCCCCCCCCEEEEEEEEEECCCCCCCCCCCCEEEEEECCCCCEEE
LPAGLTAATGMDALTHCIEAILTPAINPPAEGIGYDGARRAFGMDMLKRAVRDGSDEEAR
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHH
WHMMMASYEGALAFVKGLGGVHALSHAAGRLHDKKLHHGTLNAVFLPHILRFHNGAADEK
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHH
YARLREAMGLKANADLADAIQDLNDAIGIPKTLSAMGLSASDGPGIVEYALVDLAHAGNP
HHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHCCCC
RPMSADDYAAVYETALG
CCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]