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The map label for this gene is thrB

Identifier: 114798237

GI number: 114798237

Start: 961193

End: 962179

Strand: Reverse

Name: thrB

Synonym: HNE_0947

Alternate gene names: 114798237

Gene position: 962179-961193 (Counterclockwise)

Preceding gene: 114798525

Following gene: 114800157

Centisome position: 25.97

GC content: 62.51

Gene sequence:

>987_bases
ATGGCGGTATATACGCAAGTTTCTGATGAAGCCCTCGCAGGGTTCCTCGCCGGGTATGATCTCGGCGAGGCGCTTGCGTT
CAAGGGCATTGCCGAGGGCGTTGAGAACTCGAATTACTATCTCGAGACCCGCAAGGGCAGGTACATTCTCACCCTGTTTG
AAAAGCGGGTGAACGCGGCAGACCTCCCGTATTTCATTGGTCTGAAGCAGCATCTCTCGTCAAAGGGCTATCCCTGCCCC
GAGCCGGTCATGGGGCTTGACGGACAGGCGCTGCGCACGCTGGAAGACCGCCCGGCCGTCATCGTGACGTTCCTCGATGG
CCTCTCGCCGCGCCGCCCTACGGCGAAGCAGTGCCGCTCGCTGGGCGAAGGTCTGGCGCGGATGCATCTGGCGCTGGCGG
ATTTCAAAGGCCACCGCGAGAACGCCCTCGGGCCATCTTCCTGGCGCCGCATGTGGGACGGGCGCGGGGCAGATGCCGAG
GCGATCCAGCCGGGACTGGAAGCCGAAGTGAACGCCTGCTTCGAGCGCATCAATGCGGCGCGAGCTTTTTCGGCGAACCT
TCCGCGCGGGACCATCCATGCCGATCTCTTCCCGGACAACGCCTTCTTCCTGGGCGAGGCGTTCTCTGGCGCCATCGACT
TCTATTTCGCCTGCACCGACGCGCTGGCTTACGATCTCGCTGTCTGTCTCAATTCCTGGGCCTTCGAAGAAGGCAACGCG
ACGGATGCTTCGCGGCTGGAATACAATTTCTCCAAAGGCTCCGCACTGATCGCGGGCTACCAATCGGTCCGACCGCTTGA
AGCGGCTGAGCGGGAGGCGCTGCCTGCGCTGTGCCTCGGATCGGCGATGCGGTTTTTCCTCACGCGCCTCTCTGATTGGT
CGTCCACGCCGGCGGGCGCCCTCGTAAAGCCCAAAAACCCTCTTGAATACGCCGCTCGGCTGGCTTTCCATCGCAAGATC
GAAAGCGCCGAAGGCTATGGGGCATGA

Upstream 100 bases:

>100_bases
TCTTTGCTTCGCTCTATGGCTGGGCGGCGATCCACTACCTGCTCGCCGGCAAGACACTTAGCCGTGACATGCTCTCCAAA
ACTGCGTAAGGGCGCCGCCT

Downstream 100 bases:

>100_bases
GCGACAACGCAGGGCCTGAACCACACGTACCTCCTTCCGCACCCGACAGCCCGCTGCCCGGCTATGCTATGGCCGCGCGC
CCGCGCCGGGTGAAGCGGGT

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK

Number of amino acids: Translated: 328; Mature: 327

Protein sequence:

>328_residues
MAVYTQVSDEALAGFLAGYDLGEALAFKGIAEGVENSNYYLETRKGRYILTLFEKRVNAADLPYFIGLKQHLSSKGYPCP
EPVMGLDGQALRTLEDRPAVIVTFLDGLSPRRPTAKQCRSLGEGLARMHLALADFKGHRENALGPSSWRRMWDGRGADAE
AIQPGLEAEVNACFERINAARAFSANLPRGTIHADLFPDNAFFLGEAFSGAIDFYFACTDALAYDLAVCLNSWAFEEGNA
TDASRLEYNFSKGSALIAGYQSVRPLEAAEREALPALCLGSAMRFFLTRLSDWSSTPAGALVKPKNPLEYAARLAFHRKI
ESAEGYGA

Sequences:

>Translated_328_residues
MAVYTQVSDEALAGFLAGYDLGEALAFKGIAEGVENSNYYLETRKGRYILTLFEKRVNAADLPYFIGLKQHLSSKGYPCP
EPVMGLDGQALRTLEDRPAVIVTFLDGLSPRRPTAKQCRSLGEGLARMHLALADFKGHRENALGPSSWRRMWDGRGADAE
AIQPGLEAEVNACFERINAARAFSANLPRGTIHADLFPDNAFFLGEAFSGAIDFYFACTDALAYDLAVCLNSWAFEEGNA
TDASRLEYNFSKGSALIAGYQSVRPLEAAEREALPALCLGSAMRFFLTRLSDWSSTPAGALVKPKNPLEYAARLAFHRKI
ESAEGYGA
>Mature_327_residues
AVYTQVSDEALAGFLAGYDLGEALAFKGIAEGVENSNYYLETRKGRYILTLFEKRVNAADLPYFIGLKQHLSSKGYPCPE
PVMGLDGQALRTLEDRPAVIVTFLDGLSPRRPTAKQCRSLGEGLARMHLALADFKGHRENALGPSSWRRMWDGRGADAEA
IQPGLEAEVNACFERINAARAFSANLPRGTIHADLFPDNAFFLGEAFSGAIDFYFACTDALAYDLAVCLNSWAFEEGNAT
DASRLEYNFSKGSALIAGYQSVRPLEAAEREALPALCLGSAMRFFLTRLSDWSSTPAGALVKPKNPLEYAARLAFHRKIE
SAEGYGA

Specific function: Unknown

COG id: COG2334

COG function: function code R; Putative homoserine kinase type II (protein kinase fold)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pseudomonas-type thrB family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KHSE_HYPNA (Q0C3L9)

Other databases:

- EMBL:   CP000158
- RefSeq:   YP_759674.1
- ProteinModelPortal:   Q0C3L9
- SMR:   Q0C3L9
- STRING:   Q0C3L9
- GeneID:   4288930
- GenomeReviews:   CP000158_GR
- KEGG:   hne:HNE_0947
- NMPDR:   fig|228405.5.peg.926
- TIGR:   HNE_0947
- eggNOG:   COG2334
- HOGENOM:   HBG309377
- OMA:   ADLFRDN
- ProtClustDB:   CLSK2531789
- BioCyc:   HNEP81032:HNE_0947-MONOMER
- HAMAP:   MF_00301
- InterPro:   IPR002575
- InterPro:   IPR005280
- InterPro:   IPR011009
- TIGRFAMs:   TIGR00938

Pfam domain/function: PF01636 APH; SSF56112 Kinase_like

EC number: =2.7.1.39

Molecular weight: Translated: 35803; Mature: 35672

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVYTQVSDEALAGFLAGYDLGEALAFKGIAEGVENSNYYLETRKGRYILTLFEKRVNAA
CCEEECCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEHHHHCCCC
DLPYFIGLKQHLSSKGYPCPEPVMGLDGQALRTLEDRPAVIVTFLDGLSPRRPTAKQCRS
CCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHH
LGEGLARMHLALADFKGHRENALGPSSWRRMWDGRGADAEAIQPGLEAEVNACFERINAA
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCHHHHCCCCHHHHHHHHHHHHHH
RAFSANLPRGTIHADLFPDNAFFLGEAFSGAIDFYFACTDALAYDLAVCLNSWAFEEGNA
HHHHCCCCCCCEEEEECCCCCEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
TDASRLEYNFSKGSALIAGYQSVRPLEAAEREALPALCLGSAMRFFLTRLSDWSSTPAGA
CCHHHEEEECCCCCEEEECHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCC
LVKPKNPLEYAARLAFHRKIESAEGYGA
EECCCCHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
AVYTQVSDEALAGFLAGYDLGEALAFKGIAEGVENSNYYLETRKGRYILTLFEKRVNAA
CEEECCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEHHHHCCCC
DLPYFIGLKQHLSSKGYPCPEPVMGLDGQALRTLEDRPAVIVTFLDGLSPRRPTAKQCRS
CCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHH
LGEGLARMHLALADFKGHRENALGPSSWRRMWDGRGADAEAIQPGLEAEVNACFERINAA
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCHHHHCCCCHHHHHHHHHHHHHH
RAFSANLPRGTIHADLFPDNAFFLGEAFSGAIDFYFACTDALAYDLAVCLNSWAFEEGNA
HHHHCCCCCCCEEEEECCCCCEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
TDASRLEYNFSKGSALIAGYQSVRPLEAAEREALPALCLGSAMRFFLTRLSDWSSTPAGA
CCHHHEEEECCCCCEEEECHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCC
LVKPKNPLEYAARLAFHRKIESAEGYGA
EECCCCHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA