Click here to switch to the map view.

The map label for this gene is mmgC [H]

Identifier: 114797732

GI number: 114797732

Start: 3255025

End: 3256239

Strand: Reverse

Name: mmgC [H]

Synonym: HNE_3080

Alternate gene names: 114797732

Gene position: 3256239-3255025 (Counterclockwise)

Preceding gene: 114799896

Following gene: 114798498

Centisome position: 87.89

GC content: 60.91

Gene sequence:

>1215_bases
ATGGCTTACGATAATGCCGAGCAACTTGAAGAATTCCGCCTAGAGGCCCGCAAATGGCTCGAGGACAACTGCCCCCCCTC
CATGCGCACACCGATGCGGGATGATGAAGTCGTCTGGGGTGGGCGCAACGCAACCTTCAAGAACCCAGATTCGAAAGCCT
GGCTGGACCGTATGGGCGAGAAGGGCTGGACGGCGCCGGAATGGCCAAAGGAATATGGTGGGGGCGGCCTCTCCCGGTCA
GAAGCGCGCGTTCTTGAGCAGGAGATGCGCCGCATCAAGGCGCGCCCGCCGCTCTTTTCCTTCGGCCTCTGGATGTTTGG
CCCGGCTCTGCTGGAGTTTGGCAACCACGAGCAGAAGCTGCGCTTCATTCCCGACATCGTCAAAGGCAAAACCCGCTGGT
GTCAGGGCTATTCCGAGCCGGGCGCGGGCTCCGACCTCGCAGGCCTTCAGACCCGCTGTGAAGACAAGGGCGACCACTAT
CTGATCAATGGCCAGAAGGTGTGGACCTCTTACGCCGACAAGGCCGACTGGATTTTCTGCCTGGTACGCACCGACACCAG
CACCAAGCATGAAGGCATCAGCTTCATCCTGTTCGACATGAAGAGCCCCGGCGTGGAAGCACGCCCCATCCAGCTTATTT
CCGGCGAGAGCCCATTCTGCGAAACCTTCTTCACCGATGTGAAGGTGCCCAAGGAACAACTCGTCGGCCGGGTGAATGGC
GGCTGGGATATTGCTAAACGGCTTCTCCAGTTTGAGCGGTCGTCGATTTCCGCCGGCGGCTTTGGCGGCACTGGCGGCTC
GGGCATTCTTGGCCCGGACGAGTATGCCAAGCATCATGTCGGCACCGATGAGACCGGCCGCGTTGCAGATGGCGATCTGC
GGGGCCGTATCGCTGACCACAAGATGTACACCAAGGCGTTTGCCCTCACGGTGCAGCGTCAGACAGAACAGGCCAAGGCA
GGCCAGGCCGTCGGCCATACCGCGTCGATCCTCAAATATGCTGCCGCCAAGATGAACCAGGACCGGCACGAGCTTCTGAT
CGAGGCGCTGGGCACCGAAGGTCTCGGCTGGGAAGGCGAAGGCTTTGACAAGGGCGCCATGCGGGTCACCCGTCAATGGC
TGCGCTCGAAGGGCAATTCGATCGAGGGCGGCACGTCTGAGATCAACCTCAACGTCATCGCCAAGCGTGTCCTGGGCCTC
AAAGAGCACCAGTAA

Upstream 100 bases:

>100_bases
GCGGCAGCGTGTCATACTCTGACGCCGGGTGAGCGCTTGGCGAGCGGCGCAGCCGGGAATAGGGTGACCCAGAGACACAT
ACGCCCAAGGGAGTACCGCC

Downstream 100 bases:

>100_bases
GGCCGGCTTCGCGAAACCTGCTGCAATCCCATACAAACTTGAATTTAAGGTGCCAGAGTAATGAGCTTTGTACTGACTGA
AGACCAGGAAATGCTGCGCG

Product: acyl-CoA dehydrogenase family protein

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 404; Mature: 403

Protein sequence:

>404_residues
MAYDNAEQLEEFRLEARKWLEDNCPPSMRTPMRDDEVVWGGRNATFKNPDSKAWLDRMGEKGWTAPEWPKEYGGGGLSRS
EARVLEQEMRRIKARPPLFSFGLWMFGPALLEFGNHEQKLRFIPDIVKGKTRWCQGYSEPGAGSDLAGLQTRCEDKGDHY
LINGQKVWTSYADKADWIFCLVRTDTSTKHEGISFILFDMKSPGVEARPIQLISGESPFCETFFTDVKVPKEQLVGRVNG
GWDIAKRLLQFERSSISAGGFGGTGGSGILGPDEYAKHHVGTDETGRVADGDLRGRIADHKMYTKAFALTVQRQTEQAKA
GQAVGHTASILKYAAAKMNQDRHELLIEALGTEGLGWEGEGFDKGAMRVTRQWLRSKGNSIEGGTSEINLNVIAKRVLGL
KEHQ

Sequences:

>Translated_404_residues
MAYDNAEQLEEFRLEARKWLEDNCPPSMRTPMRDDEVVWGGRNATFKNPDSKAWLDRMGEKGWTAPEWPKEYGGGGLSRS
EARVLEQEMRRIKARPPLFSFGLWMFGPALLEFGNHEQKLRFIPDIVKGKTRWCQGYSEPGAGSDLAGLQTRCEDKGDHY
LINGQKVWTSYADKADWIFCLVRTDTSTKHEGISFILFDMKSPGVEARPIQLISGESPFCETFFTDVKVPKEQLVGRVNG
GWDIAKRLLQFERSSISAGGFGGTGGSGILGPDEYAKHHVGTDETGRVADGDLRGRIADHKMYTKAFALTVQRQTEQAKA
GQAVGHTASILKYAAAKMNQDRHELLIEALGTEGLGWEGEGFDKGAMRVTRQWLRSKGNSIEGGTSEINLNVIAKRVLGL
KEHQ
>Mature_403_residues
AYDNAEQLEEFRLEARKWLEDNCPPSMRTPMRDDEVVWGGRNATFKNPDSKAWLDRMGEKGWTAPEWPKEYGGGGLSRSE
ARVLEQEMRRIKARPPLFSFGLWMFGPALLEFGNHEQKLRFIPDIVKGKTRWCQGYSEPGAGSDLAGLQTRCEDKGDHYL
INGQKVWTSYADKADWIFCLVRTDTSTKHEGISFILFDMKSPGVEARPIQLISGESPFCETFFTDVKVPKEQLVGRVNGG
WDIAKRLLQFERSSISAGGFGGTGGSGILGPDEYAKHHVGTDETGRVADGDLRGRIADHKMYTKAFALTVQRQTEQAKAG
QAVGHTASILKYAAAKMNQDRHELLIEALGTEGLGWEGEGFDKGAMRVTRQWLRSKGNSIEGGTSEINLNVIAKRVLGLK
EHQ

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501859, Length=352, Percent_Identity=27.5568181818182, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI187960098, Length=404, Percent_Identity=25, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI4557231, Length=404, Percent_Identity=25, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI226958412, Length=263, Percent_Identity=26.9961977186312, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI4557233, Length=356, Percent_Identity=26.123595505618, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI226958414, Length=214, Percent_Identity=29.9065420560748, Blast_Score=96, Evalue=8e-20,
Organism=Homo sapiens, GI7656849, Length=261, Percent_Identity=26.4367816091954, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI4501857, Length=396, Percent_Identity=23.2323232323232, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI21361497, Length=225, Percent_Identity=26.6666666666667, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI76496475, Length=255, Percent_Identity=27.0588235294118, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI4557235, Length=235, Percent_Identity=27.6595744680851, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1786223, Length=347, Percent_Identity=21.3256484149856, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17569725, Length=355, Percent_Identity=27.0422535211268, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17508101, Length=343, Percent_Identity=27.1137026239067, Blast_Score=101, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17538396, Length=350, Percent_Identity=25.4285714285714, Blast_Score=100, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI17570075, Length=409, Percent_Identity=25.6723716381418, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17506239, Length=348, Percent_Identity=27.2988505747126, Blast_Score=95, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17534899, Length=267, Percent_Identity=25.8426966292135, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17505929, Length=209, Percent_Identity=28.7081339712919, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI32563615, Length=200, Percent_Identity=30, Blast_Score=85, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17551932, Length=200, Percent_Identity=29, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71990804, Length=215, Percent_Identity=26.046511627907, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71985184, Length=242, Percent_Identity=30.9917355371901, Blast_Score=79, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI71985192, Length=242, Percent_Identity=30.9917355371901, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17533517, Length=217, Percent_Identity=27.6497695852535, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71982178, Length=206, Percent_Identity=27.1844660194175, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI21356377, Length=347, Percent_Identity=27.9538904899135, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI21355753, Length=359, Percent_Identity=26.4623955431755, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24666513, Length=211, Percent_Identity=28.9099526066351, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24646207, Length=344, Percent_Identity=25.8720930232558, Blast_Score=88, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24660351, Length=160, Percent_Identity=33.75, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI19920834, Length=178, Percent_Identity=31.4606741573034, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI281363737, Length=238, Percent_Identity=25.6302521008403, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 45059; Mature: 44928

Theoretical pI: Translated: 7.27; Mature: 7.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYDNAEQLEEFRLEARKWLEDNCPPSMRTPMRDDEVVWGGRNATFKNPDSKAWLDRMGE
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHCC
KGWTAPEWPKEYGGGGLSRSEARVLEQEMRRIKARPPLFSFGLWMFGPALLEFGNHEQKL
CCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHH
RFIPDIVKGKTRWCQGYSEPGAGSDLAGLQTRCEDKGDHYLINGQKVWTSYADKADWIFC
HHHHHHHCCCHHHHCCCCCCCCCCCHHHHHHHHCCCCCEEEECCHHHHHHHCCCCCEEEE
LVRTDTSTKHEGISFILFDMKSPGVEARPIQLISGESPFCETFFTDVKVPKEQLVGRVNG
EEECCCCCCCCCEEEEEEECCCCCCCCCCEEEECCCCCHHHHHHHHCCCCHHHHHCCCCC
GWDIAKRLLQFERSSISAGGFGGTGGSGILGPDEYAKHHVGTDETGRVADGDLRGRIADH
CHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCHHHCCHHHH
KMYTKAFALTVQRQTEQAKAGQAVGHTASILKYAAAKMNQDRHELLIEALGTEGLGWEGE
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCC
GFDKGAMRVTRQWLRSKGNSIEGGTSEINLNVIAKRVLGLKEHQ
CCCHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AYDNAEQLEEFRLEARKWLEDNCPPSMRTPMRDDEVVWGGRNATFKNPDSKAWLDRMGE
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHCC
KGWTAPEWPKEYGGGGLSRSEARVLEQEMRRIKARPPLFSFGLWMFGPALLEFGNHEQKL
CCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHH
RFIPDIVKGKTRWCQGYSEPGAGSDLAGLQTRCEDKGDHYLINGQKVWTSYADKADWIFC
HHHHHHHCCCHHHHCCCCCCCCCCCHHHHHHHHCCCCCEEEECCHHHHHHHCCCCCEEEE
LVRTDTSTKHEGISFILFDMKSPGVEARPIQLISGESPFCETFFTDVKVPKEQLVGRVNG
EEECCCCCCCCCEEEEEEECCCCCCCCCCEEEECCCCCHHHHHHHHCCCCHHHHHCCCCC
GWDIAKRLLQFERSSISAGGFGGTGGSGILGPDEYAKHHVGTDETGRVADGDLRGRIADH
CHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCHHHCCHHHH
KMYTKAFALTVQRQTEQAKAGQAVGHTASILKYAAAKMNQDRHELLIEALGTEGLGWEGE
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCC
GFDKGAMRVTRQWLRSKGNSIEGGTSEINLNVIAKRVLGLKEHQ
CCCHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]