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The map label for this gene is murC

Identifier: 114797447

GI number: 114797447

Start: 3190739

End: 3192163

Strand: Reverse

Name: murC

Synonym: HNE_3022

Alternate gene names: 114797447

Gene position: 3192163-3190739 (Counterclockwise)

Preceding gene: 114798779

Following gene: 114799959

Centisome position: 86.16

GC content: 61.68

Gene sequence:

>1425_bases
ATGACGACCCCCACACCCTTTCCTGTTGGCCCTGCCCATATAGTCGGCATTGGCGGCATCGGTATGTCTGGCATTGCCGA
CGTCATGCTCACCATGGGTTATGAGGTTCAGGGCTCGGATGTTTCTGACAGCGCCAATGTCGAGCGCCTGCGCGCGCGCG
GCGTGAAAGTGTTCATCGGGCACAAGCCTGAGAATGTGGTGGGCGCCGGCACGGTCATCATTTCTACCGCCATCCGGCGG
GACAATCCCGAAGTTCAGGCTGCGCGCGCGGCAGGCATTCCCGTCGTGCGCCGGGCCAACATGCTGGCGGAAATCACGCG
CCTCAAATACACCGTGTGCGTCGCGGGCACGCATGGCAAGACAACCACGACCTCGCTTGTCGCCTGCCTGCTGGATGGCG
CGGGCATTGATCCGACGGTGATCAATGGCGGCATCATTCATGCTTATGGCTCGAACTACAAAGCGGGCGAAAGCGATTGG
ATGGTGGTCGAAAGTGATGAGAGCGATGGTACGTTCGCTAAGCTCCACCCGACCTGTGCCATCGTCACCAATATCGACCC
CGAGCACATGGACCATTACGGCACCATGGATAAGCTGCGCGAAGCGTTCGATACGTTCGTTGAAAATCTGCCTTTCTATG
GATTCGCCGTTCTGTGCACGGATCATCCGGAAGTGCAGGCGCTGGCCGCCCGCGTGACTGATCGTCGCCGCATCACCTAT
GGCTTCAACCTCCAGGCCGATGTGCGCGCCGTCAATCTGAGTACTGATCTCAAGGGCGCGCATTTCGATGTCGAAATCCG
CCGGGGGGCGGGCGAGGCGCCGCGCCGTATCGAGGGGCTGACGCTTCCGATGGCAGGGGAGCATAATGTCCAGAACGCAC
TGGCCGCTATCACCGTGGCATTGGAACTCGGCGCGAGTGACGAGCAGATCAGCGCGTCGCTGGCGAGTTTTGGCGGCGTG
AAGCGGCGCTTTACACCCGTGGGCGAATGGCTGCCGGCTGCCGGCGGCGAGCCGGTCAAGATTATCGATGATTATGGCCA
TCACCCGGTGGAGATTGCCGCCGTGCTGAAAGCGGCCCGCGCGATGCAGGCCGACCGCACAGTGATCGCTGTTTGCCAGC
CTCACCGCTATTCGCGCCTGAAAGACCTGTTTGAAGACTTCTCCCGCTGTTTTGACCAGGCTGACCATGTGCTGGTCGCG
CCGGTGTATGAAGCAGGCGAGACGCCGATTCCCGGTATTACCCATGAGACCCTTGTCCGCTCGATCCAGCGTAACGGTCA
TCGCAGCGCCCGCGCGCTGCCATCGCTGGCTGAGCTTCCAGAGGTGGTGAAGACGCTGGCAGGGCCGGGCGCGATGGTGG
TCTGCCTCGGGGCAGGGGACATTACCCGTTATGCCGGAGAGCTTGAGGCCAGGCTCAAGGGCTGA

Upstream 100 bases:

>100_bases
GGGCCGGTTGGCGCTGATCATTGGTGTGATGCTGCTGGTTGCGATCGTCGGCCTGTTCATGTCTCTGACGCGGCGAACGA
TGTAGGATTCAAGGTTTCCC

Downstream 100 bases:

>100_bases
CGCAAGGTCACAGACAAAACCACCTTCCGCTTTATGGATTAGCGTCTAGTCTCGCCAAACAGACGCGCGGGCACACGCGC
CGGGAGGATGCGAATGGCTC

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 474; Mature: 473

Protein sequence:

>474_residues
MTTPTPFPVGPAHIVGIGGIGMSGIADVMLTMGYEVQGSDVSDSANVERLRARGVKVFIGHKPENVVGAGTVIISTAIRR
DNPEVQAARAAGIPVVRRANMLAEITRLKYTVCVAGTHGKTTTTSLVACLLDGAGIDPTVINGGIIHAYGSNYKAGESDW
MVVESDESDGTFAKLHPTCAIVTNIDPEHMDHYGTMDKLREAFDTFVENLPFYGFAVLCTDHPEVQALAARVTDRRRITY
GFNLQADVRAVNLSTDLKGAHFDVEIRRGAGEAPRRIEGLTLPMAGEHNVQNALAAITVALELGASDEQISASLASFGGV
KRRFTPVGEWLPAAGGEPVKIIDDYGHHPVEIAAVLKAARAMQADRTVIAVCQPHRYSRLKDLFEDFSRCFDQADHVLVA
PVYEAGETPIPGITHETLVRSIQRNGHRSARALPSLAELPEVVKTLAGPGAMVVCLGAGDITRYAGELEARLKG

Sequences:

>Translated_474_residues
MTTPTPFPVGPAHIVGIGGIGMSGIADVMLTMGYEVQGSDVSDSANVERLRARGVKVFIGHKPENVVGAGTVIISTAIRR
DNPEVQAARAAGIPVVRRANMLAEITRLKYTVCVAGTHGKTTTTSLVACLLDGAGIDPTVINGGIIHAYGSNYKAGESDW
MVVESDESDGTFAKLHPTCAIVTNIDPEHMDHYGTMDKLREAFDTFVENLPFYGFAVLCTDHPEVQALAARVTDRRRITY
GFNLQADVRAVNLSTDLKGAHFDVEIRRGAGEAPRRIEGLTLPMAGEHNVQNALAAITVALELGASDEQISASLASFGGV
KRRFTPVGEWLPAAGGEPVKIIDDYGHHPVEIAAVLKAARAMQADRTVIAVCQPHRYSRLKDLFEDFSRCFDQADHVLVA
PVYEAGETPIPGITHETLVRSIQRNGHRSARALPSLAELPEVVKTLAGPGAMVVCLGAGDITRYAGELEARLKG
>Mature_473_residues
TTPTPFPVGPAHIVGIGGIGMSGIADVMLTMGYEVQGSDVSDSANVERLRARGVKVFIGHKPENVVGAGTVIISTAIRRD
NPEVQAARAAGIPVVRRANMLAEITRLKYTVCVAGTHGKTTTTSLVACLLDGAGIDPTVINGGIIHAYGSNYKAGESDWM
VVESDESDGTFAKLHPTCAIVTNIDPEHMDHYGTMDKLREAFDTFVENLPFYGFAVLCTDHPEVQALAARVTDRRRITYG
FNLQADVRAVNLSTDLKGAHFDVEIRRGAGEAPRRIEGLTLPMAGEHNVQNALAAITVALELGASDEQISASLASFGGVK
RRFTPVGEWLPAAGGEPVKIIDDYGHHPVEIAAVLKAARAMQADRTVIAVCQPHRYSRLKDLFEDFSRCFDQADHVLVAP
VYEAGETPIPGITHETLVRSIQRNGHRSARALPSLAELPEVVKTLAGPGAMVVCLGAGDITRYAGELEARLKG

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=466, Percent_Identity=42.4892703862661, Blast_Score=317, Evalue=7e-88,
Organism=Escherichia coli, GI1790680, Length=465, Percent_Identity=28.6021505376344, Blast_Score=135, Evalue=5e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_HYPNA (Q0BXU4)

Other databases:

- EMBL:   CP000158
- RefSeq:   YP_761699.1
- ProteinModelPortal:   Q0BXU4
- SMR:   Q0BXU4
- STRING:   Q0BXU4
- GeneID:   4288567
- GenomeReviews:   CP000158_GR
- KEGG:   hne:HNE_3022
- NMPDR:   fig|228405.5.peg.2897
- TIGR:   HNE_3022
- eggNOG:   COG0773
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- PhylomeDB:   Q0BXU4
- ProtClustDB:   PRK00421
- BioCyc:   HNEP81032:HNE_3022-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 50685; Mature: 50554

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPTPFPVGPAHIVGIGGIGMSGIADVMLTMGYEVQGSDVSDSANVERLRARGVKVFIG
CCCCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHCCEEEEEC
HKPENVVGAGTVIISTAIRRDNPEVQAARAAGIPVVRRANMLAEITRLKYTVCVAGTHGK
CCCCCCCCCCCEEEEHHHHCCCCCHHHHHHCCCCHHHHHHHHHHHHHEEEEEEEECCCCC
TTTTSLVACLLDGAGIDPTVINGGIIHAYGSNYKAGESDWMVVESDESDGTFAKLHPTCA
CHHHHHHHHHHCCCCCCCEEECCCEEEECCCCCCCCCCCEEEEECCCCCCCEEEECCEEE
IVTNIDPEHMDHYGTMDKLREAFDTFVENLPFYGFAVLCTDHPEVQALAARVTDRRRITY
EEECCCHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHCCCEEEEE
GFNLQADVRAVNLSTDLKGAHFDVEIRRGAGEAPRRIEGLTLPMAGEHNVQNALAAITVA
ECCCEECEEEEEECCCCCCCEEEEEEECCCCCCCCHHCCEECCCCCCCCHHHHHHHHHEE
LELGASDEQISASLASFGGVKRRFTPVGEWLPAAGGEPVKIIDDYGHHPVEIAAVLKAAR
EECCCCHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHH
AMQADRTVIAVCQPHRYSRLKDLFEDFSRCFDQADHVLVAPVYEAGETPIPGITHETLVR
HHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCEEEEEEHHCCCCCCCCCCHHHHHH
SIQRNGHRSARALPSLAELPEVVKTLAGPGAMVVCLGAGDITRYAGELEARLKG
HHHHCCCHHHHHCCCHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TTPTPFPVGPAHIVGIGGIGMSGIADVMLTMGYEVQGSDVSDSANVERLRARGVKVFIG
CCCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHCCEEEEEC
HKPENVVGAGTVIISTAIRRDNPEVQAARAAGIPVVRRANMLAEITRLKYTVCVAGTHGK
CCCCCCCCCCCEEEEHHHHCCCCCHHHHHHCCCCHHHHHHHHHHHHHEEEEEEEECCCCC
TTTTSLVACLLDGAGIDPTVINGGIIHAYGSNYKAGESDWMVVESDESDGTFAKLHPTCA
CHHHHHHHHHHCCCCCCCEEECCCEEEECCCCCCCCCCCEEEEECCCCCCCEEEECCEEE
IVTNIDPEHMDHYGTMDKLREAFDTFVENLPFYGFAVLCTDHPEVQALAARVTDRRRITY
EEECCCHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHCCCEEEEE
GFNLQADVRAVNLSTDLKGAHFDVEIRRGAGEAPRRIEGLTLPMAGEHNVQNALAAITVA
ECCCEECEEEEEECCCCCCCEEEEEEECCCCCCCCHHCCEECCCCCCCCHHHHHHHHHEE
LELGASDEQISASLASFGGVKRRFTPVGEWLPAAGGEPVKIIDDYGHHPVEIAAVLKAAR
EECCCCHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHH
AMQADRTVIAVCQPHRYSRLKDLFEDFSRCFDQADHVLVAPVYEAGETPIPGITHETLVR
HHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCEEEEEEHHCCCCCCCCCCHHHHHH
SIQRNGHRSARALPSLAELPEVVKTLAGPGAMVVCLGAGDITRYAGELEARLKG
HHHHCCCHHHHHCCCHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA