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The map label for this gene is fixR [H]

Identifier: 114797330

GI number: 114797330

Start: 467159

End: 467911

Strand: Direct

Name: fixR [H]

Synonym: HNE_0474

Alternate gene names: 114797330

Gene position: 467159-467911 (Clockwise)

Preceding gene: 114800182

Following gene: 114799707

Centisome position: 12.61

GC content: 66.4

Gene sequence:

>753_bases
ATGACCCCCAAAGGCGCGCTGGTGACGGGGGCAGGCGGACGCCTTGGCCGGGCCATGGCGCAGGCGCTGGGCGCCGATGG
CTGGGCGGTGGCGGTGCATTACCGCGACTCTGCCGACGGCGCGGAGGAAACGGCGGCCCAAATCCGGGCCGCAGGCGGAC
AGGCCGACATCATCGGCTGTGACCTGTCAGACGAGGGACAACGGGGGACACTTCTGGGACAAACCAGGACACTTCTGGAC
ACGCCCGTGACACTGCTGGTCAATTCCGCCTCCACCTTTACCGGCGACAGCACCCTTGGTCACACACGGGAGGATTGGGA
CCATCACTTCGAGCCCAACCTTCGCGCGCCGGTGCACCTGGCCCAGCAGCTGGCGGCAGACCTGCCGGAGGGAGAGCGCG
GGCTTGTGGTCAATCTGATTGACCAGAAGGTGCTGAAGCTCAATCCGCTGTTCTTCACTTATACGCTCTCCAAGGCGGCG
CTGTGGCAGGCGACGCGGATGCTGGCGCAGGGGCTGGCGCCGAATGTGCGCGTCAACGCCATCGCGCCGGGACCGACGCT
GCCGAGCGTGCATCAGAGCCCGGAGCAGTTCGCGGCCGAGCAGGCGGCGACGCTGACCGGGGAGGGCAGCTCTCCCGACG
AGATCGTCAACGCGCTGCGCTATCTGATTTCTGCCTCCAGCGTGACCGGCCAGATGATTGCGTCTGATGGCGGGCAGCAT
CTGATGTGGCAGACGCCGGACACCCAATTTTGA

Upstream 100 bases:

>100_bases
GCCGGCTTCTGGGCGTGTTACTGCTGCTGATTTATGCGGCGTATATCTATGGGCTGGTGACGGGTACAAACCTGATGGCA
CTGGCGCAGATGGCGGGCCT

Downstream 100 bases:

>100_bases
AGGAACTCCTATGAACTTCTCTTCCGACACGGCGGCGCCGGCGCATCCTTCCGTGCTGGAGGCCATGGGGCGGGCCAATG
ACGGGGCGGAGGCGAGCTAT

Product: short chain dehydrogenase/reductase family oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 250; Mature: 249

Protein sequence:

>250_residues
MTPKGALVTGAGGRLGRAMAQALGADGWAVAVHYRDSADGAEETAAQIRAAGGQADIIGCDLSDEGQRGTLLGQTRTLLD
TPVTLLVNSASTFTGDSTLGHTREDWDHHFEPNLRAPVHLAQQLAADLPEGERGLVVNLIDQKVLKLNPLFFTYTLSKAA
LWQATRMLAQGLAPNVRVNAIAPGPTLPSVHQSPEQFAAEQAATLTGEGSSPDEIVNALRYLISASSVTGQMIASDGGQH
LMWQTPDTQF

Sequences:

>Translated_250_residues
MTPKGALVTGAGGRLGRAMAQALGADGWAVAVHYRDSADGAEETAAQIRAAGGQADIIGCDLSDEGQRGTLLGQTRTLLD
TPVTLLVNSASTFTGDSTLGHTREDWDHHFEPNLRAPVHLAQQLAADLPEGERGLVVNLIDQKVLKLNPLFFTYTLSKAA
LWQATRMLAQGLAPNVRVNAIAPGPTLPSVHQSPEQFAAEQAATLTGEGSSPDEIVNALRYLISASSVTGQMIASDGGQH
LMWQTPDTQF
>Mature_249_residues
TPKGALVTGAGGRLGRAMAQALGADGWAVAVHYRDSADGAEETAAQIRAAGGQADIIGCDLSDEGQRGTLLGQTRTLLDT
PVTLLVNSASTFTGDSTLGHTREDWDHHFEPNLRAPVHLAQQLAADLPEGERGLVVNLIDQKVLKLNPLFFTYTLSKAAL
WQATRMLAQGLAPNVRVNAIAPGPTLPSVHQSPEQFAAEQAATLTGEGSSPDEIVNALRYLISASSVTGQMIASDGGQHL
MWQTPDTQF

Specific function: Unknown

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI7705925, Length=243, Percent_Identity=31.2757201646091, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI32483357, Length=244, Percent_Identity=27.8688524590164, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI2367175, Length=245, Percent_Identity=28.9795918367347, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1787905, Length=241, Percent_Identity=30.2904564315353, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787891, Length=252, Percent_Identity=27.7777777777778, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1789378, Length=246, Percent_Identity=26.8292682926829, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1789208, Length=250, Percent_Identity=28, Blast_Score=61, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI71994604, Length=253, Percent_Identity=29.6442687747036, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17562906, Length=262, Percent_Identity=29.7709923664122, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17562910, Length=269, Percent_Identity=27.1375464684015, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI71994600, Length=262, Percent_Identity=29.7709923664122, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562990, Length=274, Percent_Identity=29.9270072992701, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI193204405, Length=271, Percent_Identity=29.1512915129151, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17560676, Length=256, Percent_Identity=28.90625, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17538486, Length=270, Percent_Identity=28.1481481481481, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI115534694, Length=246, Percent_Identity=27.2357723577236, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17562908, Length=261, Percent_Identity=28.3524904214559, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI25147288, Length=241, Percent_Identity=31.1203319502075, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17531453, Length=268, Percent_Identity=27.6119402985075, Blast_Score=64, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17538480, Length=266, Percent_Identity=25.5639097744361, Blast_Score=64, Evalue=9e-11,
Organism=Drosophila melanogaster, GI23397609, Length=251, Percent_Identity=28.2868525896414, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28571526, Length=252, Percent_Identity=29.7619047619048, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24644339, Length=252, Percent_Identity=26.984126984127, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21355319, Length=242, Percent_Identity=25.2066115702479, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21357041, Length=252, Percent_Identity=28.1746031746032, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 26388; Mature: 26257

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPKGALVTGAGGRLGRAMAQALGADGWAVAVHYRDSADGAEETAAQIRAAGGQADIIGC
CCCCCCEEECCCCHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCEEEEEC
DLSDEGQRGTLLGQTRTLLDTPVTLLVNSASTFTGDSTLGHTREDWDHHFEPNLRAPVHL
CCCCCCCCCEECCCHHHHHHCCEEEEEECCCCCCCCCCCCCCHHHHHHCCCCCCCCHHHH
AQQLAADLPEGERGLVVNLIDQKVLKLNPLFFTYTLSKAALWQATRMLAQGLAPNVRVNA
HHHHHHCCCCCCCCEEEEEHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHCCCCCCEEEE
IAPGPTLPSVHQSPEQFAAEQAATLTGEGSSPDEIVNALRYLISASSVTGQMIASDGGQH
ECCCCCCCCCCCCHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHCCCCCHHHHCCCCCE
LMWQTPDTQF
EEECCCCCCC
>Mature Secondary Structure 
TPKGALVTGAGGRLGRAMAQALGADGWAVAVHYRDSADGAEETAAQIRAAGGQADIIGC
CCCCCEEECCCCHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCEEEEEC
DLSDEGQRGTLLGQTRTLLDTPVTLLVNSASTFTGDSTLGHTREDWDHHFEPNLRAPVHL
CCCCCCCCCEECCCHHHHHHCCEEEEEECCCCCCCCCCCCCCHHHHHHCCCCCCCCHHHH
AQQLAADLPEGERGLVVNLIDQKVLKLNPLFFTYTLSKAALWQATRMLAQGLAPNVRVNA
HHHHHHCCCCCCCCEEEEEHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHCCCCCCEEEE
IAPGPTLPSVHQSPEQFAAEQAATLTGEGSSPDEIVNALRYLISASSVTGQMIASDGGQH
ECCCCCCCCCCCCHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHCCCCCHHHHCCCCCE
LMWQTPDTQF
EEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3313281; 11157954; 12597275 [H]