Click here to switch to the map view.

The map label for this gene is meaA [H]

Identifier: 114797164

GI number: 114797164

Start: 3296520

End: 3298514

Strand: Reverse

Name: meaA [H]

Synonym: HNE_3115

Alternate gene names: 114797164

Gene position: 3298514-3296520 (Counterclockwise)

Preceding gene: 114799694

Following gene: 114797472

Centisome position: 89.03

GC content: 62.51

Gene sequence:

>1995_bases
ATGGCAAAAGCCACCAAAGAGTATCAGCACGAACCCGATGAGCCCTGGATCTTCCGCACCTATGCGGGCCATTCGACGGC
GAAGAAATCCAATGAACTCTATCGGCTGAACCTGTCGAAGGGGCAGACGGGGCTCTCCATCGCCTTCGACCTGCCGACCC
AGACGGCCTATGACGCCGACCATATCCTCAGCCGGGGCGAAGTCGGCAAGGTGGGCGTGCCGGTCAAGCATATGGGCGAC
ATGCGTGAGCTCTTCGCCGAGCTGCCGCTGGAGACGATGAACACCTCGATGACGATCAATGCGCCGGCGGCCTGGATGCT
GGCGCTGTATGTGGCGCTCGCCGATGAGCGGGGCGATGACCGCAAGAAGCTGCGCGGCACAACCCAGAACGACATCGTGA
AGGAATACCTCTCGCGCGGCACCTATGTGTTCCCGCCCGAGCCCTCGCTGCGCCTGATCGGCGATATGGTGAGCTGGTGC
TATCTGGAAGTTCCAAAATGGAACCCCATGAACGTTTGCTCCTATCACCTGCAGGAAGCGGGCGCGACACCGGAACAGGA
GTTGGCCTATGCGCTGGCGACCGCCATCGCCGTACTGGATACCGTGAAAGCGGGCGGGCAAGTTCCAGAATCAGACTTTG
AAACCGTGTTCGGGCGCATCTCCTTCTTTGTGAATGCCGGGGTGCGTTTCGTAACGGAACTTTGCAAGATGCGCGCTTTC
GTCGATCTCTGGGAAGAGATTGGCCGGGAGCGCTATGGTGTCACCGATCCCAAGGCGCTGCTGTTCCGCTATGGTGTGCA
GGTGAACTCGCTGGGGCTGACCGAGCCGCAGCCGGAAAACAATGTCTACCGCATCCTGATGGAAGCTCTTGCAGTGACGC
TGTCCAAGCGCGCCCGCTGCCGCGCTTTGCAGCTGCCCGCCTGGAACGAGGCGATGGGCCTGCCCCGCCCCTGGGACCAG
CAATGGTCGCTGCGCCTTCAGCAGATCCTCGCTTATGAGACCGACCTTCTGGAATTTGAAGACATCTTCGATGGCAGCCA
TGTCATCACGGCGAAGACCGAGGAACTCAAAGACAAGGCGCGCGCCGCGCTTGCGCAGATTGACGAGATCGGCGGCGCGC
AGGCGGCAATCCCGTTCATGAAGGAAAGTCTCGTCGGCGCGCATATCGACCGTATACGTGCAATTGAATCCGGCGCGCTC
ACCGTGGTGGGCGTCAACCGGTTCACCGAGACCGCAGAGAGCCCACTGGGTGGCGGCGACGGCGCGATCCAGACCGTTGA
TCCGGCCGAAGAGGCGATGCAGGTGCGCGATCTCAAAGCCTGGCGCGCTGCGCGGGACAACGGCGCAGCTGAATCCGCCC
TGGCAGAGCTGCGCGCGGCCGCCGCCGAGAACCGCAATATCATGGAGCCCTCGATCACCTGCGCCAAGGCAGGGGTGACG
ACCGGGGAATGGGGCACCGTGCTGCGCGAAGTGTTCGGCGAATTCCGCGCGCCAACTGGCGTTGCCCTCGTCGTTACAAG
CAGCGGCGAAGAAGATGTCGAGAAGGTGAAGGCAGAAGTGGCCCGCGTCTCGGAAGCTCTGGGCCGTACACTGACATATG
TGCTGGGCAAGCCCGGCCTGGATGGCCATTCCAACGGCGCCGAGCAGATCGCCGCTCGCGGGCGCGAGGTGGGCATGGAC
GTGGTCTATGAAGGCATCCGCTTTACGCCTGCCGAAATTGCCGCGCAGGCCAAGGAAGCCAAGGCGCATGTGGTCGGTCT
CTCTATCCTTTCGGGCAGCCATCTGGATCTCGTCCGCGAGACCGTGGCGGAGCTGCGCAAGCTCGGCCTCGAGAACGTGC
CGGTCGTCGTCGGCGGCATCATCCCGCCCGAAGATGGCCGCGCGCTGCGCCAGATGGGCGTGGCGGCCGTTTATACGCCC
AAGGATTTCCGTATCACGGAGATCATGGGCGATGTCACCCGCCTTGTTGAAAAAGCGTGGCTTGTGAAGGGATAA

Upstream 100 bases:

>100_bases
GCGTCTCGCCAGGCAGGCTGCAAGTGTGGCAGAGGGGATGCTTGTCAGGGATGCAGCGCTCGGTCATGTTGCGCCGCAGC
ATAGGGGAGGCCAGAAAACG

Downstream 100 bases:

>100_bases
CTCCAGAACTCTGTAGCTGGCCTTGCGGGGCGGGCAGAAAGCTGACTAACGGAGGCGAAGTCAGATGACGGAGCTCCTGC
GCCATGCCTTCTGCTGCCCC

Product: putative methylmalonyl-CoA mutase

Products: succinyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 664; Mature: 663

Protein sequence:

>664_residues
MAKATKEYQHEPDEPWIFRTYAGHSTAKKSNELYRLNLSKGQTGLSIAFDLPTQTAYDADHILSRGEVGKVGVPVKHMGD
MRELFAELPLETMNTSMTINAPAAWMLALYVALADERGDDRKKLRGTTQNDIVKEYLSRGTYVFPPEPSLRLIGDMVSWC
YLEVPKWNPMNVCSYHLQEAGATPEQELAYALATAIAVLDTVKAGGQVPESDFETVFGRISFFVNAGVRFVTELCKMRAF
VDLWEEIGRERYGVTDPKALLFRYGVQVNSLGLTEPQPENNVYRILMEALAVTLSKRARCRALQLPAWNEAMGLPRPWDQ
QWSLRLQQILAYETDLLEFEDIFDGSHVITAKTEELKDKARAALAQIDEIGGAQAAIPFMKESLVGAHIDRIRAIESGAL
TVVGVNRFTETAESPLGGGDGAIQTVDPAEEAMQVRDLKAWRAARDNGAAESALAELRAAAAENRNIMEPSITCAKAGVT
TGEWGTVLREVFGEFRAPTGVALVVTSSGEEDVEKVKAEVARVSEALGRTLTYVLGKPGLDGHSNGAEQIAARGREVGMD
VVYEGIRFTPAEIAAQAKEAKAHVVGLSILSGSHLDLVRETVAELRKLGLENVPVVVGGIIPPEDGRALRQMGVAAVYTP
KDFRITEIMGDVTRLVEKAWLVKG

Sequences:

>Translated_664_residues
MAKATKEYQHEPDEPWIFRTYAGHSTAKKSNELYRLNLSKGQTGLSIAFDLPTQTAYDADHILSRGEVGKVGVPVKHMGD
MRELFAELPLETMNTSMTINAPAAWMLALYVALADERGDDRKKLRGTTQNDIVKEYLSRGTYVFPPEPSLRLIGDMVSWC
YLEVPKWNPMNVCSYHLQEAGATPEQELAYALATAIAVLDTVKAGGQVPESDFETVFGRISFFVNAGVRFVTELCKMRAF
VDLWEEIGRERYGVTDPKALLFRYGVQVNSLGLTEPQPENNVYRILMEALAVTLSKRARCRALQLPAWNEAMGLPRPWDQ
QWSLRLQQILAYETDLLEFEDIFDGSHVITAKTEELKDKARAALAQIDEIGGAQAAIPFMKESLVGAHIDRIRAIESGAL
TVVGVNRFTETAESPLGGGDGAIQTVDPAEEAMQVRDLKAWRAARDNGAAESALAELRAAAAENRNIMEPSITCAKAGVT
TGEWGTVLREVFGEFRAPTGVALVVTSSGEEDVEKVKAEVARVSEALGRTLTYVLGKPGLDGHSNGAEQIAARGREVGMD
VVYEGIRFTPAEIAAQAKEAKAHVVGLSILSGSHLDLVRETVAELRKLGLENVPVVVGGIIPPEDGRALRQMGVAAVYTP
KDFRITEIMGDVTRLVEKAWLVKG
>Mature_663_residues
AKATKEYQHEPDEPWIFRTYAGHSTAKKSNELYRLNLSKGQTGLSIAFDLPTQTAYDADHILSRGEVGKVGVPVKHMGDM
RELFAELPLETMNTSMTINAPAAWMLALYVALADERGDDRKKLRGTTQNDIVKEYLSRGTYVFPPEPSLRLIGDMVSWCY
LEVPKWNPMNVCSYHLQEAGATPEQELAYALATAIAVLDTVKAGGQVPESDFETVFGRISFFVNAGVRFVTELCKMRAFV
DLWEEIGRERYGVTDPKALLFRYGVQVNSLGLTEPQPENNVYRILMEALAVTLSKRARCRALQLPAWNEAMGLPRPWDQQ
WSLRLQQILAYETDLLEFEDIFDGSHVITAKTEELKDKARAALAQIDEIGGAQAAIPFMKESLVGAHIDRIRAIESGALT
VVGVNRFTETAESPLGGGDGAIQTVDPAEEAMQVRDLKAWRAARDNGAAESALAELRAAAAENRNIMEPSITCAKAGVTT
GEWGTVLREVFGEFRAPTGVALVVTSSGEEDVEKVKAEVARVSEALGRTLTYVLGKPGLDGHSNGAEQIAARGREVGMDV
VYEGIRFTPAEIAAQAKEAKAHVVGLSILSGSHLDLVRETVAELRKLGLENVPVVVGGIIPPEDGRALRQMGVAAVYTPK
DFRITEIMGDVTRLVEKAWLVKG

Specific function: Required for the assimilation of methanol and ethanol [H]

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=658, Percent_Identity=34.1945288753799, Blast_Score=361, Evalue=1e-99,
Organism=Escherichia coli, GI1789284, Length=636, Percent_Identity=37.4213836477987, Blast_Score=384, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI25144500, Length=632, Percent_Identity=35.9177215189873, Blast_Score=377, Evalue=1e-104,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: 5.4.99.2

Molecular weight: Translated: 72701; Mature: 72570

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKATKEYQHEPDEPWIFRTYAGHSTAKKSNELYRLNLSKGQTGLSIAFDLPTQTAYDAD
CCCCCCHHCCCCCCCEEEEEECCCCHHHCCCCEEEEECCCCCCCEEEEEECCCCCCCCHH
HILSRGEVGKVGVPVKHMGDMRELFAELPLETMNTSMTINAPAAWMLALYVALADERGDD
HHHCCCCCCCCCCCHHHHHHHHHHHHHCCHHHCCCCEEECCCHHHHHHHHHHHHCCCCCC
RKKLRGTTQNDIVKEYLSRGTYVFPPEPSLRLIGDMVSWCYLEVPKWNPMNVCSYHLQEA
HHHHCCCCHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHC
GATPEQELAYALATAIAVLDTVKAGGQVPESDFETVFGRISFFVNAGVRFVTELCKMRAF
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VDLWEEIGRERYGVTDPKALLFRYGVQVNSLGLTEPQPENNVYRILMEALAVTLSKRARC
HHHHHHHCHHHCCCCCHHHHHHHHCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
RALQLPAWNEAMGLPRPWDQQWSLRLQQILAYETDLLEFEDIFDGSHVITAKTEELKDKA
CEECCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHH
RAALAQIDEIGGAQAAIPFMKESLVGAHIDRIRAIESGALTVVGVNRFTETAESPLGGGD
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHCCCCCCCC
GAIQTVDPAEEAMQVRDLKAWRAARDNGAAESALAELRAAAAENRNIMEPSITCAKAGVT
CCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCC
TGEWGTVLREVFGEFRAPTGVALVVTSSGEEDVEKVKAEVARVSEALGRTLTYVLGKPGL
CCHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DGHSNGAEQIAARGREVGMDVVYEGIRFTPAEIAAQAKEAKAHVVGLSILSGSHLDLVRE
CCCCCCHHHHHHCHHHCCHHHHHHCCCCCHHHHHHHHHHHHHHEEEEEEECCCHHHHHHH
TVAELRKLGLENVPVVVGGIIPPEDGRALRQMGVAAVYTPKDFRITEIMGDVTRLVEKAW
HHHHHHHCCCCCCCEEEECCCCCCCCHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHH
LVKG
HCCC
>Mature Secondary Structure 
AKATKEYQHEPDEPWIFRTYAGHSTAKKSNELYRLNLSKGQTGLSIAFDLPTQTAYDAD
CCCCCHHCCCCCCCEEEEEECCCCHHHCCCCEEEEECCCCCCCEEEEEECCCCCCCCHH
HILSRGEVGKVGVPVKHMGDMRELFAELPLETMNTSMTINAPAAWMLALYVALADERGDD
HHHCCCCCCCCCCCHHHHHHHHHHHHHCCHHHCCCCEEECCCHHHHHHHHHHHHCCCCCC
RKKLRGTTQNDIVKEYLSRGTYVFPPEPSLRLIGDMVSWCYLEVPKWNPMNVCSYHLQEA
HHHHCCCCHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHC
GATPEQELAYALATAIAVLDTVKAGGQVPESDFETVFGRISFFVNAGVRFVTELCKMRAF
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VDLWEEIGRERYGVTDPKALLFRYGVQVNSLGLTEPQPENNVYRILMEALAVTLSKRARC
HHHHHHHCHHHCCCCCHHHHHHHHCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
RALQLPAWNEAMGLPRPWDQQWSLRLQQILAYETDLLEFEDIFDGSHVITAKTEELKDKA
CEECCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHH
RAALAQIDEIGGAQAAIPFMKESLVGAHIDRIRAIESGALTVVGVNRFTETAESPLGGGD
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHCCCCCCCC
GAIQTVDPAEEAMQVRDLKAWRAARDNGAAESALAELRAAAAENRNIMEPSITCAKAGVT
CCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCC
TGEWGTVLREVFGEFRAPTGVALVVTSSGEEDVEKVKAEVARVSEALGRTLTYVLGKPGL
CCHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DGHSNGAEQIAARGREVGMDVVYEGIRFTPAEIAAQAKEAKAHVVGLSILSGSHLDLVRE
CCCCCCHHHHHHCHHHCCHHHHHHCCCCCHHHHHHHHHHHHHHEEEEEEECCCHHHHHHH
TVAELRKLGLENVPVVVGGIIPPEDGRALRQMGVAAVYTPKDFRITEIMGDVTRLVEKAW
HHHHHHHCCCCCCCEEEECCCCCCCCHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHH
LVKG
HCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (R)-methylmalonyl-CoA

Specific reaction: (R)-methylmalonyl-CoA = succinyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8868443 [H]