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The map label for this gene is ffh [H]

Identifier: 114331694

GI number: 114331694

Start: 1810787

End: 1812136

Strand: Direct

Name: ffh [H]

Synonym: Neut_1710

Alternate gene names: 114331694

Gene position: 1810787-1812136 (Clockwise)

Preceding gene: 114331691

Following gene: 114331695

Centisome position: 68.05

GC content: 50.22

Gene sequence:

>1350_bases
ATGTTTAACAATTTAACCGAACGACTTTCCGGCGTCATCAAAACTCTGCGTGGTGAAGCACGCCTGACCGAAAGCAATAT
TCAGGAAGCCCTGCGTGAGGTGCGCATAGCCCTGATTGAGGCCGATGTCGCCCTGCCTGCAATTAAAGTATTTATTGAAC
AGGTCAAACAACGCGCCATTGGTCACGAAGTACTGGGTAAACTCTCTCCCGGACAGGCTTTCATCGGCGTTGTCCATGAA
GAGCTGATGGCCATCATGGGTGGAGACAAAGCGGATATCAATCTAAATGTTGCTCCACCTGCCGTCATTTTAATGGCAGG
CCTACAGGGTGCCGGCAAGACCACCAGCAGCGGCAAGCTGGCAAAGTGGCTGATGGAACAGAAAAAAAAGAAAGTGCTGC
TGGTATCCTGTGACATTTACCGCCCAGCCGCAATTGAACAACTGGCACTTCTGGCCGAGCAAACTGGAGCTGATTTTTTT
CCGGTAAAAACCGGCCAGCAACCAGCCGAAATCAGTACTGCTGCTCTAGACTTCGCACGCAAGCATCATCATGATGTAGT
AATCGTTGATACCGCTGGGCGACTGGGTATCGACGAAGCCATGATGCAAGAAATCAGCCAGCTGGAACAATTGCTGAATC
CGGTTGAGACACTGTTTGTTGTCGATGCCATGCAGGGACAGGATGCAGTCAATACCGCCCGGGCTTTTGCGGAAGTGTTG
CCACTGACCGGGGTGATTCTTACCAAACTTGATGGTGACGCACGCGGAGGGGCGGCACTGTCCGTCCGGCACATCACTGG
TAAGCCGATTAAATTTGCTGGTGTTGCTGAAAAACTTACCGGATTGGAGCCGTTTTATCCTGATCGCATGGCCTCGCGTA
TCCTGGGCATGGGGGATGTGCTCGGATTAATCGAGGAAGCACAACGCACCACTGATCAGCAAGAAGCAGAACGCTTGATG
AAAAAAATGAAATCAGGCAAAGGCTTCGATCTGAATGATTTCCAGCAGCAATTTCAGCAAATGAAAAAAATGGGGGGCAT
GAGTGCCATGCTGGATAAATTGCCGCACCAACTCAGTCAAGCCGCCCAGAACATGAATGTGGATGAGAAAGTTATCAATC
GTACCGAAGGCATTATCAACTCCATGACGCCTCAGGAACGAGCCAAACCGGAAATCATCAAAGCCTCCCGTAAACGCCGT
ATTGCTGCAGGTTCCGGTGCTTCTGTACAGGAAGTCAATCGTTTACTTACGCAGTTTGAGCAGGCACGCAAGATGATGAA
AATGATGAATAAGGGAGGAATGGCAAAAATGATGAGAGCAGTCAAGGGAATGCTCCCCGGTATGCGGTAG

Upstream 100 bases:

>100_bases
CCTTCGTCCGGATAAAGCTGAAGTGCTGTTTGACAGTTTCCATGAAGTTTAGCATAGGGAACAACTCTCACCGGCGGATA
CCGTTTCAACAGGAGCCTAC

Downstream 100 bases:

>100_bases
AACTGCGTGTTCAGTCCCGGATGATTGTATAGATAAAACTTGTTATCCGCTGTTCATGGCGCGAGCTGTCACGAGAGCGC
TGATTTCCTCAAACCATCCG

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MFNNLTERLSGVIKTLRGEARLTESNIQEALREVRIALIEADVALPAIKVFIEQVKQRAIGHEVLGKLSPGQAFIGVVHE
ELMAIMGGDKADINLNVAPPAVILMAGLQGAGKTTSSGKLAKWLMEQKKKKVLLVSCDIYRPAAIEQLALLAEQTGADFF
PVKTGQQPAEISTAALDFARKHHHDVVIVDTAGRLGIDEAMMQEISQLEQLLNPVETLFVVDAMQGQDAVNTARAFAEVL
PLTGVILTKLDGDARGGAALSVRHITGKPIKFAGVAEKLTGLEPFYPDRMASRILGMGDVLGLIEEAQRTTDQQEAERLM
KKMKSGKGFDLNDFQQQFQQMKKMGGMSAMLDKLPHQLSQAAQNMNVDEKVINRTEGIINSMTPQERAKPEIIKASRKRR
IAAGSGASVQEVNRLLTQFEQARKMMKMMNKGGMAKMMRAVKGMLPGMR

Sequences:

>Translated_449_residues
MFNNLTERLSGVIKTLRGEARLTESNIQEALREVRIALIEADVALPAIKVFIEQVKQRAIGHEVLGKLSPGQAFIGVVHE
ELMAIMGGDKADINLNVAPPAVILMAGLQGAGKTTSSGKLAKWLMEQKKKKVLLVSCDIYRPAAIEQLALLAEQTGADFF
PVKTGQQPAEISTAALDFARKHHHDVVIVDTAGRLGIDEAMMQEISQLEQLLNPVETLFVVDAMQGQDAVNTARAFAEVL
PLTGVILTKLDGDARGGAALSVRHITGKPIKFAGVAEKLTGLEPFYPDRMASRILGMGDVLGLIEEAQRTTDQQEAERLM
KKMKSGKGFDLNDFQQQFQQMKKMGGMSAMLDKLPHQLSQAAQNMNVDEKVINRTEGIINSMTPQERAKPEIIKASRKRR
IAAGSGASVQEVNRLLTQFEQARKMMKMMNKGGMAKMMRAVKGMLPGMR
>Mature_449_residues
MFNNLTERLSGVIKTLRGEARLTESNIQEALREVRIALIEADVALPAIKVFIEQVKQRAIGHEVLGKLSPGQAFIGVVHE
ELMAIMGGDKADINLNVAPPAVILMAGLQGAGKTTSSGKLAKWLMEQKKKKVLLVSCDIYRPAAIEQLALLAEQTGADFF
PVKTGQQPAEISTAALDFARKHHHDVVIVDTAGRLGIDEAMMQEISQLEQLLNPVETLFVVDAMQGQDAVNTARAFAEVL
PLTGVILTKLDGDARGGAALSVRHITGKPIKFAGVAEKLTGLEPFYPDRMASRILGMGDVLGLIEEAQRTTDQQEAERLM
KKMKSGKGFDLNDFQQQFQQMKKMGGMSAMLDKLPHQLSQAAQNMNVDEKVINRTEGIINSMTPQERAKPEIIKASRKRR
IAAGSGASVQEVNRLLTQFEQARKMMKMMNKGGMAKMMRAVKGMLPGMR

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=457, Percent_Identity=31.5098468271335, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI226371618, Length=354, Percent_Identity=34.4632768361582, Blast_Score=182, Evalue=7e-46,
Organism=Homo sapiens, GI23308697, Length=304, Percent_Identity=29.6052631578947, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI295424842, Length=304, Percent_Identity=29.6052631578947, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI89061728, Length=164, Percent_Identity=35.3658536585366, Blast_Score=103, Evalue=4e-22,
Organism=Escherichia coli, GI1788963, Length=448, Percent_Identity=63.1696428571429, Blast_Score=549, Evalue=1e-157,
Organism=Escherichia coli, GI1789874, Length=239, Percent_Identity=35.9832635983264, Blast_Score=145, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI17539958, Length=431, Percent_Identity=29.6983758700696, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI193206261, Length=304, Percent_Identity=30.9210526315789, Blast_Score=110, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6325345, Length=362, Percent_Identity=33.9779005524862, Blast_Score=182, Evalue=9e-47,
Organism=Saccharomyces cerevisiae, GI6320498, Length=311, Percent_Identity=26.3665594855305, Blast_Score=95, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17647949, Length=444, Percent_Identity=28.8288288288288, Blast_Score=178, Evalue=8e-45,
Organism=Drosophila melanogaster, GI24641198, Length=208, Percent_Identity=33.1730769230769, Blast_Score=112, Evalue=7e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 49105; Mature: 49105

Theoretical pI: Translated: 10.04; Mature: 10.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
6.0 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
6.0 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFNNLTERLSGVIKTLRGEARLTESNIQEALREVRIALIEADVALPAIKVFIEQVKQRAI
CCCHHHHHHHHHHHHHHCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GHEVLGKLSPGQAFIGVVHEELMAIMGGDKADINLNVAPPAVILMAGLQGAGKTTSSGKL
HHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHCCCCCCCCCCCHHH
AKWLMEQKKKKVLLVSCDIYRPAAIEQLALLAEQTGADFFPVKTGQQPAEISTAALDFAR
HHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHHHH
KHHHDVVIVDTAGRLGIDEAMMQEISQLEQLLNPVETLFVVDAMQGQDAVNTARAFAEVL
HHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
PLTGVILTKLDGDARGGAALSVRHITGKPIKFAGVAEKLTGLEPFYPDRMASRILGMGDV
HHHHHHHEECCCCCCCCCEEEEEECCCCCEEHHHHHHHHCCCCCCCHHHHHHHHHCHHHH
LGLIEEAQRTTDQQEAERLMKKMKSGKGFDLNDFQQQFQQMKKMGGMSAMLDKLPHQLSQ
HHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
AAQNMNVDEKVINRTEGIINSMTPQERAKPEIIKASRKRRIAAGSGASVQEVNRLLTQFE
HHHCCCCHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
QARKMMKMMNKGGMAKMMRAVKGMLPGMR
HHHHHHHHHCCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MFNNLTERLSGVIKTLRGEARLTESNIQEALREVRIALIEADVALPAIKVFIEQVKQRAI
CCCHHHHHHHHHHHHHHCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GHEVLGKLSPGQAFIGVVHEELMAIMGGDKADINLNVAPPAVILMAGLQGAGKTTSSGKL
HHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHCCCCCCCCCCCHHH
AKWLMEQKKKKVLLVSCDIYRPAAIEQLALLAEQTGADFFPVKTGQQPAEISTAALDFAR
HHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHHHH
KHHHDVVIVDTAGRLGIDEAMMQEISQLEQLLNPVETLFVVDAMQGQDAVNTARAFAEVL
HHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
PLTGVILTKLDGDARGGAALSVRHITGKPIKFAGVAEKLTGLEPFYPDRMASRILGMGDV
HHHHHHHEECCCCCCCCCEEEEEECCCCCEEHHHHHHHHCCCCCCCHHHHHHHHHCHHHH
LGLIEEAQRTTDQQEAERLMKKMKSGKGFDLNDFQQQFQQMKKMGGMSAMLDKLPHQLSQ
HHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
AAQNMNVDEKVINRTEGIINSMTPQERAKPEIIKASRKRRIAAGSGASVQEVNRLLTQFE
HHHCCCCHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
QARKMMKMMNKGGMAKMMRAVKGMLPGMR
HHHHHHHHHCCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]